9-Day Italy Road Trip from Pisa traveling south to Florence, and Rome

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Escape the ordinary with this exciting 9-day road trip through Italy. Explore the diverse landscapes and local cultures of Pisa, Florence, Siena, Rome, and Orvieto. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pisa, 2 nights in Florence, and 4 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pisa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Pisa, Florence, Siena, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Pisa - arrival day

  • Pisa - Arrival day
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  • Piazza dei Cavalieri
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Say hello to Pisa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Pisa for 1 night before you continue your adventure!

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Pisa. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Ristorante Capodimonte Pisa, a top-rated dining spot in Pisa. If you're in the mood for something new, try Baribaldi Pisa, another premier location with a delectable menu. You might also want to book a table at Restaurant -Pizzeria Il Mio Capriccio. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pisa.

Cap off your dinner by heading to Jeffer Cocktails & Friends, ideal for a leisurely evening with a drink in hand. Le Parisien Wine Bar is another bar that offers an enjoyable setting. Similarly, Las Volta Cocktailbar is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise a toast to the start of your 9-day road trip in Italy!

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Day 2

Day 2 – Pisa, and Florence

  • Florence
  • Pisa
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Drive 94 km, 2 hours 3 min

  • Leaning Tower of Pisa
  • Angelo Caduto
  • Piazza del Duomo
  • Cattedrale di Pisa
  • More

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Pisa. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 2 nights.

Make “tuttomondo” (keith Haring) one of your first sightseeing stops in Pisa. Rated an average of 4.6 out of 5 stars by 1,937 travelers, a visit to this local attraction makes for a great introduction to the area.

Leaning Tower Of Pisa is a worthwhile attraction you can visit next. This bell tower is a valued place of interest in the area, with an average rating of 4.7 out of 5 stars from 116,882 reviews. Up to 3,200,000 travelers visit this site every year to make their time in Pisa special.

Today is also the perfect opportunity to drop by Angelo Caduto. This sightseeing destination has been rated an average of 4.5 out of 5 stars by 150 visitors.

If you’re keen to explore more, head to Piazza Del Duomo, Pisa. A trip to this popular square is also your opportunity to see if it lives up to the reputable 4.7 out of 5-star rating as given by 104,550 previous visitors.

Another top place to visit is Pisa Cathedral. This cathedral enjoys an average rating of 4.8 out of 5 stars from 8,361 local and international travelers.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Start your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative, and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary, and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

After savoring a delicious meal, step into the vibrant nightlife at Manifattura, where the evening is just getting started. In the same way, Se·sto On Arno Rooftop Bar offers a unique charm perfect for experiencing the local bar scene in Florence. Archea Brewery is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3 – Florence

  • Florence
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Drive 11 km, 1 hour 14 min

  • Cathedral of Santa Maria del Fiore
  • Accademia Gallery
  • Piazzale Michelangelo
  • The Boboli Gardens
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Day 3 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Make Central Market your first stop of the day. Previous visitors have rated this sightseeing destination an average of 4.4 out of 5 stars in 43,100 reviews.

Next up, make a stop at Cathedral Of Santa Maria Del Fiore. With an average rating of 4.8 out of 5 stars by 76,359 visitors, it's easy to understand why so many people visit this church every year.

Galleria Dell'accademia is another attraction you can visit on this day of your vacation. This national museum has an average rating of 4.6 out of 5 stars by 34,429 visitors. Up to 1,719,645 travelers come to Florence every year to see Galleria Dell'accademia with their own eyes.

When you’re finished at Galleria Dell'accademia, the perfect next stop is Piazzale Michelangelo. This square is rated an average of 4.8 out of 5 stars in 77,744 reviews.

If you’re keen to explore even more, then consider a visit to The Boboli Gardens. This park is a top place to visit, with a rating of 4.2 out of 5 stars from 25,341 reviews.

One of the most unique ways of discovering what else Florence has to offer is by going on a top-rated tour. Be sure to check out all the experiences Florence offers and add your favorites to your Italy travel package below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Trattoria Da Burde, an excellent option for tonight's dining. Looking for something different? Ristorante Buca Mario offers a tantalizing alternative with its diverse menu. And don’t miss Eataly Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4 – Florence, Siena, and Rome

  • Rome
  • Florence
  • Siena
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Drive 325 km, 4 hours 7 min

  • Piazza della Signoria
  • Uffizi Gallery
  • Ponte Vecchio
  • Piazza del Campo
  • More

Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Florence, and Siena. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 4 nights.

