12-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Savona, Florence, Rome, and Siena
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Description
Escape the ordinary with this exciting 12-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Savona, 3 nights in Florence, 4 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Genoa, Savona, Santa Margherita Ligure, Rapallo, Florence, Tivoli, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and San Piero a Grado, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
Itinerary summary
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Day 1
- Genoa - Arrival day
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- Piazza Corvetto
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.
Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Corvetto, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.
Make sure to reserve a table at 7 Sensi cucina decontaminata, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Alla Lunga Ristorante, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Grand Hotel Savoia, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Continue the enjoyment post-dinner at Scurreria Beer & Bagel, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, La Lepre offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Pisacane Iii. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Genoa
- Savona
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Drive 46 km, 1 hour 1 min
- piazza De Ferrari
- Doge's Palace
- Genoa Cathedral
- Aquarium of Genoa
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On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Genoa. When you’re not sightseeing, take time to relax at your selected hotel in Savona, where you’ll be staying for 1 night.
Prepare for a day full of family-friendly attractions, romantic experiences, and scenic views. When you’re ready, kick off your sightseeing adventure at Piazza De Ferrari. This locally renowned public square is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Doge's Palace, one of the city’s best highlights.
Next, check out Genoa Cathedral, one of the most frequently visited places to see in Genoa. This church is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Aquarium Of Genoa. Wander around and soak in the breathtaking atmosphere this aquarium offers.
At the end of the day, you will drive to Savona, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Savona. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Savor the flavors at Il Mondo Del Caffè, a top pick for dinner tonight. Alternatively, Club Nautico di Savona beckons with its unique menu offerings.
Cap off your dinner by heading to Fuoritutti Food & Beer, ideal for a leisurely evening with a drink in hand.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 3
- Savona
- Genoa
- Florence
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Drive 307 km, 4 hours 9 min
- Lighthouse of Genoa
- Spiaggia Libera
- Il Giardino di Villa Durazzo
- Rapallo Castle
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa, Santa Margherita Ligure, and Rapallo. In the evening, you’ll end up in Florence, where you will stay for 3 nights.
Today, you'll explore some of the most beautiful places in Savona, including a lighthouse, a beach, a palace, a castle and much more! Start your day with a visit to Lighthouse Of Genoa. This locally appreciated lighthouse is a must-visit in the city. When you’re ready for your next discovery, continue to Spiaggia Libera, which may be one of the most idyllic places you will experience today.
One of the best things about exploring Savona on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Villa Durazzo, an up-and-coming palace in the city. If you’re up for more discoveries, don’t forget to reserve some time for Rapallo Castle.
When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.
Treat yourself to an extraordinary dining experience at Enoteca Pinchiorri, a 3-star Michelin restaurant offering an incredible italian contemporary menu. Alternatively, if your taste buds call for something different, Santa Elisabetta is one of the best restaurants for creative and mediterranean cuisine in Florence. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Gucci Osteria da Massimo Bottura. As a top-rated establishment with 1 Michelin star, it is an ideal choice for italian contemporary and international cuisine in the city.
After your meal, keep the night alive at a bar like Manifattura, known for its lively atmosphere. Se·sto On Arno Rooftop Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Il Vinile offers an excellent atmosphere for those looking to amp up the evening.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 4
- Florence
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Drive 7 km, 52 min
- Ponte Vecchio
- Uffizi Gallery
- piazza della Signoria
- Basilica of Santa Croce in Florence
- piazzale Michelangelo
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Day 4 offers a multitude of experiences. You will stay in Florence for 2 nights more, offering you enough time to explore at a relaxed pace.
Immerse yourself in Florence’s rich culture with today's sightseeing itinerary. Start your journey at Ponte Vecchio. This culturally significant historical landmark is sure to ignite your curiosity. Next, dive into the romantic features of Uffizi Gallery, a must-visit art gallery in the city.
In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Piazza Della Signoria, an extraordinary public square. For a change of scene, check out Basilica Of Santa Croce In Florence, known for its culturally significant features.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Treat yourself to a delightful dinner at Ditta Artigianale, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trattoria Da Burde? It's another excellent option with a diverse menu. Consider reserving a table at Casa Toscana as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.
