12-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Savona, Florence, Rome, and Siena

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Escape the ordinary with this exciting 12-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Savona, 3 nights in Florence, 4 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Savona, Santa Margherita Ligure, Rapallo, Florence, Tivoli, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and San Piero a Grado, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Piazza Corvetto
piazza De FerrariDoge's PalaceGenoa CathedralAquarium of Genoa
Lighthouse of GenoaSpiaggia LiberaIl Giardino di Villa DurazzoRapallo Castle
Ponte VecchioUffizi Gallerypiazza della SignoriaBasilica of Santa Croce in Florencepiazzale Michelangelo
Galleria dell'AccademiaCathedral of Santa Maria del FioreCentral MarketBasilica of Santa Maria Novella
Villa d'EsteSaint Peter's SquareSt Peter's Basilica

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Day 1

Day 1

  • Genoa - Arrival day
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  • Piazza Corvetto
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Genoa's charm before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Corvetto, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at 7 Sensi cucina decontaminata, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Alla Lunga Ristorante offers an enticing alternative with its varied menu. Additionally, Grand Hotel Savoia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Unwind after your meal by stepping into Scurreria Beer & Bagel. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, La Lepre offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Pisacane Iii, another top-rated bar in the area.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Savona
  • More

Drive 46 km, 1 hour 1 min

  • piazza De Ferrari
  • Doge's Palace
  • Genoa Cathedral
  • Aquarium of Genoa
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa. In the evening, you’ll end up in Savona, where you will stay for 1 night.

Enjoy the perfect balance of relaxation and exploration in Genoa today. One of the most notable attractions included on the itinerary is Piazza De Ferrari. This history-steeped public square will help you start your sightseeing on top.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the increasingly popular Genoa Cathedral. After exploring the church, head to Aquarium Of Genoa. This widely recognized aquarium is a highlight in Genoa.

At the end of the day, you will drive to Savona, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Savona's best restaurants.

Savor the flavors at Il Mondo Del Caffè, a top pick for dinner tonight. Alternatively, Club Nautico di Savona beckons with its unique menu offerings.

To truly maximize your evening out, consider visiting Fuoritutti Food & Beer after dinner. This bar is known for offering some of the best drinks and vibes in the city.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Savona
  • Genoa
  • Florence
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Drive 307 km, 4 hours 9 min

  • Lighthouse of Genoa
  • Spiaggia Libera
  • Il Giardino di Villa Durazzo
  • Rapallo Castle
  • More

Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Genoa, Santa Margherita Ligure, and Rapallo. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 3 nights here for some well-deserved relaxation.

Bring your curiosity for today’s adventure around Savona. Some of the city’s most loved attractions await! Lighthouse Of Genoa is the perfect place to start. This lighthouse is one of the most often recommended places to visit in Savona. Next, head to Spiaggia Libera, a worthwhile beach, known for its romantic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Villa Durazzo. This enchanting palace is a highly recommended experience. Nearby, you'll also find Rapallo Castle. Visit these for an interesting touch to your journey.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Start your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 4

Day 4

  • Florence
  • More

Drive 7 km, 52 min

  • Ponte Vecchio
  • Uffizi Gallery
  • piazza della Signoria
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • More

Day 4 offers a multitude of experiences. You will stay in Florence for 2 nights more, offering you enough time to explore at a relaxed pace.

Brace yourself for today’s incredible lineup of attractions in Florence, featuring fun adventures, romantic experiences, and scenic views. Start at Ponte Vecchio, a timeless historical landmark in the city. Then, head to Uffizi Gallery and soak in the ambiance of this standout art gallery.

There are many interesting places to see in Florence, and when you are ready for more, go to Piazza Della Signoria. This is one of the city’s most widely recognized enchanting spots of interest. After exploring the public square, visit the locally renowned Basilica Of Santa Croce In Florence. Not far away, you'll also find Piazzale Michelangelo. This observation deck is a visually striking highlight in Florence.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Ditta Artigianale, a highly-rated dining destination in Florence. If you're eager to try something different, consider Trattoria Da Burde, another top spot with a tantalizing menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar 50 Rosso, a well-loved spot among locals and tourists. Or, head to Bitter Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.

