10-Day Italy Road Trip from Rome to Siena, Venice, Verona, and Florence

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Explore the best of Italy on a 10-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Rome, Siena, Bologna, Venice, Verona, Valeggio sul Mincio, Florence, and Orvieto. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Rome, 1 night in Siena, 1 night in Venice, 1 night in Verona, and 2 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Rome, Siena, Bologna, Venice, Verona, Valeggio sul Mincio, Florence, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Rome - arrival day

  • Rome - Arrival day
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  • Campo de' Fiori
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Welcome to Rome, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 3 nights immersing yourself in Rome's charm before embarking on the next leg of your journey.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Campo De' Fiori or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Rome. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Dine in style at La Bottega Roma, a top recommendation for dinner tonight. Or, for a change of pace, RomAntica boasts a menu that's sure to impress. Also, be sure to check out Coso Ristorante. Known as a local hotspot, it’s a great choice for tonight in Rome.

Keep the evening going at La Botticella Of Poggi Giovanni, a great choice for enjoying the after-dinner hours with a drink. You could also go to Sant' Eustachio Caffè, which offers a similarly pleasant setting and great drinks. Another option is Caffè Portofino, which provides an inviting environment for unwinding after a busy day out.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2 – Rome

  • Rome
  • More

Drive 11 km, 58 min

  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • More

On day 2 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.

Take the opportunity to see Piazza Navona. This attraction has an average rating of 4.7 out of 5 stars from 158,771 visitors.

Pantheon is another sightseeing hotspot in the area. This roman temple has been rated an average of 4.8 out of 5 stars by 189,682 travelers. Up to 30,000,000 people visit Pantheon every year.

Rome is also the home of Trevi Fountain. Around 343,494 people have rated this sculpture an average of 4.8 out of 5 stars.

Another place you’ll want to visit is Piazza Di Spagna. With an average rating of 4.7 out of 5 stars from a total of 113,658 reviews, a visit to this square is a great idea.

This day of your vacation in Rome is also your chance to admire Spanish Steps. This must-visit monumental staircase enjoys an average rating of 4.5 out of 5 stars from 57,211 reviews.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Rome has in store for you, use this day to go on a tour. Scroll down and select tours and activities to include on your itinerary for the day.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean, and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative, and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean, and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, The Apartment Bar Roma stands out as an excellent choice for a post-dinner cocktail. Alternatively, Hotel Hassler Roma offers an ideal atmosphere to enjoy the pleasures of the night.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 3

Day 3 – Rome

  • Rome
  • More

Drive 12 km, 1 hour 1 min

  • Villa Borghese
  • piazza del Popolo
  • Castel Sant'Angelo
  • Roman Forum
  • Colosseum
  • More

Day 3 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Kick off the day at Villa Borghese, a top pick for today’s sightseeing. This urban zone of rome is rated an average of 4.6 out of 5 stars in 69,749 reviews.

Today is also your chance to visit Piazza Del Popolo. Piazza Del Popolo is a square with an average rating of 4.6 out of 5 stars from 89,807 reviews.

Castel Sant'angelo is another top attraction we highly recommend you visit today. This museum is rated an average of 4.7 out of 5 stars by 72,431 visitors. In a single year, this museum hosts approximately 918,591 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit Roman Forum. This square is rated an average of 4.7 out of 5 stars by 114,450 visitors.

Lastly, don’t miss out on Colosseum, a famous roman amphitheatre in Rome. This attraction welcomes 7,400,000 visitors annually and is rated an average of 4.7 out of 5 stars by 328,821 travelers.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante Tema, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Maccheroni, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of RoYaL Art Cafè Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4 – Rome, Vatican City, and Siena

  • Siena
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Drive 245 km, 3 hours 25 min

  • Vatican Museums
  • Saint Peter's Square
  • St Peter's Basilica
  • Sistine Chapel
  • More

Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 1 night.

When you’ve had your share of Rome, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Vatican City, Vatican City. Your travel time is around 12 min.

When you’re ready for some sightseeing, make your way to Vatican Museums. This much-appreciated art museum is rated 4.6 out of 5 stars in 133,310 reviews. Each year, 1,612,530 people visit this site to admire its unique features.

Next up is Saint Peter's Square. This square has an average rating of 4.8 out of 5 stars from 38,954 visitors.

Another top sightseeing recommendation is St. Peter's Basilica. This major basilica has been rated 4.8 out of 5 stars in 131,043 reviews. Every year, 11,000,000 travelers include this attraction on their travel itinerary.

