9-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Florence, Rome, and Siena

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Experience the freedom of the open road in Italy as you embark on an unforgettable 9-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Florence, Nazzano, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and Pisa.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Florence, 3 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Florence, Nazzano, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and Pisa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
porto anticoVia GaribaldiAquarium of Genoa
Cathedral of Santa Maria del Fiorepiazza della SignoriaPonte VecchioUffizi Gallerypiazzale Michelangelo
Riserva Naturale Regionale Nazzano Tevere-FarfaSaint Peter's SquareSt Peter's Basilica
ColosseumRoman ForumPantheonPiazza NavonaCastel Sant'Angelo
Villa Borghesepiazza del PopoloPiazza di SpagnaTrevi FountainAltare della Patria

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Genoa's charm before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Savor the flavors at 7 Sensi cucina decontaminata, a top pick for dinner tonight. Alternatively, Alla Lunga Ristorante beckons with its unique menu offerings. Also, consider Grand Hotel Savoia. With its consistent customer satisfaction, it’s an excellent option for dining in Genoa tonight.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Scurreria Beer & Bagel, known for its inviting atmosphere. La Lepre is another great option if you’re looking for a place to get the night started. Similarly, Bar Pisacane Iii provides a great setting to enjoy the night away.

Raise a toast to the start of your 9-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Florence
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Drive 254 km, 3 hours 38 min

  • porto antico
  • Via Garibaldi
  • Aquarium of Genoa
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On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Discover a day packed with fun adventures, romantic experiences, and scenic views in Genoa. Begin your sightseeing with Porto Antico. This interesting public square is one of the top attractions in the city. Proceed to Via Garibaldi, another must-visit attraction.

As you wander through the inviting streets of Genoa, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Aquarium Of Genoa. This famous aquarium is a traveler-favorite.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Dive into a culinary adventure like no other in Florence by booking a table at Enoteca Pinchiorri. This popular restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another culinary dining option, venture to Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Gucci Osteria da Massimo Bottura, a top local restaurant known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it promises an exceptional dining experience not to be missed.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Manifattura, known for its inviting atmosphere. Se·sto On Arno Rooftop Bar is another great option if you’re looking for a place to get the night started. Similarly, Il Vinile provides a great setting to enjoy the night away.

Raise your glass to another unforgettable day in Italy!

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Day 3

Day 3

  • Florence
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Drive 7 km, 56 min

  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • Ponte Vecchio
  • Uffizi Gallery
  • piazzale Michelangelo
  • More

Day 3 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Today's adventure in Florence promises more breathtaking discoveries and enriching experiences! Begin at Cathedral Of Santa Maria Del Fiore. This romantic church is a highlight of any visit in the city. Then, enjoy Piazza Della Signoria, another enchanting attraction that never fails to captivate visitors. Next, head over to Ponte Vecchio, one of the city’s most timeless attractions, known for its visually striking features.

If you’re looking for more, spend time soaking in the atmosphere of Uffizi Gallery. This picture-perfect art gallery is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazzale Michelangelo, an impressive observation deck, and take a stroll around the area.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Ditta Artigianale, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Trattoria Da Burde, another top spot with a mouthwatering menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

After your meal, keep the night alive at a bar like Bar 50 Rosso, known for its lively atmosphere. Bitter Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Archea Brewery offers an excellent atmosphere for those looking to amp up the evening.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4

  • Florence
  • Rome
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Drive 290 km, 3 hours 55 min

  • Riserva Naturale Regionale Nazzano Tevere-Farfa
  • Saint Peter's Square
  • St Peter's Basilica
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Nazzano and Vatican City. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 3 nights here for some well-deserved relaxation.

Begin your adventure at Riserva Naturale Regionale Nazzano Tevere-farfa. This is an underrated nature reserve you should not miss. Another must-see is Saint Peter's Square, a popular square in Florence.

When you’re ready for the next sight, head to St. Peter's Basilica.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Experience a harmony of flavors at La Pergola in Rome by securing a reservation in advance. Known for its 3-star Michelin status, La Pergola offers a delightful variety of dishes highlighting its delicious mediterranean and contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Il Pagliaccio, a highly recommended restaurant known for its enticing creative and innovative cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Enoteca La Torre, a highly acclaimed restaurant celebrated for its exceptional mediterranean and creative menu.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Rome
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Drive 9 km, 1 hour 11 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
  • Castel Sant'Angelo
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Day 5 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Discover a day packed with family-friendly attractions, breathtaking views, and picturesque spots in Rome. Begin your sightseeing with Colosseum. This globally renowned archeological site is one of the top attractions in the city. Proceed to Roman Forum, another must-visit attraction.

