6-Day Italy Self-Drive Road Trip With Itinerary from Ancona traveling south to L'aquila, Rome, and Siena

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 3 destinations, Ancona, San Vittore, and Loreto. When you’re not sightseeing, take time to relax at your selected hotel in L'aquila, where you’ll be staying for 1 night.

Today’s route brings fun adventures, romantic experiences, and natural wonders. The first attraction of today is Parco Belvedere Posatora. This frequently visited park is a serene place to see in Ancona.

As you’ve unraveled the marvels of Ancona, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to San Vittore may take around 42 min. Upon your arrival in San Vittore, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Spend your afternoon discovering Frasassi Caves, an interesting cave system known for its instagrammable features.

When you’re ready to jump back into the car and say goodbye to San Vittore, you’ll hit the road in the direction of Loreto. This drive usually takes around 1 hour 1 min. When you arrive, enjoy some sightseeing.

Sanctuary Of The Holy House Of Loreto is a locally renowned church we recommend making time to visit today. Discover its historic features before continuing your self-guided tour.

At the end of the day, you will drive to L'aquila, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in L'aquila. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to an extraordinary dining experience at FØRMA contemporary restaurant, a Bib Gourmand restaurant offering an incredible contemporary and creative menu. Alternatively, if your taste buds call for something different, DECA is another top choice with a popular menu.

After enjoying a fulfilling meal, continue your evening at Art Cafè L'aquila, ideal for those looking to unwind with a drink in a comfortable setting.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 1 night.

Enjoy the perfect balance of relaxation and exploration in Vatican City today.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Set your GPS to Vatican City, Vatican City and hit the road. Expect a journey of approximately 1 hour 38 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Vatican City beckons with new experiences!

One of our top recommendations for your sightseeing is Vatican Museums. Then, head to Saint Peter's Square. This notable square is a traveler-favorite in the city. Not far away, you’ll also find Sistine Chapel. Feed your curiosity by learning something new about the chapel. Next, continue your journey to St. Peter's Basilica, a wondrous major basilica.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Siena. You will spend 1 night here for some well-deserved relaxation.

Set out on a day brimming with family-friendly attractions, breathtaking views, and picturesque spots. Start at the world-famous Roman Forum, an awe-inspiring archeological site in Rome. Next, go to Colosseum.

After visiting Roman Forum and Colosseum, take time to explore Rome's streets and absorb its charm. Continue your sightseeing by heading to Piazza Navona. This enchanting public square offers a unique experience. Pantheon is another noteworthy stop. End your self-guided sightseeing tour on top with a visit to Trevi Fountain, one of the most visually striking places to visit in Rome.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Siena, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Enoteca I Terzi, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Ristorante Tar-Tufo offers an enticing alternative with its varied menu. Additionally, Antica Trattoria Papei is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Siena.

After savoring a delicious meal, step into the vibrant nightlife at Meet Life Cafè, where the evening is just getting started. In the same way, Maudit Pub offers a unique charm perfect for experiencing the local bar scene in Siena. Bar Impero Siena is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Savor another day of unforgettable experiences in Italy!

On day 5 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Siena and Santa Maria degli Angeli. In the evening, you’ll end up in Ancona, where you will stay for 1 night.

Savor the day by visiting some of the best places to see in Siena, including a public square, a church, and a monument. Start your adventure at Piazza Del Campo. This widely recognized public square is a must-visit for travelers looking for a unique holiday experience. Make your way to Siena Cathedral located in Siena for an enchanting atmosphere.

Next, immerse yourself in the setting of Fortezza Medicea (siena). Its breathtaking features will captivate you.

Set your GPS to Santa Maria degli Angeli and hit the road. Expect a journey of approximately 1 hour 41 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Santa Maria degli Angeli beckons with new experiences!

One of our top recommendations for your sightseeing is Basilica Of San Francesco D'assisi. Spend some time admiring the UNESCO world heritage-listed features of the church before you continue to your next stop.

At the end of the day, you will drive to Ancona, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Ancona's most popular restaurants, and connect with friendly locals for an authentic adventure.

Set out on a gastronomic journey in Ancona by reserving a table at Sot'Ajarchi. Renowned for its Bib Gourmand award, this restaurant presents an outstanding menu of seafood and from the marches cuisine. Looking for something different? Bontà delle Marche offers a tantalizing alternative with its diverse menu. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Ancona.

To truly maximize your evening out, consider visiting Alla Tazza D'oro after dinner. This bar is known for offering some of the best drinks and vibes in the city.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.