12-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling east to Rome, Naples, Salerno, and Pescara
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Explore the best of Italy on a 12-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Perugia, Rome, Naples, Ercolano, Ottaviano, Pompei, Salerno, Amalfi, Caserta, Pescara, and Santa Maria degli Angeli. This road trip itinerary in Italy seamlessly combines exploration with relaxation.
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Perugia, 4 nights in Rome, 3 nights in Naples, 1 night in Salerno, and 1 night in Pescara. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Perugia, Rome, Naples, Ercolano, Ottaviano, Pompei, Salerno, Amalfi, Caserta, Pescara, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
Itinerary summary
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Day 1
- Perugia - Arrival day
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- Rocca Paolina
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Welcome to Perugia, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Perugia's charm before embarking on the next leg of your journey.
Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Rocca Paolina, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
Find your way to your hotel in Perugia. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.
Treat yourself to a wonderful meal at Ristorante Settimo Sigillo, a top-rated dining spot in Perugia. If you're in the mood for something new, try Caffè Baglioni, another premier location with a delectable menu. You might also want to book a table at Bar Pellas. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Perugia.
Round off your dining experience by visiting Tommi Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Valentina, a bar catering to every mood and preference. Caffe Dal Perugino likewise offers a unique atmosphere, perfect for a memorable night out.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Perugia
- Rome
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Drive 185 km, 2 hours 30 min
- The Fontana Maggiore
- Perugia Sotterranea Accesso
- Piazza IV Novembre
- National Gallery
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Embark on another extraordinary experience on day 2 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Perugia. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 4 nights.
Get ready for an exciting day in Perugia. Today’s sightseeing agenda includes a monument, a cave system, a public square, an art gallery and much more! Begin your adventure at The Fontana Maggiore. This is a locally appreciated monument you should not miss. Another must-see is Perugia Sotterranea Accesso, a locally appreciated cave system in Perugia.
When you’re ready for the next sight, head to Piazza Iv Novembre. From there, take a leisurely stroll to National Gallery, another of the city’s underrated attractions.
At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.
Have a memorable dining experience in Rome by booking a table at La Pergola, renowned as a 3-star Michelin restaurant presenting an exceptional mediterranean and contemporary menu. For a different culinary experience in Rome, Il Pagliaccio shines as one of the top destinations, known for its delicious creative and innovative cuisine. This 2-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Enoteca La Torre is known as a top local spot for its delicious mediterranean and creative cuisine in Rome. This 2-star Michelin awardee is a highly recommended choice for an unforgettable meal.
To truly maximize your evening out, consider visiting La Botticella Of Poggi Giovanni after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Almalu Trastevere, another bar with an inviting ambiance. Similarly, Bar Viminale Di Pepi Maurilio also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 3
- Rome
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Drive 10 km, 55 min
- Vatican Museums
- Saint Peter's Square
- Sistine Chapel
- St Peter's Basilica
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On day 3 of your road trip, you’ll start and end your day in Rome, where you'll stay for 3 nights more.
Saint Peter's Square is your next stop. This well-known square is one of the best-rated sights in Rome.
Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Sistine Chapel. To round off your sightseeing experience, visit St. Peter's Basilica.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Have a fantastic dining experience at RomAntica, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Coso Ristorante offers an enticing alternative with its varied menu. Additionally, DEROMA - Farine Romane is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.
Let the evening flow smoothly from dinner to drinks at Sant' Eustachio Caffè, a top-rated bar in the area. For other recommendations, Yellowsquare Rome provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffè Portofino offers a memorable night with diverse drink options and excellent service.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 4
- Rome
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Drive 6 km, 1 hour 24 min
- Pantheon
- largo di Torre Argentina
- Roman Forum
- Colosseum
- Basilica di Santa Maria Maggiore
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Day 4 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.
Today's adventure in Rome promises more breathtaking discoveries and enriching experiences! Begin at Pantheon. This culturally significant monument is a highlight of any visit in the city. Then, enjoy Largo Di Torre Argentina, another photogenic attraction that never fails to captivate visitors. Next, head over to Roman Forum, one of the city’s most world-famous attractions, known for its breathtaking features.
If you’re looking for more, spend time soaking in the atmosphere of Colosseum. This breathtaking archeological site is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Basilica Di Santa Maria Maggiore, a captivating church, and take a stroll around the area.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.
Dine in style at Hotel de Russie, a top recommendation for dinner tonight. Or, for a change of pace, La Taverna Italiana boasts a menu that's sure to impress. Also, be sure to check out The Parrot Bar. Known as a local hotspot, it’s a great choice for tonight in Rome.
After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at The Apartment Bar Roma, a well-loved spot among locals and tourists. Or, head to Hotel Hassler Roma. This bar boasts a welcoming environment that is perfect for winding down.
Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!
Day 5
- Rome
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Drive 10 km, 1 hour 7 min
- Villa Borghese
- piazza del Popolo
- Castel Sant'Angelo
- Piazza Navona
- Campo de' Fiori
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Day 5 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.