Sistine Chapel is another attraction you have the opportunity to visit today. This chapel has an average rating of 4.7 out of 5 stars from 52,083 reviews.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a wonderful meal at Antica Trattoria Papei, a top-rated dining spot in Siena. If you're in the mood for something new, try Osteria Quattro Venti, another premier location with a delectable menu. You might also want to book a table at Osteria da Divo. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Siena.

Cap off your dinner by heading to Meet Life Cafè, ideal for a leisurely evening with a drink in hand. Maudit Pub is another bar that offers an enjoyable setting. Similarly, Bar Impero Siena is also a popular place to go on a night out, perfect for relaxing and socializing.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 5

Day 5 – Siena, Bologna, and Venice

  • Venice
  • Siena
  • Bologna
  • More

Drive 323 km, 3 hours 49 min

  • piazza del Campo
  • Siena Cathedral
  • Ducati Museum
  • More

On day 5 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Siena, and Bologna. In the evening, you’ll end up in Venice, where you will stay for 1 night.

Start your sightseeing with a visit to Piazza Del Campo. This square is rated an average of 4.8 out of 5 stars from 64,175 visitors.

Siena Cathedral is another popular attraction you could visit today. This domus has a rating of 4.8 out of 5 stars from 21,656 visitors.

After soaking in Siena’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Bologna. Expect your car journey to take a minimum of 1 hour 56 min. When you arrive in Bologna, it's time to take a break from the road.

When you’re ready for some sightseeing, make your way to Ducati Museum. This much-appreciated industry museum is rated 4.5 out of 5 stars in 4,028 reviews. Each year, 7,600 people visit this site to admire its unique features.

When you’re done exploring for the day, you’ll drive to Venice, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Venice, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Experience a harmony of flavors at Local in Venice by securing a reservation in advance. Known for its 1-star Michelin status, Local offers a delightful variety of dishes highlighting its delicious contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Wistèria, a highly recommended restaurant known for its enticing contemporary, and venetian cuisine. This popular 1-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Quadri, a highly acclaimed restaurant celebrated for its exceptional modern menu.

After enjoying a fulfilling meal, continue your evening at Al Parlamento, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Adagio offers a welcoming atmosphere for easing into the nightlife. Similarly, Il Mercante provides an excellent environment for a relaxed and enjoyable evening.

Raise your glass to another unforgettable day in Italy!

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Day 6

Day 6 – Venice, and Verona

  • Verona
  • Venice
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Drive 122 km, 1 hour 41 min

  • Rialto Bridge
  • Piazza San Marco
  • Doge's Palace
  • Bridge of Sighs
  • St Mark's Basilica
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Venice. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Verona. You will spend 1 night here for some well-deserved relaxation.

Make Rialto Bridge one of your first sightseeing stops in Venice. Rated an average of 4.7 out of 5 stars by 141,666 travelers, a visit to this local attraction makes for a great introduction to the area.

Piazza San Marco is a worthwhile attraction you can visit next. This square is a valued place of interest in the area, with an average rating of 4.7 out of 5 stars from 152,982 reviews.

Today is also the perfect opportunity to drop by Doge's Palace. This palace has been rated an average of 4.7 out of 5 stars by 24,775 visitors. Up to 318,104 people travel to this site annually.

If you’re keen to explore more, head to Bridge Of Sighs. A trip to this popular footbridge is also your opportunity to see if it lives up to the reputable 4.6 out of 5-star rating as given by 18,223 previous visitors.

Another top place to visit is St Mark's Basilica. This cathedral enjoys an average rating of 4.7 out of 5 stars from 18,439 local and international travelers.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Verona. Verona offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Verona. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy an outstanding dining experience at Osteria Mondo d'Oro, a Bib Gourmand restaurant offering an exceptional italian, and seasonal menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 2-star Michelin-awardee, Casa Perbellini 12 Apostoli, known for its delicious creative, and contemporary cuisine. Another highly-recommended restaurant in Verona is Il Desco, a renowned restaurant with a 1-star Guide Michelin recognition, known for its delicious italian contemporary menu.

Round off your dining experience by visiting Archivio, a prime location for a drink. Alternatively, explore the distinctive characteristics of La Segreteria Café, a bar catering to every mood and preference. Duchi Café likewise offers a unique atmosphere, perfect for a memorable night out.

Head back to your accommodation in Verona and get some rest in preparation for another magical day of your road trip in Italy!

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Day 7

Day 7 – Verona, Valeggio sul Mincio, and Florence

  • Florence
  • Verona
  • Valeggio sul Mincio
  • More

Drive 270 km, 4 hours 12 min

  • Castelvecchio Museum
  • piazza dei Signori
  • Verona Arena
  • Parco Giardino Sigurtà
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Verona, and Valeggio sul Mincio. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 2 nights.

