12-Day Italy Road Trip from Perugia to Assisi, Rome, Vicenza & Siena

Your amazing road trip adventure in Italy begins when you reach the incredible city of Assisi. There, you'll have your choice of the best hotels and places to stay.

We also recommend the best 3-star hotels, like the Domus Pacis Assisi. This hotel has an average rating of 4.3 out of 5 stars by 958 guests.

If these hotels are not available during your trip to the city of Assisi, our system will automatically help you find the best hotel for your stay.

Assisi has many popular destinations you can explore.

Assisi also has several great bars that will fit all travel budgets. One of the best bars in the city of Assisi is Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil and Chocolate Tastings. This bar has an average rating of 4.9 out of 5 stars by 878 customers.

Enjoy toasting the start of your 12-day vacation in Italy!

On day 2 of your road trip, you’ll explore the area around the region of Province of Perugia. You’ll be able to visit amazing attractions, like the incredible Basilica of San Francesco d'Assisi, Rocca Paolina, Piazza IV Novembre, and many more.

One of the best travel destinations in the region of Province of Perugia is Basilica of San Francesco d'Assisi. This incredible attraction is a papal basilica and has an average rating of 4.9 out of 5 stars by 32,721 visitors.

Rocca Paolina is another popular attraction you'll visit in the region of Province of Perugia. This spectacular attraction has an average rating of 4.7 out of 5 stars by 32,721 visitors.

Another of the best travel destinations you can visit in the region of Province of Perugia is Piazza IV Novembre. This amazing attraction is a square and is rated an average of 4.6 out of 5 stars by 9,048 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Spoleto Cathedral. This cathedral and place of interest is rated an average of 4.7 out of 5 stars by 5,604 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Assisi.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 3 of your road trip, you’ll explore the area around the region of Province of Perugia. You’ll be able to visit amazing attractions, like the incredible Basilica di Santa Chiara, Basilica di Santa Maria degli Angeli, Parco Regionale del Lago Trasimeno, and many more.

One of the best travel destinations in the region of Province of Perugia is Basilica di Santa Chiara. This incredible attraction is a minor basilica and has an average rating of 4.7 out of 5 stars by 9,542 visitors.

Basilica di Santa Maria degli Angeli is another popular attraction you'll visit in the region of Province of Perugia. This spectacular attraction has an average rating of 4.8 out of 5 stars by 9,542 visitors.

Another of the best travel destinations you can visit in the region of Province of Perugia is Parco Regionale del Lago Trasimeno. This amazing attraction is a park and is rated an average of 4.4 out of 5 stars by 8,816 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Borgo di Rasiglia. This place of interest is rated an average of 4.6 out of 5 stars by 8,870 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Assisi.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 4 of your road trip, you’ll explore the area around the region of Province of Perugia. You’ll be able to visit amazing attractions, like the incredible San Damiano, Eremo delle Carceri, Piazza del Popolo, Todi, and many more.

One of the best travel destinations in the region of Province of Perugia is San Damiano. This incredible attraction is a church building and has an average rating of 4.8 out of 5 stars by 4,798 visitors.

Eremo delle Carceri is another popular attraction you'll visit in the region of Province of Perugia. This spectacular attraction has an average rating of 4.8 out of 5 stars by 4,798 visitors.

Another of the best travel destinations you can visit in the region of Province of Perugia is Piazza del Popolo, Todi. This amazing attraction is a square and is rated an average of 4.6 out of 5 stars by 4,291 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Fonti del Clitunno. This roman deity and place of interest is rated an average of 4.3 out of 5 stars by 6,510 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Assisi.

Raise your glass and relax after another big day of your road trip adventure through Italy!

Day 5 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Altar of the Fatherland, Trevi Fountain, Pantheon, and many more.

One of the best places to visit in the city of Rome is the amazing Altar of the Fatherland. As such, over 1,683,070 people visit Altar of the Fatherland yearly. This attraction is an architectural structure and is rated an average of 4.8 out of 5 stars by 44,037 visitors.

You could also stop at the incredible sculpture, Trevi Fountain.

Another unforgettable travel destination in the city of Rome is the outstanding Pantheon. This roman temple has an average rating of 4.8 out of 5 stars by 176,062 visitors. Approximately 1,683,070 travelers come to Rome every year to see the stunning Altar of the Fatherland with their own eyes.

