6-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Trikala and Thessaloniki

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Explore the best of Greece on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Ioannina, Perama, Neo Bizani, Trikala, Kastraki, Thessaloniki, and Edessa. This road trip itinerary in Greece seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Ioannina, 1 night in Trikala, and 2 nights in Thessaloniki. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Ioannina, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Meteora, learn more about the unique Waterfalls Park, Edessa, and immerse yourself in the vibrant atmosphere of The Umbrellas Sculpture By Zogolopoulos.

As you hit the open road and drive through Ioannina, Perama, Neo Bizani, Trikala, Kastraki, Thessaloniki, and Edessa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ioannina Castle
Cave of PeramaMuseum "Arslan Pasha"Ich Kale Acropolis of IoanninaSilversmithing MuseumVrellis Greek History Museum (Wax Museum)
Trikala City Center SquareMatsopoulos ParkThe Great Meteoron Holy Monastery of the Transfiguration of the SaviourMeteora
Edessa WaterfallsThe Umbrellas by ZongolopoulosWhite Tower of ThessalonikiArch of GaleriusHeptapyrgion of Thessalonica
KapaniAgias Sofias SquareAristotelous Square
The Clock Tower of Ioannina

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Day 1

Day 1

  • Ioannina - Arrival day
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  • Ioannina Castle
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Say hello to Ioannina! Your exciting road trip through Greece is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Ioannina for 1 night before you continue your adventure!

Ioannina is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ioannina Castle, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Ioannina. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at To Dodeka Cafe Bar, a highly-rated dining destination in Ioannina. If you're eager to try something different, consider Mustagogia, another top spot with a tantalizing menu. You might also want to secure a reservation at Accademia Del Panino. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Ioannina this evening.

Continue your lively evening at ⚜ V E D E M A ⚜, a perfect place for winding down or revving up the night, depending on which mood you’re in. Hogwarts Tales And Spirits is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Chevalier ensures a night out tailored to your taste.

Raise a toast to the start of your 6-day road trip in Greece!

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Day 2

Day 2

  • Ioannina
  • Trikala
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Drive 148 km, 2 hours 51 min

  • Cave of Perama
  • Museum "Arslan Pasha"
  • Ich Kale Acropolis of Ioannina
  • Silversmithing Museum
  • Vrellis Greek History Museum (Wax Museum)
  • More

Experience an unparalleled adventure on day 2 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Perama, Ioannina, and Neo Bizani. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Trikala. You will spend 1 night here for some well-deserved relaxation.

Ioannina is home to plenty of attractions that offer fun adventures, natural wonders, and breathtaking views! Start at Cave Of Perama, a worthwhile cave that is worthwhile a visit in the town. Continue your exploration at Ic Kale Acropolis Of Ioannina. This archeological site is one of the town’s most intriguing spots.

Enjoy the freedom of exploring Ioannina at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Silversmithing Museum Of Ioannina. After exploring the museum, head to the curiosity-inducing Moyseio Ellinikis Istorias Payloy Vrelli.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Trikala. Trikala offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Trikala's best restaurants.

Treat yourself to a delightful dinner at ALVEO, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trikala Fortress? It's another excellent option with a diverse menu. Consider reserving a table at Palia Istoria as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Trikala.

If you’re not ready to end the night just yet, Soyita Art Cafe offers a perfect venue to relax and savor a drink. Similarly, Factory Café is well-suited for those looking to unwind in a social setting. The Love Shake is another excellent spot to enjoy a nightcap after a delightful meal.

Head back to your accommodation in Trikala and get some rest in preparation for another magical day of your road trip in Greece!

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Day 3

Day 3

  • Trikala
  • Thessaloniki
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Drive 257 km, 4 hours 16 min

  • Trikala City Center Square
  • Matsopoulos Park
  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Meteora
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you will explore Trikala and Kastraki, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Thessaloniki. You’ll stay here for 2 nights.

Set out on a day brimming with family-friendly attractions, romantic experiences, and breathtaking views. Start at the worthwhile Trikala City Center Square, a stunning public square in Trikala. Next, go to Matsopoulos Park.

After visiting Trikala City Center Square and Matsopoulos Park, have a stroll along Trikala's streets and take in the local charm. Continue your sightseeing by heading to Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. This historic monastery offers a unique experience. Meteora is another noteworthy attraction worthwhile a visit.

