4-Day Sicily Road Trip from Palermo traveling south to Syracuse

Welcome to Palermo, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Palermo's charm before embarking on the next leg of your journey.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Quattro Canti or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Palermo. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Palermo. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Celebrated as a restaurant, it boasts an exceptional menu. This establishment consistently wows guests, making it a memorable stop during your holiday. Nestled in the city's heart, is a perfect choice for discerning cuisine enthusiasts seeking a new experience. Enjoy a sumptuous meal at Eremiti Restaurant, a highly-rated dining destination in Palermo. If you're eager to try something different, consider Osteria Mercede, another top spot with a tantalizing menu. You might also want to secure a reservation at Trattoria Del Massimo. With a reputation for consistently satisfied customers, it’s an excellent choice to enhance your stay in Palermo this evening.

Unwind after your meal by stepping into Malox Cult. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Ai Giudici offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Italico, another top-rated bar in the area.

Raise a toast to the start of your 4-day road trip in Sicily!

On day 2 of your road trip in Sicily, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Palermo. In the evening, you’ll end up in Syracuse, where you will stay for 1 night.

Embrace the thrill of the open road as you wave goodbye to Palermo and set your GPS to Syracuse. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 57 min. Upon reaching Syracuse, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

An excellent attraction to start your day with is Catacombe dei Cappuccini. This museum is rated an average of 4.3 out of 5 stars in 10,859 reviews.

Continue your journey at Norman Palace. This museum is rated 4.5 out of 5 stars by 19,949 travelers from near and far.

Palermo is also the home of Palermo Cathedral. This cathedral has an average rating of 4.7 out of 5 stars from 35,799 visitors.

You can continue your self-guided sightseeing tour at Foro Italico. Rated 4.3 out of 5 stars by 9,558 visitors, a visit to this top sight is time well spent.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Syracuse. Syracuse offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

As you explore more of Syracuse, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

This -awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. This awardee is a highly recommended choice for an unforgettable meal. Make sure to reserve a table at A Putia, an iconic dining spot in Syracuse. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Dock Café Restaurant, a popular restaurant in Syracuse. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Olivia Natural Bistrot | Pizzeria, Ristorante vegetariano - vegano, a hidden gem nestled in Syracuse. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Explore the vibrant nightlife at Barcollo after your meal, a hub for lively evenings and memorable moments. Or, head to Bar Pasticceria Midolo for a great selection of flavorful drinks and a charming setting. Furthermore, BOATS is perfect for those looking to extend their night with a touch of local flavor.

Relax and reminisce about your day in Sicily and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 3 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Syracuse and Agrigento. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Palermo. You will spend 1 night here for some well-deserved relaxation.

Fasten your seatbelt and make your way to your next stop. Agrigento, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Syracuse to Agrigento may take around 2 hours 27 min without traffic disruptions. Upon arrival in Agrigento, we highly recommend checking out some of the top attractions.

A top pick for your self-guided sightseeing tour today is Temple of Apollo. Previous visitors have rated this ancient greek temple an average of 4.4 out of 5 stars in 16,056 reviews.

Ear of Dionysius is a local recommendation that you also can pay a visit today. This cave is rated an average of 4.5 out of 5 stars in 8,144 reviews.

Another attraction you won't want to miss is Neapolis Archaeological Park. This park is rated an average of 4.3 out of 5 stars in 18,306 reviews.

Fasten your seatbelt and make your way to your next stop. Agrigento, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Syracuse to Agrigento may take around 2 hours 27 min without traffic disruptions. Upon arrival in Agrigento, we highly recommend checking out some of the top attractions.

Make Valle dei Templi one of your first sightseeing stops in Agrigento. Rated an average of 4.7 out of 5 stars by 45,296 travelers, a visit to this local attraction makes for a great introduction to the area. This archaeological site attracts 445,925 visitors every year.

When you’re done exploring for the day, you’ll drive to Palermo, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

Indulge in a memorable dining experience at one of Palermo's most popular restaurants, and connect with friendly locals for an authentic adventure.

This popular -awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Have a fantastic dining experience at Grand Hotel Piazza Borsa, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Ai Cascinari offers an enticing alternative with its varied menu. Additionally, Locale is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Palermo.

Unwind after your meal by stepping into SPINA BAR PALERMO. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Monkey pub offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Touring, another top-rated bar in the area.

Head back to your accommodation in Palermo and get some rest in preparation for another magical day of your road trip in Sicily!

Day 4 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

On your last day in Sicily, take time to indulge in shopping at Palermo’s popular marketplace. Thanks to your accommodation’s strategic location, the city’s bustling commercial district is only a stone’s throw away, giving you ample time to leisurely explore the area, filled with local shops.

Take time to find the perfect present, reminding you of the charms of Sicily. Each store here is brimming with unique finds. These souvenirs will help you treasure your memories of Sicily forever.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

Celebrated as a restaurant, it boasts an exceptional menu. This establishment consistently wows guests, making it a memorable stop during your holiday. Nestled in the city's heart, is a perfect choice for discerning cuisine enthusiasts seeking a new experience. If you're eager to try something different, consider Sikulo, another top spot with a tantalizing menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!