10-Day Italy Self-Drive Road Trip With Itinerary from Rome traveling west to Pisa, Turin, Milan, and Florence

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Rome, 1 night in Pisa, 1 night in Turin, 1 night in Milan, and 2 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Rome, Pisa, Genoa, Turin, Cavoretto, Milan, and Florence, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Altare della Patria
Orange GardenCircus MaximusColosseumRoman ForumPantheonTrevi Fountain
Trevi FountainPiazza di SpagnaSpanish Stepspiazza del PopoloVilla Borghese
Castel Sant'AngeloPiazza NavonaCampo de' FioriPonte MilvioTrevi Fountain
Leaning Tower of PisaPiazza del Duomo, PisaPisa Cathedralpiazza De Ferrari
Egyptian MuseumMole AntonellianaMuseo Nazionale dell'AutomobileParco del Valentino

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Day 1

Day 1 – Rome - arrival day

  • Rome - Arrival day
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  • Altare della Patria
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Your road trip adventure in Italy begins as soon as you reach Rome and pick up your car. You’ll stay in Rome for 3 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Altare Della Patria or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Rome. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Dine in style at La Bottega Roma, a top recommendation for dinner tonight. Or, for a change of pace, Pasta In Corso boasts a menu that's sure to impress. Also, be sure to check out Trattoria Vecchia Roma. Known as a local hotspot, it’s a great choice for tonight in Rome.

Round off your dining experience by visiting La Botticella Of Poggi Giovanni, a prime location for a drink. Alternatively, explore the distinctive characteristics of Almalu Trastevere, a bar catering to every mood and preference. Bar Viminale Di Pepi Maurilio likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2 – Rome

  • Rome
  • More

Drive 5 km, 1 hour 15 min

  • Orange Garden
  • Circus Maximus
  • Colosseum
  • Roman Forum
  • Pantheon
  • Trevi Fountain
  • More

Day 2 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Prepare for a day full of a romantic, a stunning, an instagrammable, a history-steeped, a majestic, an UNESCO world heritage-listed, a profound, and a detailed. When you’re ready, kick off your sightseeing adventure at Orange Garden. This popular park is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Circus Maximus, one of the city’s most promising highlights.

Next, check out Colosseum, one of the most iconic places to see in Rome. This archeological site is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Roman Forum. Wander around and soak in the picture-perfect atmosphere this archeological site offers. Finally, take the path to the iconic Pantheon, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Dive into a culinary adventure like no other in Rome by booking a table at La Pergola. This popular restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another culinary dining option, venture to Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Enoteca La Torre, a top local restaurant known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it promises an exceptional dining experience not to be missed.

Extend your evening after a delightful meal by visiting Sant' Eustachio Caffè, which offers the perfect atmosphere for a night out. Moreover, Yellowsquare Rome is another popular option for a drink or two. Likewise, Caffè Portofino also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 3

Day 3 – Rome

  • Rome
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Drive 8 km, 1 hour 2 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • Villa Borghese
  • More

Day 3 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Rome is home to plenty of attractions that offer a romantic, a gorgeous, an instagrammable, a history-steeped, a symbolic, a remarkable, and a picturesque! Start at Piazza Di Spagna, an iconic public square that is worthwhile a visit in the city. Nearby, you’ll find Spanish Steps, enchanting visitors with its enchanting appeal. Continue your exploration at Piazza Del Popolo. This public square is one of the city’s most famous spots.

Enjoy the freedom of exploring Rome at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Villa Borghese.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Hotel de Russie, a highly-rated dining destination in Rome. If you're eager to try something different, consider La Taverna Italiana, another top spot with a tantalizing menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 4

Day 4 – Rome and Pisa

  • Rome
  • Pisa
  • More

Drive 362 km, 4 hours 28 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Campo de' Fiori
  • Ponte Milvio
  • Trevi Fountain
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Rome, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Pisa. You’ll stay here for 1 night.

Rome is brimming with adventures. Today’s wonderful stops include a castle, a public square, and a monument. Begin your sightseeing adventure at the astonishing Castel Sant'angelo. Just a short distance away is Piazza Navona, a masterful public square that draws visitors from far and near.

Continue your journey to Campo De' Fiori, one of the city’s most impressive spots that you shouldn’t miss. Another great site to visit is the popular Ponte Milvio.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Anima di Grano Pizzeria Napoletana Pisa Italy, a highly-rated dining destination in Pisa. If you're eager to try something different, consider il Mercante, another top spot with a tantalizing menu. You might also want to secure a reservation at La Ghiotteria. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Pisa this evening.

Let the evening flow smoothly from dinner to drinks at Jeffer Cocktails & Friends, a top-rated bar in the area. For other recommendations, Le Parisien Wine Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Las Volta Cocktailbar offers a memorable night with diverse drink options and excellent service.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 5

Day 5 – Pisa, Genoa, and Turin

  • Pisa
  • Genoa
  • Turin
  • More

Drive 342 km, 4 hours 26 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • piazza De Ferrari
  • More

On day 5 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Genoa. In the evening, you’ll end up in Turin, where you will stay for 1 night.

A blend of a gorgeous, a picture-perfect, a standout, a grand, a noteworthy, an UNESCO world heritage-listed, and a culturally significant await you in Pisa on today’s itinerary. First up is the world-famous monument, Leaning Tower Of Pisa. It's a standout spot that offers a memorable visit. Afterward, continue to Piazza Del Duomo, Pisa. A visit to this public square is an enriching experience for all.

As you explore Pisa’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Pisa Cathedral. This frequently visited church is an essential stop that should not be missed.

When you’ve had your share of Pisa, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Genoa. Your travel time is around 1 hour 56 min.

