9-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Florence, Rome, and Siena

Day 3 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Florence.

One of the most widely recognized attractions included on the itinerary is Cathedral Of Santa Maria Del Fiore. This enchanting church will help you start your sightseeing on top. Then, take a leisurely stroll to Piazza Della Signoria and learn what makes this enchanting public square unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the world-famous Ponte Vecchio. After exploring the historical landmark, head to Uffizi Gallery. This top-rated art gallery is a highlight in Florence. As your day continues, stop by Piazzale Michelangelo, known for its grand features.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Ditta Artigianale, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Trattoria Da Burde, another top spot with a mouthwatering menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

Keep the evening going at Bar 50 Rosso, a great choice for enjoying the after-dinner hours with a drink. You could also go to Bitter Bar, which offers a similarly pleasant setting and great drinks. Another option is Archea Brewery, which provides an inviting environment for unwinding after a busy day out.

Relax and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Nazzano and Vatican City. At the end of the day, you will retreat to the hotel of your choice in Rome, where will spend 3 nights.

Embrace the thrill of the open road as you wave goodbye to Florence and set your GPS to Nazzano. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 42 min. Upon reaching Nazzano, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Our first attraction recommendation in Nazzano is Riserva Naturale Regionale Nazzano Tevere-farfa, an increasingly popular nature reserve that draws attention for its gorgeous features.

It’s time to gear up for the next part of your road trip adventure. Set course for Vatican City! Under favorable conditions, your drive to Vatican City may take around 51 min. Upon your arrival in Vatican City, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Saint Peter's Square is a popular square we recommend visiting today.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Experience a symphony of flavors at La Pergola in Rome by securing a reservation in advance. Renowned for its 3-star Michelin distinction, La Pergola delights its guests with its exceptional variety of meals showcasing delicious mediterranean and contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Il Pagliaccio, acclaimed for its delectable creative and innovative specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Enoteca La Torre, a top-rated restaurant known for its outstanding menu. Known as a top-rated 2-star Michelin establishment, it's a top choice for mediterranean and creative cuisine in the city.

Continue the enjoyment post-dinner at La Botticella Of Poggi Giovanni, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Almalu Trastevere offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Viminale Di Pepi Maurilio. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.

Day 5 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Check out the timeless archeological site, Colosseum. Afterward, continue to Roman Forum, an archeological site every traveler should visit. As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Pantheon. This world-famous monument is an essential stop. Following that, head to Piazza Navona, another must-visit site that will enhance your experience. Don’t forget to stop by Castel Sant'angelo, an impressive castle in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at RomAntica, a top-rated dining spot in Rome. If you're in the mood for something new, try Coso Ristorante, another premier location with a delectable menu. You might also want to book a table at DEROMA - Farine Romane. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

Unwind after your meal by stepping into Sant' Eustachio Caffè. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Yellowsquare Rome offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Caffè Portofino, another top-rated bar in the area.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 6 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Enjoy all that Villa Borghese has to offer. This is a spectacular park you should not miss. Another must-see is Piazza Del Popolo, an extraordinary public square in Rome.

When you’re ready for the next sight, head to Piazza Di Spagna. From there, take a leisurely stroll to Trevi Fountain, another of the city’s timeless attractions. We recommend continuing your self-guided tour at Altare Della Patria, a picture-perfect place of interest in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Savor the flavors at Hotel de Russie, a top pick for dinner tonight. Alternatively, La Taverna Italiana beckons with its unique menu offerings. Also, consider The Parrot Bar. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

After savoring a delicious meal, step into the vibrant nightlife at The Apartment Bar Roma, where the evening is just getting started. In the same way, Hotel Hassler Roma offers a unique charm perfect for experiencing the local bar scene in Rome.

Celebrate another amazing day of your road trip adventure in Italy!

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 3 destinations, including Pescia Fiorentina, Ansedonia, and Grosseto. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Pescia Fiorentina. This drive usually takes around 1 hour 35 min, without any stops or traffic disruptions.

The Tarot Garden is an underrated sculpture garden we recommend visiting today. Discover its awe-inspiring features before continuing your self-guided tour.

When you’ve had your share of Pescia Fiorentina, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Ansedonia. Your travel time is around 16 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Spacco Della Regina, an often recommended cave that everyone visiting Ansedonia should see.

After soaking in Ansedonia’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Grosseto. Expect your car journey to take a minimum of 39 min. When you arrive in Grosseto, it's time to take a break from the road.

Set out on a self-guided sightseeing tour at River Park Ombrone Silvano Signori and explore the enchanting features.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Enoteca I Terzi, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorante Tar-Tufo is another top choice with a popular menu. You could also check for a table at Antica Trattoria Papei. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Siena tonight.

Continue your lively evening at Meet Life Cafè, a perfect place for winding down or revving up the night, depending on which mood you’re in. Maudit Pub is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Impero Siena ensures a night out tailored to your taste.

Celebrate another amazing day of your road trip adventure in Italy!

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Siena and Pisa. When you’re not sightseeing, take time to relax at your chosen hotel in Genoa, where you’ll be staying for 1 night.

No visit to Siena is complete without Piazza Del Campo. This top-rated public square is one of the top attractions in the city. Proceed to Opera Delle Metropolitana, another must-visit attraction.

As you wander through the inviting streets of Siena, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Siena Cathedral. This locally renowned church is a traveler-favorite.

Embrace the thrill of the open road as you wave goodbye to Siena and set your GPS to Pisa. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 43 min. Upon reaching Pisa, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Set out on a self-guided sightseeing tour at Cittadella Nuova and explore the visually striking features.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine.

Start your culinary exploration in Genoa by securing a reservation at San Giorgio. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of modern and ligurian cuisine. For another dining delight, visit The Cook, celebrated for its delectable modern menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Marin, a top local spot known for its tantalizing seafood and contemporary menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Raise your glass and celebrate another amazing day of your road trip in Italy!