6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Portofino and Florence

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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Portofino, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazza Della Signoria, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
piazza De FerrariGenoa CathedralDoge's PalaceAquarium of GenoaLighthouse of GenoaArea Marina Protetta di Portofino
Manarola Overlook ViewpointCinque Terre National ParkRuins of Doria TowerScalinata Lardarina
Leaning Tower of PisaPiazza del Duomo, PisaPorta NuovaUffizi GalleryPonte Vecchiopiazza della Signoria
Basilica of Santa Croce in FlorenceVilla Calcinaia - Conti CapponiPorta San GiovanniSanGimignano1300Piazza del Duomo, San Gimignano
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at 7 Sensi cucina decontaminata, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Alla Lunga Ristorante is another top choice with a popular menu. You could also check for a table at Grand Hotel Savoia. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Genoa tonight.

After savoring a delicious meal, step into the vibrant nightlife at Scurreria Beer & Bagel, where the evening is just getting started. In the same way, La Lepre offers a unique charm perfect for experiencing the local bar scene in Genoa. Bar Pisacane Iii is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 48 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Aquarium of Genoa
  • Lighthouse of Genoa
  • Area Marina Protetta di Portofino
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Genoa and San Fruttuoso di Camogli. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Portofino. You will spend 2 nights here for some well-deserved relaxation.

Prepare for a day full of family-friendly attractions, romantic experiences, and breathtaking views. When you’re ready, kick off your sightseeing adventure at Piazza De Ferrari. This well-known public square is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Genoa Cathedral, one of the city’s best highlights.

Next, check out Doge's Palace, one of the most locally appreciated places to see in Genoa. This museum is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Aquarium Of Genoa. Wander around and soak in the mesmerizing atmosphere this aquarium offers. Then, head to Lighthouse Of Genoa, a top-rated lighthouse that adds another dimension to your day. Finally, visit the curiosity-inducing Area Marina Protetta Di Portofino, the last of our attraction recommendations for today.

At the end of the day, you will drive to Portofino, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Portofino's best restaurants.

Make sure to reserve a table at Trattoria Concordia, an iconic dining spot in Portofino. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti, a popular restaurant in Portofino. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Puny, a hidden gem nestled in Portofino. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 3

Day 3

  • Portofino
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Drive 211 km, 4 hours 15 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • Scalinata Lardarina
  • More

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Portofino, we encourage you to seize the day and discover the unexplored beauty of the village’s surroundings!

Bring your curiosity for today’s adventure around Portofino. Some of the village’s most loved attractions await. Manarola Overlook Viewpoint is the perfect place to start. This observation deck is one of the most curiosity-inducing places to visit in Portofino. Next, head to Cinque Terre National Park, a well-known national park, known for its romantic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Ruins Of Doria Tower. This symbolic monument offers a unique experience that is highly recommended. Meanwhile, Scalinata Lardarina adds its own distinct charm to your journey.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Portofino.

As dinnertime approaches, it's time to head out for a bite to eat in Portofino. If you are looking to dine at a popular restaurant in the village, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at I Gemelli, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Taverna del marinaio, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Lo Stella. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

Head back to your accommodation in Portofino and get some rest in preparation for another magical day of your road trip in Italy!

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Day 4

Day 4

  • Portofino
  • Florence
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Drive 230 km, 3 hours 24 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Porta Nuova
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Florence. In the evening, you’ll end up in Florence, where you will stay for 1 night.

Enjoy the perfect balance of relaxation and exploration in Portofino today. One of the most iconic attractions included on the itinerary is Leaning Tower Of Pisa. This noteworthy monument will help you start your sightseeing on top. Then, take a leisurely stroll to Piazza Del Duomo, Pisa and learn what makes this stunning public square unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the worthwhile Porta Nuova. After exploring the monument, head to Uffizi Gallery. This famous art gallery is a highlight in Portofino. Lastly, don’t forget to check out the timeless Ponte Vecchio. Enjoy exploring this incredible historical landmark at your own pace.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Ristorante Oliviero 1962, an excellent option for tonight's dining. Looking for something different? Di Poneta Novoli offers a tantalizing alternative with its diverse menu. And don’t miss Caffe San Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Following your dinner, dive into the local bar culture at Manifattura. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Se·sto On Arno Rooftop Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Il Vinile provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 5

Day 5

  • Florence
  • Genoa
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Drive 313 km, 4 hours 42 min

  • Basilica of Santa Croce in Florence
  • Villa Calcinaia - Conti Capponi
  • Porta San Giovanni
  • SanGimignano1300
  • Piazza del Duomo, San Gimignano
  • More

Embark on another extraordinary experience on day 5 of your road trip in Italy. Today, you will make 3 stops and experience some of the highlights of Florence, Greti, and San Gimignano. At the end of the day, you will enjoy the comforts of a top-rated hotel in Genoa, which will be your home away from home for 1 night.

Start by visiting Basilica Of Santa Croce In Florence, a prime spot to begin your journey. This monumental church is sure to impress. Next on your list is Villa Calcinaia - Conti Capponi, another must-visit landmark and worthwhile winery renowned for its instagrammable features.

While exploring and sightseeing, take time to savor the ambiance of Florence by sampling some local delicacies or having a drink. When you’re ready for more sightseeing, head to Porta San Giovanni. This culturally significant monument is a remarkable attraction that offers a unique experience. Sangimignano1300 also adds charm to your journey, and Piazza Del Duomo wraps up your day with its inviting appeal.

When you’re done exploring for the day, you’ll drive to your hotel in Genoa. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Genoa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Zeffirino, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider Trattoria Vegia Zena, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria delle Grazie. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.

Head back to your accommodation in Genoa and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Via Garibaldi. This underrated street is a popular place to see in the city.

Maximize your last day in Italy and go on a shopping spree in Genoa’s shopping center, the lively Via Garibaldi. Browse for souvenirs to remind you of your wonderful journey in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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