6-Day Italy Self-Drive Road Trip With Itinerary from Rome to Florence

On day 2 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Rome, there’s no need to rush. Experience Rome and Vatican City to the fullest today with this curated day itinerary.

Rome is brimming with adventures.

Enjoy all that Colosseum has to offer. This is an iconic archeological site you should not miss. Another must-see is Roman Forum, a timeless archeological site in Rome.

When you’re ready for the next sight, head to Trevi Fountain. From there, take a leisurely stroll to Piazza Di Spagna, another of the city’s world-famous attractions. We recommend continuing your self-guided tour at Spanish Steps, an enchanting place of interest in the city.

Vatican City’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 14 min. Vatican City welcomes you with a multitude of unique vacation experiences.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to St. Peter's Basilica, a timeless major basilica that everyone visiting Vatican City should see.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Savor the flavors at RomAntica, a top pick for dinner tonight. Alternatively, Coso Ristorante beckons with its unique menu offerings. Also, consider DEROMA - Farine Romane. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Let the evening flow smoothly from dinner to drinks at Sant' Eustachio Caffè, a top-rated bar in the area. For other recommendations, Yellowsquare Rome provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffè Portofino offers a memorable night with diverse drink options and excellent service.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

On day 3 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Florence are on today's agenda. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Florence.

After soaking in Rome’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Florence. Expect your car journey to take a minimum of 3 hours 2 min. When you arrive in Florence, it's time to take a break from the road.

When you're ready for some sights, head to Basilica Of Santa Croce In Florence, an interesting church in Florence. Explore its respected features at your own pace before you continue your journey to your next attraction, Uffizi Gallery. This impressive art gallery is a top recommendation in the area.

When you’re ready to explore more, Ponte Vecchio is an excellent choice. Spend some time discovering what some claim to be the most romantic historical landmark in the region. Next, continue your sightseeing at the interesting Piazza Della Repubblica and discover what makes this public square unique. If you’re up for one more stop in the city, head to Cathedral Of Santa Maria Del Fiore, a romantic church many travelers find the visit worthwhile.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.

Keep the evening going at Manifattura, a great choice for enjoying the after-dinner hours with a drink. You could also go to Se·sto On Arno Rooftop Bar, which offers a similarly pleasant setting and great drinks. Another option is Il Vinile, which provides an inviting environment for unwinding after a busy day out.

Savor another day of unforgettable experiences in Italy!

On day 4 of your road trip, you’ll start and end your day in Florence, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Pisa and Lucca.

Continue your road trip and head to your next destination, Pisa. This car ride takes around 1 hour 16 min.

When you're ready for some sights, head to Piazza Del Duomo, Pisa, a wondrous public square in Pisa. Explore its UNESCO world heritage-designated features at your own pace before you continue your journey to your next attraction, Pisa Cathedral. This curiosity-inducing church is a top recommendation in the area.

When you’re ready to explore more, Leaning Tower Of Pisa is an excellent choice. Spend some time discovering what some claim to be the most breathtaking monument in the region.

When you’re ready to jump back into the car and say goodbye to Pisa, you’ll hit the road in the direction of Lucca. This drive usually takes around 31 min.

Set out on a self-guided sightseeing tour at Mura Di Lucca and explore the respected features. Next, make your way to Piazza Napoleone, another highlight in Lucca.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Enjoy a delicious meal at Ditta Artigianale, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Trattoria Da Burde, another top spot with a mouthwatering menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

After your meal, keep the night alive at a bar like Bar 50 Rosso, known for its lively atmosphere. Bitter Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Archea Brewery offers an excellent atmosphere for those looking to amp up the evening.

Relax and recharge in preparation for another adventurous day in Italy!

Your itinerary for day 5 of your road trip in Italy includes 2 stops and features some of the highlights of Siena and San Gimignano. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 1 night.

Continue your road trip and head to your next destination, Siena. This car ride takes around 1 hour 12 min.

For a more meaningful self-guided tour of the city's best attractions, visit Siena Cathedral, an interesting church that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Piazza Del Campo and admire its enchanting features.

When you’re ready, continue to Pubblico Palace, a frequently visited palace beloved by locals and tourists alike.

San Gimignano’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Siena behind. This drive usually takes around 45 min. San Gimignano welcomes you with a multitude of unique vacation experiences.

Spend your afternoon discovering Parco Della Rocca, an intriguing park known for its enchanting features.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Don’t miss out on dining at Hotel de Russie, a top-rated dining destination in Rome. If you're in the mood to try something new, consider La Taverna Italiana, another top spot with a mouthwatering menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Continue the enjoyment post-dinner at The Apartment Bar Roma, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Hotel Hassler Roma offers a vibrant space for indulging in well-crafted drinks and engaging conversation.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.