Rome is brimming with adventures. Today’s wonderful stops include a park, a public square, and a castle. Begin your sightseeing adventure at the astonishing Villa Borghese and allow yourself time to explore. Just a short distance away you'll find your next stop, Piazza Del Popolo, a culturally significant public square that draws visitors from far and near.
Continue your journey to Castel Sant'angelo, one of the city’s most astonishing spots that you shouldn’t miss. Another great site to visit is the iconic Piazza Navona. When you're finished at the public square, Campo De' Fiori awaits your visit. This public square is a romantic highlight on today's itinerary.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at Sofitel Roma Villa Borghese, a highly-rated dining destination in Rome. If you're eager to try something different, consider Centro, another top spot with a tantalizing menu. You might also want to secure a reservation at Ristorante Tema. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.
Say good night to Rome and look forward to another great day of your road trip in Italy!
Day 6
- Rome
- Naples
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Drive 231 km, 3 hours 16 min
- Altare della Patria
- Trevi Fountain
- Spanish Steps
- Piazza di Spagna
- Archbasilica of St. John Lateran
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Dive into day 6 of your remarkable road trip in Italy. Today you will explore Rome, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Naples. You’ll stay here for 3 nights.
Today’s agenda in Rome includes a monument, a public square, and a church. Altare Della Patria is must-visit monument and a great starting point for the day. Next, continue your journey to Trevi Fountain, a globally renowned monument, located just a leisurely stroll away. Next, head to Spanish Steps, an enchanting public square, also available for your discovery today.
Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Rome. When you're ready, let your sightseeing route take you to the world-famous Piazza Di Spagna. If you’re looking for more, Archbasilica Of St. John Lateran is also an interesting attraction that is worthwhile a visit.
When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and spend some time relaxing before you head out to tour the city.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Get ready for an unforgettable culinary journey in Naples by reserving a table at Veritas. Renowned as a 1-star Michelin restaurant, it offers an exceptional campanian and contemporary menu. For a different taste experience, head to Il Comandante, recognized for its delicious creative and mediterranean dishes. This 1-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit ARIA, a local favorite known for its delightful contemporary and modern cuisine in Naples. Nestled in the heart of the city, this restaurant with 1 Michelin star is an ideal choice for discerning contemporary and modern foodies seeking culinary excellence.
Continue your evening by exploring the vibrant nightlife scene at Happening Cocktail Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Shanti Art Musik Bar, a bar that offers unique local touches. Likewise, Gran Caffè Gambrinus provides an excellent alternative for a fun evening.
Head back to your accommodation in Naples and get some rest in preparation for another magical day of your road trip in Italy!
Day 7
- Naples
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Drive 4 km, 54 min
- Castel Nuovo
- San Carlo Theatre
- Royal Palace of Naples
- piazza del Plebiscito
- Ovo Castle
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On day 7 of your road trip, you will have an entire day to explore Naples. You’ll stay in Naples for 2 nights and discover all the best things to see and do in the area.
Discover a day packed with family-friendly attractions, breathtaking views, and picturesque spots in Naples. Begin your sightseeing with Castel Nuovo. This captivating castle is one of the top attractions in the city. Proceed to San Carlo Theatre, another must-visit attraction.
As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Royal Palace Of Naples. This beloved palace is a traveler-favorite. Not far away, you’ll find Piazza Del Plebiscito, another key site on your sightseeing itinerary. Ovo Castle is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Make sure to reserve a table at Antica Pizzeria Di Matteo, an iconic dining spot in Naples. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mercure Napoli Centro Angioino, a popular restaurant in Naples. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Lazzara Trattoria e Pizzeria, a hidden gem nestled in Naples. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Keep the excitement of the evening going by visiting a bar or two. Archivio Storico - Cocktail Bar & Wonderfood is an excellent place to start. You could also check out Archeobar, offering a different kind of charm. A last recommendation for the day is Babette Pub. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
Raise your glass to another unforgettable day in Italy!
Day 8
- Naples
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Drive 6 km, 54 min
- Chiesa del Gesù Nuovo
- Cappella Sansevero
- Napoli Sotterranea Percorso Ufficiale
- Naples National Archaeological Museum
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Day 8 of your road trip across Italy promises a magnificent time exploring Naples. You have 1 night left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.
Enjoy the perfect balance of relaxation and exploration in Naples today. One of the most interesting attractions included on the itinerary is Chiesa Del Gesù Nuovo. This monumental church will help you start your sightseeing on top. Then, take a leisurely stroll to Cappella Sansevero and learn what makes this standout museum unique.
Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the captivating Napoli Sotterranea Percorso Ufficiale. After exploring the cave system, head to Naples National Archaeological Museum. This well-known museum is a highlight in Naples.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for an authentic adventure.
Have a fantastic dining experience at Opera Restaurant, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria San Ferdinando offers an enticing alternative with its varied menu. Additionally, Anonymous Trattoria Gourmet is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Naples.
If you’re not ready to end the night just yet, Gran Caffè Cimmino offers a perfect venue to relax and savor a drink. Similarly, Flanagan's Bar is well-suited for those looking to unwind in a social setting. Bar Napoli is another excellent spot to enjoy a nightcap after a delightful meal.
