10-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, and Rome
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Explore the best of Italy on a 10-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Corniglia, Manarola, Riomaggiore, La Spezia, Pisa, Florence, Siena, San Gimignano, Rome, and Orvieto. This road trip itinerary in Italy seamlessly combines exploration with relaxation.
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Genoa, 1 night in La Spezia, 2 nights in Florence, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Genoa, Corniglia, Manarola, Riomaggiore, La Spezia, Pisa, Florence, Siena, San Gimignano, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
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Day 1
- Genoa - Arrival day
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- piazza De Ferrari
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights immersing yourself in Genoa's charm before embarking on the next leg of your journey.
Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.
Dine in style at 7 Sensi cucina decontaminata, a top recommendation for dinner tonight. Or, for a change of pace, Alla Lunga Ristorante boasts a menu that's sure to impress. Also, be sure to check out Grand Hotel Savoia. Known as a local hotspot, it’s a great choice for tonight in Genoa.
Let the evening flow smoothly from dinner to drinks at Scurreria Beer & Bagel, a top-rated bar in the area. For other recommendations, La Lepre provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Pisacane Iii offers a memorable night with diverse drink options and excellent service.
Raise a toast to the start of your 10-day road trip in Italy!
Day 2
- Genoa
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Drive 13 km, 1 hour 13 min
- Lighthouse of Genoa
- Galata - Museo del mare
- Via Garibaldi
- Palazzo Podestà
- Aquarium of Genoa
- porto antico
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Day 2 offers a multitude of experiences. You will stay in Genoa for 1 night more, offering you enough time to explore at a relaxed pace.
A blend of family-friendly attractions, breathtaking views, and picturesque spots await you in Genoa on today’s itinerary. First up is the beloved lighthouse, Lighthouse Of Genoa. Afterward, continue to Galata Museo Del Mare (complex), a maritime museum every traveler should visit.
As you explore Genoa’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Via Garibaldi. This up-and-coming street is an essential stop. Following that, head to Palazzo Podestà, another must-visit site that will enhance your experience. Don’t forget to stop by Aquarium Of Genoa, a top-rated aquarium in the city. Finally, end your day with a visit to Porto Antico, an instagrammable public square that offers the perfect conclusion to your sightseeing of the day.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Don’t miss out on dining at Zeffirino, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider Trattoria Vegia Zena, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria delle Grazie. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.
Get a good night's sleep and look forward to another great day on the road in Italy!
Day 3
- Genoa
- La Spezia
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Drive 132 km, 3 hours 14 min
- Cinque Terre National Park
- Manarola Overlook Viewpoint
- Riomaggiore
- Castle of Riomaggiore
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Corniglia, Manarola, and Riomaggiore. In the evening, you’ll end up in La Spezia, where you will stay for 1 night.
A blend of fun adventures, romantic experiences, and natural wonders await you in Genoa on today’s itinerary. First up is the interesting national park, Cinque Terre National Park. Afterward, continue to Manarola Overlook Viewpoint, an observation deck every traveler should visit.
As you explore Genoa’s charming streets, take in the lively atmosphere and get to know the character of the village. Next, make your way to Riomaggiore. This underrated point of interest is an essential stop. Following that, head to Castle Of Riomaggiore, another must-visit site that will enhance your experience.
When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and spend some time relaxing before you head out to tour the city.
After a day of adventure, treat yourself to an exquisite dinner at one of La Spezia's best restaurants.
Savor the flavors at The Colombaio Park, a top pick for dinner tonight.
Head back to your accommodation in La Spezia and get some rest in preparation for another magical day of your road trip in Italy!
Day 4
- La Spezia
- Florence
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Drive 171 km, 2 hours 42 min
- Leaning Tower of Pisa
- Angelo Caduto
- Pisa Cathedral
- Piazza del Duomo, Pisa
- Campo santo
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Dive into day 4 of your remarkable road trip in Italy. Today you will explore Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 2 nights.
Start your day at Leaning Tower Of Pisa. This breathtaking monument is a world-famous place to see in La Spezia. Then, wander over to Angelo Caduto. Nearby, you’ll also find Pisa Cathedral. This historic church is a favorite among visitors.
La Spezia offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Piazza Del Duomo, Pisa is an iconic spot in the city that will captivate you with its unique charm. When you’re done at the public square, don’t forget to check out the picture-perfect Campo Santo. Take a moment to appreciate the fascinating details of this curiosity-inducing cemetery.
At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.
Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.
Raise your glass to another unforgettable day in Italy!
Day 5
- Florence
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Drive 2 km, 36 min
- Basilica of Santa Croce in Florence
- Uffizi Gallery
- Ponte Vecchio
- Palazzo Vecchio
- piazza della Signoria
- Cathedral of Santa Maria del Fiore
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Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.
Today’s agenda in Florence includes a church, an art gallery, a historical landmark, a palace, a public square and much more! Basilica Of Santa Croce In Florence is must-visit church and a great starting point for the day. Next, continue your journey to Uffizi Gallery, a top-rated art gallery, located just a leisurely stroll away. Next, head to Ponte Vecchio, an enchanting historical landmark, also available for your discovery today.
Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Florence. When you're ready, let your sightseeing route take you to the well-known Palazzo Vecchio. If you’re looking for more, Piazza Della Signoria is also an extraordinary attraction that is worthwhile a visit. Lastly, don’t miss Cathedral Of Santa Maria Del Fiore, a place of culturally significant interest in the city.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.
