7-Day Italy Self-Drive Road Trip With Itinerary from Genoa to Florence

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Explore the best of Italy on a 7-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Manarola, Corniglia, Vernazza, Pisa, Florence, Siena, and Lucca. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Genoa and 2 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Cathedral Of Santa Maria Del Fiore.

As you hit the open road and drive through Genoa, Manarola, Corniglia, Vernazza, Pisa, Florence, Siena, and Lucca, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
Lighthouse of GenoaGalata - Museo del mareAquarium of GenoaGenoa CathedralDoge's Palacepiazza De Ferrari
Manarola Overlook ViewpointCinque Terre National ParkRuins of Doria TowerChurch of St. Margaret of AntiochScalinata Lardarina
“Tuttomondo” (Keith Haring)Santa Maria della SpinaKnights' SquareLeaning Tower of PisaPiazza del Duomo, PisaPisa Cathedral
Cathedral of Santa Maria del Fiorepiazza della SignoriaPonte VecchioUffizi GalleryBasilica of Santa Croce in Florencepiazzale Michelangelo
Siena Cathedralpiazza del CampoWalls of LuccaPorta San Pietro
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 3 nights before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Dine in style at 7 Sensi cucina decontaminata, a top recommendation for dinner tonight. Or, for a change of pace, Alla Lunga Ristorante boasts a menu that's sure to impress. Also, be sure to check out Grand Hotel Savoia. Known as a local hotspot, it’s a great choice for tonight in Genoa.

To truly maximize your evening out, consider visiting Scurreria Beer & Bagel after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to La Lepre, another bar with an inviting ambiance. Similarly, Bar Pisacane Iii also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Raise a toast to the start of your 7-day road trip in Italy!

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Day 2

Day 2

  • Genoa
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Drive 11 km, 48 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Aquarium of Genoa
  • Genoa Cathedral
  • Doge's Palace
  • piazza De Ferrari
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring Genoa. You have 2 nights left in Genoa. Take the opportunity to experience more of the best attractions and activities in the city.

Lighthouse Of Genoa is must-visit lighthouse and a great starting point for the day. Next, continue your journey to Galata Museo Del Mare (complex), a curiosity-inducing maritime museum, located just a leisurely stroll away. Next, head to Aquarium Of Genoa, an eye-catching aquarium, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Genoa. If you’re looking for more, Genoa Cathedral is also an up-and-coming attraction that is worthwhile a visit. Lastly, don’t miss Doge's Palace, a locally appreciated gem to see in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Make sure to reserve a table at Zeffirino, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Vegia Zena, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria delle Grazie, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 3

Day 3

  • Genoa
  • More

Drive 249 km, 4 hours 46 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • Church of St. Margaret of Antioch
  • Scalinata Lardarina
  • More

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Genoa, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Genoa allows for both. Start by heading to Manarola Overlook Viewpoint. This frequently visited observation deck provides an insightful glimpse into the village's identity. Next, discover Cinque Terre National Park, an UNESCO world heritage-designated national park, promising a delightful encounter.

Continue your sightseeing with a visit to Ruins Of Doria Tower, a locally appreciated monument. When you’re done, don’t forget to make a stop at the frequently visited Church Of St. Margaret Of Antioch. Round off your day at Scalinata Lardarina, another gem in Genoa with enchanting features to discover.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Genoa.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Osteria Sant'Ilario, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Cialtroneria, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Manhattan Bar, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 4

Day 4

  • Genoa
  • Florence
  • More

Drive 271 km, 3 hours 58 min

  • “Tuttomondo” (Keith Haring)
  • Santa Maria della Spina
  • Knights' Square
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Pisa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Enjoy the perfect balance of relaxation and exploration in Genoa today. One of the most beloved attractions included on the itinerary is “tuttomondo” (keith Haring). This remarkable art installation will help you start your sightseeing on top. Then, take a leisurely stroll to Santa Maria Della Spina and learn what makes this visually striking church unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the worthwhile Knights' Square. After exploring the public square, head to Leaning Tower Of Pisa. This globally renowned monument is a highlight in Genoa. Lastly, don’t forget to check out the wondrous Piazza Del Duomo, Pisa. Enjoy exploring this incredible public square at your own pace.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a delicious meal at Ristorante Oliviero 1962, a highly-rated dining destination in Florence. If you're eager to try something different, consider Di Poneta Novoli, another top spot with a tantalizing menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

To truly maximize your evening out, consider visiting Manifattura after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Se·sto On Arno Rooftop Bar, another bar with an inviting ambiance. Similarly, Il Vinile also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 5

Day 5

  • Florence
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Drive 8 km, 1 hour 2 min

  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • More

Day 5 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

A blend of family-friendly attractions, romantic experiences, and breathtaking views await you in Florence on today’s itinerary. First up is the impressive church, Cathedral Of Santa Maria Del Fiore. Afterward, continue to Piazza Della Signoria, a public square every traveler should visit.

As you explore Florence’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Ponte Vecchio. This globally renowned historical landmark is an essential stop. Following that, head to Uffizi Gallery, another must-visit site that will enhance your experience. Don’t forget to stop by Basilica Of Santa Croce In Florence, a captivating church in the city. Finally, end your day with a visit to Piazzale Michelangelo, a history-steeped observation deck that offers the perfect conclusion to your sightseeing of the day.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Let the evening flow smoothly from dinner to drinks at Bar 50 Rosso, a top-rated bar in the area. For other recommendations, Bitter Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Archea Brewery offers a memorable night with diverse drink options and excellent service.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 6

Day 6

  • Florence
  • Genoa
  • More

Drive 380 km, 4 hours 59 min

  • Siena Cathedral
  • piazza del Campo
  • Walls of Lucca
  • Porta San Pietro
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Siena and Lucca, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Set out on a day brimming with family-friendly attractions, romantic experiences, and scenic views. Start at the locally renowned Siena Cathedral, a visually striking church in Florence. Next, go to Piazza Del Campo.

After visiting Siena Cathedral and Piazza Del Campo, take time to explore Florence's streets and absorb its charm. Continue your sightseeing by heading to Mura Di Lucca. This romantic historical landmark offers a unique experience. Porta San Pietro is another noteworthy stop.

When you’re done exploring for the day, you’ll drive to your hotel in Genoa. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Don’t miss out on dining at Vivarelli, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider Trattoria Ugo, another top spot with a mouthwatering menu. You might also want to secure a reservation at TAZZE PAZZE Specialty Coffee. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 7

Day 7

  • Genoa - Departure day
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  • Via Garibaldi
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Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Via Garibaldi, a visually striking street before you head out.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area, Via Garibaldi. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Treat yourself to a delightful dinner at Bar Festival, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Il Marin? It's another excellent option with a diverse menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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