Piazza De Ferrari is a well-known public square we recommend making time to visit today. Discover its romantic features before continuing your self-guided tour.

At the end of the day, you will drive to Turin, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Turin's best restaurants.

Begin your culinary exploration in Turin by securing a reservation at Vintage 1997. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of italian and classic cuisine. For another dining delight, visit Unforgettable, celebrated for its delectable innovative and italian contemporary menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Piano 35, a top local spot known for its tantalizing italian contemporary and piedmontese menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Continue the enjoyment post-dinner at Oinos Vini - Wine Bar - Caffetteria, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Piper Pub offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Tclub Street Bar. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 6

Day 6 – Turin, Cavoretto, and Milan

  • Turin
  • Cavoretto
  • Milan
  • More

Drive 155 km, 2 hours 35 min

  • Egyptian Museum
  • Mole Antonelliana
  • Museo Nazionale dell'Automobile
  • Parco del Valentino
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Turin and Cavoretto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Milan. You will spend 1 night here for some well-deserved relaxation.

Get ready for a day filled with an eye-catching, a history-steeped, an awe-inspiring, a culturally significant, a charming, a beautiful, and a masterful in the charming city of Turin. Your adventure starts at Egyptian Museum, a notable local hot spot. Another notable attraction to explore is Mole Antonelliana. This well-known monument is known for its history-steeped appeal.

After soaking in the highlights of these sights, take some time to wander Turin's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Parco Del Valentino. This eye-catching park offers a fascinating experience that many visitors find memorable.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Cavoretto.

Savor the rest of your day by heading to Museo Nazionale Dell'automobile, an interesting museum that draws visitors from near and far.

When you’re done exploring for the day, you’ll drive to your hotel in Milan. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Milan. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Start your culinary exploration in Milan by securing a reservation at Enrico Bartolini al Mudec. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of creative cuisine. For another dining delight, visit Seta by Antonio Guida, celebrated for its delectable international and contemporary menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Luogo Aimo e Nadia, a top local spot known for its tantalizing italian contemporary and modern menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Unwind after your meal by stepping into Nottingham Forest. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Armani/bamboo Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Mag Cafe, another top-rated bar in the area.

Raise your glass to another unforgettable day in Italy!

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Day 7

Day 7 – Milan and Florence

  • Milan
  • Florence
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Drive 319 km, 4 hours 4 min

  • Duomo di Milano
  • Galleria Vittorio Emanuele II
  • Castello Sforzesco
  • Sempione Park
  • More

Embark on another extraordinary experience on day 7 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Milan. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 2 nights.

Get ready to discover some of the most iconic wonders in Milan, including a church, a shopping mall, a castle, a park and much more! Start your day at Duomo Di Milano Museum. This grand church is a globally renowned place to see in Milan. Then, wander over to Galleria Vittorio Emanuele Ii. If visually striking sites excite you, this shopping mall will be right up your alley. Nearby, you’ll also find Sforzesco Castle Art Library. This stunning castle is a favorite among visitors.

Milan offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Parco Sempione is an extraordinary spot in the city that will captivate you with its unique charm.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to an extraordinary dining experience at Enoteca Pinchiorri, a 3-star Michelin restaurant offering an incredible italian contemporary menu. Alternatively, if your taste buds call for something different, Santa Elisabetta is one of the best restaurants for creative and mediterranean cuisine in Florence. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Gucci Osteria da Massimo Bottura. As a top-rated establishment with 1 Michelin star, it is an ideal choice for italian contemporary and international cuisine in the city.

Following your dinner, dive into the local bar culture at Manifattura. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Se·sto On Arno Rooftop Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Il Vinile provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 8

Day 8 – Florence

  • Florence
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Drive 4 km, 1 hour 6 min

  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • Ponte Vecchio
  • Uffizi Gallery
  • piazzale Michelangelo
  • More

On day 8 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.

Savor the day by visiting some of the best places to see in Florence, including a church, a public square, a historical landmark, an art gallery, an observation deck and much more! Start your adventure at Cathedral Of Santa Maria Del Fiore. This impressive church is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Della Signoria located in Florence for an enchanting atmosphere.

Next, immerse yourself in the setting of Ponte Vecchio. Its history-steeped features will captivate you. After the historical landmark, continue your tour of the city with a visit to Uffizi Gallery. This art gallery has a romantic appeal. For a change of pace, head to Piazzale Michelangelo. As one of the most spectacular attractions in Florence, this observation deck is an excellent place to end your self-guided tour.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Continue the enjoyment post-dinner at Bar 50 Rosso, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Bitter Bar offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Archea Brewery. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 9

Day 9 – Florence, Vatican City, and Rome

  • Florence
  • Rome
  • More

Drive 285 km, 3 hours 57 min

  • Sistine Chapel
  • St Peter's Basilica
  • Saint Peter's Square
  • Vatican Museums
  • Ponte Vecchio
  • More

On day 9 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Vatican City. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 1 night.

Embrace the thrill of the open road as you wave goodbye to Florence and set your GPS to Vatican City, Vatican City. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 3 hours 14 min. Upon reaching Vatican City, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Next, visit Saint Peter's Square, an interesting square that offers a unique experience. Be sure to also explore Vatican Museums, a nearby art museum, which is highly recommended by other travelers.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Don’t miss out on dining at Sofitel Roma Villa Borghese, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Centro, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Tema. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 10

Day 10 – Rome - departure day

  • Rome - Departure day
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  • largo di Torre Argentina
  • Trevi Fountain
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Get ready for a day filled with a visually striking and a historic in the charming city of Rome. Your adventure starts at Largo Di Torre Argentina, a popular local hot spot.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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