When you’re done exploring for the day, you’ll drive to your hotel in Thessaloniki. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Thessaloniki, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Kitchen Bar, a top-rated dining destination in Thessaloniki. If you're in the mood to try something new, consider The Greek, another top spot with a mouthwatering menu. You might also want to secure a reservation at Phanós. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Thessaloniki this evening.

Continue your lively evening at Beetle Bar, a perfect place for winding down or revving up the night, depending on which mood you’re in. Vogatsikou 3 is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Souel ensures a night out tailored to your taste.

Raise your glass to another unforgettable day in Greece!

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Day 4

Day 4

  • Thessaloniki
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Drive 185 km, 3 hours 28 min

  • Edessa Waterfalls
  • The Umbrellas by Zongolopoulos
  • White Tower of Thessaloniki
  • Arch of Galerius
  • Heptapyrgion of Thessalonica
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At the end of the day, you'll drive back to Thessaloniki, where you'll stay for 1 night more.

Discover a day packed with fun adventures, romantic experiences, and natural wonders in Thessaloniki. Begin your sightseeing with Waterfalls Park, Edessa. This popular waterfall is one of the top attractions in the city. Proceed to The Umbrellas Sculpture By Zogolopoulos, another must-visit attraction.

As you wander through the inviting streets of Thessaloniki, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to White Tower Of Thessaloniki. This spectacular monument is a traveler-favorite. Not far away, you’ll find Arch Of Galerius And Rotunda, another key site on your sightseeing itinerary. Heptapyrgion Of Thessaloniki is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Thessaloniki.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Mamalouka, a top-rated dining destination in Thessaloniki. If you're in the mood to try something new, consider Clochard, another top spot with a mouthwatering menu. You might also want to secure a reservation at Sofi's House Restaurant. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Thessaloniki this evening.

Extend your evening after a delightful meal by visiting Castra- All Day Terrace Bar, which offers the perfect atmosphere for a night out. Moreover, Barbaben - Bar/ba/ben is another popular option for a drink or two. Likewise, Apallou also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Relax and recharge in preparation for another adventurous day in Greece!

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Day 5

Day 5

  • Thessaloniki
  • Ioannina
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Drive 263 km, 3 hours 19 min

  • Kapani
  • Agias Sofias Square
  • Aristotelous Square
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Embark on another extraordinary experience on day 5 of your road trip in Greece. Today, you will make 1 stop and experience some of the highlights of Thessaloniki. At the end of the day, you will enjoy the comforts of a top-rated hotel in Ioannina, which will be your home away from home for 1 night.

Get ready to discover some of the most iconic wonders in Thessaloniki, including a market and a public square. Start your day at Kapani. This instagrammable market is a captivating place to see in Thessaloniki. Then, wander over to Agias Sofias Square. If culturally significant sites excite you, this public square will be right up your alley. Nearby, you’ll also find Aristotelous Square. This history-steeped public square is a favorite among visitors.

At the end of the day, you will drive to Ioannina, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Ioannina. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at Spitaki me thea, a popular restaurant in Ioannina. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Ioannina at Frontzoy Politeia - Frontzu Politia Restaurant, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Papi Cafe Bistro. It’s yet another ideal choice to enhance your time in Ioannina tonight.

Continue your evening by exploring the vibrant nightlife scene at Scala, a prime destination for a thrilling night out. Also, don’t forget to check out Route 66 Bar, a bar that offers unique local touches. Likewise, Palia Agora provides an excellent alternative for a fun evening.

Raise your glass and celebrate another amazing day of your road trip in Greece!

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Day 6

Day 6

  • Ioannina - Departure day
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  • The Clock Tower of Ioannina
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Day 6 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Ioannina before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Clock Tower Of Ioannina. This worthwhile monument is a popular place to see in the city.

Make the most of your final day in Greece by visiting Ioannina’s iconic markets and shopping establishments in the buzzing Epirus Street. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Greece. You can also browse through boutiques for stylish fashion choices. Savor your final moments in Greece at a cozy cafe while relaxing with a cup of coffee or tea.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Ioannina.

If you're eager to try something different, consider Frontzu Politia - Hotel, another top spot with a tantalizing menu.

You’ll then say farewell to Ioannina. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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