12-Day Italy Self-Drive Road Trip With Itinerary from Pescara traveling west to Santa Maria degli Angeli, Florence, Siena, and Rome
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Description
Escape the ordinary with this exciting 12-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Pescara, 1 night in Santa Maria degli Angeli, 2 nights in Florence, 2 nights in Siena, and 3 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Pescara, Santa Maria degli Angeli, Florence, Siena, San Gimignano, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
Itinerary summary
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Day 1
- Pescara - Arrival day
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- Parco Giochi Paperopoli
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Your road trip adventure in Italy begins as soon as you reach Pescara and pick up your car. You’ll stay in Pescara for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.
Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Parco Giochi Paperopoli, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Pescara. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.
Dine in style at Taverna 58, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Carlo Ferraioli boasts a menu that's sure to impress. Also, be sure to check out Sesamo Nero. Known as a local hotspot, it’s a great choice for tonight in Pescara.
After enjoying a fulfilling meal, continue your evening at Posa Caffè Pescara, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Bar Mixer offers a welcoming atmosphere for easing into the nightlife. Similarly, Temple Bar Irish Pub provides an excellent environment for a relaxed and enjoyable evening.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Pescara
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Drive 3 km, 28 min
- Museo delle Genti d'Abruzzo
- Gabriele D'Annunzio's Birthplace Museum
- Pescara Cathedral
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Day 2 of your road trip across Italy promises a magnificent time exploring Pescara. You have 1 night left in Pescara. Take the opportunity to experience more of the best attractions and activities in the city.
Pescara is home to plenty of attractions that offer fun adventures, photo-friendly spots, and historic treasures! Start at Museo Delle Genti D'abruzzo, a worthwhile museum that is worthwhile a visit in the city. Nearby, you’ll find Gabriele D'annunzio's Birthplace Museum, enchanting visitors with its visually striking appeal. Continue your exploration at Pescara Cathedral. This church is one of the city’s most locally appreciated spots.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As dinnertime approaches, it's time to head out for a bite to eat in Pescara. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Don’t miss out on dining at Ciacco, a top-rated dining destination in Pescara. If you're in the mood to try something new, consider Bar Sara, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Franco. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pescara this evening.
If you’re not ready to end the night just yet, Bar Napoli offers a perfect venue to relax and savor a drink. Similarly, Bar Supermarket is well-suited for those looking to unwind in a social setting. Post Bar is another excellent spot to enjoy a nightcap after a delightful meal.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 3
- Pescara
- Assisi
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Drive 235 km, 3 hours 24 min
- Basilica of Santa Maria degli Angeli
- Basilica di Santa Chiara
- Basilica of San Francesco d'Assisi
- Piazza del Comune
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Embark on another extraordinary experience on day 3 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Santa Maria degli Angeli. At the end of the day, you will enjoy the comforts of a top-rated hotel in Santa Maria degli Angeli, which will be your home away from home for 1 night.
Pescara is home to plenty of attractions that offer family-friendly attractions, breathtaking views, and picturesque spots! Start at Basilica Of Santa Maria Degli Angeli, a popular church that is worthwhile a visit in the village. Nearby, you’ll find Basilica Di Santa Chiara, enchanting visitors with its historic appeal. Continue your exploration at Basilica Of San Francesco D'assisi. This church is one of the village’s most popular spots.
Enjoy the freedom of exploring Pescara at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Piazza Del Comune.
At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Santa Maria degli Angeli. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Continue the enjoyment post-dinner at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a cherished local gathering spot renowned for its welcoming atmosphere.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 4
- Assisi
- Florence
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Drive 174 km, 2 hours 30 min
- piazzale Michelangelo
- Ponte Vecchio
- Uffizi Gallery
- piazza della Signoria
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On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Florence, where you will stay for 2 nights.
Get ready for a day filled with fun adventures, romantic experiences, and scenic views in the charming city of Santa Maria degli Angeli. Your adventure starts at Piazzale Michelangelo, an astonishing local hot spot. Another notable attraction to explore is Ponte Vecchio. This globally renowned historical landmark is known for its history-steeped appeal.