After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar 50 Rosso, a well-loved spot among locals and tourists. Or, head to Bitter Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 5
- Florence
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Drive 3 km, 49 min
- Galleria dell'Accademia
- Cathedral of Santa Maria del Fiore
- Central Market
- Basilica of Santa Maria Novella
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Day 5 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.
Discover a day packed with family-friendly attractions, photo-friendly spots, and historic treasures in Florence. Begin your sightseeing with Galleria Dell'accademia. This locally renowned art gallery is one of the top attractions in the city. Proceed to Cathedral Of Santa Maria Del Fiore, another must-visit attraction that enhances the city’s allure.
As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Central Market. This locally renowned food market is a traveler-favorite. Not far away, you’ll find Basilica Di Santa Maria Novella, Firenze (fi), another key site on your sightseeing itinerary.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.
Dine in style at Ristorante Buca Mario, a top recommendation for dinner tonight. Or, for a change of pace, Agricola Toscana boasts a menu that's sure to impress. Also, be sure to check out Eataly Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.
Explore the vibrant nightlife at Gosh* after your meal, a hub for lively evenings and memorable moments. Or, head to Antico Caffè Del Moro - Art Bar Firenze for a great selection of flavorful drinks and a charming setting. Furthermore, Quelo Bar is perfect for those looking to extend their night with a touch of local flavor.
Savor another day of unforgettable experiences in Italy!
Day 6
- Florence
- Rome
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Drive 325 km, 4 hours 19 min
- Villa d'Este
- Saint Peter's Square
- St Peter's Basilica
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Dive into day 6 of your remarkable road trip in Italy. Today you will explore Tivoli and Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 4 nights.
Villa D'este is must-visit palace and a great starting point for the day. Next, continue your journey to Saint Peter's Square, an interesting square, located just a leisurely stroll away.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Experience a symphony of flavors at La Pergola in Rome by securing a reservation in advance. Renowned for its 3-star Michelin distinction, La Pergola delights its guests with its exceptional variety of meals showcasing delicious mediterranean and contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Il Pagliaccio, acclaimed for its delectable creative and innovative specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Enoteca La Torre, a top-rated restaurant known for its outstanding menu. Known as a top-rated 2-star Michelin establishment, it's a top choice for mediterranean and creative cuisine in the city.
After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 7
- Rome
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Drive 5 km, 1 hour 15 min
- Piazza Navona
- Pantheon
- Roman Forum
- Colosseum
- Circus Maximus
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On day 7 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 3 nights and discover all the best things to see and do in the area.
Rome is brimming with adventures. Today’s wonderful stops include a public square, a monument, and an archeological site. Begin your sightseeing adventure at the timeless Piazza Navona. Just a short distance away is Pantheon, a respected monument that draws visitors from far and near.
Continue your journey to Roman Forum, one of the city’s most timeless spots that you shouldn’t miss. Another great site to visit is the globally renowned Colosseum. Last up on today’s itinerary is an archeological site. Make your way to Circus Maximus for some final sightseeing. Each attraction will leave you with lasting memories and a deeper appreciation for the rich heritage of Rome.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Enjoy a lovely dining experience at RomAntica, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at Coso Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated DEROMA - Farine Romane. It’s yet another ideal choice to enhance your time in Rome tonight.
To truly maximize your evening out, consider visiting Sant' Eustachio Caffè after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Yellowsquare Rome, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Raise your glass to another unforgettable day in Italy!
Day 8
- Rome
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Drive 13 km, 1 hour 16 min
- Basilica di Santa Maria Maggiore
- Altare della Patria
- Trevi Fountain
- Piazza di Spagna
- Spanish Steps
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Day 8 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in Rome by discovering the best things there are to see and do in the city.
Savor the day by visiting some of the best places to see in Rome, including a church, a monument, and a public square. Start your adventure at Basilica Di Santa Maria Maggiore. This notable church is a must-visit for travelers looking for a unique holiday experience. Make your way to Altare Della Patria located in Rome for an enchanting atmosphere.
