One-Week Italy Road Trip from Ancona traveling south to Pescara, Rome, and Perugia

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Experience the freedom of the open road in Italy as you embark on an unforgettable 8-day road trip! This experience caters to every traveler, featuring destinations like Ancona, Loreto, Pescara, Rome, Perugia, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Ancona, 1 night in Pescara, 3 nights in Rome, and 1 night in Perugia. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Ancona, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Ancona, Loreto, Pescara, Rome, Perugia, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Ancona - arrival day

  • Ancona - Arrival day
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  • Parco Della Cittadella di Ancona
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Your road trip adventure in Italy begins as soon as you reach Ancona and pick up your car. You’ll stay in Ancona for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Ancona is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Parco Della Cittadella Di Ancona or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Ancona. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat in Ancona. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Playa Solero, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Zucchero a Velò offers an enticing alternative with its varied menu. Additionally, Ristorante Il Giardino is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Ancona.

Round off your dining experience by visiting Posa Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Bar Four Roses, a bar catering to every mood and preference. Amarillo Beer Bar Ancona likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 8-day road trip in Italy!

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Day 2

Day 2 – Ancona, Loreto, and Pescara

  • Pescara
  • Ancona
  • Loreto
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Drive 169 km, 2 hours 36 min

  • Porta Pia
  • Lazzaretto of Ancona
  • Sanctuary of the Holy House of Loreto
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Ancona, and Loreto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pescara. You will spend 1 night here for some well-deserved relaxation.

Begin your sightseeing with a visit to Porta Pia. This city gate is rated an average of 4.4 out of 5 stars in 130 reviews.

Next up, make your way to Lazzaretto Of Ancona. This building has an average rating of 4.4 out of 5 stars from 4,023 reviews.

When you’ve had your share of Ancona, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Loreto. Your travel time is around 33 min.

Begin your sightseeing with a visit to Sanctuary Of The Holy House Of Loreto. This extraordinary church is rated an average of 4.8 out of 5 stars by 19,100 visitors.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Pescara. Pescara offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you explore more of Pescara, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Begin your culinary exploration in Pescara by securing a reservation at Nole. This renowned restaurant holds a Bib Gourmand award and offers an exceptional menu of italian contemporary, and italian cuisine. For another dining delight, visit Estrò, celebrated for its delectable contemporary, and country cooking menu. This acclaimed Bib Gourmand-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Taverna 58, a top local spot known for its tantalizing from abruzzo, and traditional menu. With a Bib Gourmand recognition, it guarantees an exceptional dining adventure.

Following your dinner, dive into the local bar culture at Posa Caffè Pescara. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bar Mixer, the perfect place for those looking to experience the best of the nightlife. Similarly, Temple Bar Irish Pub provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 3

Day 3 – Pescara, Vatican City, and Rome

  • Rome
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Drive 226 km, 3 hours 7 min

  • Vatican Museums
  • Saint Peter's Square
  • Sistine Chapel
  • St Peter's Basilica
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Rome, where you will stay for 3 nights.

Fasten your seatbelt and make your way to your next stop. Vatican City, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Pescara to Vatican City may take around 2 hours 23 min without traffic disruptions. Upon arrival in Vatican City, we highly recommend checking out some of the top attractions.

Journey into the unknown at Vatican Museums, a unique attraction awaiting your visit. This remarkable art museum has an average rating of 4.6 out of 5 stars from 133,310 reviews. Every year, Vatican Museums welcomes more than 1,612,530 curious visitors.

When you’re ready to continue your sightseeing, Saint Peter's Square is a recommended place to visit. This square is rated an average of 4.8 out of 5 stars in 38,954 reviews.

Another must-see attraction in Vatican City is Sistine Chapel. Rated an average of 4.7 out of 5 stars by 52,083 travelers, this popular tourist destination in Vatican City offers an experience you will remember.

St. Peter's Basilica is another popular stop on travelers' itineraries in Vatican City. This major basilica promises memorable moments of exploring. Other travelers have rated this attraction 4.8 out of 5 stars in 131,043 reviews. Each year, approximately 11,000,000 people travel to visit St. Peter's Basilica.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Set out on a gastronomic journey in Rome by reserving a table at La Pergola. Renowned for its 3-star Michelin recognition, this restaurant presents an outstanding menu of mediterranean, and contemporary cuisine. For a different taste, head over to Il Pagliaccio, renowned for its delectable creative, and innovative dishes. This distinguished 2-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Enoteca La Torre, a highly rated local gem known for its exquisite mediterranean, and creative menu. With a 2-star Michelin acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Round off your dining experience by visiting La Botticella Of Poggi Giovanni, a prime location for a drink. Alternatively, explore the distinctive characteristics of Sant' Eustachio Caffè, a bar catering to every mood and preference. Caffè Portofino likewise offers a unique atmosphere, perfect for a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 4

Day 4 – Rome

  • Rome
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Drive 4 km, 54 min

  • Altare della Patria
  • Capitoline Hill
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • More

On day 4 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.

Start your sightseeing with a visit to Altare Della Patria. This architectural structure is rated an average of 4.8 out of 5 stars from 49,843 visitors. Altare Della Patria welcomes around 1,683,070 visitors every year.

Capitoline Hill is another popular attraction you could visit today. This hill has a rating of 4.7 out of 5 stars from 19,557 visitors.

Roman Forum is also highly recommended by travelers. This square has a rating of 4.7 out of 5 stars from 114,450 visitors.

Colosseum is an attraction you won’t want to miss. Around 7,400,000 people visit this place every year. This roman amphitheatre is rated an average of 4.7 out of 5 stars in 328,821 reviews.

