5-Day Italy Self-Drive Road Trip With Itinerary from Pescara to Rome and Florence

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View of the Pescara city hall and surrounding buildings, Pescara, Italy.
A visit in the biggest city of Abruzzo region, in the Adriatic sea.
The historic center of the sea city in Abruzzo region, during a summer sunday morning.
The Ponte del Mare monumental bridge and the Ferris wheel at the dusk, in the canal and port of Pescara city, Abruzzo region
Photo of Tourist port "Marina di Pescara".
Church Of The Sacred Heart of Jesus in Pescara city, Abruzzo region, Italy.
The view in the dusk from Ponte del Mare monumental bridge in the canal and port of Pescara city, Abruzzo region.
Photo of "Callalily" mural by Italian artist Pep Marchegiani on a motorway pylon.
Photo of  "La nave" (the boat) by italian sculptor Pietro Cascella.
Photo of Ponte del Mare (Sea Bridge) and boats anchored in the harbor in the channel of the Pescara River and the Majella mountain in the background
View of the Pescara seafront, with the bell tower of the Divino Amore church and the Gran Sasso
view of the city of Pescara in Italy, with the Adriatic Sea in the background
Facade of the building of the Province of Pescara in Abruzzo
Pescara
Colosseum, Rome, Italy.
Photo of piazza de spagna in Rome, Italy.
Photo of Fountain di Trevi in Rome, Italy.
Bridge Il Tevere a Ponte Vittorio Emanuele II in Rome, Italy.
Hadrian Mausoleum, Rome, Italy.
 Vatican dome of San Pietro and Sant Angelo Bridge, over Tiber river in Rome, Italy.
panoramic view of Rome and St. Peter's Basilica, Italy.
View of Pantheon in the morning, Rome, Italy.
Rome, Italy. Stunning twilight view of Forum ancient ruins, seen from Capitoline hill with Colosseum in background.
Aerial view of forum romanum and surrounding areas of historical centre of italian capital rome.
Cozy old street in Trastevere in Rome, Italy. Trastevere is rione of Rome, on the west bank of the Tiber in Rome, Lazio, Italy. Architecture and landmark of Rome.
Aerial panorama of St. Peter's Square in Vatican with Rome in the background. Italy.
photo of view of Illuminated Fontana Di Trevi, Trevi Fountain at Dusk, Rome, Italy.
photo of view of Spanish Step, Rome, Italy.
photo of view of Museum Luasanne, Rome, Italy.
photo of view Roma Wall of Lugo, Rome, Italy.
photo of view of Roman Bridge Cordoba, Rome, Italy.
photo of view of Roman ruins in Rome, Forum, Rome, Italy.
photo of view of Roman Bridge of Cordoba, Rome, Italy.
photo of view of The Iconic, the legendary Coliseum of Rome, Italy.
photo of view of Rome, Italy: The Roman Forum, Latin: Forum Romanum, Italian: Foro Romano, Rome, Italy.
photo of view of Trevi Fountain (Fontana di Trevi) in Rome, Italy. Trevi is most famous fountain of Rome. Architecture and landmark of Rome, Postcard of Rome, Italy.
Aerial view of the Cattedrale di Santa Maria del Fiore in Florence, Italy, overlooking the city
Photo of Florence Aerial View of Ponte Vecchio Bridge during Beautiful Sunny Day, Italy.
Photo of Woman enjoys beautiful view on famous Duomo cathedral in Florence, standing on empty cathedral square during morning time.
Photo of Summer street cafe on Piazza della Repubblica in Florence, Toscana province, Italy.
Photo of Giotto's Campanile - An aerial dusk view of Giotto's Campanile and the historical Old Town of Florence, as seen from the top of Brunelleschi's Dome of the Florence Cathedral. Florence, Tuscany, Italy.
Photo of Ponte Vecchio, old bridge over Arno River, Florence, Tuscany, Italy.
Photo of The Colossus of the Apennines, majestic stone sculpture by Giambologna located in the park of Villa Demidoff in Florence, Italy.
Photo of Fountain of Neptune in Florence in early morning.
Photo of Sunset view of Florence, Ponte Vecchio, Palazzo Vecchio and Florence Duomo, Italy. Architecture and landmark of Florence. Cityscape of Florence.
Vintage carousel and tourists in Piazza della Repubblica (Republic Square) and the arch in honor of the first king of united Italy on background in Florence, Italy.
Photo of Arches of the Vasari Corridor (Corridoio Vasariano) in Florence, Tuscany, Italy. View of the Lungarno degli Archibusieri.
cheerful senior woman cycling with her electric mountain bike above downtown of Florence with stunning view over the old city, Tuscany, Italy
Facade of Palazzo Pitti palace with Gallery of Modern Art large building on Piazza dei Pitti square in historical centre of Florence city, blue sky white clouds, Tuscany, Italy
photo of view of Florence,Italy.
photo of view of Florence,Italy.
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Explore the best of Italy on a 5-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Pescara, Rome, Florence, Siena, and Santa Maria degli Angeli. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pescara, 1 night in Rome, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Ponte Vecchio.

