11-Day Italy Road Trip from Pisa traveling east to Siena, Rome, and Florence

Your road trip adventure in Italy begins as soon as you reach Pisa and pick up your car. You’ll stay in Pisa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pisa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Ristorante Capodimonte Pisa, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider Baribaldi Pisa, another top spot with a mouthwatering menu. You might also want to secure a reservation at Restaurant -Pizzeria Il Mio Capriccio. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Pisa this evening.

Continue your evening by exploring the vibrant nightlife scene at JEFFER cocktails & friends, a prime destination for a thrilling night out. Also, don’t forget to check out Le Parisien Wine Bar, a bar that offers unique local touches. Likewise, Las Volta cocktailbar provides an excellent alternative for a fun evening.

Raise a toast to the start of your 11-day road trip in Italy!

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Pisa and Cascine Vecchie. When you’re not sightseeing, take time to relax at your selected hotel in Siena, where you’ll be staying for 1 night.

A top pick for your self-guided sightseeing tour today is Leaning Tower of Pisa. Over 3,200,000 travelers visit this attraction every year. Previous visitors have rated this bell tower an average of 4.7 out of 5 stars in 116,882 reviews.

Angelo Caduto is a local recommendation that you also can pay a visit today. This point of interest is rated an average of 4.5 out of 5 stars in 150 reviews.

Another attraction you won't want to miss is Piazza del Duomo, Pisa. This square is rated an average of 4.7 out of 5 stars in 104,550 reviews.

Pisa Cathedral is another outstanding experience in Pisa. Around 8,361 travelers have rated this cathedral an average of 4.8 out of 5 stars.

Fasten your seatbelt and make your way to your next stop. Cascine Vecchie, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Upon arrival in Cascine Vecchie, we highly recommend checking out some of the top attractions.

An excellent attraction to start your day with is Parco Regionale Migliarino, San Rossore, Massaciuccoli. This park is rated an average of 4.4 out of 5 stars in 9,632 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Siena. Siena offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena.

Treat yourself to a delightful dinner at Antica Trattoria Papei, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Osteria Quattro Venti? It's another excellent option with a diverse menu. Consider reserving a table at Osteria da Divo as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Siena.

After enjoying a fulfilling meal, continue your evening at Meet Life Cafè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Maudit Pub offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Impero Siena provides an excellent environment for a relaxed and enjoyable evening.

Raise your glass to another unforgettable day in Italy!

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Siena. In the evening, you’ll end up in Rome, where you will stay for 5 nights.

Begin your sightseeing with a visit to Siena Cathedral. This domus is rated an average of 4.8 out of 5 stars in 21,656 reviews.

Next up, make your way to Opera delle Metropolitana. This museum has an average rating of 4.2 out of 5 stars from 879 reviews.

When you’re ready for your next sight of the day, continue to piazza del Campo. This square has an average rating of 4.8 out of 5 stars from 64,175 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Tower of Mangia. This point of interest is rated an average of 4.6 out of 5 stars by 673 visitors.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Experience a harmony of flavors at La Pergola in Rome by securing a reservation in advance. Known for its 3-star Michelin status, La Pergola offers a delightful variety of dishes highlighting its delicious mediterranean and contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Il Pagliaccio, a highly recommended restaurant known for its enticing creative and innovative cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Enoteca La Torre, a highly acclaimed restaurant celebrated for its exceptional mediterranean and creative menu.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella of Poggi Giovanni, known for its inviting atmosphere. Sant' Eustachio Caffè is another great option if you’re looking for a place to get the night started. Similarly, Caffè Portofino provides a great setting to enjoy the night away.

Relax and recharge in preparation for another adventurous day in Italy!

Day 4 of your road trip across Italy promises a magnificent time exploring Vatican City. You have 4 nights left in Vatican City. Take the opportunity to experience more of the best attractions and activities in the city.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to reserve a table at DEROMA - Farine Romane, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Centro, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting The Apartment Bar Roma, a prime location for a drink. Alternatively, explore the distinctive characteristics of Hotel Hassler Roma, a bar catering to every mood and preference.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Day 5 of your road trip will take you to the best attractions Rome has to offer. Cherish the 3 nights you have left in Rome by discovering the best things there are to see and do in the city.

Make Piazza Navona one of your first sightseeing stops in Rome. Rated an average of 4.7 out of 5 stars by 158,771 travelers, a visit to this local attraction makes for a great introduction to the area.