Piazza Navona is another popular attraction you can visit in the city of Rome. This spectacular attraction has an average rating of 4.7 out of 5 stars by 147,536 visitors.

If you’re keen to explore even more, then consider a visit to the fantastic Colosseum. This roman amphitheatre is a popular attraction with an average rating of 4.7 out of 5 stars from 308,140 visitors. Colosseum hosts around 7,400,000 annually so be sure to stop at this attraction so you won't miss out!

At the end of the day, you will drive to the city of Rome, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Rome is the 3-star Ibis Roma Fiera. This hotel has an average rating of 3.8 out of 5 stars by 1,099 guests.

You can also stay at one of the best 4-star hotel. The hotel Residence Mallia Hotel is a luxurious place to stay in the city of Rome. This hotel is rated an average of 4.2 out of 5 stars by 619 guests.

After a long day of driving and exploring, we recommend you try Cantina e Cucina, one of the best restaurants in the city of Rome. This restaurant has an average rating of 4.6 out of 5 stars by 7,907 customers.

Locals also recommend Ai Tre Scalini as one of the best restaurants in the city of Rome. Ai Tre Scalini is rated an average of 4.4 out of 5 stars by 2,950 customers.

Another of the best restaurants in the city of Rome is 433. This restaurant has been rated an average of 4.4 out of 5 stars by 2,341 customers.

After dinner, visit D’Angelo Caffè & Gastronomia - Bar Bistro Caffetteria Napoletana a Roma, which is considered one of the best bars in the city of Rome. This bar is rated an average of 4.7 out of 5 stars by 1,054 customers.

You can also enjoy drinks at a popular bar like Cantina e Cucina. This bar has an average rating of 4.6 out of 5 stars by 7,907 customers.

Alternatively, Ai Tre Scalini is one of the best bars that locals recommend in the city of Rome. This bar is rated an average of 4.4 out of 5 stars by 2,950 customers.

Raise your glass in celebration of your incredible road trip adventure through Italy!

On day 6 of your road trip, you’ll explore the area around the city of Rome. You’ll be able to visit amazing attractions, like the incredible Roman Forum, Villa Borghese, Piazza del Popolo, and many more.

One of the best travel destinations in the city of Rome is Roman Forum. This incredible attraction is a square and has an average rating of 4.7 out of 5 stars by 111,431 visitors.

Villa Borghese is another popular attraction you'll visit in the city of Rome. This spectacular attraction has an average rating of 4.6 out of 5 stars by 111,431 visitors.

Another of the best travel destinations you can visit in the city of Rome is Piazza del Popolo. This amazing attraction is a square and is rated an average of 4.6 out of 5 stars by 83,790 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Castel Sant'Angelo. This museum and place of interest is rated an average of 4.7 out of 5 stars by 66,971 visitors. Each year, approximately 918,591 come to this beautiful attraction to enhance their travel experience in Rome.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Rome.

We recommend eating at one of the best restaurants in the city of Rome, like Roma Sparita. This restaurant has an average rating of 4.4 out of 5 stars by 2,073 customers.

La Taverna Italiana is another of the best restaurant options in the city of Rome. This restaurant is rated an average of 4.5 out of 5 stars by 1,897 customers.

Locals enjoy Ristorante Amedeo, one of the most popular restaurants in the city of Rome. The restaurant has an average rating of 4.3 out of 5 stars by 1,798 customers.

After dinner, visit one of the best bars in the city of Rome, VinAllegro. This bar is rated an average of 4.3 out of 5 stars by 1,167 customers.

You can also enjoy drinks at a popular bar that locals recommend, like Ristorante Tema. This bar has an average rating of 4.4 out of 5 stars by 939 customers.

Bar Tornatora Rome is another of the best bars in the city of Rome. This bar is rated an average of 4.3 out of 5 stars by 952 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 7 of your road trip, you’ll explore the area around the city of Rome. You’ll be able to visit amazing attractions, like the incredible Campo de' Fiori, Largo di Torre Argentina, Campidoglio, and many more.

One of the best travel destinations in the city of Rome is Campo de' Fiori. This incredible attraction is a square and has an average rating of 4.4 out of 5 stars by 47,948 visitors.

Largo di Torre Argentina is another popular attraction you'll visit in the city of Rome. This spectacular attraction has an average rating of 4.5 out of 5 stars by 47,948 visitors.