Say good night to Florence and look forward to another great day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 3 km, 49 min

  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Central Market
  • Basilica of Santa Maria Novella
  • More

On day 5 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.

Prepare for a day full of family-friendly attractions, photo-friendly spots, and history-rich sites. When you’re ready, kick off your sightseeing adventure at Galleria Dell'accademia. This popular art gallery is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Cathedral Of Santa Maria Del Fiore, one of the city’s best highlights.

Next, check out Central Market, one of the most locally renowned places to see in Florence. This food market is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Basilica Di Santa Maria Novella, Firenze (fi). Wander around and soak in the visually striking atmosphere this church offers.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Ristorante Buca Mario, a top-rated dining spot in Florence. If you're in the mood for something new, try Agricola Toscana, another premier location with a delectable menu. You might also want to book a table at Eataly Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

After your meal, keep the night alive at a bar like Gosh*, known for its lively atmosphere. Antico Caffè Del Moro - Art Bar Firenze is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Quelo Bar offers an excellent atmosphere for those looking to amp up the evening.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 6

Day 6

  • Florence
  • Rome
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Drive 325 km, 4 hours 19 min

  • Villa d'Este
  • Saint Peter's Square
  • St Peter's Basilica
  • More

Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Tivoli and Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 4 nights.

Florence is home to plenty of attractions that offer family-friendly attractions, romantic experiences, and scenic views! Start at Villa D'este, a notable palace that is worthwhile a visit in the town. Continue your exploration at St. Peter's Basilica. This major basilica is one of the town’s most iconic spots.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy an outstanding dining experience at La Pergola, a 3-star Michelin restaurant offering an exceptional mediterranean and contemporary menu. Alternatively, if you're in the mood for something different, consider the nearby 2-star Michelin-awardee, Il Pagliaccio, known for its delicious creative and innovative cuisine. Another highly-recommended place to eat in Rome is Enoteca La Torre, a renowned restaurant with a 2-star Guide Michelin recognition and a delicious mediterranean and creative menu.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Say good night to Rome and look forward to another great day of your road trip in Italy!

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Day 7

Day 7

  • Rome
  • More

Drive 5 km, 1 hour 15 min

  • Piazza Navona
  • Pantheon
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • More

Day 7 of your road trip will take you to the best attractions Rome has to offer. Cherish the 3 nights you have left in Rome by discovering the best things there are to see and do in the city.

Today’s agenda in Rome includes a public square, a monument, and an archeological site. Piazza Navona is must-visit public square and a great starting point for the day. Next, continue your journey to Pantheon, a world-famous monument, located just a leisurely stroll away. Next, head to Roman Forum, a culturally significant archeological site, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Rome. When you're ready, let your sightseeing route take you to the globally renowned Colosseum. If you’re looking for more, Circus Maximus is also a popular attraction that is worthwhile a visit.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at RomAntica, an excellent option for tonight's dining. Looking for something different? Coso Ristorante offers a tantalizing alternative with its diverse menu. And don’t miss DEROMA - Farine Romane. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Continue the enjoyment post-dinner at Sant' Eustachio Caffè, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Yellowsquare Rome offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Caffè Portofino. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 8

Day 8

  • Rome
  • More

Drive 13 km, 1 hour 16 min

  • Basilica di Santa Maria Maggiore
  • Altare della Patria
  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • More

Day 8 of your road trip across Italy promises a magnificent time exploring Rome. You have 2 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Today's adventure in Rome promises more breathtaking discoveries and enriching experiences! Begin at Basilica Di Santa Maria Maggiore. This culturally significant church is a highlight of any visit in the city. Then, enjoy Altare Della Patria, another noteworthy attraction that never fails to captivate visitors. Next, head over to Trevi Fountain, one of the city’s most wondrous attractions, known for its history-steeped features.

