6-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Agrigento and surrounding area

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Photo of Palermo, Sicily, Italy. Seafront view.
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Experience the freedom of the open road on an unforgettable 6-day road trip in Sicily! Embark on a self-drive tour that caters to every traveler, featuring destinations like Palermo, Nubia, Xitta, Erice, Agrigento, and Castellammare del Golfo.

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 4 nights in Palermo and 1 night in Agrigento. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Palermo Cathedral and Quattro Canti are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Palermo, Nubia, Xitta, Erice, Agrigento, and Castellammare del Golfo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Palermo - Arrival day
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  • Foro Italico
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Your road trip adventure in Sicily begins as soon as you reach Palermo and pick up your car. You’ll stay here for 3 nights and explore what to see in Palermo, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Palermo. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Cotto e Bollito, a top-rated dining destination in Palermo. If you're in the mood to try something new, consider Bebop, another top spot with a mouthwatering menu. You might also want to secure a reservation at Eremiti Restaurant. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Palermo this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Malox Cult stands out as an excellent choice for a post-dinner cocktail. Alternatively, Ai Giudici offers an ideal atmosphere to enjoy the pleasures of the night. Bar Italico is also a great option that provides a perfect setting for a relaxing evening.

Raise a toast to the start of your 6-day road trip in Sicily!

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Day2

Day 2

  • Palermo
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Drive 33 km, 1 hour 22 min

  • Catacombe dei Cappuccini
  • Norman Palace
  • Palermo Cathedral
  • Santuario di Santa Rosalia, Palermo
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Day 2 of your road trip across Sicily promises a magnificent time exploring what to see in Palermo. You have 2 nights left in Palermo. Take the opportunity to experience more of the best attractions and activities in the city.

Your adventure in Palermo is only getting started when you visit Catacombe Dei Cappuccini, a popular local hot spot. Another notable attraction to explore is Norman Palace. This captivating palace is known for its heritage-rich appeal.

After soaking in the highlights of these sights, take some time to wander Palermo's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Palermo Cathedral. This majestic church offers a fascinating experience that many visitors find memorable. Santuario Di Santa Rosalia, Palermo is also worth visiting.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Sicily. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Prepare for an extraordinary culinary adventure in Palermo by booking a table at Buatta Cucina Popolana, a Bib Gourmand restaurant that boasts an exceptional sicilian menu. For a different flavor experience, head to Mec Restaurant, renowned for its delectable sicilian and contemporary dishes. This 1-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Gagini Restaurant, a local gem known for its delightful creative and contemporary cuisine in Palermo. Nestled in the city's heart, this 1-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.

To truly maximize your evening out, consider visiting Spina Bar Palermo after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Torrefazione Castagnetta Massimiliano (gelateria), another bar with an inviting ambiance. Similarly, Monkey Pub also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Head back to your accommodation in Palermo and get some rest to prepare for another magical day of your road trip in Sicily.

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Day3

Day 3

  • Palermo
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Drive 41 km, 1 hour 42 min

  • Orto botanico di Palermo
  • Church of St. Mary of the Admiral
  • Fontana Pretoria
  • Quattro Canti
  • Riserva Naturale di Capo Gallo
  • More

On day 3 of your road trip, you will have an entire day to discover what to see in Palermo. You’ll stay in Palermo for 1 night.

Orto Botanico Di Palermo leaves a lasting impression. This botanical garden is one of the most intriguing places to visit in Palermo. Next, head to Martorana, a curiosity-inducing church, known for its breathtaking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Fontana Pretoria. This visually striking monument is a highly recommended experience. Nearby, you'll also find Quattro Canti and Riserva Naturale Di Capo Gallo Visit these for an interesting touch to your journey.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Sicily. You can explore and select activities under each day of your itinerary.

Palermo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Palermo.

Enjoy a lovely meal at Splendid Hotel la Torre, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorantino Sobremesa is another top choice with a popular menu. You could also check for a table at Ristorante Quattro mani. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Palermo tonight.

Unwind after your meal by stepping into Bar Touring. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Palermo Football Store offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Goccio - L’arte Del Miscelare, another top-rated bar in the area.

Relax and recharge in preparation for another adventurous day in Sicily!

