10-Day Italy Self-Drive Road Trip With Itinerary from Rome traveling west to Florence

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Rome and 6 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Rome, Florence, Siena, San Gimignano, Pisa, Riomaggiore, Manarola, Corniglia, Vernazza, Bologna, and Modena, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
St Peter's BasilicaColosseumRoman ForumPiazza di SpagnaSpanish StepsPantheonTrevi FountainVia dei Condotti
Bargello National MuseumPalazzo VecchioUffizi GalleryPonte Vecchiopiazza della Signoria
Central MarketGalleria dell'AccademiaCathedral of Santa Maria del FioreBasilica of Santa Croce in FlorenceThe Boboli Gardenspiazzale MichelangeloOltrarno
Basilica of San DomenicoSiena Cathedralpiazza del CampoTower of MangiaPubblico PalacePorta Pispini
Piazza del Duomo, San GimignanoPalazzo BluLeaning Tower of PisaPisa CathedralPiazza del Duomo, Pisa

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Day 1

Day 1

  • Rome - Arrival day
  • More

Welcome to Rome, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights immersing yourself in Rome's charm before embarking on the next leg of your journey.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Rome. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, La Botticella Of Poggi Giovanni stands out as an excellent choice for a post-dinner cocktail. Alternatively, Almalu Trastevere offers an ideal atmosphere to enjoy the pleasures of the night. Bar Viminale Di Pepi Maurilio is also a great option that provides a perfect setting for a relaxing evening.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Rome
  • More

Drive 13 km, 1 hour 44 min

  • St Peter's Basilica
  • Colosseum
  • Roman Forum
  • Piazza di Spagna
  • Spanish Steps
  • Pantheon
  • Trevi Fountain
  • Via dei Condotti
  • More

On day 2 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you will return to Rome for 1 night more, there’s no need to rush. Experience Vatican City and Rome to the fullest today with this curated day itinerary!

One of the most iconic places you can visit today in Vatican City is Via dei Condotti. Allow yourself some time to leisurely explore this street and discover its unique quirks. You'll also find many of the best sightseeing spots nearby.

Start your adventure at St. Peter's Basilica. This globally renowned major basilica is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the breathtaking wonders of Colosseum, a must-see archeological site in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Roman Forum. This world-famous archeological site offers an enriching experience. For a change of pace, head to Piazza Di Spagna, where you can take in symbolic features. Conclude your self-guided sightseeing tour with a visit to Spanish Steps. This romantic public square offers a fulfilling end to a perfect day.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Dine in style at RomAntica, a top recommendation for dinner tonight. Or, for a change of pace, Coso Ristorante boasts a menu that's sure to impress. Also, be sure to check out DEROMA - Farine Romane. Known as a local hotspot, it’s a great choice for tonight in Rome.

Keep the evening going at Sant' Eustachio Caffè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Yellowsquare Rome, which offers a similarly pleasant setting and great drinks. Another option is Caffè Portofino, which provides an inviting environment for unwinding after a busy day out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Rome
  • Florence
  • More

Drive 278 km, 3 hours 21 min

  • Bargello National Museum
  • Palazzo Vecchio
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Florence, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 6 nights.

Rome is home to plenty of attractions that offer fun adventures, photo-friendly spots, and history-rich sites! Start at Bargello National Museum, a curiosity-inducing museum that is worthwhile a visit in the city. Nearby, you’ll find Palazzo Vecchio, enchanting visitors with its respected appeal. Continue your exploration at Uffizi Gallery. This art gallery is one of the city’s most widely recognized spots.

Enjoy the freedom of exploring Rome at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Ponte Vecchio. After exploring the historical landmark, head to the extraordinary Piazza Della Signoria. This public square will wrap up today’s self-guided sightseeing tour in the city.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Don’t miss out on dining at Ristorante Oliviero 1962, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Di Poneta Novoli, another top spot with a mouthwatering menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

Continue the enjoyment post-dinner at Manifattura, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Se·sto On Arno Rooftop Bar offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Il Vinile. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 4

Day 4

  • Florence
  • More

Drive 17 km, 1 hour 15 min

  • Central Market
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Basilica of Santa Croce in Florence
  • The Boboli Gardens
  • piazzale Michelangelo
  • Oltrarno
  • More

Day 4 of your road trip will take you to the best attractions Florence has to offer. Cherish the 5 nights you have left in Florence by discovering the best things there are to see and do in the city.

Oltrarno is a neighborhood that stands out as one of the must-see places in Florence. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

Brace yourself for today’s incredible lineup of attractions in Florence, featuring family-friendly attractions, photo-friendly spots, and wallet-friendly activities. Start at Central Market, a locally renowned food market in the city. Then, head to Galleria Dell'accademia and soak in the ambiance of this detailed art gallery.

There are many interesting places to see in Florence and when you are ready for more, go to Cathedral Of Santa Maria Del Fiore. This is one of the city’s most extraordinary spots. After exploring the church, visit the locally renowned Basilica Of Santa Croce In Florence. Before wrapping up your self-guided sightseeing tour, head to the locally renowned The Boboli Gardens, a locally renowned botanical garden in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at Ditta Artigianale, an excellent option for tonight's dining. Looking for something different? Trattoria Da Burde offers a tantalizing alternative with its diverse menu. And don’t miss Casa Toscana. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

After savoring a delicious meal, step into the vibrant nightlife at Bar 50 Rosso, where the evening is just getting started. In the same way, Bitter Bar offers a unique charm perfect for experiencing the local bar scene in Florence. Archea Brewery is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 153 km, 2 hours 47 min

  • Basilica of San Domenico
  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • Pubblico Palace
  • Porta Pispini
  • More

Greet day 5 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Florence for your remaining 4 nights in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Siena.