Pantheon is a worthwhile attraction you can visit next. This roman temple is a valued place of interest in the area, with an average rating of 4.8 out of 5 stars from 189,682 reviews. Up to 30,000,000 travelers visit this site every year to make their time in Rome special.

Today is also the perfect opportunity to drop by Trevi Fountain. This sculpture has been rated an average of 4.8 out of 5 stars by 343,494 visitors.

If you’re keen to explore more, head to Piazza di Spagna. A trip to this popular square is also your opportunity to see if it lives up to the reputable 4.7 out of 5-star rating as given by 113,658 previous visitors.

Another top place to visit is Spanish Steps. This monumental staircase enjoys an average rating of 4.5 out of 5 stars from 57,211 local and international travelers.

One of the most unique ways of discovering what else Rome has to offer is by going on a top-rated tour. Be sure to check out all the experiences Rome offers and add your favorites to your Italy travel package below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

This renowned restaurant holds , and offers an exceptional menu of cuisine. Make sure to reserve a table at Ristorante Tema, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Maccheroni, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of RoYaL Art Cafè Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Savor another day of unforgettable experiences in Italy!

Day 6 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

A top pick for your self-guided sightseeing tour today is Roman Forum. Previous visitors have rated this square an average of 4.7 out of 5 stars in 114,450 reviews.

Colosseum is a local recommendation that you also can pay a visit today. This roman amphitheatre is rated an average of 4.7 out of 5 stars in 328,821 reviews. The attraction welcomes 7,400,000 visitors every year.

Another attraction you won't want to miss is Basilica di Santa Maria Maggiore. This major basilica is rated an average of 4.8 out of 5 stars in 27,678 reviews.

Piazza del Popolo is another outstanding experience in Rome. Around 89,807 travelers have rated this square an average of 4.6 out of 5 stars.

If you long for more, Villa Borghese is not far away. This urban zone of rome is a lovely addition to your itinerary. Previous visitors have rated it an average of 4.6 out of 5 stars in 69,749 reviews. The attraction gets an estimated 7,400,000 visitors every year.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Rome has in store for you, use this day to go on a tour. This tour allows curious travelers like you to experience the best of the country. You can make the most of your time in Italy by scrolling down and selecting tours and activities to include on your itinerary for the day.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Esteemed as a restaurant, it features an exceptional menu. Treat yourself to a wonderful meal at Harry's Bar, a top-rated dining spot in Rome. If you're in the mood for something new, try Ristorante Amedeo, another premier location with a delectable menu. You might also want to book a table at VinAllegro. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

On day 7 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 1 night and discover all the best things to see and do in the area.

Start your sightseeing with a visit to Circus Maximus. This circus is rated an average of 4.4 out of 5 stars from 44,741 visitors.

Altare della Patria is another popular attraction you could visit today. This architectural structure has a rating of 4.8 out of 5 stars from 49,843 visitors. Altare della Patria attracts up to 1,683,070 visitors every year.

Largo di Torre Argentina is also highly recommended by travelers. This square has a rating of 4.5 out of 5 stars from 30,433 visitors.

Campo de' Fiori is an attraction you won’t want to miss. This square is rated an average of 4.4 out of 5 stars in 51,133 reviews.

Another attraction you have the opportunity to visit today is Castel Sant'Angelo. This museum has received an average rating of 4.7 out of 5 stars from 72,431 travelers. This local favorite gets around 918,591 visitors each year.

Your discoveries in Rome do not have to stop there. Check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You can select your tours below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome.

Make sure to book a table at Cantina e Cucina, a popular restaurant in Rome. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Rome at Bono Bottega Nostrana - Piazza Di Spagna, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Ai Tre Scalini. As a dining spot that gains consistently high praise from guests, it’s an ideal choice to enhance your time to Rome tonight.

Take some time to reflect on your day and savor another beautiful night in Italy.

Embark on another extraordinary experience on day 8 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Orvieto. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 2 nights.

Orvieto’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 1 hour 38 min. Orvieto welcomes you with a multitude of unique vacation experiences.

Be one of the day’s first visitors at Orvieto Cathedral. This catholic cathedral is rated an average of 4.8 out of 5 stars by 15,057 visitors.

When you’re finished at Orvieto Cathedral, head to Orvieto Underground. This one-of-a-kind archaeological site is rated an average of 4.6 out of 5 stars in 1,517 reviews. Every year, approximately 37,000 travelers come here to experience the archaeological site for themselves.

