One-Week Italy Self-Drive Road Trip With Itinerary from Pisa traveling west to Genoa and Milan

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Escape the ordinary with this exciting 8-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Pisa, 1 night in Genoa, and 3 nights in Milan. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pisa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Duomo Di Milano Museum and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Pisa, Tirrenia, Corniglia, Genoa, Milan, and Priorato, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Pisa - arrival day

  • Pisa - Arrival day
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  • Knights' Square
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Your road trip adventure in Italy begins as soon as you reach Pisa and pick up your car. You’ll stay in Pisa for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Pisa. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Anima di Grano Pizzeria Napoletana Pisa Italy, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of il Mercante, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Ghiotteria, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

If you’re not ready to end the night just yet, Jeffer Cocktails & Friends offers a perfect venue to relax and savor a drink. Similarly, Le Parisien Wine Bar is well-suited for those looking to unwind in a social setting. Las Volta Cocktailbar is another excellent spot to enjoy a nightcap after a delightful meal.

Raise a toast to the start of your 8-day road trip in Italy!

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Day 2

Day 2 – Pisa, Tirrenia, and Cascine Vecchie

  • Pisa
  • Tirrenia
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Drive 44 km, 1 hour 20 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • Parco Regionale Migliarino, San Rossore, Massaciuccoli
  • More

On day 2 of your road trip, you’ll start and end your day in Pisa, where you'll stay for 1 night more.

Discover a day packed with a mesmerizing, a picture-perfect, a heritage-rich, a grand, a noteworthy, an UNESCO world heritage-listed, and an inviting in Pisa. Begin your sightseeing with Leaning Tower Of Pisa. This world-famous monument is one of the top attractions in the city. Proceed to Piazza Del Duomo, Pisa, another must-visit attraction that enhances the city’s allure.

As you wander through the inviting streets of Pisa, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Pisa Cathedral. This increasingly popular church is a traveler-favorite.

Continue your road trip and head to your next destination, Tirrenia. This car ride takes around 22 min.

One of our top recommendations for your sightseeing is Bagno Degli Americani.

Embrace the thrill of the open road as you wave goodbye to Tirrenia and set your GPS to Cascine Vecchie. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 25 min. Upon reaching Cascine Vecchie, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Savor the rest of your day by heading to Parco Regionale Migliarino, San Rossore, Massaciuccoli, a worthwhile nature reserve that draws visitors from near and far.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Pisa.

As you explore more of Pisa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Dine in style at Ristorante Capodimonte Pisa, a top recommendation for dinner tonight. Or, for a change of pace, La Locanda Dei Pisani Doc Pisa boasts a menu that's sure to impress. Also, be sure to check out Baribaldi Pisa. Known as a local hotspot, it’s a great choice for tonight in Pisa.

Continue your evening by exploring the vibrant nightlife scene at Bar Mocambo, a prime destination for a thrilling night out. Also, don’t forget to check out Tree, a bar that offers unique local touches. Likewise, Chupiteria provides an excellent alternative for a fun evening.

Say good night to Pisa and look forward to another great day of your road trip in Italy!

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Day 3

Day 3 – Pisa, Corniglia, and Genoa

  • Pisa
  • Corniglia
  • Genoa
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Drive 212 km, 3 hours 35 min

  • Palazzo Blu
  • Santa Maria della Spina
  • Cittadella Nuova
  • Cinque Terre National Park
  • Leaning Tower of Pisa
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Pisa and Corniglia, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Pisa allows for both. Start by heading to Palazzo Blu. This curiosity-inducing art gallery provides an insightful glimpse into the city's identity. Next, discover Santa Maria Della Spina, a romantic church, promising a delightful encounter.

Continue your sightseeing with a visit to Cittadella Nuova, a locally appreciated park.

As you’ve unraveled the marvels of Pisa, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Corniglia may take around 1 hour 34 min. Upon your arrival in Corniglia, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Take your self-guided tour to Cinque Terre National Park, a notable national park that everyone visiting Corniglia should see. Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Experience a taste of local culinary excellence while in Genoa by securing a table at San Giorgio. An esteemed 1-star Michelin restaurant, it features an exceptional modern and ligurian menu. For an alternative taste experience, visit The Cook, famous for its scrumptious modern dishes. This 1-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover Il Marin, a local favorite celebrated for its exquisite seafood and contemporary cuisine in Genoa. Located in the heart of the city, this 1-star Michelin restaurant is an ideal pick for seafood and contemporary cuisine lovers seeking top-notch culinary experiences.

Keep the evening going at Scurreria Beer & Bagel, a great choice for enjoying the after-dinner hours with a drink. You could also go to La Lepre, which offers a similarly pleasant setting and great drinks. Another option is Bar Pisacane Iii, which provides an inviting environment for unwinding after a busy day out.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4 – Genoa and Milan

  • Genoa
  • Milan
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Drive 144 km, 2 hours 17 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Aquarium of Genoa
  • porto antico
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On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Genoa. When you’re not sightseeing, take time to relax at your selected hotel in Milan, where you’ll be staying for 3 nights.

Brace yourself for today’s incredible lineup of attractions in Genoa, featuring a romantic, a breathtaking, an instagrammable, a historically significant, a grand, and a culturally significant. Start at Piazza De Ferrari, a popular public square in the city. Then, head to Genoa Cathedral and soak in the ambiance of this photogenic church.

There are many interesting places to see in Genoa and when you are ready for more, go to Aquarium Of Genoa. This is one of the city’s most top-rated spots. After exploring the aquarium, visit the well-known Porto Antico.

