12-Day Italy Road Trip from Ancona to Bologna, Venice, Florence, Siena, and Rome

Dive into day 2 of your remarkable road trip in Italy. Today you will explore San Vittore, and Senigallia, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Bologna. You’ll stay here for 1 night.

After soaking in Ancona’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: San Vittore. Expect your car journey to take a minimum of 52 min. When you arrive in San Vittore, it's time to take a break from the road.

A top pick for your self-guided sightseeing tour today is Frasassi Caves. Previous visitors have rated this show cave an average of 4.8 out of 5 stars in 20,728 reviews.

San Vittore Alle Chiuse is a local recommendation that you also can pay a visit today. This church building is rated an average of 4.5 out of 5 stars in 1,053 reviews.

Embrace the thrill of the open road as you wave goodbye to San Vittore and set your GPS to Senigallia. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 50 min. Upon reaching Senigallia, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Journey into the unknown at Rocca Roveresca, a unique attraction awaiting your visit. This remarkable sightseeing destination has an average rating of 4.5 out of 5 stars from 5,207 reviews.

At the end of the day, you will drive to Bologna, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Bologna, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to an extraordinary dining experience at Ahimè, a Bib Gourmand restaurant offering an incredible country cooking menu. Alternatively, if your taste buds call for something different, I Portici is one of the best restaurants for creative, and contemporary cuisine in Bologna. This 1-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Trattoria di Via Serra. As a top-rated establishment with a Bib Gourmand status, it is an ideal choice for emilian cuisine in the city.

Unwind after your meal by stepping into Bar Freud E Squisito. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Osteria Del Sole offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Macondo - Cocktail Bar, another top-rated bar in the area.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Bologna, and Padua. When you’re not sightseeing, take time to relax at your selected hotel in Venice, where you’ll be staying for 1 night.

Make Piazza Maggiore your first stop of the day. Previous visitors have rated this square an average of 4.7 out of 5 stars in 64,523 reviews.

Next up, make a stop at Two Towers. With an average rating of 4.7 out of 5 stars by 25,975 visitors, it's easy to understand why so many people visit this tower every year.

Piazza Santo Stefano is another attraction you can visit on this day of your vacation. This square has an average rating of 4.8 out of 5 stars by 7,617 visitors.

Padua’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Bologna behind. This drive usually takes around 1 hour 28 min. Padua welcomes you with a multitude of unique vacation experiences.

Start your sightseeing with a visit to The Basilica Of St. Anthony. This church is rated an average of 4.8 out of 5 stars from 38,852 visitors.

Prato Della Valle is another popular attraction you could visit today. This square has a rating of 4.6 out of 5 stars from 47,576 visitors.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Venice. Venice offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Venice. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy an outstanding dining experience at Local, a 1-star Michelin restaurant offering an exceptional contemporary menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 1-star Michelin-awardee, Wistèria, known for its delicious contemporary, and venetian cuisine. Another highly-recommended restaurant in Venice is Quadri, a renowned restaurant with a 1-star Guide Michelin recognition, known for its delicious modern menu.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Al Parlamento, known for its inviting atmosphere. Adagio is another great option if you’re looking for a place to get the night started. Similarly, Il Mercante provides a great setting to enjoy the night away.

Raise your glass to another unforgettable day in Italy!

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Venice. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Start your sightseeing with a visit to Rialto Bridge. This stone bridge is rated an average of 4.7 out of 5 stars from 141,666 visitors.

Palazzo Contarini Del Bovolo is another popular attraction you could visit today. This sightseeing destination has a rating of 4.5 out of 5 stars from 11,745 visitors.

Piazza San Marco is also highly recommended by travelers. This square has a rating of 4.7 out of 5 stars from 152,982 visitors.

Doge's Palace is an attraction you won’t want to miss. Around 318,104 people visit this place every year. This palace is rated an average of 4.7 out of 5 stars in 24,775 reviews.

Another attraction you have the opportunity to visit today is Bridge Of Sighs. This footbridge has received an average rating of 4.6 out of 5 stars from 18,223 travelers.