After soaking in the highlights of these sights, take some time to wander Santa Maria degli Angeli's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Uffizi Gallery. This romantic art gallery offers a fascinating experience that many visitors find memorable. Piazza Della Signoria is also worth visiting.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.
Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
To truly maximize your evening out, consider visiting Manifattura after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Se·sto On Arno Rooftop Bar, another bar with an inviting ambiance. Similarly, Il Vinile also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Say good night to Florence and look forward to another great day of your road trip in Italy!
Day 5
- Florence
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Drive 3 km, 48 min
- Basilica of Santa Croce in Florence
- Cathedral of Santa Maria del Fiore
- Galleria dell'Accademia
- Central Market
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On day 5 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.
A blend of family-friendly attractions, photo-friendly spots, and historic treasures await you in Florence on today’s itinerary. First up is the captivating church, Basilica Of Santa Croce In Florence. Afterward, continue to Cathedral Of Santa Maria Del Fiore.
As you explore Florence’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Galleria Dell'accademia. This popular art gallery is an essential stop that should not be missed. Following that, head to Central Market, another must-visit site that will enhance your experience.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a lovely dining experience at Ditta Artigianale, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Trattoria Da Burde, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Casa Toscana. It’s yet another ideal choice to enhance your time in Florence tonight.
Continue your lively evening at Bar 50 Rosso, a perfect place for winding down or revving up the night, depending on which mood you’re in. Bitter Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Archea Brewery ensures a night out tailored to your taste.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 6
- Florence
- Siena
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Drive 77 km, 1 hour 41 min
- Fortezza Medicea
- Basilica of San Domenico
- Siena Cathedral
- piazza del Campo
- Tower of Mangia
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On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Siena. When you’re not sightseeing, take time to relax at your selected hotel in Siena, where you’ll be staying for 2 nights.
Enjoy the perfect balance of relaxation and exploration in Florence today. One of the most curiosity-inducing attractions included on the itinerary is Fortezza Medicea (siena). This culturally significant monument will help you start your sightseeing on top. Then, take a leisurely stroll to Basilica Of San Domenico and learn what makes this stunning church unique.
Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the locally renowned Siena Cathedral. After exploring the church, head to Piazza Del Campo. This spectacular public square is a highlight in Florence. Lastly, don’t forget to check out the underrated Tower Of Mangia. Enjoy exploring this incredible monument at your own pace.
When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.
As dinnertime approaches, it's time to head out for a bite to eat in Siena. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Dine in style at Enoteca I Terzi, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Tar-Tufo boasts a menu that's sure to impress. Also, be sure to check out Antica Trattoria Papei. Known as a local hotspot, it’s a great choice for tonight in Siena.
Following your dinner, dive into the local bar culture at Meet Life Cafè. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Maudit Pub, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Impero Siena provides excellent drinks and a great atmosphere, ensuring a memorable night out.
Celebrate another amazing day of your road trip adventure in Italy!
Day 7
- Siena
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Drive 82 km, 1 hour 40 min
- Porta San Giovanni
- Galleria Continua
- Piazza del Duomo, San Gimignano
- Parco della Rocca
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Wake up to day 7 of your extraordinary road trip in Italy. With 1 night left in Siena, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
Today’s agenda in Siena includes a monument, an art gallery, a public square, a park and much more! Porta San Giovanni is must-visit monument and a great starting point for the day. Next, continue your journey to Galleria Continua, an up-and-coming art gallery, located just a leisurely stroll away. Next, head to Piazza Del Duomo, an instagrammable public square, also available for your discovery today.
Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Siena. If you’re looking for more, Parco Della Rocca is also a curiosity-inducing attraction that is worthwhile a visit.
When you’re done exploring for the day, you’ll return to Siena and your accommodation.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Don’t miss out on dining at Osteria Quattro Venti, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Fischi per Fiaschi, another top spot with a mouthwatering menu. You might also want to secure a reservation at Osteria da Divo. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Siena this evening.
After enjoying a fulfilling meal, continue your evening at Charlie Mixology Bar Di Aldinucci Riccardo, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Bar Pinacoteca offers a welcoming atmosphere for easing into the nightlife. Similarly, San Paolo Pub provides an excellent environment for a relaxed and enjoyable evening.
