6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Portofino and Florence

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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Portofino, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazza Della Signoria, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
piazza De FerrariGenoa CathedralDoge's PalaceAquarium of GenoaLighthouse of GenoaArea Marina Protetta di Portofino
Manarola Overlook ViewpointCinque Terre National ParkRuins of Doria TowerScalinata Lardarina
Leaning Tower of PisaPiazza del Duomo, PisaPorta NuovaUffizi GalleryPonte Vecchiopiazza della Signoria
Basilica of Santa Croce in FlorenceVilla Calcinaia - Conti CapponiPorta San GiovanniSanGimignano1300Piazza del Duomo, San Gimignano
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Genoa's charm before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at 7 Sensi cucina decontaminata, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Alla Lunga Ristorante? It's another excellent option with a diverse menu. Consider reserving a table at Grand Hotel Savoia as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Genoa.

Explore the vibrant nightlife at Scurreria Beer & Bagel after your meal, a hub for lively evenings and memorable moments. Or, head to La Lepre for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Pisacane Iii is perfect for those looking to extend their night with a touch of local flavor.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 48 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Aquarium of Genoa
  • Lighthouse of Genoa
  • Area Marina Protetta di Portofino
  • More

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Genoa and San Fruttuoso di Camogli. When you’re not sightseeing, take time to relax at your selected hotel in Portofino, where you’ll be staying for 2 nights.

Start your adventure at Piazza De Ferrari. This well-known public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the culturally significant wonders of Genoa Cathedral, a must-see church in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Doge's Palace. This underrated museum offers an enriching experience. For a change of pace, head to Aquarium Of Genoa, where you can take in picture-perfect features. Conclude your self-guided sightseeing tour with a visit to Lighthouse Of Genoa and Area Marina Protetta Di Portofino. These sights offer a fulfilling end to a perfect day.

When you’re done exploring for the day, you’ll drive to your hotel in Portofino. Check in and spend some time relaxing before you head out to tour the village.

As you explore more of Portofino, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Don’t miss out on dining at Trattoria Concordia, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Puny. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 3

Day 3

  • Portofino
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Drive 211 km, 4 hours 15 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • Scalinata Lardarina
  • More

Greet day 3 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Portofino for your remaining 1 night in the village later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Manarola, Corniglia, and Vernazza.

Enjoy the perfect balance of relaxation and exploration in Portofino today. One of the most beloved attractions included on the itinerary is Manarola Overlook Viewpoint. This romantic observation deck will help you start your sightseeing on top. Then, take a leisurely stroll to Cinque Terre National Park and learn what makes this romantic national park unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the up-and-coming Ruins Of Doria Tower. After exploring the monument, head to Scalinata Lardarina. This underrated hiking area is a highlight in Portofino.

When you’re done exploring for the day, you’ll return to Portofino and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Portofino. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at I Gemelli, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Taverna del marinaio, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Lo Stella. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Portofino
  • Florence
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Drive 230 km, 3 hours 24 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Porta Nuova
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Florence. In the evening, you’ll end up in Florence, where you will stay for 1 night.

Get ready for a day filled with family-friendly attractions, scenic views, and picturesque spots in the charming city of Portofino. Your adventure starts at Leaning Tower Of Pisa, a wondrous local hot spot. Another notable attraction to explore is Piazza Del Duomo, Pisa. This wondrous public square is known for its culturally significant appeal.

After soaking in the highlights of these sights, take some time to wander Portofino's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Porta Nuova. This culturally significant monument offers a fascinating experience that many visitors find memorable. Uffizi Gallery is also worth visiting, along with Ponte Vecchio. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Piazza Della Signoria. This astonishing public square provides a fitting finale to your sightseeing.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at Ristorante Oliviero 1962, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Di Poneta Novoli offers an enticing alternative with its varied menu. Additionally, Caffe San Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • Genoa
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Drive 313 km, 4 hours 42 min

  • Basilica of Santa Croce in Florence
  • Villa Calcinaia - Conti Capponi
  • Porta San Giovanni
  • SanGimignano1300
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Florence, Greti, and San Gimignano, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Start by visiting Basilica Of Santa Croce In Florence, a prime spot to begin your journey. This respected church is sure to impress. Next on your list is Villa Calcinaia - Conti Capponi, another must-visit landmark and increasingly popular winery renowned for its history-steeped features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Porta San Giovanni. This UNESCO world heritage-designated monument is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Sangimignano1300, an increasingly popular museum. Nearby, you'll also find Piazza Del Duomo, ready to add charm to your journey.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Enjoy a lovely meal at Zeffirino, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Vegia Zena is another top choice with a popular menu. You could also check for a table at Trattoria delle Grazie. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Genoa tonight.

Raise your glass to another unforgettable day in Italy!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Via Garibaldi. This increasingly popular street is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Have a fantastic dining experience at Osteria Sant'Ilario, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Cialtroneria offers an enticing alternative with its varied menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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