Orvieto’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 1 hour 38 min. Orvieto welcomes you with a multitude of unique vacation experiences.

When you're ready to see some sights, Well of St. Patrick is a great place to start. This point of interest is rated an average of 4.5 out of 5 stars by 14,274 visitors.

When you’re done exploring for the day, you’ll drive to Florence, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Dive into a culinary adventure like no other in Florence by booking a table at Enoteca Pinchiorri. This popular restaurant holds , and offers an exceptional menu of italian contemporary cuisine. For another culinary dining option, venture to Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Gucci Osteria da Massimo Bottura, a top local restaurant known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it promises an exceptional dining experience not to be missed.

Let the evening flow smoothly from dinner to drinks at Manifattura, a top-rated bar in the area. For other recommendations, SE·STO on Arno Rooftop Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Archea Brewery offers a memorable night with diverse drink options and excellent service.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

Day 9 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Journey into the unknown at Ponte Vecchio, a unique attraction awaiting your visit. This remarkable deck arch bridge has an average rating of 4.7 out of 5 stars from 118,099 reviews.

When you’re ready to continue your sightseeing, Uffizi Gallery is a recommended place to visit. This national museum is rated an average of 4.7 out of 5 stars in 61,794 reviews. Based on recent data, the attraction hosts 2,011,219 visitors per year.

Another must-see attraction in Florence is piazza della Signoria. Rated an average of 4.8 out of 5 stars by 66,956 travelers, this popular tourist destination in Florence offers an experience you will remember.

Basilica of Santa Croce in Florence is another popular stop on travelers' itineraries in Florence. This church promises memorable moments of exploring. Other travelers have rated this attraction 4.7 out of 5 stars in 28,544 reviews.

Lastly, don't miss out on piazzale Michelangelo. Rated 4.8 out of 5 stars by 77,744 local and international travelers, it's a popular place to visit.

To do something one-of-a-kind on this day of your trip, you can join a tour. You can discover all of the most fun and eye-opening experiences in your destination below and secure your spot here.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Dine in style at Trattoria Da Burde, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Buca Mario boasts a menu that's sure to impress. Also, be sure to check out Eataly Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Florence. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Journey into the unknown at Cathedral of Santa Maria del Fiore, a unique attraction awaiting your visit. This remarkable church has an average rating of 4.8 out of 5 stars from 76,359 reviews.

When you’re ready to continue your sightseeing, Galleria dell'Accademia is a recommended place to visit. This national museum is rated an average of 4.6 out of 5 stars in 34,429 reviews. Based on recent data, the attraction hosts 1,719,645 visitors per year.

Another must-see attraction in Florence is Central Market. Rated an average of 4.4 out of 5 stars by 43,100 travelers, this popular tourist destination in Florence offers an experience you will remember.

Basilica di Santa Maria Novella, Firenze (FI) is another popular stop on travelers' itineraries in Florence. This archives promises memorable moments of exploring. Other travelers have rated this attraction 4.7 out of 5 stars in 23,075 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to book a table at Ristorante alle Bandierine, a popular restaurant in Pisa. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Pisa at Barrique Cocktail And Bistrot, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Filter Coffee Lab. As a dining spot that gains consistently high praise from guests, it’s an ideal choice to enhance your time to Pisa tonight.

After savoring a delicious meal, step into the vibrant nightlife at Bar Mocambo, where the evening is just getting started. In the same way, Tree offers a unique charm perfect for experiencing the local bar scene in Pisa. Chupiteria is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Day 11 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As you approach the end of your journey in Italy, take a moment for some retail therapy in Pisa’s celebrated shopping district. Thanks to your stay’s premier location, you can easily visit the city’s commercial hubs and wander through its diverse range of local shops without rushing.

Whether you’re on a hunt for an ideal present to give to your friends or family or looking for a personal memento to remind you of Italy, a variety of items are waiting for you. Hold onto the magic of Italy with these wonderful souvenirs, ensuring your memories never fade.

Make Logge dei Banchi one of your first sightseeing stops in Pisa. Rated an average of 4.2 out of 5 stars by 1,128 travelers, a visit to this local attraction makes for a great introduction to the area.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

Treat yourself to a delightful dinner at Sud, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Kiste' - La Pizza Artigianale. It's the second restaurant coming from the tower. ? It's another excellent option with a diverse menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!