7-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Rome, and Siena

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Genoa. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 1 night.

Make time for Via Garibaldi, an up-and-coming street that is worthwhile a visit in the city. Nearby, you’ll find Galata Museo Del Mare (complex), enchanting visitors with its photogenic appeal. Continue your exploration at Aquarium Of Genoa. This aquarium is one of the city’s most spectacular spots.

Enjoy the freedom of exploring Genoa at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Porto Antico.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Experience a harmony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Known for its 3-star Michelin status, Enoteca Pinchiorri offers a delightful variety of dishes highlighting its delicious italian contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Santa Elisabetta, a highly recommended restaurant known for its enticing creative and mediterranean cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Gucci Osteria da Massimo Bottura, a highly acclaimed restaurant celebrated for its exceptional italian contemporary and international menu.

Keep the excitement of the evening going by visiting a bar or two. Manifattura is an excellent place to start. You could also check out Se·sto On Arno Rooftop Bar, offering a different kind of charm. A last recommendation for the day is Il Vinile. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and look forward to more memorable moments to come!

Your itinerary for day 3 of your road trip in Italy includes 1 stop and features some of the highlights of Florence. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 2 nights.

Experience Piazza Della Signoria, a famous public square in the city. Then, head to Ponte Vecchio and soak in the ambiance of this romantic historical landmark.

There are many interesting places to see in Florence, and when you are ready for more, go to Cathedral Of Santa Maria Del Fiore. This is one of the city’s most top-rated UNESCO world heritage-designated spots of interest. After exploring the church, visit the extraordinary Piazzale Michelangelo. Not far away, you'll also find Tower Of San Niccolò. This monument is a respected highlight in Florence.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Get ready for an unforgettable culinary journey in Rome by reserving a table at La Pergola. Renowned as a 3-star Michelin restaurant, it offers an exceptional mediterranean and contemporary menu. For a different taste experience, head to Il Pagliaccio, recognized for its delicious creative and innovative dishes. This 2-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit Enoteca La Torre, a local favorite known for its delightful mediterranean and creative cuisine in Rome. Nestled in the heart of the city, this restaurant with 2 Michelin star is an ideal choice for mediterranean and creative foodies seeking culinary excellence.

Keep the evening going at La Botticella Of Poggi Giovanni, a great choice for enjoying the after-dinner hours with a drink. You could also go to Almalu Trastevere, which offers a similarly pleasant setting and great drinks. Another option is Bar Viminale Di Pepi Maurilio, which provides an inviting environment for unwinding after a busy day out.

Take some time to reflect on your day and savor another beautiful night in Italy.

On day 4 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Colosseum leaves a lasting impression. This archeological site is one of the most iconic places to visit in Rome. Next, head to Roman Forum, an iconic archeological site, known for its UNESCO world heritage-designated features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Pantheon. This photogenic monument is a highly recommended experience. Nearby, you'll also find Piazza Navona and Castel Sant'angelo Visit these for an interesting touch to your journey.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Dine in style at RomAntica, a top recommendation for dinner tonight. Or, for a change of pace, Coso Ristorante boasts a menu that's sure to impress. Also, be sure to check out DEROMA - Farine Romane. Known as a local hotspot, it’s a great choice for tonight in Rome.

Extend your evening after a delightful meal by visiting Sant' Eustachio Caffè, which offers the perfect atmosphere for a night out. Moreover, Yellowsquare Rome is another popular option for a drink or two. Likewise, Caffè Portofino also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Celebrate another amazing day of your road trip adventure in Italy!

Dive into day 5 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Rome and Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Your adventure in Rome is only getting started when you visit Trevi Fountain, a world-famous local hot spot. Another notable attraction to explore is Piazza Di Spagna. This timeless public square is known for its romantic appeal.

After soaking in the highlights of these sights, take some time to wander Rome's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Spanish Steps. This visually striking public square offers a fascinating experience that many visitors find memorable. Piazza Del Popolo is also worth visiting, along with St. Peter's Basilica. These standout landmarks offer unique experiences that add to the day’s enjoyment.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Treat yourself to a wonderful meal at Enoteca I Terzi, a top-rated dining spot in Siena. If you're in the mood for something new, try Ristorante Tar-Tufo, another premier location with a delectable menu. You might also want to book a table at Antica Trattoria Papei. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Siena.

Round off your dining experience by visiting Meet Life Cafè, a prime location for a drink. Alternatively, explore the distinctive characteristics of Maudit Pub, a bar catering to every mood and preference. Bar Impero Siena likewise offers a unique atmosphere, perfect for a memorable night out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

On day 6 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Siena and Pisa are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

One of the most top-rated attractions included on the itinerary is Piazza Del Campo. This romantic public square will help you start your sightseeing on top. Then, take a leisurely stroll to Opera Delle Metropolitana and learn what makes this stunning museum unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the locally renowned Siena Cathedral. After exploring the church, head to Logge Dei Banchi. This worthwhile public square is a highlight in Siena.

When you’re done exploring for the day, you’ll drive to your hotel in Genoa. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Discover the culinary delights of Genoa by securing a reservation at San Giorgio. Esteemed for its 1-star Guide Michelin recognition, this restaurant offers a remarkable selection of modern and ligurian cuisine. For an alternative dining experience, try The Cook, renowned for its delicious modern dishes. This esteemed 1-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to Il Marin, a highly recommended local eatery celebrated for its mouthwatering seafood and contemporary menu. With its 1-star Michelin recognition, it offers an unforgettable dining adventure.

Get a good night's sleep and look forward to another great day on the road in Italy!