Another of the best travel destinations you can visit in the city of Rome is Campidoglio. This amazing attraction is a hill and is rated an average of 4.7 out of 5 stars by 18,784 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Giardino degli Aranci. This park and place of interest is rated an average of 4.7 out of 5 stars by 16,817 visitors.

If you’re keen to explore even more, then consider a visit to the fantastic Baths of Caracalla. This thermae is a popular attraction with an average rating of 4.6 out of 5 stars from 17,216 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Rome.

We recommend eating at one of the best restaurants in the city of Rome, like La Taverna dei Fori Imperiali. This restaurant has an average rating of 4.4 out of 5 stars by 1,637 customers.

Maccheroni is another of the best restaurant options in the city of Rome. This restaurant is rated an average of 4.3 out of 5 stars by 1,633 customers.

Locals enjoy Coso Ristorante, one of the most popular restaurants in the city of Rome. The restaurant has an average rating of 4.3 out of 5 stars by 1,275 customers.

After dinner, visit one of the best bars in the city of Rome, Tigelleria Romana - Bistrot & Cafè. This bar is rated an average of 4.3 out of 5 stars by 792 customers.

You can also enjoy drinks at a popular bar that locals recommend, like La Botticella of Poggi Giovanni. This bar has an average rating of 4.7 out of 5 stars by 655 customers.

La Licata is another of the best bars in the city of Rome. This bar is rated an average of 4.5 out of 5 stars by 2,067 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 8 of your road trip, you’ll explore the area around the city of Rome. You’ll be able to visit amazing attractions, like the incredible Piazza di Spagna, Spanish Steps, Basilica Papale di Santa Maria Maggiore, and many more.

One of the best travel destinations in the city of Rome is Piazza di Spagna. This incredible attraction is a square and has an average rating of 4.7 out of 5 stars by 105,496 visitors.

Spanish Steps is another popular attraction you'll visit in the city of Rome. This spectacular attraction has an average rating of 4.5 out of 5 stars by 105,496 visitors.

Another of the best travel destinations you can visit in the city of Rome is Basilica Papale di Santa Maria Maggiore. This amazing attraction is a major basilica and is rated an average of 4.8 out of 5 stars by 25,526 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit the outstanding Circus Maximus. This circus and place of interest is rated an average of 4.4 out of 5 stars by 41,568 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Rome.

We recommend eating at one of the best restaurants in the city of Rome, like VinAllegro. This restaurant has an average rating of 4.3 out of 5 stars by 1,167 customers.

Pierluigi is another of the best restaurant options in the city of Rome. This restaurant is rated an average of 4.3 out of 5 stars by 1,123 customers.

Locals enjoy Ristorante Tema, one of the most popular restaurants in the city of Rome. The restaurant has an average rating of 4.4 out of 5 stars by 939 customers.

After dinner, visit one of the best bars in the city of Rome, Bar Gelateria Made in Italy. This bar is rated an average of 4.5 out of 5 stars by 458 customers.

You can also enjoy drinks at a popular bar that locals recommend, like Elegance Cafe - Locale Jazz Roma. This bar has an average rating of 4.3 out of 5 stars by 320 customers.

Wine Bar All Brothers is another of the best bars in the city of Rome. This bar is rated an average of 4.4 out of 5 stars by 308 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

Day 9 of your road trip through Italy gives you the opportunity to experience two places in one day.

One of the best places to visit in the region of Emilia-Romagna is the amazing Piazza Santo Stefano. This attraction is a square and is rated an average of 4.8 out of 5 stars by 6,882 visitors.

You could also stop at the incredible square, Piazza Maggiore.

At the end of the day, you will drive to the city of Vicenza, where will have access to the best hotels and places to stay.

You can also stay at one of the best 4-star hotel. The hotel SHG Hotel de la Ville is a luxurious place to stay in the city of Vicenza. This hotel is rated an average of 4.1 out of 5 stars by 1,083 guests.

After a long day of driving and exploring, we recommend you try Gusto Rosso Vicenza - (Tonazzo 1888) Ristorante Carneria Veggeria, one of the best restaurants in the city of Vicenza. This restaurant has an average rating of 4.3 out of 5 stars by 1,646 customers.

Locals also recommend Al Moraro as one of the best restaurants in the city of Vicenza. Al Moraro is rated an average of 4.3 out of 5 stars by 1,190 customers.

Another of the best restaurants in the city of Vicenza is Mama L'oca Street Bar. This restaurant has been rated an average of 4.4 out of 5 stars by 1,137 customers.