As you hit the open road and drive through Pescara, Rome, Florence, Siena, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ponte del Mare
ColosseumRoman ForumTrevi FountainSpanish StepsPantheonPiazza Navona
piazzale MichelangeloBasilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioPiazza della Repubblicapiazza della Signoria
FontebrandaSiena Cathedralpiazza del CampoBasilica of San Francesco d'Assisi
Nature Reserve Pineta Dannunziana

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Day 1

Day 1

  • Pescara - Arrival day
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  • Ponte del Mare
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Your road trip adventure in Italy begins as soon as you reach Pescara and pick up your car. You’ll stay in Pescara for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ponte Del Mare, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Pescara. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Taverna 58, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Ristorante Carlo Ferraioli offers an enticing alternative with its varied menu. Additionally, Sesamo Nero is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Pescara.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Posa Caffè Pescara, known for its inviting atmosphere. Bar Mixer is another great option if you’re looking for a place to get the night started. Similarly, Temple Bar Irish Pub provides a great setting to enjoy the night away.

Raise a toast to the start of your 5-day road trip in Italy!

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Day 2

Day 2

  • Pescara
  • Rome
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Drive 214 km, 3 hours 32 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Spanish Steps
  • Pantheon
  • Piazza Navona
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Bring your curiosity for today’s adventure around Pescara. Some of the city’s most loved attractions await! Colosseum is the perfect place to start. This archeological site is one of the most wondrous places to visit in Pescara. Next, head to Roman Forum, a world-famous archeological site, known for its breathtaking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Trevi Fountain. This romantic monument is a highly recommended experience. Nearby, you'll also find Spanish Steps and Pantheon. Visit these for an interesting touch to your journey. Finish the day with a visit to Piazza Navona, a romantic public square in Pescara.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 3

Day 3

  • Rome
  • Florence
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Drive 281 km, 3 hours 51 min

  • piazzale Michelangelo
  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Piazza della Repubblica
  • piazza della Signoria
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 1 night.

Get ready to discover some of the most iconic wonders in Rome, including an observation deck, a church, an art gallery, a historical landmark, a public square and much more! Start your day at Piazzale Michelangelo. This symbolic observation deck is an impressive place to see in Rome. Then, wander over to Basilica Of Santa Croce In Florence. If culturally significant sites excite you, this church will be right up your alley. Nearby, you’ll also find Uffizi Gallery. This romantic art gallery is a favorite among visitors.

Rome offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Ponte Vecchio is a wondrous spot in the city that will captivate you with its unique charm. When you’re done at the historical landmark, don’t forget to check out the visually striking Piazza Della Repubblica. Take a moment to appreciate the fascinating details of this locally renowned public square. Wrap up your self-guided tour of Rome's top attractions with a visit to Piazza Della Signoria.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

Unwind after your meal by stepping into Manifattura. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Se·sto On Arno Rooftop Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Il Vinile, another top-rated bar in the area.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 4

Day 4

  • Florence
  • Pescara
  • More

Drive 434 km, 5 hours 46 min

  • Fontebranda
  • Siena Cathedral
  • piazza del Campo
  • Basilica of San Francesco d'Assisi
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Siena and Santa Maria degli Angeli. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pescara. You will spend 1 night here for some well-deserved relaxation.

Prepare for a day full of fun adventures, picturesque spots, and historic treasures. When you’re ready, kick off your sightseeing adventure at Fontebranda. This intriguing historical landmark is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Siena Cathedral, one of the city’s best highlights.

Next, check out Piazza Del Campo, one of the most extraordinary places to see in Florence. This public square is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Basilica Of San Francesco D'assisi. Wander around and soak in the historic atmosphere this church offers.

At the end of the day, you will drive to Pescara, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Pescara. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Ciacco, a top-rated dining destination in Pescara. If you're in the mood to try something new, consider Bar Sara, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Franco. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pescara this evening.

Following your dinner, dive into the local bar culture at Bar Napoli. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bar Supermarket, the perfect place for those looking to experience the best of the nightlife. Similarly, Post Bar provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Pescara - Departure day
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  • Nature Reserve Pineta Dannunziana
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Day 5 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Nature Reserve Pineta Dannunziana. This increasingly popular nature reserve is a popular place to see in the city.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Pescara's best shopping area, Centro Commerciale Pescara Porta Nuova. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.

If you're in the mood to try something new, consider La Taverna Antica, another top spot with a mouthwatering menu.

You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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