Start your sightseeing with a visit to Piazza Della Signoria. This square is a popular stop on travelers’ itineraries in Florence, with an average rating of 4.8 out of 5 stars by 66,956 visitors.

Uffizi Gallery is another popular place of interest you can visit today. The average rating of 4.7 out of 5 stars from 61,794 reviews gives you an idea of other visitors’ experience at this attraction. It’s estimated that around 2,011,219 people visit this national museum every year.

If it’s still bright and early, make your way to Ponte Vecchio. Visitors have rated this deck arch bridge an average of 4.7 out of 5 stars in 118,099 reviews.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Siena. This drive usually takes around 1 hour 8 min, without any stops or traffic disruptions.

Start your sightseeing with a visit to Piazza Del Campo. This square is a popular stop on travelers’ itineraries in Siena, with an average rating of 4.8 out of 5 stars by 64,175 visitors.

When you’re done exploring for the day, you’ll drive to Rome, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Set out on a gastronomic journey in Rome by reserving a table at La Pergola. Renowned for its 3-star Michelin recognition, this restaurant presents an outstanding menu of mediterranean, and contemporary cuisine. For a different taste, head over to Il Pagliaccio, renowned for its delectable creative, and innovative dishes. This distinguished 2-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Enoteca La Torre, a highly rated local gem known for its exquisite mediterranean, and creative menu. With a 2-star Michelin acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Sant' Eustachio Caffè, the perfect place for those looking to experience the best of the nightlife. Similarly, Caffè Portofino provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5 – Rome

  • Rome
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Drive 10 km, 1 hour 2 min

  • Circus Maximus
  • Pantheon
  • Piazza Navona
  • Campo de' Fiori
  • Castel Sant'Angelo
  • More

On day 5 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 3 nights and discover all the best things to see and do in the area.

Journey into the unknown at Circus Maximus, a unique attraction awaiting your visit. This remarkable circus has an average rating of 4.4 out of 5 stars from 44,741 reviews.

When you’re ready to continue your sightseeing, Pantheon is a recommended place to visit. This roman temple is rated an average of 4.8 out of 5 stars in 189,682 reviews. Based on recent data, the attraction hosts 30,000,000 visitors per year.

Another must-see attraction in Rome is Piazza Navona. Rated an average of 4.7 out of 5 stars by 158,771 travelers, this popular tourist destination in Rome offers an experience you will remember.

Campo De' Fiori is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.4 out of 5 stars in 51,133 reviews.

Lastly, don't miss out on Castel Sant'angelo. Rated 4.7 out of 5 stars by 72,431 local and international travelers, it's a popular place to visit. This museum gets closer to 918,591 visits every year.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a lovely meal at DEROMA - Farine Romane, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Taverna Italiana is another top choice with a popular menu. You could also check for a table at Centro. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

Round off your dining experience by visiting The Apartment Bar Roma, a prime location for a drink. Alternatively, explore the distinctive characteristics of Hotel Hassler Roma, a bar catering to every mood and preference.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 6

Day 6 – Rome

  • Rome
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Drive 8 km, 1 hour 2 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • Piazza del Popolo
  • Villa Borghese
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Day 6 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Take the opportunity to see Trevi Fountain. This attraction has an average rating of 4.8 out of 5 stars from 343,494 visitors.

Piazza Di Spagna is another sightseeing hotspot in the area. This square has been rated an average of 4.7 out of 5 stars by 113,658 travelers.

Rome is also the home of Spanish Steps. Around 57,211 people have rated this monumental staircase an average of 4.5 out of 5 stars.

Another place you’ll want to visit is Piazza Del Popolo. With an average rating of 4.6 out of 5 stars from a total of 89,807 reviews, a visit to this square is a great idea.

This day of your vacation in Rome is also your chance to admire Villa Borghese. This must-visit urban zone of rome enjoys an average rating of 4.6 out of 5 stars from 69,749 reviews.