After dinner, visit Mama L'oca Street Bar, which is considered one of the best bars in the city of Vicenza. This bar is rated an average of 4.4 out of 5 stars by 1,137 customers.

You can also enjoy drinks at a popular bar like Il Ceppo. This bar has an average rating of 4.4 out of 5 stars by 916 customers.

Alternatively, Busa dei Briganti Pub - Vicenza is one of the best bars that locals recommend in the city of Vicenza. This bar is rated an average of 4.3 out of 5 stars by 803 customers.

Raise your glass in celebration of your incredible road trip adventure through Italy!

Day 10 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Gardaland Resort, Verona Arena, Ponte Pietra, and many more.

One of the best places to visit in the region of Veneto is the amazing Gardaland Resort. This attraction is an amusement park and is rated an average of 4.5 out of 5 stars by 94,935 visitors.

You could also stop at the incredible opera house, Verona Arena. With an average rating of 4.6 out of 5 stars by 116,086 visitors, it's easy to understand why Verona Arena welcomes around 195,540 yearly visitors.

Another unforgettable travel destination in the region of Veneto is the outstanding Ponte Pietra. This deck arch bridge has an average rating of 4.7 out of 5 stars by 11,651 visitors.

At the end of the day, you will drive to the city of Siena, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Siena is the 3-star Hotel Chiusarelli. This hotel has an average rating of 4.4 out of 5 stars by 1,224 guests.

You can also stay at one of the best 4-star hotel. The hotel Executive Hotel is a luxurious place to stay in the city of Siena. This hotel is rated an average of 4.1 out of 5 stars by 1,241 guests.

If you’re looking for the best cheap hotel, we recommend staying at the 3-star Sangallo Park Hotel. This 3-star hotel has an average rating of 4.5 out of 5 stars by 705 guests.

After a long day of driving and exploring, we recommend you try La Taverna di San Giuseppe, one of the best restaurants in the city of Siena. This restaurant has an average rating of 4.7 out of 5 stars by 1,767 customers.

Locals also recommend Osteria degli Svitati as one of the best restaurants in the city of Siena. Osteria degli Svitati is rated an average of 4.7 out of 5 stars by 911 customers.

Another of the best restaurants in the city of Siena is Osteria Il Carroccio. This restaurant has been rated an average of 4.7 out of 5 stars by 895 customers.

After dinner, visit La Taverna di San Giuseppe, which is considered one of the best bars in the city of Siena. This bar is rated an average of 4.7 out of 5 stars by 1,767 customers.

You can also enjoy drinks at a popular bar like Ristorante Gallo Nero. This bar has an average rating of 4.4 out of 5 stars by 829 customers.

Alternatively, San Paolo Pub is one of the best bars that locals recommend in the city of Siena. This bar is rated an average of 4.3 out of 5 stars by 704 customers.

Raise your glass in celebration of your incredible road trip adventure through Italy!

Day 11 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Piazzale Michelangelo, Piazza del Duomo, Piazza della Signoria, and many more.

One of the best places to visit in the region of Tuscany is the amazing Piazzale Michelangelo. This attraction is a square and is rated an average of 4.8 out of 5 stars by 73,198 visitors.

You could also stop at the incredible Piazza del Duomo.

Another unforgettable travel destination in the region of Tuscany is the outstanding Piazza della Signoria. This square has an average rating of 4.8 out of 5 stars by 63,038 visitors.

Ponte Vecchio is another popular attraction you can visit in the region of Tuscany. This spectacular attraction has an average rating of 4.7 out of 5 stars by 112,589 visitors.

If you’re keen to explore even more, then consider a visit to the fantastic Piazza Grande. This square is a popular attraction with an average rating of 4.6 out of 5 stars from 13,065 visitors.

At the end of the day, you will drive to the city of Assisi, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Assisi is the 3-star Domus Pacis Assisi. This hotel has an average rating of 4.3 out of 5 stars by 958 guests.

Raise your glass in celebration of your incredible road trip adventure through Italy!

Day 12 of your road trip in Italy is your departure day. This is your chance to catch one last glimpse of Assisi before saying goodbye to this wonderful destination. When you have time to explore the area before you make your way home, we recommend visiting some of the following attractions.

Your accommodation will also be strategically located for some last-minute shopping in the city of Assisi before you conclude your short European break.

You’ll then say farewell to Italy and begin your journey home, now filled with memories of unforgettable experiences in Italy!