Have a fantastic dining experience at Ditta Artigianale, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Da Burde offers an enticing alternative with its varied menu. Additionally, Casa Toscana is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.
Unwind after your meal by stepping into Bar 50 Rosso. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Bitter Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Archea Brewery, another top-rated bar in the area.
Relax and recharge in preparation for another adventurous day in Italy!
Day 6
- Florence
- San Gimignano
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Drive 122 km, 2 hours 19 min
- Siena Cathedral
- piazza del Campo
- Tower of Mangia
- Chiesa di Sant'Agostino
- Town Hall, Picture Gallery and Great Tower
- Piazza del Duomo, San Gimignano
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Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Siena and San Gimignano. At the end of the day, you will enjoy the comforts of a top-rated hotel in San Gimignano, which will be your home away from home for 1 night.
Florence is brimming with adventures. Today’s wonderful stops include a church, a public square, a monument, a museum and much more! Begin your sightseeing adventure at the interesting Siena Cathedral and allow yourself time to explore. Just a short distance away you'll find your next stop, Piazza Del Campo, a visually striking public square that draws visitors from far and near.
Continue your journey to Tower Of Mangia, one of the city’s most increasingly popular spots that you shouldn’t miss. Another great site to visit is the intriguing Chiesa Di Sant'agostino. When you're finished at the church, Palazzo Comunale, Pinacoteca, Torre Grossa awaits your visit. This museum is a historic highlight on today's itinerary. Last up is a public square - the up-and-coming Piazza Del Duomo.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in San Gimignano. San Gimignano offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Get a good night's sleep and look forward to another great day on the road in Italy!
Day 7
- San Gimignano
- Rome
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Drive 281 km, 4 hours 6 min
- Castel Sant'Angelo
- Spanish Steps
- Piazza di Spagna
- Trevi Fountain
- Altare della Patria
- Circus Maximus
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On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 2 nights.
Today's adventure in San Gimignano promises more breathtaking discoveries and enriching experiences! Begin at Castel Sant'angelo. This history-steeped castle is a highlight of any visit in the city. Then, enjoy Spanish Steps, another enchanting attraction that never fails to captivate visitors. Next, head over to Piazza Di Spagna, one of the city’s most wondrous attractions, known for its history-steeped features.
If you’re looking for more, spend time soaking in the atmosphere of Trevi Fountain. This romantic monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Altare Della Patria, an interesting monument, and take a stroll around the area. If you want to extend your self-guided sightseeing tour, go check out Circus Maximus before you head back to your hotel.
When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.
If you’re not ready to end the night just yet, La Botticella Of Poggi Giovanni offers a perfect venue to relax and savor a drink. Similarly, Almalu Trastevere is well-suited for those looking to unwind in a social setting. Bar Viminale Di Pepi Maurilio is another excellent spot to enjoy a nightcap after a delightful meal.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 8
- Rome
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Drive 11 km, 1 hour 1 min
- St Peter's Basilica
- Roman Forum
- Colosseum
- Pantheon
- Piazza Navona
- Trastevere
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Wake up to day 8 of your extraordinary road trip in Italy. With 1 night left in Rome, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
A top thing to do today is to explore Trastevere, a must-see neighborhood in Vatican City. It's the perfect starting point for touring the top attractions in the area.
Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Rome allows for both. Start by heading to St. Peter's Basilica. This world-famous major basilica provides an insightful glimpse into the city's identity. Next, discover Roman Forum, an awe-inspiring archeological site, promising a delightful encounter.
Continue your sightseeing with a visit to Colosseum, a timeless archeological site. When you’re done, don’t forget to make a stop at the world-famous Pantheon. Round off your day at Piazza Navona, another gem in Rome with enchanting features to discover.
When you’re done exploring for the day, you’ll return to Rome and your accommodation.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.
Keep the excitement of the evening going by visiting a bar or two. Sant' Eustachio Caffè is an excellent place to start. You could also check out Yellowsquare Rome, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
Say good night to Rome and look forward to another great day of your road trip in Italy!
Day 9
- Rome
- Genoa
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Drive 519 km, 6 hours 15 min
- Well of St Patrick
- Orvieto Cathedral
- Orvieto subterranea
- Torre del Moro Orvieto
- Pozzo della Cava
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Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Orvieto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Genoa. You will spend 1 night here for some well-deserved relaxation.
Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most well-known attractions included on the itinerary is Well Of St. Patrick. This breathtaking monument will help you start your sightseeing on top. Then, take a leisurely stroll to Orvieto Cathedral and learn what makes this inviting church unique.
Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the beloved Orvieto Underground. After exploring the cave system, head to Torre Del Moro Orvieto. This intriguing monument is a highlight in Rome. As your day continues, stop by Pozzo Della Cava, known for its heritage-rich features.
At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.
Dine in style at Osteria Sant'Ilario, a top recommendation for dinner tonight. Or, for a change of pace, La Cialtroneria boasts a menu that's sure to impress. Also, be sure to check out Manhattan Bar. Known as a local hotspot, it’s a great choice for tonight in Genoa.
Say good night to Genoa and look forward to another great day of your road trip in Italy!
Day 10
- Genoa - Departure day
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- AMT GENOVA - Ferrovia Genova Casella
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Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, we recommend visiting Amt Genova - Ferrovia Genova Casella, a breathtaking heritage railway before you head out.
Make the most of your final day in Italy by visiting Genoa’s iconic markets and shopping establishments in the buzzing Porto Antico. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.
If you're in the mood to try something new, consider Trattoria Ugo, another top spot with a mouthwatering menu.
You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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