6-Day Italy Road Trip from Rome to Florence, and Perugia

Say hello to Rome! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Rome for 2 nights before you continue your adventure!

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Altare della Patria or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Rome. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a memorable dining experience in Rome by booking a table at La Pergola, renowned as a 3-star Michelin restaurant presenting an exceptional mediterranean, and contemporary menu. For a different culinary experience, Il Pagliaccio shines as one of the top destinations known for its delicious creative, and innovative cuisine in Rome. This 2-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Enoteca La Torre is known as a top local spot for its delicious mediterranean, and creative cuisine in Rome. This 2-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Let the evening flow smoothly from dinner to drinks at La Botticella of Poggi Giovanni, a top-rated bar in the area. For other recommendations, Sant' Eustachio Caffè provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffè Portofino offers a memorable night with diverse drink options and excellent service.

Raise a toast to the start of your 6-day road trip in Italy!

Day 2 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Begin your sightseeing with a visit to Colosseum. This extraordinary roman amphitheatre is rated an average of 4.7 out of 5 stars by 328,821 visitors. Each year, around 7,400,000 people visit this site to learn more about it.

Next, make your way to Roman Forum. This top attraction is a square with an average rating of 4.7 out of 5 stars by 114,450 visitors.

We also recommend a visit to Pantheon. Hosting 30,000,000 visitors every year, Pantheon is one of the most popular places to visit in Rome. This roman temple is rated 4.8 out of 5 stars by 189,682 travelers.

If you’re keen to keep exploring, visit Piazza Navona. This highly recommended sightseeing destination has received an average rating of 4.7 out of 5 stars from 158,771 travelers.

Today is also your chance to spend some time at Castel Sant'Angelo. This museum is rated an average of 4.7 out of 5 stars by 72,431 travelers. It’s estimated that 918,591 people visit this fantastic attraction every year.

If you have an appetite for more adventure, check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You'll find the most recommended ones below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to book a table at DEROMA - Farine Romane, a popular restaurant in Rome. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Rome at La Taverna Italiana, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Centro. As a dining spot that gains consistently high praise from guests, it’s an ideal choice to enhance your time to Rome tonight.

After savoring a delicious meal, step into the vibrant nightlife at The Apartment Bar Roma, where the evening is just getting started. In the same way, Hotel Hassler Roma offers a unique charm perfect for experiencing the local bar scene in Rome.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Embark on another extraordinary experience on day 3 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 1 night.

A top pick for your self-guided sightseeing tour today is Trevi Fountain. Previous visitors have rated this sculpture an average of 4.8 out of 5 stars in 343,494 reviews.

Piazza di Spagna is a local recommendation that you also can pay a visit today. This square is rated an average of 4.7 out of 5 stars in 113,658 reviews.

Another attraction you won't want to miss is Spanish Steps. This monumental staircase is rated an average of 4.5 out of 5 stars in 57,211 reviews.

Piazza del Popolo is another outstanding experience in Rome. Around 89,807 travelers have rated this square an average of 4.6 out of 5 stars.

If you long for more, Villa Borghese is not far away. This urban zone of rome is a lovely addition to your itinerary. Previous visitors have rated it an average of 4.6 out of 5 stars in 69,749 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Florence. Florence offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a memorable dining experience in Florence by booking a table at Enoteca Pinchiorri, renowned as a 3-star Michelin restaurant presenting an exceptional italian contemporary menu. For a different culinary experience, Santa Elisabetta shines as one of the top destinations known for its delicious creative, and mediterranean cuisine in Florence. This 2-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Gucci Osteria da Massimo Bottura is known as a top local spot for its delicious italian contemporary, and international cuisine in Florence. This 1-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Unwind after your meal by stepping into Manifattura. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, SE·STO on Arno Rooftop Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Archea Brewery, another top-rated bar in the area.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Florence, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Perugia. You’ll stay here for 1 night.

Begin your sightseeing with a visit to piazza della Signoria. This square is rated an average of 4.8 out of 5 stars in 66,956 reviews.

Next up, make your way to Cathedral of Santa Maria del Fiore. This church has an average rating of 4.8 out of 5 stars from 76,359 reviews.

When you’re ready for your next sight of the day, continue to Ponte Vecchio. This deck arch bridge has an average rating of 4.7 out of 5 stars from 118,099 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Uffizi Gallery. This national museum is rated an average of 4.7 out of 5 stars by 61,794 visitors. Visiting Uffizi Gallery means you'll be one of 2,011,219 people who do so every year.

If you’re keen to explore even more, then consider a visit to piazzale Michelangelo. This square is a much-appreciated attraction with an average rating of 4.8 out of 5 stars from 77,744 visitors.

At the end of the day, you will drive to Perugia, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Perugia's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Ristorante Settimo Sigillo, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Bar Pellas offers an enticing alternative with its varied menu. Additionally, La Taverna is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Perugia.

Keep the excitement of the evening going by going to a bar or two. Tommi Bar is an excellent place to start. You could also check out Valentina, offering a different kind of charm. A last recommendation for the day is Caffe Dal Perugino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and recharge in preparation for another adventurous day in Italy!

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Vatican City. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 1 night here for some well-deserved relaxation.

Admire the views and listen to some good music as you drive in the direction of Vatican City.

Kick off the day at Vatican Museums, a top pick for today’s sightseeing. Attracting approximately 1,612,530 visits every year, this attraction is a must-see. This art museum is rated an average of 4.6 out of 5 stars in 133,310 reviews.

Today is also your chance to visit Saint Peter's Square. Saint Peter's Square is a square with an average rating of 4.8 out of 5 stars from 38,954 reviews.

Sistine Chapel is another top attraction we highly recommend you visit today. This chapel is rated an average of 4.7 out of 5 stars by 52,083 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit St. Peter's Basilica. This major basilica is rated an average of 4.8 out of 5 stars by 131,043 visitors. Visiting St. Peter's Basilica means you'll be one of 11,000,000 people who do so every year.

When you’re done exploring for the day, you’ll drive to Rome, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Ristorante Tema, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Maccheroni, another top spot with a mouthwatering menu. You might also want to secure a reservation at RoYaL Art Cafè Roma. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Raise your glass to another unforgettable day in Italy!

Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

On your last day in Italy, take time to indulge in shopping at Rome’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.

Make Campo de' Fiori your first stop of the day. Previous visitors have rated this square an average of 4.4 out of 5 stars in 51,133 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

This renowned restaurant holds and offers an exceptional menu of cuisine.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!