6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Arezzo, Rome, and Pisa

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Description

Experience the freedom of the open road in Italy as you embark on an unforgettable 6-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Arezzo, Rome, and Pisa.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Arezzo, 1 night in Rome, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Pantheon are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Navona, learn more about the unique St. Peter's Basilica, and immerse yourself in the vibrant atmosphere of Vatican Museums.

As you hit the open road and drive through Genoa, Arezzo, Rome, and Pisa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
piazza De FerrariGenoa CathedralAquarium of Genoa
Vatican MuseumsSaint Peter's SquareSistine ChapelSt Peter's Basilica
Trevi FountainPantheonPiazza NavonaForo Italico
Knights' SquareLeaning Tower of PisaPisa CathedralPiazza del Duomo, PisaBattistero di San Giovanni
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 1 night before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at 7 Sensi cucina decontaminata, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at Alla Lunga Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Grand Hotel Savoia. It’s yet another ideal choice to enhance your time in Genoa tonight.

Keep the evening going at Scurreria Beer & Bagel, a great choice for enjoying the after-dinner hours with a drink. You could also go to La Lepre, which offers a similarly pleasant setting and great drinks. Another option is Bar Pisacane Iii, which provides an inviting environment for unwinding after a busy day out.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Arezzo
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Drive 313 km, 3 hours 37 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Aquarium of Genoa
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Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Genoa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Arezzo. You will spend 1 night here for some well-deserved relaxation.

Brace yourself for today’s incredible lineup of attractions in Genoa, featuring fun adventures, romantic experiences, and scenic views. Start at Piazza De Ferrari, an interesting public square in the city. Then, head to Genoa Cathedral and soak in the ambiance of this culturally significant church.

There are many interesting places to see in Genoa and when you are ready for more, go to Aquarium Of Genoa. This is one of the city’s most famous spots.

At the end of the day, you will drive to Arezzo, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Arezzo. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Experience a symphony of flavors at Octavin in Arezzo by securing a reservation in advance. Renowned for its 1-star Michelin distinction, Octavin delights its guests with its exceptional variety of meals showcasing delicious creative cuisine. Or, if you're feeling adventurous, why not try La Clandestina? It's another excellent option with a diverse menu.

Continue the enjoyment post-dinner at Liquid Bar, a cherished local gathering spot renowned for its welcoming atmosphere.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Arezzo
  • Rome
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Drive 228 km, 3 hours 15 min

  • Vatican Museums
  • Saint Peter's Square
  • Sistine Chapel
  • St Peter's Basilica
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Vatican City’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Arezzo behind. This drive usually takes around 2 hours 32 min. Vatican City welcomes you with a multitude of unique vacation experiences.

Next, visit Sistine Chapel, an astonishing chapel that offers a unique experience. Be sure to also explore St. Peter's Basilica, a nearby major basilica, which is highly recommended by other travelers.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Experience a harmony of flavors at La Pergola in Rome by securing a reservation in advance. Known for its 3-star Michelin status, La Pergola offers a delightful variety of dishes highlighting its delicious mediterranean and contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Il Pagliaccio, a highly recommended restaurant known for its enticing creative and innovative cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Enoteca La Torre, a highly acclaimed restaurant celebrated for its exceptional mediterranean and creative menu.

After your meal, keep the night alive at a bar like La Botticella Of Poggi Giovanni, known for its lively atmosphere. Almalu Trastevere is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Bar Viminale Di Pepi Maurilio offers an excellent atmosphere for those looking to amp up the evening.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Rome
  • Pisa
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Drive 361 km, 4 hours 25 min

  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • Foro Italico
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Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Pisa, which will be your home away from home for 1 night.

Savor the day by visiting some of the best places to see in Rome, including a monument, a public square, and a sport complex. Start your adventure at Trevi Fountain. This globally renowned monument is a must-visit for travelers looking for a unique holiday experience. Make your way to Pantheon located in Rome for an enchanting atmosphere.

Next, immerse yourself in the setting of Piazza Navona. Its romantic features will captivate you. After the public square, continue your tour of the city with a visit to Foro Italico. This sports complex has an instagrammable appeal.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Pisa's best restaurants.

Treat yourself to a delicious dinner at Anima di Grano Pizzeria Napoletana Pisa Italy, an excellent option for tonight's dining. Looking for something different? il Mercante offers a tantalizing alternative with its diverse menu. And don’t miss La Ghiotteria. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pisa.

Continue your lively evening at Jeffer Cocktails & Friends, a perfect place for winding down or revving up the night, depending on which mood you’re in. Le Parisien Wine Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Las Volta Cocktailbar ensures a night out tailored to your taste.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 5

Day 5

  • Pisa
  • Genoa
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Drive 163 km, 2 hours 17 min

  • Knights' Square
  • Leaning Tower of Pisa
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Battistero di San Giovanni
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Dive into day 5 of your remarkable road trip in Italy. Today you will explore Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Pisa is brimming with adventures. Today’s wonderful stops include a public square, a monument, and a church. Begin your sightseeing adventure at the frequently visited Knights' Square. Just a short distance away is Leaning Tower Of Pisa, a noteworthy monument that draws visitors from far and near.

Continue your journey to Pisa Cathedral, one of the city’s most increasingly popular spots that you shouldn’t miss. Another great site to visit is the globally renowned Piazza Del Duomo, Pisa. Last up on today’s itinerary is a church. Make your way to Battistero Di San Giovanni for some final sightseeing. Each attraction will leave you with lasting memories and a deeper appreciation for the rich heritage of Pisa.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Begin your culinary exploration in Genoa by securing a reservation at San Giorgio. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of modern and ligurian cuisine. For another dining delight, visit The Cook, celebrated for its delectable modern menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Marin, a top local spot known for its tantalizing seafood and contemporary menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Head back to your accommodation in Genoa and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Genoa is home to plenty of attractions that offer fun adventures, romantic experiences, and scenic views! Start at Via Garibaldi, a beloved street that is worthwhile a visit in the city.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Have a fantastic dining experience at Osteria Sant'Ilario, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Cialtroneria offers an enticing alternative with its varied menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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