Head back to your accommodation in Siena and get some rest in preparation for another magical day of your road trip in Italy!
Day 8
- Siena
- Rome
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Drive 242 km, 3 hours 31 min
- Colosseum
- Roman Forum
- Pantheon
- Piazza Navona
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Dive into day 8 of your remarkable road trip in Italy. Today you will explore Rome, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 3 nights.
Today, you'll explore some of the most beautiful places in Siena, including an archeological site, a monument, and a public square. Start your day with a visit to Colosseum. This globally renowned archeological site is a must-visit in the city. When you’re ready for your next discovery, continue to Roman Forum, which may be one of the most breathtaking places you will experience today.
One of the best things about exploring Siena on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Pantheon, an iconic monument in the city. If you’re up for more discoveries, don’t forget to reserve some time for Piazza Navona.
At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.
Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.
Raise your glass to another unforgettable day in Italy!
Day 9
- Rome
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Drive 7 km, 48 min
- piazza del Popolo
- Piazza di Spagna
- Trevi Fountain
- Via del Corso
- Via dei Condotti
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Day 9 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in Rome by discovering the best things there are to see and do in the city.
A top thing to do today is to explore Via del Corso, a must-see street in Rome. It's the perfect starting point for exploring the top attractions in the area.
Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Rome allows for both. Start by heading to Piazza Del Popolo. This impressive public square provides an insightful glimpse into the city's identity. Next, discover Piazza Di Spagna, a visually striking public square, promising a delightful encounter.
Continue your sightseeing with a visit to Trevi Fountain, a timeless monument.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
To truly maximize your evening out, consider visiting Sant' Eustachio Caffè after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Yellowsquare Rome, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Savor another day of unforgettable experiences in Italy!
Day 10
- Rome
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Drive 9 km, 41 min
- Vatican Museums
- Sistine Chapel
- St Peter's Basilica
- Trastevere
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At the end of the day, you'll drive back to Rome, where you'll stay for 1 night more.
Trastevere is a neighborhood that stands out as one of the must-see places in Vatican City. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.
Start by visiting Vatican Museums, a prime spot to begin your journey.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Treat yourself to a delicious dinner at Hotel de Russie, an excellent option for tonight's dining. Looking for something different? La Taverna Italiana offers a tantalizing alternative with its diverse menu. And don’t miss The Parrot Bar. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.
Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 11
- Rome
- Pescara
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Drive 425 km, 5 hours 2 min
- Well of St Patrick
- Orvieto Cathedral
- Torre del Moro Orvieto
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Experience an unparalleled adventure on day 11 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Orvieto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pescara. You will spend 1 night here for some well-deserved relaxation.
Today’s well-planned self-sightseeing route offers several fun adventures, breathtaking views, and photo-friendly spots. Whether you decide to explore Rome on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Well Of St. Patrick is the first of them. Spend some time admiring this breathtaking monument before continuing your journey. Orvieto Cathedral is your next stop. This notable church is one of the best-rated sights in Rome.
Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Torre Del Moro Orvieto. This culturally significant monument is a sight to behold.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Pescara. Pescara offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
After a day of adventure, treat yourself to an exquisite dinner at one of Pescara's best restaurants.
Savor the flavors at MuuLab. Cucina e Distillati, a top pick for dinner tonight. Alternatively, La Taverna Antica beckons with its unique menu offerings. Also, consider Ristorante La griglia dell'Orso. With its consistent customer satisfaction, it’s an excellent option for dining in Pescara tonight.
Explore the vibrant nightlife at Enoteca Visaggio Cocktails And Wine after your meal, a hub for lively evenings and memorable moments. Or, head to Giro' Loungebar for a great selection of flavorful drinks and a charming setting. Furthermore, Caffè Ideale is perfect for those looking to extend their night with a touch of local flavor.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 12
- Pescara - Departure day
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- Ponte del Mare
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, begin at Ponte Del Mare. This increasingly popular boardwalk is a popular place to see in the city.
Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.
If you're eager to try something different, consider Somari, another top spot with a tantalizing menu.
You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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