10-Day Italy Self-Drive Road Trip With Itinerary from Pisa to Rome, Florence, Milan, and Turin and surrounding area

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Pisa, 2 nights in Rome, 1 night in Florence, 1 night in Milan, and 2 nights in Turin. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pisa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Duomo Di Milano Museum.

As you hit the open road and drive through Pisa, San Vincenzo, Rome, Florence, Milan, Turin, Cavoretto, and Genoa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Knights' Square
Piazza del Duomo, PisaPisa CathedralLeaning Tower of PisaAngelo CadutoParco Regionale Migliarino, San Rossore, Massaciuccoli
San Vincenzo MarinaSaint Peter's SquareSt Peter's Basilica
ColosseumRoman ForumPantheonPiazza NavonaCastel Sant'Angelo
Altare della PatriaTrevi FountainPiazza di Spagnapiazza del PopoloVilla Borghese
piazza della SignoriaCathedral of Santa Maria del FiorePonte Vecchiopiazzale Michelangelo

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Day 1

Day 1

  • Pisa - Arrival day
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  • Knights' Square
  • More

Say hello to Pisa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Pisa for 2 nights before you continue your adventure!

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pisa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pisa, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Anima di Grano Pizzeria Napoletana Pisa Italy, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of il Mercante, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Ghiotteria, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Explore the vibrant nightlife at Jeffer Cocktails & Friends after your meal, a hub for lively evenings and memorable moments. Or, head to Le Parisien Wine Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Las Volta Cocktailbar is perfect for those looking to extend their night with a touch of local flavor.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Pisa
  • More

Drive 14 km, 43 min

  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • Leaning Tower of Pisa
  • Angelo Caduto
  • Parco Regionale Migliarino, San Rossore, Massaciuccoli
  • More

At the end of the day, you'll drive back to Pisa, where you'll stay for 1 night more.

Begin your adventure at Piazza Del Duomo, Pisa. This is a globally renowned public square you should not miss. Another must-see is Pisa Cathedral, an underrated church in Pisa.

When you’re ready for the next sight, head to Leaning Tower Of Pisa. From there, take a leisurely stroll to Angelo Caduto, another of the city’s beloved attractions.

As you’ve unraveled the marvels of Pisa, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Cascine Vecchie may take around 9 min. Upon your arrival in Cascine Vecchie, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Begin your journey at Parco Regionale Migliarino, San Rossore, Massaciuccoli and explore the romantic features.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Pisa.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Pisa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Ristorante Capodimonte Pisa, a top-rated dining spot in Pisa. If you're in the mood for something new, try La Locanda Dei Pisani Doc Pisa, another premier location with a delectable menu. You might also want to book a table at Baribaldi Pisa. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pisa.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar Mocambo, a well-loved spot among locals and tourists. Or, head to Tree. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Chupiteria, another top-rated place in the area.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Pisa
  • San Vincenzo, Tuscany
  • Rome
  • More

Drive 338 km, 4 hours 11 min

  • San Vincenzo Marina
  • Saint Peter's Square
  • St Peter's Basilica
  • More

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in San Vincenzo and Vatican City. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Embrace the thrill of the open road as you wave goodbye to Pisa and set your GPS to San Vincenzo. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 57 min. Upon reaching San Vincenzo, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Begin your journey at San Vincenzo Marina and explore the gorgeous features.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

If you’re not ready to end the night just yet, La Botticella Of Poggi Giovanni offers a perfect venue to relax and savor a drink. Similarly, Almalu Trastevere is well-suited for those looking to unwind in a social setting. Bar Viminale Di Pepi Maurilio is another excellent spot to enjoy a nightcap after a delightful meal.

Savor another day of unforgettable experiences in Italy!

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Day 4

Day 4

  • Rome
  • More

Drive 9 km, 1 hour 11 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
  • Castel Sant'Angelo
  • More

Day 4 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Savor the day by visiting some of the best places to see in Rome, including an archeological site, a monument, a public square, a castle and much more! Start your adventure at Colosseum. This iconic archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Roman Forum located in Rome for an enchanting atmosphere.