Another attraction you have the opportunity to visit today is Circus Maximus. This circus has received an average rating of 4.4 out of 5 stars from 44,741 travelers.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Make sure to reserve a table at DEROMA - Farine Romane, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Centro, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Raise your glass to another unforgettable day in Italy!

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Day 5

Day 5 – Rome

  • Rome
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Drive 6 km, 57 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • largo di Torre Argentina
  • Campo de' Fiori
  • More

Day 5 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Drop by the renowned Castel Sant'angelo. This popular museum has been rated an average of 4.7 out of 5 stars by 72,431 visitors. Based on recent data, this attraction is visited by more than 918,591 travelers every year.

Another unforgettable place to experience is Piazza Navona. Rated 4.7 out of 5 stars by 158,771 visitors, this square deserves a spot on today's sightseeing itinerary.

We also recommend a visit to Pantheon. Hosting around 30,000,000 visitors every year, the fascinating Pantheon is one of the best places to visit in Rome. This roman temple has been rated an average of 4.8 out of 5 stars in 189,682 reviews.

Another favorite attraction in the area is Largo Di Torre Argentina. This square and popular place of interest enjoys a rating of 4.5 out of 5 stars from 30,433 local and international travelers.

If you’re keen to explore even more, then consider a visit to Campo De' Fiori. With an average rating of 4.4 out of 5 stars from 51,133 travelers, this square is an attraction many avid travelers highly recommend visiting while in Rome.

One of the most unique ways of discovering what else Rome has to offer is by going on a top-rated tour. Be sure to check out all the experiences Rome offers and add your favorites to your Italy travel package below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to reserve a table at Ristorante Tema, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Maccheroni, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of RoYaL Art Cafè Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 6

Day 6 – Rome, and Perugia

  • Perugia
  • Rome
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Drive 174 km, 2 hours 58 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • Villa Borghese
  • More

Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Perugia, which will be your home away from home for 1 night.

Journey into the unknown at Trevi Fountain, a unique attraction awaiting your visit. This remarkable sculpture has an average rating of 4.8 out of 5 stars from 343,494 reviews.

When you’re ready to continue your sightseeing, Piazza Di Spagna is a recommended place to visit. This square is rated an average of 4.7 out of 5 stars in 113,658 reviews.

Another must-see attraction in Rome is Spanish Steps. Rated an average of 4.5 out of 5 stars by 57,211 travelers, this popular tourist destination in Rome offers an experience you will remember.

Piazza Del Popolo is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.6 out of 5 stars in 89,807 reviews.

Lastly, don't miss out on Villa Borghese. Rated 4.6 out of 5 stars by 69,749 local and international travelers, it's a popular place to visit.

When you’re done exploring for the day, you’ll drive to Perugia, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As dinnertime approaches, it's time to head out for a bite to eat in Perugia. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to book a table at Ristorante Settimo Sigillo, a popular restaurant in Perugia. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Perugia at Bar Pellas, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is La Taverna. As a dining spot that gains high praise from guests, it’s an ideal choice to enhance your time to Perugia tonight.

Cap off your dinner by heading to Tommi Bar, ideal for a leisurely evening with a drink in hand. Valentina is another bar that offers an enjoyable setting. Similarly, Caffe Dal Perugino is also a popular place to go on a night out, perfect for relaxing and socializing.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7 – Perugia, Santa Maria degli Angeli, and Ancona

  • Ancona
  • Santa Maria degli Angeli
  • Assisi
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Drive 191 km, 2 hours 51 min

  • Basilica of Santa Maria degli Angeli
  • Basilica of San Francesco d'Assisi
  • Piazza del Comune
  • Basilica di Santa Chiara
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Santa Maria degli Angeli. When you’re not sightseeing, take time to relax at your selected hotel in Ancona, where you’ll be staying for 1 night.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Santa Maria degli Angeli. This drive usually takes around 25 min, without any stops or traffic disruptions.

Start your sightseeing with a visit to Basilica Of Santa Maria Degli Angeli. This papal basilica is a popular stop on travelers’ itineraries in Santa Maria degli Angeli, with an average rating of 4.8 out of 5 stars by 19,258 visitors.

Set your GPS to Santa Maria degli Angeli and hit the road. Expect a journey of approximately 9 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Santa Maria degli Angeli beckons with new experiences!

Take the opportunity to see Basilica Of San Francesco D'assisi. This attraction has an average rating of 4.9 out of 5 stars from 33,258 visitors.

Piazza Del Comune is another sightseeing hotspot in the area. This sightseeing destination has been rated an average of 4.6 out of 5 stars by 3,057 travelers.

Santa Maria degli Angeli is also the home of Basilica Di Santa Chiara. Around 9,628 people have rated this minor basilica an average of 4.7 out of 5 stars.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Ancona. Ancona offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

After a day of adventure, treat yourself to an exquisite dinner at one of Ancona's best restaurants.

Treat yourself to an extraordinary dining experience at Sot'Ajarchi, a Bib Gourmand restaurant offering an incredible seafood, and from the marches menu. Alternatively, if your taste buds call for something different, Bontà delle Marche is another top choice with a popular menu.

To truly maximize your evening out, consider visiting Alla Tazza D'oro after dinner. This bar is known for offering some of the best drinks and vibes in the city.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 8

Day 8 – Ancona - departure day

  • Ancona - Departure day
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  • Piazza del Plebiscito
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Day 8 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Ancona before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

When you’re ready for some sightseeing, make your way to Piazza Del Plebiscito. This much-appreciated square is rated 4.4 out of 5 stars in 2,631 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Ancona.

If you're in the mood to try something new, consider Mixer Bar, another top spot with a mouthwatering menu.

You’ll then say farewell to Ancona. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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