5-Day Sicily Road Trip from Palermo to Agrigento

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Explore the best of Sicily on a 5-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Palermo, Agrigento, Xitta, San Vito Lo Capo, and Castellammare del Golfo. This road trip itinerary in Sicily seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Sicily takes you through some of the best places to see in the country. You will spend 3 nights in Palermo, and 1 night in Agrigento. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Palermo Cathedral and Quattro Canti are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Palermo, Agrigento, Xitta, San Vito Lo Capo, and Castellammare del Golfo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Day 1

Day 1 – Palermo - arrival day

  • Palermo - Arrival day
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  • Foro Italico
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Your road trip adventure in Sicily begins as soon as you reach Palermo and pick up your car. You’ll stay in Palermo for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Palermo. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Palermo. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Eremiti Restaurant, a top-rated dining destination in Palermo. If you're in the mood to try something new, consider Osteria Mercede, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Del Massimo. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Palermo this evening.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Malox Cult, known for its inviting atmosphere. Ai Giudici is another great option if you’re looking for a place to get the night started. Similarly, Bar Italico provides a great setting to enjoy the night away.

Raise a toast to the start of your 5-day road trip in Sicily!

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Day 2

Day 2 – Palermo

  • Palermo
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Drive 50 km, 2 hours 10 min

  • Fontana Pretoria
  • Quattro Canti
  • Church of St. Mary of the Admiral
  • Santuario di Santa Rosalia, Palermo
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Day 2 of your road trip across Sicily promises a magnificent time exploring Palermo. You have 1 night left in Palermo. Take the opportunity to experience more of the best attractions and activities in the city.

Make Fontana Pretoria your first stop of the day. Previous visitors have rated this fountain an average of 4.7 out of 5 stars in 6,001 reviews.

Next up, make a stop at Quattro Canti. With an average rating of 4.6 out of 5 stars by 21,970 visitors, it's easy to understand why so many people visit this square every year.

Martorana is another attraction you can visit on this day of your vacation. This church building has an average rating of 4.7 out of 5 stars by 4,036 visitors.

When you’re finished at Martorana, the perfect next stop is Riserva Naturale Di Capo Gallo. This park is rated an average of 4.6 out of 5 stars in 4,204 reviews.

If you’re keen to explore even more, then consider a visit to Santuario Di Santa Rosalia, Palermo. This shrine is a top place to visit, with a rating of 4.7 out of 5 stars from 5,720 reviews.

To do something one-of-a-kind on this day of your trip, you can join a tour. You can discover all of the most fun and eye-opening experiences in your destination below and secure your spot here.

As you explore more of Palermo, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Set out on a gastronomic journey in Palermo by reserving a table at Buatta Cucina Popolana. Renowned for its Bib Gourmand award, this restaurant presents an outstanding menu of sicilian cuisine. For a different taste, head over to Mec Restaurant, renowned for its delectable sicilian, and contemporary dishes. This distinguished 1-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Gagini Restaurant, a highly rated local gem known for its exquisite creative, and contemporary menu. With a 1-star Michelin acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Palermo.

After enjoying a fulfilling meal, continue your evening at Spina Bar Palermo, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Monkey Pub offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Touring provides an excellent environment for a relaxed and enjoyable evening.

Get a good night's sleep and look forward to another great day on the road in Sicily!

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Day 3

Day 3 – Palermo, and Agrigento

  • Agrigento
  • Palermo
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Drive 137 km, 2 hours 31 min

  • Norman Palace
  • Palermo Cathedral
  • Orto botanico di Palermo
  • Catacombe dei Cappuccini
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Dive into day 3 of your remarkable road trip in Sicily. Today you will explore Palermo, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Agrigento. You’ll stay here for 1 night.

An excellent attraction to start your day with is Norman Palace. This museum is rated an average of 4.5 out of 5 stars in 19,949 reviews.

Continue your journey at Palermo Cathedral. This cathedral is rated 4.7 out of 5 stars by 35,799 travelers from near and far.

Palermo is also the home of Orto Botanico Di Palermo. This botanical garden has an average rating of 4.4 out of 5 stars from 6,568 visitors.

You can continue your self-guided sightseeing tour at Catacombe Dei Cappuccini. Rated 4.3 out of 5 stars by 10,859 visitors, a visit to this top sight is time well spent.

At the end of the day, you will drive to Agrigento, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Agrigento. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a memorable dining experience in Agrigento by booking a table at Osteria Expanificio, renowned as a Bib Gourmand restaurant presenting an exceptional sicilian, and traditional menu. Immerse yourself in the culinary delights of Le Cuspidi, a popular restaurant in Agrigento. With a menu designed to delight, it ensures a dining experience that transcends the ordinary.

Savor another day of unforgettable experiences in Sicily!

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Day 4

Day 4 – Agrigento, Xitta, San Vito Lo Capo, Castellammare del Golfo, and Palermo

  • Palermo
  • Xitta
  • San Vito Lo Capo
  • Castellammare del Golfo
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Drive 312 km, 4 hours 40 min

  • Riserva Naturale Orientata dello Zingaro
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Experience an unparalleled adventure on day 4 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Xitta, San Vito Lo Capo, and Castellammare del Golfo. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Palermo. You will spend 1 night here for some well-deserved relaxation.

Embrace the thrill of the open road as you wave goodbye to Agrigento and set your GPS to Xitta. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 8 min. Upon reaching Xitta, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

A top pick for your self-guided sightseeing tour today is Saline Di Trapani E Paceco. Previous visitors have rated this park an average of 4.4 out of 5 stars in 3,325 reviews.

Continue your road trip and head to your next destination, San Vito Lo Capo. This car ride takes around 47 min.

Begin your sightseeing with a visit to Riserva Naturale Orientata Dello Zingaro, Ingresso Sud. This park is rated an average of 4.7 out of 5 stars in 6,019 reviews.

When you’re done exploring for the day, you’ll drive to Palermo, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Palermo, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely meal at CUMA Natural Bar & Fresh Market, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Sikulo is another top choice with a popular menu. You could also check for a table at Vespa Café. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Palermo tonight.

Extend your evening after a delightful meal by visiting Palermo Football Store, which offers the perfect atmosphere for a night out. Moreover, Goccio - L’arte Del Miscelare is another popular option for a drink or two. Likewise, Pasticceria Massaro also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Sicily.

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Day 5

Day 5 – Palermo - departure day

  • Palermo - Departure day
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  • Garden Zisa
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Day 5 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Sicily unfolds, enjoy a last-minute shopping spree in Palermo's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Sicily.

Begin your sightseeing with a visit to Giardino Della Zisa. This park is rated an average of 4.1 out of 5 stars in 1,272 reviews.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

If you're in the mood to try something new, consider Ristorante Pizzeria Italia, another top spot with a mouthwatering menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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