12-Day Italy Self-Drive Road Trip With Itinerary from Pescara traveling west to Santa Maria degli Angeli, Florence, Siena, and Rome

On day 2 of your road trip, you will have an entire day to explore Pescara. You’ll stay in Pescara for 1 night and discover all the best things to see and do in the area.

Start your adventure at Church Stella Maris. This often recommended church is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the serene wonders of Nature Reserve Pineta Dannunziana, a must-see nature reserve in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Museo Delle Genti D'abruzzo. This frequently visited museum offers an enriching experience. For a change of pace, head to Ponte Del Mare, where you can take in eye-catching features. Conclude your self-guided sightseeing tour with a visit to Parco Giochi Paperopoli. These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Experience shopping bliss at Pescara as you explore Centro Commerciale Pescara Porta Nuova. Take a leisurely stroll through unique and shops, where local treasures are waiting to be found. Beyond shopping, Centro Commerciale Pescara Porta Nuova offers more options, including restaurants, unique attractions, key services, and vibrant events.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Pescara. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Ciacco, an iconic dining spot in Pescara. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bar Sara, a popular restaurant in Pescara. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Franco, a hidden gem nestled in Pescara. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your evening by exploring the vibrant nightlife scene at Bar Napoli, a prime destination for a thrilling night out. Also, don’t forget to check out Bar Supermarket, a bar that offers unique local touches. Likewise, Post Bar provides an excellent alternative for a fun evening.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Santa Maria degli Angeli. You’ll stay here for 1 night.

Discover a day packed with family-friendly attractions, natural wonders, and breathtaking views in Pescara. Begin your sightseeing with Eremo Delle Carceri. This beloved monastery is one of the top attractions in the town. Proceed to Basilica Of Santa Maria Degli Angeli, another must-visit attraction.

As you wander through the inviting streets of Pescara, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Basilica Of San Francesco D'assisi. This popular church is a traveler-favorite. Not far away, you’ll find Rocca Maggiore, another key site on your sightseeing itinerary. Piazza Del Comune is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Santa Maria degli Angeli's best restaurants.

Continue your lively evening at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a perfect place for winding down or revving up the night, depending on which mood you’re in.

Relax and recharge in preparation for another adventurous day in Italy!

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Start by visiting Piazzale Michelangelo, a prime spot to begin your journey. This history-steeped observation deck is sure to impress. Next on your list is Basilica Of Santa Croce In Florence, another must-visit landmark and notable church renowned for its culturally significant features.

While exploring and sightseeing, take time to savor the culture of Santa Maria degli Angeli by sampling some local delicacies. When you’re ready for more sightseeing, head to Ponte Vecchio. This romantic historical landmark is an essential place to visit for anyone looking for the full Santa Maria degli Angeli experience. We also recommend visiting Uffizi Gallery, an extraordinary art gallery. Nearby, you'll also find Palazzo Vecchio, ready to add charm to your journey. End your self-guided sightseeing tour with a stop at Piazza Della Signoria and wrap up your day with its romantic appeal.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Ristorante Oliviero 1962, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Di Poneta Novoli offers an enticing alternative with its varied menu. Additionally, Caffe San Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

After enjoying a fulfilling meal, continue your evening at Manifattura, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Se·sto On Arno Rooftop Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Il Vinile provides an excellent environment for a relaxed and enjoyable evening.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Day 5 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

At the top of the list of things to do today is to explore Oltrarno, a neighborhood that captures the true essence of Florence. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions.

Get ready for an exciting day in Florence. Today’s sightseeing agenda includes a botanical garden, a church, a food market, an art gallery and much more! Begin your adventure at The Boboli Gardens. This is a well-known botanical garden you should not miss. Another must-see is Basilica Of San Lorenzo, an underrated church in Florence.

When you’re ready for the next sight, head to Central Market. From there, take a leisurely stroll to Galleria Dell'accademia, another of the city’s well-known attractions. We recommend continuing your self-guided tour at Cathedral Of Santa Maria Del Fiore, an enchanting place of interest in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Ditta Artigianale, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Da Burde is another top choice with a popular menu. You could also check for a table at Casa Toscana. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.

After savoring a delicious meal, step into the vibrant nightlife at Bar 50 Rosso, where the evening is just getting started. In the same way, Bitter Bar offers a unique charm perfect for experiencing the local bar scene in Florence. Archea Brewery is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Siena. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Siena. You will spend 2 nights here for some well-deserved relaxation.

Get ready to discover some of the most iconic wonders in Florence, including a monument, a church, a palace, a public square and much more! Start your day at Fortezza Medicea (siena). This historic monument is an often recommended place to see in Florence. Then, wander over to Basilica Of San Domenico. If majestic sites excite you, this church will be right up your alley. Nearby, you’ll also find Siena Cathedral. This history-steeped church is a favorite among visitors.