If you’re looking for more, spend time soaking in the atmosphere of Piazza Di Spagna. This enchanting public square is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Spanish Steps, a famous public square, and take a stroll around the area.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Hotel de Russie, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Taverna Italiana offers an enticing alternative with its varied menu. Additionally, The Parrot Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 9

Day 9

  • Rome
  • More

Drive 10 km, 1 hour 5 min

  • Villa Borghese
  • piazza del Popolo
  • Castel Sant'Angelo
  • Campo de' Fiori
  • largo di Torre Argentina
  • More

Day 9 offers a multitude of experiences. You will stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.

Rome is home to plenty of attractions that offer family-friendly attractions, romantic experiences, and natural wonders! Start at Villa Borghese, an extraordinary park that is worthwhile a visit in the city. Nearby, you’ll find Piazza Del Popolo, enchanting visitors with its romantic appeal. Continue your exploration at Castel Sant'angelo. This castle is one of the city’s most top-rated spots.

Enjoy the freedom of exploring Rome at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Campo De' Fiori. After exploring the public square, head to the popular Largo Di Torre Argentina.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Enjoy a lovely dining experience at Sofitel Roma Villa Borghese, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at Centro, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Ristorante Tema. It’s yet another ideal choice to enhance your time in Rome tonight.

Savor another day of unforgettable experiences in Italy!

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Day 10

Day 10

  • Rome
  • Siena
  • More

Drive 261 km, 3 hours 37 min

  • The Tarot Garden
  • Spacco della Regina
  • River Park Ombrone Silvano Signori
  • More

Dive into day 10 of your remarkable road trip in Italy. Today you will explore Pescia Fiorentina, Ansedonia, and Grosseto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Siena. You’ll stay here for 1 night.

Brace yourself for today’s incredible lineup of attractions in Rome, featuring family-friendly attractions, romantic experiences, and breathtaking views. Start at The Tarot Garden, an increasingly popular sculpture garden in the village. Then, head to Spacco Della Regina and soak in the ambiance of this majestic cave.

There are many interesting places to see in Rome, and when you are ready for more, go to River Park Ombrone Silvano Signori. This is one of the village’s most underrated visually striking spots of interest.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Enoteca I Terzi, a highly-rated dining destination in Siena. If you're eager to try something different, consider Ristorante Tar-Tufo, another top spot with a tantalizing menu. You might also want to secure a reservation at Antica Trattoria Papei. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Siena this evening.

Let the evening flow smoothly from dinner to drinks at Meet Life Cafè, a top-rated bar in the area. For other recommendations, Maudit Pub provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Impero Siena offers a memorable night with diverse drink options and excellent service.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 11

Day 11

  • Siena
  • Genoa
  • More

Drive 297 km, 3 hours 55 min

  • piazza del Campo
  • Siena Cathedral
  • Church of Saint Peter a Grado
  • More

On day 11 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Siena and San Piero a Grado. When you’re not sightseeing, take time to relax at your selected hotel in Genoa, where you’ll be staying for 1 night.

Today’s itinerary in Siena covers several incredible sights, including a public square and a church. Start your adventure at Piazza Del Campo. This impressive public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the history-steeped wonders of Siena Cathedral, a must-see church in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to San Piero A Grado. This increasingly popular church offers an enriching experience. These sights offer a fulfilling end to a perfect day.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Experience a symphony of flavors at San Giorgio in Genoa by securing a reservation in advance. Renowned for its 1-star Michelin distinction, San Giorgio delights its guests with its exceptional variety of meals showcasing delicious modern and ligurian cuisine. For a palate-pleasing alternative, make sure to dine at The Cook, acclaimed for its delectable modern specialties. This local 1-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Il Marin, a top-rated restaurant known for its outstanding menu. Known as a top-rated 1-star Michelin establishment, it's a top choice for seafood and contemporary cuisine in the city.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 12

Day 12

  • Genoa - Departure day
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  • Via Garibaldi
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Via Garibaldi, a respected street before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Savor the flavors at Osteria Sant'Ilario, a top pick for dinner tonight. Alternatively, La Cialtroneria beckons with its unique menu offerings.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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