7-Day Sicily Self-Drive Road Trip With Itinerary from Palermo traveling east to Catania

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Photo of Palermo, Sicily, Italy. Seafront view.
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Explore the best of Sicily on a remarkable 7-day road trip! Combine exploration with relaxation on a self-drive tour featuring Palermo, Cefalù, Taormina, Catania, Syracuse, and Agrigento.

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 4 nights in Palermo and 2 nights in Catania. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Valle Dei Templi and Palermo Cathedral are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Palermo, Cefalù, Taormina, Catania, Syracuse, and Agrigento, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Palermo - Arrival day
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  • Foro Italico
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Your road trip adventure in Sicily begins as soon as you reach Palermo and pick up your car. You’ll stay here for 3 nights and explore what to see in Palermo, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Palermo. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Dine in style at Cotto e Bollito, a top recommendation for dinner tonight. Or, for a change of pace, Bebop boasts a menu that's sure to impress. Also, be sure to check out Eremiti Restaurant. Known as a local hotspot, it’s a great choice for tonight in Palermo.

Unwind after your meal by stepping into Malox Cult. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Ai Giudici offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Italico, another top-rated bar in the area.

Raise a toast to the start of your 7-day road trip in Sicily!

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Day2

Day 2

  • Palermo
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Drive 31 km, 1 hour 38 min

  • Norman Palace
  • Palermo Cathedral
  • Quattro Canti
  • Fontana Pretoria
  • Orto botanico di Palermo
  • Santuario di Santa Rosalia, Palermo
  • More

Day 2 of your road trip will take you to the best attractions Palermo has to offer. Cherish the 2 nights you have left in the city and use the provided itinerary to discover what to see in Palermo.

Norman Palace is an ideal stop early in the day. This locally renowned palace is a must-visit in the city. When you’re ready for your next discovery, continue to Palermo Cathedral, which may be one of the most symbolic places you will experience today.

One of the best things about exploring Palermo on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Quattro Canti, a notable public square in the city. If you’re up for more discoveries, don’t forget to reserve some time for Fontana Pretoria and Orto Botanico Di Palermo. End your day with a visit to Santuario Di Santa Rosalia, Palermo, a worthwhile church that’s sure to leave a lasting impression.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Sicily. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Palermo's best restaurants.

Enjoy a delicious meal at Osteria Mercede, a top-rated dining destination in Palermo. If you're in the mood to try something new, consider Trattoria Del Massimo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Grand Hotel Piazza Borsa. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Palermo this evening.

Cap off your dinner by heading to Spina Bar Palermo, ideal for a leisurely evening with a drink in hand. Torrefazione Castagnetta Massimiliano (gelateria) is another bar that offers an enjoyable setting. Similarly, Monkey Pub is also a popular place to go on a night out, perfect for relaxing and socializing.

As the sun sets, rest up and recharge for the next leg of your road trip in Sicily.

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Day3

Day 3

  • Palermo
  • More

Drive 145 km, 2 hours 34 min

  • Castello di Cefalù
  • Rocca di Cefalù
  • Cathedral of Cefalù
  • Porta della Pescara (Porta Marina)
  • Lavatoio Medievale Fiume Cefalino - Cefalù (pa)
  • Cefalù Beach
  • More

On day 3 of your road trip, you’ll start and end your day in Palermo, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Cefalù.

Let Castello Di Cefalù set the tone for the day. Spend some time admiring this visually striking castle before continuing your journey. Rocca Di Cefalù is your next stop. This locally appreciated castle is one of the best-rated sights in Palermo.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Cefalù Cathedral. This romantic church is a sight to behold. To round off your sightseeing experience, visit Porta Pescara (porta Marina) and Lavatoio Medievale Fiume Cefalino - Cefalù (pa). If time allows, end your day with Spiaggia Di Cefalù, an instagrammable beach that offers a memorable conclusion to your exploration.

When you’re done exploring for the day, you’ll return to Palermo and your accommodation.

Palermo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Palermo.

Enjoy a lovely meal at Splendid Hotel la Torre, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorantino Sobremesa is another top choice with a popular menu. You could also check for a table at Ristorante Quattro mani. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Palermo tonight.

To truly maximize your evening out, consider visiting Bar Touring after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Palermo Football Store, another bar with an inviting ambiance. Similarly, Goccio - L’arte Del Miscelare also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the sun sets, rest up and recharge for the next leg of your road trip in Sicily.

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Day4

Day 4

  • Palermo
  • Catania
  • More

Drive 332 km, 5 hours 14 min

  • Chiesa Madonna della Rocca
  • Porta Catania
  • Basilica of St. Nicholas of Bari
  • Ancient theatre of Taormina
  • Villa Comunale di Taormina
  • Isola Bella
  • More

Experience an unparalleled adventure on day 4 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Taormina and Mazzarò. At the end of the day, you will retreat to the hotel of your choice in Catania, where will spend 2 nights.