Next, immerse yourself in the setting of Trevi Fountain. Its grand features will captivate you. After the monument, continue your tour of the city with a visit to Piazza Di Spagna. This public square has a visually striking appeal. For a change of pace, head to Spanish Steps. As one of the most extraordinary attractions in Rome, this public square is an excellent place to end your self-guided tour.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.
Treat yourself to a wonderful meal at Hotel de Russie, a top-rated dining spot in Rome. If you're in the mood for something new, try La Taverna Italiana, another premier location with a delectable menu. You might also want to book a table at The Parrot Bar. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.
After your meal, keep the night alive at a bar like The Apartment Bar Roma, known for its lively atmosphere. Hotel Hassler Roma is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance.
Say good night to Rome and look forward to another great day of your road trip in Italy!
Day 9
- Rome
- More
Drive 10 km, 1 hour 5 min
- Villa Borghese
- piazza del Popolo
- Castel Sant'Angelo
- Campo de' Fiori
- largo di Torre Argentina
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Day 9 offers a multitude of experiences. You will stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.
Set out on a day brimming with fun adventures, romantic experiences, and natural wonders. Start at the extraordinary Villa Borghese, a mesmerizing park in Rome. Next, go to Piazza Del Popolo.
After visiting Villa Borghese and Piazza Del Popolo, take time to explore Rome's streets and absorb its charm. Continue your sightseeing by heading to Castel Sant'angelo. This enchanting castle offers a unique experience. Campo De' Fiori is another noteworthy stop. End your self-guided sightseeing tour on top with a visit to Largo Di Torre Argentina, one of the most photogenic places to visit in Rome.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Make sure to reserve a table at Sofitel Roma Villa Borghese, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Centro, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Tema, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!
Day 10
- Rome
- Siena
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Drive 261 km, 3 hours 37 min
- The Tarot Garden
- Spacco della Regina
- River Park Ombrone Silvano Signori
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Embark on another extraordinary experience on day 10 of your road trip in Italy. Today, you will make 3 stops and experience some of the highlights of Pescia Fiorentina, Ansedonia, and Grosseto. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 1 night.
Get ready for an exciting day in Rome. Today’s sightseeing agenda includes a sculpture garden, a cave, and a park. Begin your adventure at The Tarot Garden. This is an up-and-coming sculpture garden you should not miss. Another must-see is Spacco Della Regina, a worthwhile cave in Rome.
When you’re ready for the next sight, head to River Park Ombrone Silvano Signori.
At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at Enoteca I Terzi, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Ristorante Tar-Tufo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Antica Trattoria Papei. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Siena this evening.
Let the evening flow smoothly from dinner to drinks at Meet Life Cafè, a top-rated bar in the area. For other recommendations, Maudit Pub provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Impero Siena offers a memorable night with diverse drink options and excellent service.
Head back to your accommodation in Siena and get some rest in preparation for another magical day of your road trip in Italy!
Day 11
- Siena
- Genoa
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Drive 297 km, 3 hours 55 min
- piazza del Campo
- Siena Cathedral
- Church of Saint Peter a Grado
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Experience an unparalleled adventure on day 11 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Siena and San Piero a Grado. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Genoa. You will spend 1 night here for some well-deserved relaxation.
A blend of family-friendly attractions, romantic experiences, and breathtaking views await you in Siena on today’s itinerary. First up is the famous public square, Piazza Del Campo. Afterward, continue to Siena Cathedral, a church every traveler should visit.
As you explore Siena’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to San Piero A Grado. This worthwhile church is an essential stop.
When you’re done exploring for the day, you’ll drive to your hotel in Genoa. Check in and spend some time relaxing before you head out to tour the city.
After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.
Begin your culinary exploration in Genoa by securing a reservation at San Giorgio. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of modern and ligurian cuisine. For another dining delight, visit The Cook, celebrated for its delectable modern menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Marin, a top local spot known for its tantalizing seafood and contemporary menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.
Get a good night's sleep and look forward to another great day on the road in Italy!
Day 12
- Genoa - Departure day
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- Via Garibaldi
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, begin at Via Garibaldi. This locally appreciated street is a popular place to see in the city.
On your last day in Italy, take time to indulge in shopping at Genoa’s popular marketplace, Porto Antico. Look for keepsakes or souvenirs to remind you of your trip.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.
You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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