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Day4

Day 4

  • Palermo
  • Nubia
  • Xitta
  • Erice
  • Agrigento
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Drive 316 km, 4 hours 31 min

  • Salt Museum
  • Saline di Trapani e Paceco
  • Castello di Venere
  • More

Experience an unparalleled adventure on day 4 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 3 places, which are Nubia, Xitta, and Erice. At the end of the day, you will retreat to the hotel of your choice in Agrigento, where will spend 1 night.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Continue your road trip and head to your next destination, Nubia. This car ride takes around 1 hour 22 min.

Spend your afternoon discovering Salt Museum, a locally appreciated museum known for its breathtaking features.

Embrace the thrill of the open road as you wave goodbye to Nubia and set your GPS to Xitta. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 10 min. Upon reaching Xitta, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Set out on a self-guided sightseeing tour at Saline Di Trapani E Paceco and explore the serene features.

Erice’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Xitta behind. This drive usually takes around 31 min. Erice welcomes you with a multitude of unique vacation experiences.

One of our top recommendations for your sightseeing is Castello Di Venere. Spend some time admiring the culturally significant features of the castle before you continue to your next stop.

When you’re done exploring for the day, you’ll drive to your hotel in Agrigento. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Agrigento's best restaurants.

Enjoy a delicious meal at Ambasciata di Sicilia, a highly-rated dining destination in Agrigento. If you're eager to try something different, consider Le Cuspidi, another top spot with a tantalizing menu. You might also want to secure a reservation at Yellove RistoVintage. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Agrigento this evening.

Raise your glass to another unforgettable day in Sicily!

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Day5

Day 5

  • Agrigento
  • Castellammare del Golfo
  • Palermo
  • More

Drive 252 km, 4 hours 17 min

  • Riserva Naturale Orientata dello Zingaro
  • Cala Mazzo di Sciacca
  • Belvedere Castellammare del Golfo
  • Marina di Castellammare del Golfo
  • More

On day 5 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 2 destinations, including San Vito Lo Capo and Castellammare del Golfo. When you’re not sightseeing, take time to relax at your chosen hotel in Palermo, where you’ll be staying for 1 night.

Embrace the thrill of the open road as you wave goodbye to Agrigento and set your GPS to San Vito Lo Capo. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 7 min. Upon reaching San Vito Lo Capo, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

When you're ready for some sights, head to Riserva Naturale Orientata Dello Zingaro, Ingresso Sud, an increasingly popular nature reserve in San Vito Lo Capo. Explore its eye-catching features at your own pace before you continue your journey.

Fasten your seatbelt and make your way to your next stop — Palermo, home to many well-known sights in the region. Keep in mind that your travel time from Castellammare del Golfo to Palermo may take around 58 min without traffic disruptions. Upon arrival in Palermo, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Cala Mazzo Di Sciacca, a locally appreciated beach known for its romantic features.

When you’ve had your share of Castellammare del Golfo, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Palermo. Your travel time is around 58 min.

When you're ready for some sights, head to Belvedere Castellammare Del Golfo, an up-and-coming observation deck in Castellammare del Golfo. Explore its enchanting features at your own pace before you continue your journey to your next attraction, Marina Di Castellammare Del Golfo. This intriguing marina is a top recommendation in the area.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Palermo. Palermo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Palermo's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Trattoria Ai Cascinari, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Villa Boscogrande - Chef Natale Di Maria offers an enticing alternative with its varied menu. Additionally, MadoniEAT is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Palermo.

Extend your evening after a delightful meal by visiting Pasticceria Massaro, which offers the perfect atmosphere for a night out. Moreover, Bar Sanremo - Palermo is another popular option for a drink or two. Likewise, Bar Touring also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Celebrate another amazing day of your road trip adventure in Sicily!

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Day6

Day 6

  • Palermo - Departure day
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  • Garden Zisa
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Day 6 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Giardino Della Zisa. This beloved park is a hotspot among locals.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

Treat yourself to a delicious dinner at Ristorante Ferro, an excellent option for tonight's dining. Looking for something different? RISTORANTE PRIMI PIATTI offers a tantalizing alternative with its diverse menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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