6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Portofino and Florence

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Photo of Sand beach in Camogli by Genoa, Italy.
Photo of Piazza De Ferrari main square in Genoa Italy.
Photo of Courtyard of Palazzo Reale in Genoa, Italy.
Photo of View of Genoa at sunset from "Spianata Castelletto", Italy.
Photo of Sestri Levante - Paradise Bay of Silence with its boats and its lovely beach. Beautiful coast at Province of Genoa in Liguria, Italy - Europe.
Photo of Genoa, Liguria, Italy downtown city skyline from above at dusk.
Photo of The Aquarium of Genoa is the largest aquarium in Italy. Located in the old harbor area of Genova.
Photo of Genoa port from above at night.
Photo of Palace of St George (Palazzo San Giorgio), Genoa, Italy.
Photo of Genova Brignole Railway Station in the evening.
Photo of View of Bogliasco. Bogliasco is a ancient fishing village in Italy, Genoa, Liguria. Mediterranean Sea, sandy beach and architecture of Bogliasco town.
Photo of Beach with tourists in San Fruttuoso bay with the ancient Abbey (San Fruttuoso di Capodimonte), X-XI century, and Andrea Doria tower. Portofino and Camogli, Genoa province, Liguria, Italy, Europe.
Photo of View of Pieve Ligure and on Sori on the background, italian towns of ligurian riviera, Genoa (Genova) province, Italy.
photo of view of Bogliasco, Genoa, Italy town skyline on the Mediterranean sea at sunset.
Photo of Portofino in Italy by Pascvii
Aerial view of the Cattedrale di Santa Maria del Fiore in Florence, Italy, overlooking the city
Photo of Florence Aerial View of Ponte Vecchio Bridge during Beautiful Sunny Day, Italy.
Photo of Woman enjoys beautiful view on famous Duomo cathedral in Florence, standing on empty cathedral square during morning time.
Photo of Summer street cafe on Piazza della Repubblica in Florence, Toscana province, Italy.
Photo of Giotto's Campanile - An aerial dusk view of Giotto's Campanile and the historical Old Town of Florence, as seen from the top of Brunelleschi's Dome of the Florence Cathedral. Florence, Tuscany, Italy.
Photo of Ponte Vecchio, old bridge over Arno River, Florence, Tuscany, Italy.
Photo of The Colossus of the Apennines, majestic stone sculpture by Giambologna located in the park of Villa Demidoff in Florence, Italy.
Photo of Fountain of Neptune in Florence in early morning.
Photo of Sunset view of Florence, Ponte Vecchio, Palazzo Vecchio and Florence Duomo, Italy. Architecture and landmark of Florence. Cityscape of Florence.
Vintage carousel and tourists in Piazza della Repubblica (Republic Square) and the arch in honor of the first king of united Italy on background in Florence, Italy.
Photo of Arches of the Vasari Corridor (Corridoio Vasariano) in Florence, Tuscany, Italy. View of the Lungarno degli Archibusieri.
cheerful senior woman cycling with her electric mountain bike above downtown of Florence with stunning view over the old city, Tuscany, Italy
Facade of Palazzo Pitti palace with Gallery of Modern Art large building on Piazza dei Pitti square in historical centre of Florence city, blue sky white clouds, Tuscany, Italy
photo of view of Florence,Italy.
photo of view of Florence,Italy.
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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Portofino, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazza Della Signoria, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
piazza De FerrariGenoa CathedralDoge's PalaceAquarium of GenoaLighthouse of GenoaArea Marina Protetta di Portofino
Manarola Overlook ViewpointCinque Terre National ParkRuins of Doria TowerScalinata Lardarina
Leaning Tower of PisaPiazza del Duomo, PisaPorta NuovaUffizi GalleryPonte Vecchiopiazza della Signoria
Basilica of Santa Croce in FlorenceVilla Calcinaia - Conti CapponiPorta San GiovanniSanGimignano1300Piazza del Duomo, San Gimignano
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Genoa's charm before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at 7 Sensi cucina decontaminata, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Alla Lunga Ristorante offers an enticing alternative with its varied menu. Additionally, Grand Hotel Savoia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

After savoring a delicious meal, step into the vibrant nightlife at Scurreria Beer & Bagel, where the evening is just getting started. In the same way, La Lepre offers a unique charm perfect for experiencing the local bar scene in Genoa. Bar Pisacane Iii is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 48 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Aquarium of Genoa
  • Lighthouse of Genoa
  • Area Marina Protetta di Portofino
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On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa and San Fruttuoso di Camogli. In the evening, you’ll end up in Portofino, where you will stay for 2 nights.