If you have an appetite for more adventure, check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You'll find the most recommended ones below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Don’t miss out on dining at Ristorante Tema, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Maccheroni, another top spot with a mouthwatering menu. You might also want to secure a reservation at RoYaL Art Cafè Roma. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 7

Day 7 – Rome

  • Rome
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Drive 6 km, 1 hour 22 min

  • Largo di Torre Argentina
  • Altar of the Fatherland
  • Roman Forum
  • Colosseum
  • Basilica Papale di Santa Maria Maggiore
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Day 7 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Seize the day by visiting some of the best attractions in the area, like Largo Di Torre Argentina. This extraordinary square has an average rating of 4.5 out of 5 stars from 30,433 visitors.

Next, make your way to Altare Della Patria. This architectural structure welcomes around 1,683,070 visitors yearly and is rated an average of 4.8 out of 5 stars in 49,843 reviews.

While in Rome, we also recommend a visit to Roman Forum. This square has been rated an average of 4.7 out of 5 stars in 114,450 reviews.

If you’re keen to explore even more, then consider a visit to Colosseum. This attraction gets around 7,400,000 yearly visitors. With an average rating of 4.7 out of 5 stars by 328,821 travelers, this roman amphitheatre is a highly recommended stop on your sightseeing around Rome.

Make your way to Basilica Di Santa Maria Maggiore, perhaps the most famous major basilica in Rome. This attraction is rated an average of 4.8 out of 5 stars in 27,678 reviews.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Rome has in store for you, use this day to go on a tour. Scroll down and select tours and activities to include on your itinerary for the day.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Harry's Bar, a highly-rated dining destination in Rome. If you're eager to try something different, consider Ristorante Amedeo, another top spot with a tantalizing menu. You might also want to secure a reservation at VinAllegro. With a reputation for consistently satisfied customers, it’s an excellent choice to enhance your stay in Rome this evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 8

Day 8 – Rome, Vatican City, Orvieto, and Pisa

  • Pisa
  • Orvieto
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Drive 371 km, 4 hours 39 min

  • Vatican Museums
  • Sistine Chapel
  • Well of St Patrick
  • More

On day 8 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City, and Orvieto. In the evening, you’ll end up in Pisa, where you will stay for 1 night.

Fasten your seatbelt and make your way to your next stop. Vatican City, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Rome to Vatican City may take around 12 min without traffic disruptions. Upon arrival in Vatican City, we highly recommend checking out some of the top attractions.

Make Vatican Museums one of your first sightseeing stops in Vatican City. Rated an average of 4.6 out of 5 stars by 133,310 travelers, a visit to this local attraction makes for a great introduction to the area. This art museum attracts 1,612,530 visitors every year.

Sistine Chapel is a worthwhile attraction you can visit next. This chapel is a valued place of interest in the area, with an average rating of 4.7 out of 5 stars from 52,083 reviews.

When you’ve had your share of Vatican City, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Orvieto, Italy. Your travel time is around 1 hour 36 min.

Journey into the unknown at Well Of St. Patrick, a unique attraction awaiting your visit. This remarkable sightseeing destination has an average rating of 4.5 out of 5 stars from 14,274 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Ristorante alle Bandierine, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider Barrique Cocktail And Bistrot, another top spot with a mouthwatering menu. You might also want to secure a reservation at Filter Coffee Lab. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Pisa this evening.

Continue your evening by exploring the vibrant nightlife scene at Bar Mocambo, a prime destination for a thrilling night out. Also, don’t forget to check out Tree, a bar that offers unique local touches. Likewise, Chupiteria provides an excellent alternative for a fun evening.

Raise your glass to another unforgettable day in Italy!

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Day 9

Day 9 – Pisa - departure day

  • Pisa - Departure day
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  • Palazzo Gambacorti
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Day 9 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Pisa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Begin your sightseeing with a visit to Palazzo Gambacorti. This palace is rated an average of 4.3 out of 5 stars in 309 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

Treat yourself to a delightful dinner at Sud, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Kiste' - La Pizza Artigianale. It's the second restaurant coming from the tower. ? It's another excellent option with a diverse menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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