6-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Florence

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Experience the freedom of the open road in Italy as you embark on an unforgettable 6-day road trip! This experience caters to every traveler, featuring destinations like Perugia, Santa Maria degli Angeli, Florence, Pisa, Lucca, Siena, and San Gimignano.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Perugia and 2 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Cathedral Of Santa Maria Del Fiore.

As you hit the open road and drive through Perugia, Santa Maria degli Angeli, Florence, Pisa, Lucca, Siena, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Piazza IV Novembre
Rocca PaolinaNational Archaeological Museum of UmbriaBasilica of San Francesco d'AssisiPiazza del ComuneBasilica di Santa ChiaraMount Subasio
piazzale MichelangeloBasilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioCathedral of Santa Maria del Fiorepiazza della Signoria
Piazza del Duomo, PisaLeaning Tower of PisaPiazza dell'AnfiteatroSan Michele in ForoPorta San PietroWalls of Lucca
Fortezza MediceaTower of Mangiapiazza del CampoSiena CathedralChiesa di Sant'AgostinoPiazza del Duomo, San Gimignano
Etruscan Arch

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Day 1

Day 1

  • Perugia - Arrival day
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  • Piazza IV Novembre
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Say hello to Perugia! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Perugia for 2 nights before you continue your adventure!

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Iv Novembre, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Perugia. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Savor the flavors at Ristorante Settimo Sigillo, a top pick for dinner tonight. Alternatively, Caffè Baglioni beckons with its unique menu offerings. Also, consider Bar Pellas. With its consistent customer satisfaction, it’s an excellent option for dining in Perugia tonight.

Extend your evening after a delightful meal by visiting Tommi Bar, which offers the perfect atmosphere for a night out. Moreover, Valentina is another popular option for a drink or two. Likewise, Caffe Dal Perugino also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Perugia
  • More

Drive 57 km, 1 hour 42 min

  • Rocca Paolina
  • National Archaeological Museum of Umbria
  • Basilica of San Francesco d'Assisi
  • Piazza del Comune
  • Basilica di Santa Chiara
  • Mount Subasio
  • More

On day 2 of your road trip, you’ll start and end your day in Perugia, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Perugia and Santa Maria degli Angeli. You still have 1 night left in Perugia.

Perugia is brimming with adventures. Today’s wonderful stops include a historical landmark, a museum, a church, a public square, a mountain range and much more! Begin your sightseeing adventure at the often recommended Rocca Paolina. Just a short distance away is National Archaeological Museum Of Umbria, an instagrammable museum that draws visitors from far and near.

Continue your journey to Basilica Of San Francesco D'assisi, one of the city’s most notable spots that you shouldn’t miss. Another great site to visit is the often recommended Piazza Del Comune. Last up on today’s itinerary is a church. Make your way to Basilica Di Santa Chiara for some final sightseeing. Each attraction will leave you with lasting memories and a deeper appreciation for the rich heritage of Perugia.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Perugia.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Perugia. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely meal at La Taverna, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorante del Sole is another top choice with a popular menu. You could also check for a table at Al Mangiar Bene. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Perugia tonight.

Continue the enjoyment post-dinner at Caffè Fortebraccio, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Caffe Del Banco offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Dempsey's Perugia. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise your glass to another unforgettable day in Italy!

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Day 3

Day 3

  • Perugia
  • Florence
  • More

Drive 152 km, 2 hours 38 min

  • piazzale Michelangelo
  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • More

Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Florence. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Prepare for a day full of family-friendly attractions, romantic experiences, and breathtaking views. When you’re ready, kick off your sightseeing adventure at Piazzale Michelangelo. This top-rated observation deck is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Basilica Of Santa Croce In Florence, one of the city’s best highlights.

Next, check out Uffizi Gallery, one of the most astonishing places to see in Perugia. This art gallery is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Ponte Vecchio. Wander around and soak in the enchanting atmosphere this historical landmark offers. Then, head to Cathedral Of Santa Maria Del Fiore, a top-rated church that adds another dimension to your day. Finally, visit the spectacular Piazza Della Signoria, the last of our attraction recommendations for today.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at Ristorante Oliviero 1962, an excellent option for tonight's dining. Looking for something different? Di Poneta Novoli offers a tantalizing alternative with its diverse menu. And don’t miss Caffe San Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

After your meal, keep the night alive at a bar like Manifattura, known for its lively atmosphere. Se·sto On Arno Rooftop Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Il Vinile offers an excellent atmosphere for those looking to amp up the evening.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 4

Day 4

  • Florence
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Drive 196 km, 3 hours 17 min

  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Piazza dell'Anfiteatro
  • San Michele in Foro
  • Porta San Pietro
  • Walls of Lucca
  • More

Wake up to day 4 of your extraordinary road trip in Italy. With 1 night left in Florence, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Enjoy the perfect balance of relaxation and exploration in Florence today. One of the most globally renowned attractions included on the itinerary is Piazza Del Duomo, Pisa. This picture-perfect public square will help you start your sightseeing on top. Then, take a leisurely stroll to Leaning Tower Of Pisa and learn what makes this UNESCO world heritage-listed monument unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the interesting Piazza Dell'anfiteatro. After exploring the public square, head to San Michele In Foro. This increasingly popular church is a highlight in Florence. Lastly, don’t forget to check out the underrated Porta San Pietro. Enjoy exploring this incredible monument at your own pace.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Don’t miss out on dining at Ditta Artigianale, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Trattoria Da Burde, another top spot with a mouthwatering menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

Continue your evening by exploring the vibrant nightlife scene at Bar 50 Rosso, a prime destination for a thrilling night out. Also, don’t forget to check out Bitter Bar, a bar that offers unique local touches. Likewise, Archea Brewery provides an excellent alternative for a fun evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 5

Day 5

  • Florence
  • Perugia
  • More

Drive 267 km, 4 hours 27 min

  • Fortezza Medicea
  • Tower of Mangia
  • piazza del Campo
  • Siena Cathedral
  • Chiesa di Sant'Agostino
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Siena and San Gimignano, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Perugia. You’ll stay here for 1 night.

Savor the day by visiting some of the best places to see in Florence, including a monument, a public square, and a church. Start your adventure at Fortezza Medicea (siena). This beloved monument is a must-visit for travelers looking for a unique holiday experience. Make your way to Tower Of Mangia located in Florence for an enchanting atmosphere.

Next, immerse yourself in the setting of Piazza Del Campo. Its visually striking features will captivate you. After the public square, continue your tour of the city with a visit to Siena Cathedral. This church has a romantic appeal. For a change of pace, head to Chiesa Di Sant'agostino. As one of the most increasingly popular attractions in Florence, this church is an excellent place to end your self-guided tour.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Perugia. Perugia offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Perugia. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Perugia Plaza Hotel, a popular restaurant in Perugia. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Perugia at Elfo Pub Perugia, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Sangallo Palace Hotel. It’s yet another ideal choice to enhance your time in Perugia tonight.

Unwind after your meal by stepping into Il Birrino. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Quei Bravi Ragazzi offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Lo Chalet - Lounge Bar, another top-rated bar in the area.

Say good night to Perugia and look forward to another great day of your road trip in Italy!

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Day 6

Day 6

  • Perugia - Departure day
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  • Etruscan Arch
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Etruscan Arch, a breathtaking historical landmark before you head out.

On your last day in Italy, take time to indulge in shopping at Perugia’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

Savor the flavors at Alphaville, a top pick for dinner tonight. Alternatively, Osteria a Priori beckons with its unique menu offerings.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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