Brace yourself for today’s incredible lineup of attractions in Genoa, featuring family-friendly attractions, romantic experiences, and scenic views. Start at Piazza De Ferrari, a captivating public square in the city. Then, head to Genoa Cathedral and soak in the ambiance of this monumental church.

After exploring the museum, visit the famous Aquarium Of Genoa. Not far away, you'll also find Lighthouse Of Genoa. This lighthouse is a culturally significant highlight in Genoa. Before wrapping up your self-guided sightseeing tour, head to Area Marina Protetta Di Portofino, an up-and-coming nature reserve in the city.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Portofino. Portofino offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Portofino. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Trattoria Concordia, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Puny. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

Head back to your accommodation in Portofino and get some rest in preparation for another magical day of your road trip in Italy!

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Day 3

Day 3

  • Portofino
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Drive 211 km, 4 hours 15 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • Scalinata Lardarina
  • More

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Portofino, we encourage you to seize the day and discover the unexplored beauty of the village’s surroundings!

Get ready for an exciting day in Portofino. Today’s sightseeing agenda includes an observation deck, a national park, a monument, a hiking area and much more! Begin your adventure at Manarola Overlook Viewpoint. This is an underrated observation deck you should not miss. Another must-see is Cinque Terre National Park, a well-known national park in Portofino.

When you’re ready for the next sight, head to Ruins Of Doria Tower. From there, take a leisurely stroll to Scalinata Lardarina, another of the village’s up-and-coming attractions.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Portofino.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Portofino. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor the flavors at I Gemelli, a top pick for dinner tonight. Alternatively, Ristorante Taverna del marinaio beckons with its unique menu offerings. Also, consider Ristorante Lo Stella. With its consistent customer satisfaction, it’s an excellent option for dining in Portofino tonight.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 4

Day 4

  • Portofino
  • Florence
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Drive 230 km, 3 hours 24 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Porta Nuova
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Pisa and Florence, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 1 night.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Portofino allows for both. Start by heading to Leaning Tower Of Pisa. This iconic monument provides an insightful glimpse into the city's identity. Next, discover Piazza Del Duomo, Pisa, a stunning public square, promising a delightful encounter.

Continue your sightseeing with a visit to Porta Nuova, a curiosity-inducing monument. When you’re done, don’t forget to make a stop at the widely recognized Uffizi Gallery. Not far away from the art gallery, you will find the visually striking Piazza Della Signoria, perfect for a quick visit. Round off your day at Ponte Vecchio, another gem in Portofino with enchanting features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Ristorante Oliviero 1962, a top pick for dinner tonight. Alternatively, Di Poneta Novoli beckons with its unique menu offerings. Also, consider Caffe San Firenze. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 5

Day 5

  • Florence
  • Genoa
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Drive 313 km, 4 hours 42 min

  • Basilica of Santa Croce in Florence
  • Villa Calcinaia - Conti Capponi
  • Porta San Giovanni
  • SanGimignano1300
  • Piazza del Duomo, San Gimignano
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On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 3 destinations, Florence, Greti, and San Gimignano. When you’re not sightseeing, take time to relax at your selected hotel in Genoa, where you’ll be staying for 1 night.

Start by visiting Basilica Of Santa Croce In Florence, a prime spot to begin your journey. This standout church is sure to impress. Next on your list is Villa Calcinaia - Conti Capponi, another must-visit landmark and intriguing winery renowned for its romantic features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Porta San Giovanni. This UNESCO world heritage-designated monument is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Sangimignano1300, a curiosity-inducing museum. Nearby, you'll also find Piazza Del Duomo, ready to add charm to your journey.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Make sure to reserve a table at Zeffirino, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Vegia Zena, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria delle Grazie, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Raise your glass to another unforgettable day in Italy!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Via Garibaldi. This up-and-coming street is a popular place to see in the city.

Make the most of your final day in Italy by visiting Genoa’s iconic markets and shopping establishments in the buzzing Via Garibaldi. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Have a fantastic dining experience at Osteria Sant'Ilario, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Cialtroneria offers an enticing alternative with its varied menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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