Begin your sightseeing with a visit to Castelvecchio Museum. This art museum gets 35,031 visitors each year and is rated an average of 4.6 out of 5 stars in 13,854 reviews.

Next up, make your way to Piazza Dei Signori. This square has an average rating of 4.7 out of 5 stars from 4,542 reviews.

When you’re ready for your next sight of the day, continue to Verona Arena. This opera house has an average rating of 4.7 out of 5 stars from 123,818 visitors. Up to 195,540 people visit this place of interest annually.

As you’ve unraveled the marvels of Verona, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Valeggio sul Mincio may take around 50 min. Upon your arrival in Valeggio sul Mincio, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Drop by the renowned Parco Giardino Sigurtà. This popular park has been rated an average of 4.6 out of 5 stars by 27,387 visitors.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Dive into a culinary adventure like no other in Florence by booking a table at Enoteca Pinchiorri. This popular restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another culinary dining option, venture to Santa Elisabetta, celebrated for its delectable creative, and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Gucci Osteria da Massimo Bottura, a top local restaurant known for its tantalizing italian contemporary, and international menu. With a 1-star Michelin recognition, it promises an exceptional dining experience not to be missed.

Let the evening flow smoothly from dinner to drinks at Manifattura, a top-rated bar in the area. For other recommendations, Se·sto On Arno Rooftop Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Archea Brewery offers a memorable night with diverse drink options and excellent service.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 8

Day 8 – Florence

  • Florence
  • More

Drive 4 km, 1 hour 10 min

  • piazzale Michelangelo
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • Basilica of Santa Croce in Florence
  • More

Day 8 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

An excellent attraction to start your day with is Piazzale Michelangelo. This square is rated an average of 4.8 out of 5 stars in 77,744 reviews.

Continue your journey at Uffizi Gallery. This national museum is rated 4.7 out of 5 stars by 61,794 travelers from near and far. Approximately 2,011,219 people come to this place of interest every year to enjoy a unique experience in Florence.

Florence is also the home of Ponte Vecchio. This deck arch bridge has an average rating of 4.7 out of 5 stars from 118,099 visitors.

You can continue your self-guided sightseeing tour at Piazza Della Signoria. Rated 4.8 out of 5 stars by 66,956 visitors, a visit to this top sight is time well spent.

Lastly, don't miss out on Basilica Of Santa Croce In Florence. With an average rating of 4.7 out of 5 stars from 28,544 reviews, it’s hard to refuse the opportunity to see this church.

If you have an appetite for more adventure, check out the fantastic selection of tours and tickets offered in Florence on this day of your trip. You'll find the most recommended ones below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at Trattoria Da Burde, an excellent option for tonight's dining. Looking for something different? Ristorante Buca Mario offers a tantalizing alternative with its diverse menu. And don’t miss Eataly Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 9

Day 9 – Florence, Orvieto, and Rome

  • Rome
  • Florence
  • Orvieto
  • More

Drive 296 km, 3 hours 55 min

  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • Well of St Patrick
  • More

Dive into day 9 of your remarkable road trip in Italy. Today you will explore Florence, and Orvieto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 1 night.

Kick off the day at Cathedral Of Santa Maria Del Fiore, a top pick for today’s sightseeing. This church is rated an average of 4.8 out of 5 stars in 76,359 reviews.

Today is also your chance to visit Central Market. Central Market is a sightseeing destination with an average rating of 4.4 out of 5 stars from 43,100 reviews.

Galleria Dell'accademia is another top attraction we highly recommend you visit today. This national museum is rated an average of 4.6 out of 5 stars by 34,429 visitors. In a single year, this national museum hosts approximately 1,719,645 visitors.

Continue your road trip and head to your next destination, Orvieto. This car ride takes around 1 hour 53 min.

Make Well Of St. Patrick your first stop of the day. Previous visitors have rated this point of interest an average of 4.5 out of 5 stars in 14,274 reviews.

When you’re done exploring for the day, you’ll drive to Rome, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Harry's Bar, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Ristorante Amedeo, another top spot with a mouthwatering menu. You might also want to secure a reservation at VinAllegro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Say good night to Rome and look forward to another great day of your road trip in Italy!

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Day 10

Day 10 – Rome - departure day

  • Rome - Departure day
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  • Altare della Patria
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Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Rome's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

When you’re ready for some sightseeing, make your way to Altare Della Patria. This much-appreciated architectural structure is rated 4.8 out of 5 stars in 49,843 reviews. Each year, 1,683,070 people visit this site to admire its unique features.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

Have a fantastic dining experience at Cantina e Cucina, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Bono Bottega Nostrana - Piazza Di Spagna offers an enticing alternative with its varied menu.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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