Florence offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Pubblico Palace is a curiosity-inducing spot in the city that will captivate you with its unique charm. When you’re done at the palace, don’t forget to check out the enchanting Piazza Del Campo. Take a moment to appreciate the fascinating details of this widely recognized public square. Wrap up your self-guided tour of Florence's top attractions with a visit to Tower Of Mangia.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Enoteca I Terzi, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Ristorante Tar-Tufo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Antica Trattoria Papei. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Siena this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Meet Life Cafè stands out as an excellent choice for a post-dinner cocktail. Alternatively, Maudit Pub offers an ideal atmosphere to enjoy the pleasures of the night. Bar Impero Siena is also a great option that provides a perfect setting for a relaxing evening.

Celebrate another amazing day of your road trip adventure in Italy!

Greet day 7 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Siena for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in San Gimignano.

Siena is brimming with adventures. Today’s wonderful stops include a monument, a museum, a public square, a park, a church and much more! Begin your sightseeing adventure at the worthwhile Porta San Giovanni and allow yourself time to explore. Just a short distance away you'll find your next stop, Sangimignano1300, a heritage-rich museum that draws visitors from far and near.

Continue your journey to Palazzo Comunale, Pinacoteca, Torre Grossa, one of the village’s most curiosity-inducing spots that you shouldn’t miss. Another great site to visit is the frequently visited Piazza Del Duomo. When you're finished at the public square, Parco Della Rocca awaits your visit. This park is a romantic highlight on today's itinerary. Last up is a church - the worthwhile Chiesa Di Sant'agostino.

When you’re done exploring for the day, you’ll return to Siena and your accommodation.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Osteria Quattro Venti, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Fischi per Fiaschi offers an enticing alternative with its varied menu. Additionally, Osteria da Divo is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Siena.

Keep the evening going at Charlie Mixology Bar Di Aldinucci Riccardo, a great choice for enjoying the after-dinner hours with a drink. You could also go to Bar Pinacoteca, which offers a similarly pleasant setting and great drinks. Another option is San Paolo Pub, which provides an inviting environment for unwinding after a busy day out.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

At the end of the day, you'll drive back to Rome, where you'll stay for 2 nights more.

Vatican Museums is must-visit art museum and a great starting point for the day. Next, continue your journey to Sistine Chapel, an extraordinary chapel, located just a leisurely stroll away.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Rome. When you're ready, let your sightseeing route take you to the iconic Piazza Navona. If you’re looking for more, Pantheon is also a world-famous attraction that is worthwhile a visit. Lastly, don’t miss Trevi Fountain, a place of detailed interest in the city.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at RomAntica, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Coso Ristorante is another top choice with a popular menu. You could also check for a table at DEROMA - Farine Romane. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

Keep the excitement of the evening going by visiting a bar or two. Sant' Eustachio Caffè is an excellent place to start. You could also check out Yellowsquare Rome, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 10 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Via del Corso is a street that stands out as one of the must-see places in Rome. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away. For another highlight, head to Via dei Condotti, a street offering its own unique experiences.

Start by visiting Castel Sant'angelo, a prime spot to begin your journey. This enchanting castle is sure to impress. Next on your list is Piazza Di Spagna, another must-visit landmark and iconic public square renowned for its culturally significant features.

While exploring and sightseeing, take time to savor the culture of Rome by sampling some local delicacies. When you’re ready for more sightseeing, head to Spanish Steps. This romantic public square is an essential place to visit for anyone looking for the full Rome experience. We also recommend visiting Villa Borghese, a spectacular park.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Have a fantastic dining experience at Hotel de Russie, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Taverna Italiana offers an enticing alternative with its varied menu. Additionally, The Parrot Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

After your delicious meal, get a taste of the vibrant nightlife with a visit to The Apartment Bar Roma, known for its inviting atmosphere. Hotel Hassler Roma is another great option if you’re looking for a place to get the night started.

Celebrate another amazing day of your road trip adventure in Italy!

On day 11 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Orvieto. When you’re not sightseeing, take time to relax at your selected hotel in Pescara, where you’ll be staying for 1 night.

Immerse yourself in Rome’s rich culture with today's sightseeing itinerary. Start your journey at Well Of St. Patrick. This instagrammable monument is sure to ignite your curiosity. Next, dive into the majestic features of Orvieto Cathedral, a must-visit church in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Museo Dell'opera Del Duomo, a locally appreciated museum. For a change of scene, check out Orvieto Underground, known for its respected features. We also recommend visiting Torre Del Moro Orvieto. This monument is a must for anyone looking to experience the village to the fullest. Lastly, end your day with a visit to Pozzo Della Cava, yet another worthwhile attraction in Rome.

At the end of the day, you will drive to Pescara, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Pescara. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at MuuLab. Cucina e Distillati, an excellent option for tonight's dining. Looking for something different? La Taverna Antica offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante La griglia dell'Orso. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pescara.

After your meal, keep the night alive at a bar like Enoteca Visaggio Cocktails And Wine, known for its lively atmosphere. Giro' Loungebar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Caffè Ideale offers an excellent atmosphere for those looking to amp up the evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!