Celebrate another amazing day of your road trip adventure in Italy!
Day 9
- Naples
- Salerno
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Drive 82 km, 2 hours 6 min
- Archaeological Park of Herculaneum
- Mount Vesuvius
- Vesuvio National Park
- Archaeological Park of Pompeii
- Teatro Grande
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On day 9 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 3 destinations, Ercolano, Ottaviano, and Pompei. When you’re not sightseeing, take time to relax at your selected hotel in Salerno, where you’ll be staying for 1 night.
Today, you'll explore some of the most beautiful places in Naples, including an archeological site, a volcano, and a national park. Start your day with a visit to Archaeological Park Of Herculaneum. This worthwhile archeological site is a must-visit in the town. When you’re ready for your next discovery, continue to Mount Vesuvius, which may be one of the most majestic places you will experience today.
One of the best things about exploring Naples on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Vesuvio National Park, a well-known national park in the town. If you’re up for more discoveries, don’t forget to reserve some time for Archaeological Park Of Pompeii and Teatro Grande.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Salerno. Salerno offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Salerno. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Experience a taste of local culinary excellence while in Salerno by securing a table at Re Maurì. An esteemed 1-star Michelin restaurant, it features an exceptional creative menu. If you're in the mood for something new, try L'Unico Drink & Food Salerno, another premier location with a delectable menu.
Let the evening flow smoothly from dinner to drinks at Hilton Bar E Gastronomia, a top-rated bar in the area. For other recommendations, The Black Monday Speakeasy Tbm provides a perfect setting for rounding out your night with style and great drinks. Likewise, Dòmo I' Vinaino Wine Bar - Enogastronomia offers a memorable night with diverse drink options and excellent service.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 10
- Salerno
- Pescara
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Drive 376 km, 5 hours 51 min
- Amalfi Coast
- Palace of Caserta
- Giardini Reali - Parco Reggia di Caserta
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On day 10 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Amalfi and Caserta. In the evening, you’ll end up in Pescara, where you will stay for 1 night.
Prepare for a day full of family-friendly attractions, romantic experiences, and breathtaking views. When you’re ready, kick off your sightseeing adventure at Amalfi Coast. This famous coast is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Palace Of Caserta, one of the village’s best highlights.
Next, check out Giardini Reali - Parco Reggia Di Caserta, one of the most well-known places to see in Salerno. This park is a favorite among locals and travelers alike.
At the end of the day, you will drive to Pescara, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As dinnertime approaches, it's time to head out for a bite to eat in Pescara. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to an extraordinary dining experience at Nole, a Bib Gourmand restaurant offering an incredible italian contemporary and italian menu. Alternatively, if your taste buds call for something different, Estrò is one of the best restaurants for contemporary and country cooking cuisine in Pescara. This Bib Gourmand-awardee earns consistently high praises from guests. We also recommend checking out the menu at Taverna 58. As a top-rated establishment with a Bib Gourmand status, it is an ideal choice for from abruzzo and traditional cuisine in the city.
Following your dinner, dive into the local bar culture at Posa Caffè Pescara. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bar Mixer, the perfect place for those looking to experience the best of the nightlife. Similarly, Temple Bar Irish Pub provides excellent drinks and a great atmosphere, ensuring a memorable night out.
Savor another day of unforgettable experiences in Italy!
Day 11
- Pescara
- Perugia
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Drive 302 km, 3 hours 58 min
- Frasassi Caves
- Basilica of San Francesco d'Assisi
- Basilica of Santa Maria degli Angeli
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Experience an unparalleled adventure on day 11 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - San Vittore and Santa Maria degli Angeli. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Perugia. You will spend 1 night here for some well-deserved relaxation.
Today’s route brings family-friendly attractions, natural wonders, and breathtaking views. The first attraction of today is Frasassi Caves. This captivating cave system is an instagrammable place to see in Pescara. Continue your discovery at Basilica Of San Francesco D'assisi, a breathtaking church with stories to tell.
As you stroll around Pescara, take in the distinct atmosphere and learn what makes this hamlet so unique. Maximize your sightseeing with a visit to Basilica Of Santa Maria Degli Angeli. This locally renowned church offers a historic encounter with Pescara. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Pescara.
When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Perugia's most popular restaurants, and connect with friendly locals for an authentic adventure.
Make sure to reserve a table at La Taverna, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante del Sole, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Al Mangiar Bene, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Keep the evening going at Caffè Fortebraccio, a great choice for enjoying the after-dinner hours with a drink. You could also go to Caffe Del Banco, which offers a similarly pleasant setting and great drinks. Another option is Dempsey's Perugia, which provides an inviting environment for unwinding after a busy day out.
Celebrate another amazing day of your road trip adventure in Italy!
Day 12
- Perugia - Departure day
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- Arco dei Gigli
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
On your last day in Italy, take time to indulge in shopping at Perugia’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.
If you're in the mood to try something new, consider Elfo Pub Perugia, another top spot with a mouthwatering menu.
You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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