7-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Rome, and Siena

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Genoa. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 1 night.

Via Garibaldi makes a great addition to your morning plans. This often recommended street is a visually striking place to see in Genoa. Continue your discovery at Galata Museo Del Mare (complex), an eye-catching maritime museum with stories to tell.

As you stroll around Genoa, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Aquarium Of Genoa. This spectacular aquarium offers an instagrammable encounter with Genoa. Next, make your way to Porto Antico to add another highlight to your day. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Genoa.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Dive into a culinary adventure like no other in Florence by booking a table at Enoteca Pinchiorri. This popular restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining option, venture to Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Gucci Osteria da Massimo Bottura, a top local restaurant known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it promises an exceptional dining experience not to be missed.

Continue your lively evening at Manifattura, a perfect place for winding down or revving up the night, depending on which mood you’re in. Se·sto On Arno Rooftop Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Il Vinile ensures a night out tailored to your taste.

Celebrate another amazing day of your road trip adventure in Italy!

Your itinerary for day 3 of your road trip in Italy includes 1 stop and features some of the highlights of Florence. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 2 nights.

Visiting Piazza Della Signoria is always a good idea. This spectacular public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the symbolic wonders of Ponte Vecchio, a must-see historical landmark in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Cathedral Of Santa Maria Del Fiore. This spectacular church offers an enriching experience. For a change of pace, head to Piazzale Michelangelo, where you can take in enchanting features. Conclude your self-guided sightseeing tour with a visit to Tower Of San Niccolò. These sights offer a fulfilling end to a perfect day.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Get ready for an unforgettable culinary journey in Rome by reserving a table at La Pergola. Renowned as a 3-star Michelin restaurant, it offers an exceptional mediterranean and contemporary menu. For a different taste experience, head to Il Pagliaccio, recognized for its delicious creative and innovative dishes. This 2-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit Enoteca La Torre, a local favorite known for its delightful mediterranean and creative cuisine in Rome. Nestled in the heart of the city, this restaurant with 2 Michelin star is an ideal choice for mediterranean and creative foodies seeking culinary excellence.

Continue your evening by exploring the vibrant nightlife scene at La Botticella Of Poggi Giovanni, a prime destination for a thrilling night out. Also, don’t forget to check out Almalu Trastevere, a bar that offers unique local touches. Likewise, Bar Viminale Di Pepi Maurilio provides an excellent alternative for a fun evening.

Relax and recharge in preparation for another adventurous day in Italy!

Day 4 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Experience Colosseum, an iconic archeological site in the city. Then, head to Roman Forum and soak in the ambiance of this breathtaking archeological site.

There are many interesting places to see in Rome, and when you are ready for more, go to Pantheon. This is one of the city’s most world-famous photogenic spots of interest. After exploring the monument, visit the timeless Piazza Navona. Not far away, you'll also find Castel Sant'angelo. This castle is an enchanting highlight in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at RomAntica, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Coso Ristorante? It's another excellent option with a diverse menu. Consider reserving a table at DEROMA - Farine Romane as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

After enjoying a fulfilling meal, continue your evening at Sant' Eustachio Caffè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Yellowsquare Rome offers a welcoming atmosphere for easing into the nightlife. Similarly, Caffè Portofino provides an excellent environment for a relaxed and enjoyable evening.

Savor another day of unforgettable experiences in Italy!

Dive into day 5 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Rome and Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Your adventure in Rome is only getting started when you visit Trevi Fountain, an iconic local hot spot. Another notable attraction to explore is Piazza Di Spagna. This timeless public square is known for its grand appeal.

After soaking in the highlights of these sights, take some time to wander Rome's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Spanish Steps. This visually striking public square offers a fascinating experience that many visitors find memorable. Piazza Del Popolo is also worth visiting, along with St. Peter's Basilica. These standout landmarks offer unique experiences that add to the day’s enjoyment.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Siena is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Siena.

Enjoy a lovely dining experience at Enoteca I Terzi, a popular restaurant in Siena. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Siena at Ristorante Tar-Tufo, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Antica Trattoria Papei. It’s yet another ideal choice to enhance your time in Siena tonight.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Meet Life Cafè, known for its inviting atmosphere. Maudit Pub is another great option if you’re looking for a place to get the night started. Similarly, Bar Impero Siena provides a great setting to enjoy the night away.

Savor another day of unforgettable experiences in Italy!

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Siena and Pisa. At the end of the day, you will retreat to the hotel of your choice in Genoa, where will spend 1 night.

Whatever your travel style is, Piazza Del Campo is an essential stop in Siena. This widely recognized public square provides an insightful glimpse into the city's identity. Next, discover Opera Delle Metropolitana, a stunning museum, promising a delightful encounter.

Continue your sightseeing with a visit to Siena Cathedral, a well-known church. When you’re done, don’t forget to make a stop at the locally appreciated Logge Dei Banchi.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Set out on a gastronomic journey in Genoa by reserving a table at San Giorgio. Renowned for its 1-star Michelin recognition, this restaurant presents an outstanding menu of modern and ligurian cuisine. For a different taste, head over to The Cook, renowned for its delectable modern dishes. This distinguished 1-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Il Marin, a highly rated local gem known for its exquisite seafood and contemporary menu. With a 1-star Michelin acclaim, it promises a dining experience you won't want to miss. Known for great service, it’s a fantastic choice for tonight in Genoa.

Raise your glass to another unforgettable day in Italy!