When you’re done exploring for the day, you’ll drive to Florence, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Experience a harmony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Known for its 3-star Michelin status, Enoteca Pinchiorri offers a delightful variety of dishes highlighting its delicious italian contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Santa Elisabetta, a highly recommended restaurant known for its enticing creative, and mediterranean cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Gucci Osteria da Massimo Bottura, a highly acclaimed restaurant celebrated for its exceptional italian contemporary, and international menu.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Manifattura, a well-loved spot among locals and tourists. Or, head to Se·sto On Arno Rooftop Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.

Say good night to Florence and look forward to another great day of your road trip in Italy!

Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.

Make Basilica Of Santa Croce In Florence one of your first sightseeing stops in Florence. Rated an average of 4.7 out of 5 stars by 28,544 travelers, a visit to this local attraction makes for a great introduction to the area.

Piazza Della Signoria is a worthwhile attraction you can visit next. This square is a valued place of interest in the area, with an average rating of 4.8 out of 5 stars from 66,956 reviews.

Today is also the perfect opportunity to drop by Ponte Vecchio. This deck arch bridge has been rated an average of 4.7 out of 5 stars by 118,099 visitors.

If you’re keen to explore more, head to Uffizi Gallery and find out why 2,011,219 people visit this spot every year. A trip to this popular national museum is also your opportunity to see if it lives up to the reputable 4.7 out of 5-star rating as given by 61,794 previous visitors.

Another top place to visit is Piazzale Michelangelo. This square enjoys an average rating of 4.8 out of 5 stars from 77,744 local and international travelers.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Florence has in store for you, use this day to go on a tour. Scroll down and select tours and activities to include on your itinerary for the day.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Don’t miss out on dining at Trattoria Da Burde, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Ristorante Buca Mario, another top spot with a mouthwatering menu. You might also want to secure a reservation at Eataly Firenze. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Florence this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Florence. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Siena. You will spend 1 night here for some well-deserved relaxation.

Journey into the unknown at Cathedral Of Santa Maria Del Fiore, a unique attraction awaiting your visit. This remarkable church has an average rating of 4.8 out of 5 stars from 76,359 reviews.

When you’re ready to continue your sightseeing, Galleria Dell'accademia is a recommended place to visit. This national museum is rated an average of 4.6 out of 5 stars in 34,429 reviews. Based on recent data, the attraction hosts 1,719,645 visitors per year.

Another must-see attraction in Florence is Central Market. Rated an average of 4.4 out of 5 stars by 43,100 travelers, this popular tourist destination in Florence offers an experience you will remember.

Basilica Di Santa Maria Novella, Firenze (fi) is another popular stop on travelers' itineraries in Florence. This archives promises memorable moments of exploring. Other travelers have rated this attraction 4.7 out of 5 stars in 23,075 reviews.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Make sure to reserve a table at Antica Trattoria Papei, an iconic dining spot in Siena. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Osteria Quattro Venti, a popular restaurant in Siena. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Osteria da Divo, a hidden gem nestled in Siena. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Meet Life Cafè, ideal for a leisurely evening with a drink in hand. Maudit Pub is another bar that offers an enjoyable setting. Similarly, Bar Impero Siena is also a popular place to go on a night out, perfect for relaxing and socializing.

Take some time to reflect on your day and savor another beautiful night in Italy.

Embark on another extraordinary experience on day 7 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Siena, and Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 4 nights.

When you’re ready for some sightseeing, make your way to Piazza Del Campo. This much-appreciated square is rated 4.8 out of 5 stars in 64,175 reviews.

Next up is Siena Cathedral. This domus has an average rating of 4.8 out of 5 stars from 21,656 visitors.

Set your GPS to Vatican City, Vatican City and hit the road. Expect a journey of approximately 2 hours 45 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Vatican City beckons with new experiences!

Take the opportunity to see Saint Peter's Square. This attraction has an average rating of 4.8 out of 5 stars from 38,954 visitors.

St. Peter's Basilica is another sightseeing hotspot in the area. This major basilica has been rated an average of 4.8 out of 5 stars by 131,043 travelers. Up to 11,000,000 people visit St. Peter's Basilica every year.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Get ready for an unforgettable culinary journey in Rome by reserving a table at La Pergola. Renowned as a 3-star Michelin restaurant, it offers an exceptional mediterranean, and contemporary menu. For a different taste experience, head to Il Pagliaccio, recognized for its delicious creative, and innovative dishes. This 2-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit Enoteca La Torre, a local favorite known for its delightful mediterranean, and creative cuisine in Rome. Nestled in the heart of the city, this restaurant with 2 Michelin star is an ideal choice for discerning mediterranean, and creative foodies seeking culinary excellence.