When you’re done exploring for the day, you’ll drive to your hotel in Milan. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Milan. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy an outstanding dining experience at Enrico Bartolini al Mudec, a 3-star Michelin restaurant offering an exceptional creative menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 2-star Michelin-awardee, Seta by Antonio Guida, known for its delicious international and contemporary cuisine. Another highly-recommended restaurant in Milan is Il Luogo Aimo e Nadia, a renowned restaurant with a 1-star Guide Michelin recognition, known for its delicious italian contemporary and modern menu.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Nottingham Forest stands out as an excellent choice for a post-dinner cocktail. Alternatively, Armani/bamboo Bar offers an ideal atmosphere to enjoy the pleasures of the night. Mag Cafe is also a great option that provides a perfect setting for a relaxing evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 5

Day 5 – Milan

  • Milan
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Drive 9 km, 1 hour

  • Leonardo da Vinci Museum of Science and Technology
  • Santa Maria delle Grazie Church
  • Castello Sforzesco
  • Sempione Park
  • Arch of Peace
  • Duomo di Milano
  • More

Day 5 offers a multitude of experiences. You will stay in Milan for 2 nights more, offering you enough time to explore at a relaxed pace.

Get ready for a day filled with a picture-perfect, a respected, a sacred, an UNESCO world heritage-listed, an awe-inspiring, a grand, a charming, a beautiful, and a noteworthy in the charming city of Milan. Your adventure starts at Museo Della Scienza E Della Tecnologia "leonardo Da Vinci", a captivating local hot spot. Another notable attraction to explore is Santa Maria Delle Grazie Church. This locally renowned church is known for its standout appeal.

After soaking in the highlights of these sights, take some time to wander Milan's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Sforzesco Castle Art Library. This historic castle offers a fascinating experience that many visitors find memorable. Parco Sempione is also worth visiting, along with Arch Of Peace. These standout landmarks offer unique experiences that add to the day’s enjoyment.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Milan's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Dessert Bar Milano, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Radisson Blu Hotel Milan offers an enticing alternative with its varied menu. Additionally, Ristorante Qui Si Mangia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Milan.

Explore the vibrant nightlife at Kilburn Cocktail Bar Milano after your meal, a hub for lively evenings and memorable moments. Or, head to Bar Frida for a great selection of flavorful drinks and a charming setting. Furthermore, The Friends Pub Milano is perfect for those looking to extend their night with a touch of local flavor.

Head back to your accommodation in Milan and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6 – Milan

  • Milan
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Drive 15 km, 1 hour 16 min

  • Piazza Gae Aulenti
  • Pinacoteca di Brera
  • Basilica di Sant'Ambrogio
  • MUDEC - Museum of Cultures
  • Duomo di Milano
  • More

On day 6 of your road trip, you will have an entire day to explore Milan. You’ll stay in Milan for 1 night and discover all the best things to see and do in the area.

Get ready for an exciting day in Milan. Today’s sightseeing agenda includes a public square, an art gallery, a church, a museum and much more! Begin your adventure at Piazza Gae Aulenti. This is an interesting public square you should not miss. Another must-see is Pinacoteca Di Brera, a notable art gallery in Milan.

When you’re ready for the next sight, head to Basilica Di Sant'ambrogio. From there, take a leisurely stroll to Mudec - Museum Of Cultures, another of the city’s notable attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Milan. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to book a table at Bice Restaurant, a popular restaurant in Milan. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Milan at Alto Ristorante, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Nero 9. As a dining spot that gains high praise from guests, it’s an ideal choice to enhance your time to Milan tonight.

Round off your dining experience by visiting Bhangrabar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Rufus Cocktail Bar, a bar catering to every mood and preference. Ostello Bello Grande likewise offers a unique atmosphere, perfect for a memorable night out.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7 – Milan, Priorato, and Pisa

  • Milan
  • Priorato
  • Pisa
  • More

Drive 289 km, 3 hours 45 min

  • La Scala
  • Galleria Vittorio Emanuele II
  • Duomo di Milano
  • More

Embark on another extraordinary experience on day 7 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Milan and Priorato. At the end of the day, you will enjoy the comforts of a top-rated hotel in Pisa, which will be your home away from home for 1 night.

Savor the day by visiting some of the best places to see in Milan, including an opera house and a shopping mall. Start your adventure at La Scala. This popular opera house is a must-visit for travelers looking for a unique holiday experience. Make your way to Galleria Vittorio Emanuele Ii located in Milan for an enchanting atmosphere.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Priorato. This drive usually takes around 1 hour 24 min, without any stops or traffic disruptions.

Spend your afternoon discovering Rocca Sanvitale, a beloved castle known for its history-steeped features.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

After a day of adventure, treat yourself to an exquisite dinner at one of Pisa's best restaurants.

Treat yourself to a delicious dinner at Restaurant -Pizzeria Il Mio Capriccio, an excellent option for tonight's dining. Looking for something different? Ristorante alle Bandierine offers a tantalizing alternative with its diverse menu. And don’t miss Barrique Cocktail And Bistrot. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pisa.

Continue your evening by exploring the vibrant nightlife scene at Bar Livorno, a prime destination for a thrilling night out.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 8

Day 8 – Pisa - departure day

  • Pisa - Departure day
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  • Leaning Tower of Pisa
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Day 8 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Pisa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Prepare for a day full of a picture-perfect and a noteworthy. When you’re ready, kick off your sightseeing adventure at “tuttomondo” (keith Haring). This underrated art installation is a must-visit for anyone seeking a unique vacation experience.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

Treat yourself to a delightful dinner at Anita Osteria, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La corte di San Leonardo? It's another excellent option with a diverse menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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