Next, immerse yourself in the setting of Pantheon. Its heritage-rich features will captivate you. After the monument, continue your tour of the city with a visit to Piazza Navona. This public square has a visually striking appeal. For a change of pace, head to Castel Sant'angelo. As one of the most top-rated attractions in Rome, this castle is an excellent place to end your self-guided tour.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at RomAntica, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Coso Ristorante is another top choice with a popular menu. You could also check for a table at DEROMA - Farine Romane. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

Extend your evening after a delightful meal by visiting Sant' Eustachio Caffè, which offers the perfect atmosphere for a night out. Moreover, Yellowsquare Rome is another popular option for a drink or two. Likewise, Caffè Portofino also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Rome
  • Florence
  • More

Drive 280 km, 3 hours 54 min

  • Altare della Patria
  • Trevi Fountain
  • Piazza di Spagna
  • piazza del Popolo
  • Villa Borghese
  • More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 1 night here for some well-deserved relaxation.

Today’s itinerary in Rome covers several incredible sights, including a monument, a public square, and a park. Start your adventure at Altare Della Patria. This notable monument is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the enchanting wonders of Trevi Fountain, a must-see monument in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Di Spagna. This world-famous public square offers an enriching experience. For a change of pace, head to Piazza Del Popolo, where you can take in its enchanting features. Conclude your self-guided sightseeing tour with a visit to Villa Borghese. This mesmerizing park offers a fulfilling end to a perfect day.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Dive into a culinary adventure like no other in Florence by booking a table at Enoteca Pinchiorri. This popular restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another culinary dining option, venture to Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Gucci Osteria da Massimo Bottura, a top local restaurant known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it promises an exceptional dining experience not to be missed.

After enjoying a fulfilling meal, continue your evening at Manifattura, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Se·sto On Arno Rooftop Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Il Vinile provides an excellent environment for a relaxed and enjoyable evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 6

Day 6

  • Florence
  • Milan
  • More

Drive 309 km, 4 hours 7 min

  • piazza della Signoria
  • Cathedral of Santa Maria del Fiore
  • Ponte Vecchio
  • piazzale Michelangelo
  • More

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Milan, where you’ll be staying for 1 night.

Florence is home to plenty of attractions that offer family-friendly attractions, romantic experiences, and scenic views! Start at Piazza Della Signoria, a widely recognized public square that is worthwhile a visit in the city. Nearby, you’ll find Cathedral Of Santa Maria Del Fiore, enchanting visitors with its history-steeped appeal. Continue your exploration at Ponte Vecchio. This historical landmark is one of the city’s most timeless spots.

Enjoy the freedom of exploring Florence at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Piazzale Michelangelo.

At the end of the day, you will drive to Milan, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Milan's best restaurants.

Experience a symphony of flavors at Enrico Bartolini al Mudec in Milan by securing a reservation in advance. Renowned for its 3-star Michelin distinction, Enrico Bartolini al Mudec delights its guests with its exceptional variety of meals showcasing delicious creative cuisine. For a palate-pleasing alternative, make sure to dine at Seta by Antonio Guida, acclaimed for its delectable international and contemporary specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Il Luogo Aimo e Nadia, a top-rated restaurant known for its outstanding menu. Known as a top-rated 1-star Michelin establishment, it's a top choice for italian contemporary and modern cuisine in the city.

Continue your evening by exploring the vibrant nightlife scene at Nottingham Forest, a prime destination for a thrilling night out. Also, don’t forget to check out Armani/bamboo Bar, a bar that offers unique local touches. Likewise, Mag Cafe provides an excellent alternative for a fun evening.

Head back to your accommodation in Milan and get some rest in preparation for another magical day of your road trip in Italy!

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Day 7

Day 7

  • Milan
  • Turin
  • More

Drive 145 km, 2 hours 22 min

  • Duomo di Milano
  • Galleria Vittorio Emanuele II
  • La Scala
  • Castello Sforzesco
  • Sempione Park
  • More

Dive into day 7 of your remarkable road trip in Italy. Today you will explore Milan, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Turin. You’ll stay here for 2 nights.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Milan allows for both. Start by heading to Duomo Di Milano Museum. This timeless church provides an insightful glimpse into the city's identity. Next, discover Galleria Vittorio Emanuele Ii, a remarkable shopping mall, promising a delightful encounter.