Continue the enjoyment post-dinner at La Botticella Of Poggi Giovanni, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Sant' Eustachio Caffè offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Caffè Portofino. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 8 offers a multitude of experiences. You will stay in Rome for 3 nights more, offering you enough time to explore at a relaxed pace.

A top pick for your self-guided sightseeing tour today is Trevi Fountain. Previous visitors have rated this sculpture an average of 4.8 out of 5 stars in 343,494 reviews.

Pantheon is a local recommendation that you also can pay a visit today. This roman temple is rated an average of 4.8 out of 5 stars in 189,682 reviews. The attraction welcomes 30,000,000 visitors every year.

Another attraction you won't want to miss is Altare Della Patria. This architectural structure is rated an average of 4.8 out of 5 stars in 49,843 reviews. Every year, around 1,683,070 travelers visit this site to discover its unique features.

Roman Forum is another outstanding experience in Rome. Around 114,450 travelers have rated this square an average of 4.7 out of 5 stars.

If you long for more, Colosseum is not far away. This roman amphitheatre is a lovely addition to your itinerary. Previous visitors have rated it an average of 4.7 out of 5 stars in 328,821 reviews. The attraction gets an estimated 30,000,000 visitors every year.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Savor the flavors at DEROMA - Farine Romane, a top pick for dinner tonight. Alternatively, La Taverna Italiana beckons with its unique menu offerings. Also, consider Centro. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

If you’re not ready to end the night just yet, The Apartment Bar Roma offers a perfect venue to relax and savor a drink. Similarly, Hotel Hassler Roma is well-suited for those looking to unwind in a social setting.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 9 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.

Start your sightseeing with a visit to Basilica Di Santa Maria Maggiore. This major basilica is a popular stop on travelers’ itineraries in Rome, with an average rating of 4.8 out of 5 stars by 27,678 visitors.

Spanish Steps is another popular place of interest you can visit today. The average rating of 4.5 out of 5 stars from 57,211 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to Piazza Di Spagna. Visitors have rated this square an average of 4.7 out of 5 stars in 113,658 reviews.

Villa Borghese is another unique site you can experience today. This attraction is an urban zone of rome rated an average of 4.6 out of 5 stars in 69,749 reviews.

Make your way to the fantastic Piazza Del Popolo, perhaps the most famous square in Rome. This attraction is rated 4.6 out of 5 stars by 89,807 travelers.

If you have an appetite for more adventure, check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You'll find the most recommended ones below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at Ristorante Tema, a top recommendation for dinner tonight. Or, for a change of pace, Maccheroni boasts a menu that's sure to impress. Also, be sure to check out RoYaL Art Cafè Roma. Known as a local hotspot, it’s a great choice for tonight in Rome.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 10 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Seize the day by visiting some of the best attractions in the area, like Circus Maximus. This extraordinary circus has an average rating of 4.4 out of 5 stars from 44,741 visitors.

Next, make your way to Largo Di Torre Argentina. This square is rated an average of 4.5 out of 5 stars in 30,433 reviews.

While in Rome, we also recommend a visit to Campo De' Fiori. This square has been rated an average of 4.4 out of 5 stars in 51,133 reviews.

If you’re keen to explore even more, then consider a visit to Piazza Navona. With an average rating of 4.7 out of 5 stars by 158,771 travelers, this square is a highly recommended stop on your sightseeing around Rome.

Make your way to Castel Sant'angelo, perhaps the most famous museum in Rome. This attraction welcomes around 918,591 visitors annually and is rated an average of 4.7 out of 5 stars in 72,431 reviews.

Your discoveries in Rome do not have to stop there. Check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You can select your tours below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Harry's Bar, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Ristorante Amedeo, another top spot with a mouthwatering menu. You might also want to secure a reservation at VinAllegro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Relax and recharge in preparation for another adventurous day in Italy!