6-Day Italy Self-Drive Road Trip With Itinerary from Pisa to Florence, Siena, and Lucca and surrounding area

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Experience the freedom of the open road in Italy as you embark on an unforgettable 6-day road trip! This experience caters to every traveler, featuring destinations like Pisa, Florence, Siena, San Gimignano, Lucca, Corniglia, Vernazza, and Manarola.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pisa, 1 night in Florence, 1 night in Siena, and 1 night in Lucca. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pisa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Cathedral Of Santa Maria Del Fiore.

As you hit the open road and drive through Pisa, Florence, Siena, San Gimignano, Lucca, Corniglia, Vernazza, and Manarola, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Knights' Square
Leaning Tower of PisaPiazza del Duomo, PisaPisa Cathedralpiazzale MichelangeloGalleria dell'AccademiaCathedral of Santa Maria del Fiore
piazza della SignoriaPonte VecchioUffizi GalleryBasilica of Santa Croce in FlorenceSiena Cathedralpiazza del Campo
Piazza del Duomo, San GimignanoPiazza dell'AnfiteatroGuinigi TowerSt Martin CathedralPorta San PietroWalls of Lucca
Scalinata LardarinaChiesa Di San PietroRuins of Doria TowerChurch of St. Margaret of AntiochCinque Terre National ParkManarola Overlook Viewpoint
Palazzo Blu

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Day 1

Day 1

  • Pisa - Arrival day
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  • Knights' Square
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Say hello to Pisa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Pisa for 1 night before you continue your adventure!

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pisa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pisa, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Anima di Grano Pizzeria Napoletana Pisa Italy, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider il Mercante, another top spot with a mouthwatering menu. You might also want to secure a reservation at La Ghiotteria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pisa this evening.

If you’re not ready to end the night just yet, Jeffer Cocktails & Friends offers a perfect venue to relax and savor a drink. Similarly, Le Parisien Wine Bar is well-suited for those looking to unwind in a social setting. Las Volta Cocktailbar is another excellent spot to enjoy a nightcap after a delightful meal.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Pisa
  • Florence
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Drive 96 km, 2 hours 2 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • piazzale Michelangelo
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Florence. In the evening, you’ll end up in Florence, where you will stay for 1 night.

Today’s route brings fun adventures, breathtaking views, and picturesque spots. The first attraction of today is Leaning Tower Of Pisa. This globally renowned monument is a picture-perfect place to see in Pisa. Continue your discovery at Piazza Del Duomo, Pisa, a breathtaking public square with stories to tell.

As you stroll around Pisa, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Pisa Cathedral. This locally appreciated church offers a breathtaking encounter with Pisa. Next, make your way to Piazzale Michelangelo to add another highlight to your day. After that, visit Galleria Dell'accademia, an interesting art gallery that’s sure to impress. If you’re up for more, end your self-guided sightseeing tour at Cathedral Of Santa Maria Del Fiore, an extraordinary church in the city. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Pisa.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Ristorante Oliviero 1962, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Di Poneta Novoli, another top spot with a mouthwatering menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

Unwind after your meal by stepping into Manifattura. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Se·sto On Arno Rooftop Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Il Vinile, another top-rated bar in the area.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Florence
  • Siena
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Drive 80 km, 1 hour 34 min

  • piazza della Signoria
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • Siena Cathedral
  • piazza del Campo
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Florence and Siena. When you’re not sightseeing, take time to relax at your selected hotel in Siena, where you’ll be staying for 1 night.

Today’s itinerary in Florence covers several incredible sights, including a public square, a historical landmark, an art gallery, a church and much more! Start your adventure at Piazza Della Signoria. This impressive public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the romantic wonders of Ponte Vecchio, a must-see historical landmark in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Uffizi Gallery. This astonishing art gallery offers an enriching experience. For a change of pace, head to Basilica Of Santa Croce In Florence, where you can take in culturally significant features. Conclude your self-guided sightseeing tour with a visit to Siena Cathedral and Piazza Del Campo. These sights offer a fulfilling end to a perfect day.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Enjoy a lovely dining experience at Enoteca I Terzi, a popular restaurant in Siena. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Siena at Ristorante Tar-Tufo, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Antica Trattoria Papei. It’s yet another ideal choice to enhance your time in Siena tonight.

Keep the evening going at Meet Life Cafè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Maudit Pub, which offers a similarly pleasant setting and great drinks. Another option is Bar Impero Siena, which provides an inviting environment for unwinding after a busy day out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Siena
  • Lucca
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Drive 126 km, 2 hours 52 min

  • Piazza del Duomo, San Gimignano
  • Piazza dell'Anfiteatro
  • Guinigi Tower
  • St Martin Cathedral
  • Porta San Pietro
  • Walls of Lucca
  • More

Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of San Gimignano and Lucca. At the end of the day, you will enjoy the comforts of a top-rated hotel in Lucca, which will be your home away from home for 1 night.

Set out on a day brimming with family-friendly attractions, romantic experiences, and scenic views. Start at the locally appreciated Piazza Del Duomo, a romantic public square in Siena. Next, go to Piazza Dell'anfiteatro.

After visiting Piazza Del Duomo and Piazza Dell'anfiteatro, have a stroll along Siena's streets and take in the local charm. Continue your sightseeing by heading to Guinigi Tower. This symbolic monument offers a unique experience. St Martin Cathedral is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Porta San Pietro, one of the most culturally significant places to visit in Siena. If you still have some time left for sightseeing, we also recommend stopping by Mura Di Lucca.

At the end of the day, you will drive to Lucca, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Lucca. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely meal at Gli Orti di Via Elisa, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Bar Caffè Ristretto is another top choice with a popular menu. You could also check for a table at Ristorante Schiaffino. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Lucca tonight.

Following your dinner, dive into the local bar culture at Lebowski - Cocktail Bar. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Blend, the perfect place for those looking to experience the best of the nightlife. Similarly, Franklin'33 provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Lucca
  • Pisa
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Drive 226 km, 4 hours 9 min

  • Scalinata Lardarina
  • Chiesa Di San Pietro
  • Ruins of Doria Tower
  • Church of St. Margaret of Antioch
  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Corniglia, Vernazza, and Manarola. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Start by visiting Scalinata Lardarina, a prime spot to begin your journey. This enchanting hiking area is sure to impress. Next on your list is Chiesa Di San Pietro, another must-visit landmark and increasingly popular church renowned for its history-steeped features.

While exploring and sightseeing, take time to savor the culture of Lucca by sampling some local delicacies. When you’re ready for more sightseeing, head to Ruins Of Doria Tower. This grand monument is an essential place to visit for anyone looking for the full Lucca experience. We also recommend visiting Church Of St. Margaret Of Antioch, an increasingly popular church. Nearby, you'll also find Cinque Terre National Park, ready to add charm to your journey. End your self-guided sightseeing tour with a stop at Manarola Overlook Viewpoint and wrap up your day with its mesmerizing appeal.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Ristorante Capodimonte Pisa, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider La Locanda Dei Pisani Doc Pisa, another top spot with a mouthwatering menu. You might also want to secure a reservation at Baribaldi Pisa. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pisa this evening.

Keep the excitement of the evening going by visiting a bar or two. Bar Mocambo is an excellent place to start. You could also check out Tree, offering a different kind of charm. A last recommendation for the day is Chupiteria. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 6

Day 6

  • Pisa - Departure day
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  • Palazzo Blu
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Palazzo Blu, a heritage-rich art gallery before you head out.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Pisa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

Enjoy a lovely meal at Restaurant -Pizzeria Il Mio Capriccio, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorante alle Bandierine is another top choice with a popular menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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