Continue your sightseeing with a visit to La Scala, a locally renowned opera house. When you’re done, don’t forget to make a stop at the extraordinary Sforzesco Castle Art Library. Round off your day at Parco Sempione, another gem in Milan with romantic features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Turin. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Turin. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Start your culinary exploration in Turin by securing a reservation at Vintage 1997. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of italian and classic cuisine. For another dining delight, visit Unforgettable, celebrated for its delectable innovative and italian contemporary menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Piano 35, a top local spot known for its tantalizing italian contemporary and piedmontese menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Let the evening flow smoothly from dinner to drinks at Oinos Vini - Wine Bar - Caffetteria, a top-rated bar in the area. For other recommendations, Piper Pub provides a perfect setting for rounding out your night with style and great drinks. Likewise, Tclub Street Bar offers a memorable night with diverse drink options and excellent service.

Raise your glass to another unforgettable day in Italy!

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Day 8

Day 8

  • Turin
  • Cavoretto
  • More

Drive 13 km, 1 hour 5 min

  • Mole Antonelliana
  • Egyptian Museum
  • Parco del Valentino
  • Museo Nazionale dell'Automobile
  • More

On day 8 of your road trip in Italy, you’ll start and end your day in Turin, but spend the day exploring what’s beyond the city. Since you will return to Turin for 1 night more, there’s no need to rush. Experience Turin and Cavoretto to the fullest today with this curated day itinerary!

Start by visiting Mole Antonelliana, a prime spot to begin your journey. This instagrammable monument is sure to impress. Next on your list is Egyptian Museum, another must-visit landmark and locally renowned museum renowned for its historic features.

While exploring and sightseeing, take time to savor the ambiance of Turin by sampling some local delicacies or having a drink. When you’re ready for more sightseeing, head to Parco Del Valentino. This masterful park is a remarkable attraction that offers a unique experience.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Cavoretto. This drive usually takes around 8 min, without any stops or traffic disruptions.

Your self-guided tour starts at Museo Nazionale Dell'automobile, a captivating museum that is sure to impress. Take in the surroundings and enjoy the freedom of exploring before you continue your journey.

When you’re done exploring for the day, you’ll return to Turin and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Turin's best restaurants.

Enjoy a lovely dining experience at The Loft, a popular restaurant in Turin. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Turin at El Puig D'Estelles, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated La Piola Sabauda. It’s yet another ideal choice to enhance your time in Turin tonight.

Continue the enjoyment post-dinner at Birrificio Torino, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Qc Termetorino offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Dash Kitchen. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 9

Day 9

  • Turin
  • Genoa
  • Pisa
  • More

Drive 347 km, 4 hours 25 min

  • Aquarium of Genoa
  • Doge's Palace
  • piazza De Ferrari
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Genoa. At the end of the day, you will enjoy the comforts of a top-rated hotel in Pisa, which will be your home away from home for 1 night.

As you’ve unraveled the marvels of Turin, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Genoa may take around 2 hours 4 min. Upon your arrival in Genoa, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Aquarium Of Genoa is an impressive aquarium we recommend making time to visit today. Discover its eye-catching features before continuing your self-guided tour. Next, stop by Piazza De Ferrari, a history-steeped public square.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you explore more of Pisa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at Restaurant -Pizzeria Il Mio Capriccio, an excellent option for tonight's dining. Looking for something different? Ristorante alle Bandierine offers a tantalizing alternative with its diverse menu. And don’t miss Barrique Cocktail And Bistrot. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pisa.

Continue the enjoyment post-dinner at Bar Livorno, a cherished local gathering spot renowned for its welcoming atmosphere.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 10

Day 10

  • Pisa - Departure day
  • More
  • Logge dei Banchi
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Maximize your last day in Italy and go on a shopping spree in Pisa’s shopping center. Browse for souvenirs to remind you of your wonderful journey in Italy.

Today’s well-planned self-sightseeing route offers several fun adventures, photo-friendly spots, and historic treasures. Whether you decide to explore Pisa on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Logge Dei Banchi is the first of them. Spend some time admiring this eye-catching public square before continuing your journey.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

If you're in the mood to try something new, consider La corte di San Leonardo, another top spot with a mouthwatering menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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