As you wander through the inviting streets of Rome, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Pantheon. This wondrous monument is a traveler-favorite. Not far away, you’ll find Piazza Navona, another key site on your sightseeing itinerary. Castel Sant'angelo is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Enjoy a lovely dining experience at RomAntica, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at Coso Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated DEROMA - Farine Romane. It’s yet another ideal choice to enhance your time in Rome tonight.

Keep the excitement of the evening going by visiting a bar or two. Sant' Eustachio Caffè is an excellent place to start. You could also check out Yellowsquare Rome, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6

  • Rome
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Drive 7 km, 1 hour 1 min

  • Villa Borghese
  • piazza del Popolo
  • Piazza di Spagna
  • Trevi Fountain
  • Altare della Patria
  • More

On day 6 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 1 night and discover all the best things to see and do in the area.

Get ready to discover some of the most iconic wonders in Rome, including a park, a public square, and a monument. Start your day at Villa Borghese. This eye-catching park is an astonishing place to see in Rome. Then, wander over to Piazza Del Popolo. If romantic sites excite you, this public square will be right up your alley. Nearby, you’ll also find Piazza Di Spagna. This romantic public square is a favorite among visitors.

Rome offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Trevi Fountain is a globally renowned spot in the city that will captivate you with its unique charm. When you’re done at the monument, don’t forget to check out the awe-inspiring Altare Della Patria. Take a moment to appreciate the fascinating details of this interesting monument.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Don’t miss out on dining at Hotel de Russie, a top-rated dining destination in Rome. If you're in the mood to try something new, consider La Taverna Italiana, another top spot with a mouthwatering menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Round off your dining experience by visiting The Apartment Bar Roma, a prime location for a drink. Alternatively, explore the distinctive characteristics of Hotel Hassler Roma, a bar catering to every mood and preference.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 7

Day 7

  • Rome
  • Siena
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Drive 261 km, 3 hours 37 min

  • The Tarot Garden
  • Spacco della Regina
  • River Park Ombrone Silvano Signori
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Dive into day 7 of your remarkable road trip in Italy. Today you will explore Pescia Fiorentina, Ansedonia, and Grosseto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Siena. You’ll stay here for 1 night.

Prepare for a day full of fun adventures, romantic experiences, and breathtaking views. When you’re ready, kick off your sightseeing adventure at The Tarot Garden. This frequently visited sculpture garden is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Spacco Della Regina, one of the village’s best highlights.

Next, check out River Park Ombrone Silvano Signori, one of the most underrated places to see in Rome. This park is a favorite among locals and travelers alike.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at Enoteca I Terzi, an excellent option for tonight's dining. Looking for something different? Ristorante Tar-Tufo offers a tantalizing alternative with its diverse menu. And don’t miss Antica Trattoria Papei. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Siena.

Keep the evening going at Meet Life Cafè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Maudit Pub, which offers a similarly pleasant setting and great drinks. Another option is Bar Impero Siena, which provides an inviting environment for unwinding after a busy day out.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 8

Day 8

  • Siena
  • Genoa
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Drive 286 km, 3 hours 57 min

  • piazza del Campo
  • Opera delle Metropolitana
  • Siena Cathedral
  • Cittadella Nuova
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Embark on another extraordinary experience on day 8 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Siena and Pisa. At the end of the day, you will enjoy the comforts of a top-rated hotel in Genoa, which will be your home away from home for 1 night.

Bring your curiosity for today’s adventure around Siena. Some of the city’s most loved attractions await! Piazza Del Campo is the perfect place to start. This public square is one of the most impressive places to visit in Siena. Next, head to Opera Delle Metropolitana, a beloved museum, known for its monumental features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Siena Cathedral. This visually striking church is a highly recommended experience. Nearby, you'll also find Cittadella Nuova. Visit these for an interesting touch to your journey.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Enjoy an outstanding dining experience at San Giorgio, a 1-star Michelin restaurant offering an exceptional modern and ligurian menu. Alternatively, if you're in the mood for something different, consider the nearby 1-star Michelin-awardee, The Cook, known for its delicious modern cuisine. Another highly-recommended place to eat in Genoa is Il Marin, a renowned restaurant with a 1-star Guide Michelin recognition and a delicious seafood and contemporary menu.

Head back to your accommodation in Genoa and get some rest in preparation for another magical day of your road trip in Italy!

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Day 9

Day 9

  • Genoa - Departure day
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  • Piazza Corvetto
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Day 9 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Piazza Corvetto. This often recommended public square is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're in the mood for something new, try La Cialtroneria, another premier location with a delectable menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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