5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa

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Explore the best of Greece on a 5-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa. This road trip itinerary in Greece seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Thessaloniki, 1 night in Trikala, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Meteora, learn more about the unique The Umbrellas Sculpture By Zogolopoulos, and immerse yourself in the vibrant atmosphere of Arch Of Galerius And Rotunda.

As you hit the open road and drive through Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ladadika
Aristotelous SquareAgias Sofias SquareArch of GaleriusWhite Tower of Thessaloniki
Matsopoulos ParkThe Great Meteoron Holy Monastery of the Transfiguration of the SaviourMonastery of VarlaamMeteora
Katerini Municipal ParkMuseum of the Royal Tombs at Aigai (Aegae)Holy Monastery of the Virgin Mary SoumelaLazaristes Monastery
The Umbrellas by Zongolopoulos

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Day 1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Thessaloniki's charm before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Thessaloniki. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Dine in style at Kitchen Bar, a top recommendation for dinner tonight. Or, for a change of pace, The Greek boasts a menu that's sure to impress. Also, be sure to check out Phanós. Known as a local hotspot, it’s a great choice for tonight in Thessaloniki.

Round off your dining experience by visiting Beetle Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Vogatsikou 3, a bar catering to every mood and preference. Souel likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 5-day road trip in Greece!

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Day 2

Day 2

  • Thessaloniki
  • Trikala
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Drive 217 km, 3 hours 15 min

  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
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Dive into day 2 of your remarkable road trip in Greece. Today you will explore Thessaloniki, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Trikala. You’ll stay here for 1 night.

A blend of family-friendly attractions, romantic experiences, and breathtaking views await you in Thessaloniki on today’s itinerary. First up is the notable public square, Aristotelous Square. Afterward, continue to Agias Sofias Square, a public square every traveler should visit.

As you explore Thessaloniki’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Arch Of Galerius And Rotunda. This popular monument is an essential stop. Following that, head to White Tower Of Thessaloniki, another must-visit site that will enhance your experience.

At the end of the day, you will drive to Trikala, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Trikala. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Have a fantastic dining experience at ALVEO, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trikala Fortress offers an enticing alternative with its varied menu. Additionally, Palia Istoria is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Trikala.

Extend your evening after a delightful meal by visiting Soyita Art Cafe, which offers the perfect atmosphere for a night out. Moreover, Factory Café is another popular option for a drink or two. Likewise, The Love Shake also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Relax and reminisce about your day in Greece and look forward to more memorable moments to come!

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Day 3

Day 3

  • Trikala
  • Larissa
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Drive 118 km, 2 hours 53 min

  • Matsopoulos Park
  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Meteora
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Experience an unparalleled adventure on day 3 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Trikala and Kastraki. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Larissa. You will spend 1 night here for some well-deserved relaxation.

Savor the day by visiting some of the best places to see in Trikala, including a park and a monastery. Start your adventure at Matsopoulos Park. This intriguing park is a must-visit for travelers looking for a unique holiday experience. Make your way to Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour located in Trikala for another exciting encounter.

Next, immerse yourself in the setting of Monastery Of Varlaam. Its awe-inspiring features will captivate you. After the monastery, continue your tour of the city with a visit to Meteora. Visitors usually appreciate the idyllic features of this monastery.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Larissa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Don’t miss out on dining at Nonna Rossa, a top-rated dining destination in Larissa. If you're in the mood to try something new, consider Vosporos | Restaurant • Bar, another top spot with a mouthwatering menu. You might also want to secure a reservation at THE ALLEY. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Larissa this evening.

Keep the evening going at Sherlock Easy Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Kiou, which offers a similarly pleasant setting and great drinks. Another option is Wisedog, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Greece!

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Day 4

Day 4

  • Larissa
  • Thessaloniki
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Drive 259 km, 4 hours 15 min

  • Katerini Municipal Park
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Holy Monastery of the Virgin Mary Soumela
  • Lazaristes Monastery
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, Katerini, Vergina, and Kastanéa. When you’re not sightseeing, take time to relax at your selected hotel in Thessaloniki, where you’ll be staying for 1 night.

Larissa is home to plenty of attractions that offer fun adventures, romantic experiences, and natural wonders! Start at Katerini Municipal Park, an increasingly popular park that is worthwhile a visit in the city. Nearby, you’ll find Museum Of The Royal Tombs At Aigai (aegae), enchanting visitors with its UNESCO world heritage-listed appeal. Continue your exploration at Holy Shrine Of The Virgin Mary Soumela. This church is one of the city’s most increasingly popular spots.

Enjoy the freedom of exploring Larissa at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Lazaristes Monastery.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Enjoy a lovely meal at Mamalouka, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Clochard is another top choice with a popular menu. You could also check for a table at Sofi's House Restaurant. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Thessaloniki tonight.

Continue your evening by exploring the vibrant nightlife scene at Castra- All Day Terrace Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Barbaben - Bar/ba/ben, a bar that offers unique local touches. Likewise, Apallou provides an excellent alternative for a fun evening.

Savor another day of unforgettable experiences in Greece!

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Day 5

Day 5

  • Thessaloniki - Departure day
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  • The Umbrellas by Zongolopoulos
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Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Umbrellas Sculpture By Zogolopoulos. This captivating art installation is a popular place to see in the city.

As your final day in Greece unfolds, enjoy a last-minute shopping spree in Thessaloniki's best shopping area, Tsimiski Street. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Greece. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

If you're in the mood to try something new, consider O Loytros, another top spot with a mouthwatering menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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