Prepare for a day full of family-friendly attractions, scenic views, and photo-friendly spots. When you’re ready, kick off your sightseeing adventure at Basilica Of San Domenico. This locally appreciated church is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Siena Cathedral, one of the city’s most promising highlights.

Next, check out Piazza Del Campo, one of the most extraordinary places to see in Florence. This public square is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Tower Of Mangia. Wander around and soak in the breathtaking atmosphere this monument offers. Finally, take the path to the worthwhile Pubblico Palace, the last of our attraction recommendations for today.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Ristorante Buca Mario, a top-rated dining spot in Florence. If you're in the mood for something new, try Agricola Toscana, another premier location with a delectable menu. You might also want to book a table at Eataly Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Keep the excitement of the evening going by visiting a bar or two. Gosh* is an excellent place to start. You could also check out Antico Caffè Del Moro - Art Bar Firenze, offering a different kind of charm. A last recommendation for the day is Quelo Bar. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Savor another day of unforgettable experiences in Italy!

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Day 6

Day 6

  • Florence
  • More

Drive 250 km, 4 hours 14 min

  • Piazza del Duomo, San Gimignano
  • Palazzo Blu
  • Leaning Tower of Pisa
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • More

At the end of the day, you'll drive back to Florence, where you'll stay for 3 nights more.

Today’s well-planned self-sightseeing route offers several fun adventures, romantic experiences, and breathtaking views. Whether you decide to explore Florence on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Piazza Del Duomo is the first of them. Spend some time admiring this visually striking public square before continuing your journey. Palazzo Blu is your next stop. This intriguing art gallery is one of the best-rated sights in Florence.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Leaning Tower Of Pisa. This UNESCO world heritage-designated monument is a sight to behold. To round off your sightseeing experience, visit Pisa Cathedral and Piazza Del Duomo, Pisa.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a lovely meal at Tijuana, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Djària - American Bar is another top choice with a popular menu. You could also check for a table at The Florence Irish Pub. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • Florence
  • More

Drive 366 km, 6 hours 6 min

  • Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • More

On day 7 of your road trip, you’ll start and end your day in Florence, where you'll stay for 2 nights more.

Discover a day packed with family-friendly attractions, romantic experiences, and natural wonders in Florence. Begin your sightseeing with Riomaggiore. This underrated sightseeing destination is one of the top attractions in the village. Proceed to Manarola Overlook Viewpoint, another must-visit attraction that enhances the village’s allure.

As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Cinque Terre National Park. This popular national park is a traveler-favorite. Not far away, you’ll find Ruins Of Doria Tower, another key site on your sightseeing itinerary.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Ristorante Buca Niccolini, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Essenziale, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante La Grotta Toscana, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 8

Day 8

  • Florence
  • More

Drive 234 km, 3 hours 33 min

  • Basilica of San Domenico
  • Piazza Maggiore
  • Bologna Cathedral
  • Two Towers
  • Piazza Santo Stefano
  • More

Wake up to day 8 of your extraordinary road trip in Italy. With 1 night left in Florence, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Savor the day by visiting some of the best places to see in Florence, including a church, a public square, and a monument. Start your adventure at Basilica Of San Domenico. This locally appreciated church is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Maggiore located in Florence for an enchanting atmosphere.

Next, immerse yourself in the setting of Bologna Cathedral. Its breathtaking features will captivate you. After the church, continue your tour of the city with a visit to Two Towers. This monument has a historic appeal. For a change of pace, head to Piazza Santo Stefano. As one of the most worthwhile attractions in Florence, this public square is an excellent place to end your self-guided tour.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delightful dinner at Cibrèo Caffè, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorante Le Volte Firenze? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante Romantico il Paiolo as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 9

Day 9

  • Florence
  • Rome
  • More

Drive 549 km, 6 hours 32 min

  • Enzo Ferrari Museum
  • Torre Civica - Ghirlandina
  • Modena Cathedral
  • More

On day 9 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Modena. In the evening, you’ll end up in Rome, where you will stay for 1 night.

A blend of fun adventures, photo-friendly spots, and history-rich sites await you in Florence on today’s itinerary. First up is the notable museum, Enzo Ferrari Museum. Afterward, continue to Torre Civica - Ghirlandina.

As you explore Florence’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Duomo Di Modena. This locally renowned church is an essential stop that should not be missed.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Make sure to reserve a table at Hotel de Russie, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of The Parrot Bar, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, The Apartment Bar Roma stands out as an excellent choice for a post-dinner cocktail. Alternatively, Hotel Hassler Roma offers an ideal atmosphere to enjoy the pleasures of the night.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 10

Day 10

  • Rome - Departure day
  • More
  • Piazza Navona
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Piazza Navona, an enchanting public square before you head out.

Maximize your last day in Italy and go on a shopping spree in Rome’s shopping center, the lively Galleria San Pietro. Browse for souvenirs to remind you of your wonderful journey in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

Treat yourself to a delicious dinner at Sofitel Roma Villa Borghese, an excellent option for tonight's dining. Looking for something different? Centro offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Tema.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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