Start your day at Chiesa Madonna Della Rocca. This romantic church is a curiosity-inducing place to see in Palermo. Then, wander over to Porta Catania. If culturally significant sites excite you, this monument will be right up your alley. Nearby, you’ll also find Basilica Of St. Nicholas Of Bari. This inviting church is a favorite among visitors.

Palermo offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Ancient Theatre Of Taormina is a captivating spot in the town that will captivate you with its unique charm. When you’re done at the archeological site, don’t forget to check out the noteworthy Villa Comunale Di Taormina. Take a moment to appreciate the fascinating details of this curiosity-inducing park. Wrap up your self-guided tour of Palermo's top attractions with a visit to Isola Bella.

At the end of the day, you will drive to Catania, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Catania, it's often a good idea to reserve a table in advance.

Dine in style at Ristorante da Antonio, a top recommendation for dinner tonight. Or, for a change of pace, Lido Arcobaleno boasts a menu that's sure to impress. Also, be sure to check out Lido Azzurro. Known as a local hotspot, it’s a great choice for tonight in Catania.

Following your dinner, dive into the local bar culture at Caffè Europa. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Insigne Cafè, the perfect place for those looking to experience the best of the nightlife. Similarly, Bohéme Mixology Bar provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Say good night to Catania and look forward to another great day of your road trip in Sicily!

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Day5

Day 5

  • Catania
  • More

Drive 138 km, 2 hours 12 min

  • Ear of Dionysius
  • Neapolis Archaeological Park
  • Temple of Apollo
  • Fountain of Diana
  • Island of Ortigia
  • Cathedral of Syracuse
  • More

On day 5 of your road trip, you'll get the chance to experience Syracuse. At the end of the day, you'll drive back to Catania, where you still have 1 night left to stay.

Enjoy all that Ear Of Dionysius has to offer. This is an up-and-coming cave you should not miss. Another must-see is Neapolis Archaeological Park, a captivating archeological site in Catania.

When you’re ready for the next sight, head to Temple Of Apollo. From there, take a leisurely stroll to Diana Fountain, another of the city’s curiosity-inducing attractions. We recommend continuing your self-guided tour at Ortygia, an enchanting place of interest in the city. If time allows, add Cathedral Of Syracuse to your itinerary. This curiosity-inducing church offers the perfect finishing touch to your day in Catania.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Catania.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Catania, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Il Gambero Pazzo, a top-rated dining destination in Catania. If you're in the mood to try something new, consider Deliziosa, another top spot with a mouthwatering menu. You might also want to secure a reservation at Lettera 82 Risto Pub. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Catania this evening.

Extend your evening after a delightful meal by visiting Circus Cocktail Bar, which offers the perfect atmosphere for a night out. Moreover, Caffè Opera is another popular option for a drink or two. Likewise, Chiosco Sicilia Seltz also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Savor another day of unforgettable experiences in Sicily!

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Day6

Day 6

  • Catania
  • Palermo
  • More

Drive 293 km, 4 hours 21 min

  • Tempio Di Zeus Olympios
  • Temple of Heracles
  • Valle dei Templi
  • Museo archeologico regionale Pietro Griffo
  • More

On day 6 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 1 destination, including Agrigento. When you’re not sightseeing, take time to relax at your chosen hotel in Palermo, where you’ll be staying for 1 night.

Temple Of Olympian Zeus is must-visit sightseeing destination and a great option for a daytime tour of the area. Continue your journey to Temple Of Heracles, a curiosity-inducing archeological site, located just a leisurely stroll away. Next, head to Valle Dei Templi, a majestic archeological site, also available for your discovery today.

When you’re done exploring for the day, you’ll drive to your hotel in Palermo. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Palermo. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Trattoria Ai Cascinari, an iconic dining spot in Palermo. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Villa Boscogrande - Chef Natale Di Maria, a popular restaurant in Palermo. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of MadoniEAT, a hidden gem nestled in Palermo. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Pasticceria Massaro, a great choice for enjoying the after-dinner hours with a drink. You could also go to Bar Sanremo - Palermo, which offers a similarly pleasant setting and great drinks. Another option is Bar Touring, which provides an inviting environment for unwinding after a busy day out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Sicily.

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Day7

Day 7

  • Palermo - Departure day
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  • Catacombe dei Cappuccini
  • More

Day 7 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Catacombe Dei Cappuccini, a stunning cemetery before you head out.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

Enjoy a lovely meal at Ristorante Ferro, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, RISTORANTE PRIMI PIATTI is another top choice with a popular menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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