6-Day Italy Self-Drive Road Trip With Itinerary from Pescara to Rome and Florence

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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Pescara, Rome, Florence, and Siena. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pescara, 2 nights in Rome, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Vatican Museums.

As you hit the open road and drive through Pescara, Rome, Florence, and Siena, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ponte del Mare
ColosseumRoman ForumPantheonPiazza Navona
Vatican MuseumsSistine ChapelTrevi FountainPiazza di SpagnaSpanish StepsVilla Borghese
Basilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioPiazza della RepubblicaCathedral of Santa Maria del Fiorepiazza della Signoria
Fortezza MediceaBasilica of San DomenicoSiena Cathedralpiazza del Campo
Nature Reserve Pineta Dannunziana

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Day 1

Day 1

  • Pescara - Arrival day
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  • Ponte del Mare
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Welcome to Pescara, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Pescara's charm before embarking on the next leg of your journey.

Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ponte Del Mare, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Pescara. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Taverna 58, a top-rated dining destination in Pescara. If you're in the mood to try something new, consider Ristorante Carlo Ferraioli, another top spot with a mouthwatering menu. You might also want to secure a reservation at Sesamo Nero. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pescara this evening.

Round off your dining experience by visiting Posa Caffè Pescara, a prime location for a drink. Alternatively, explore the distinctive characteristics of Bar Mixer, a bar catering to every mood and preference. Temple Bar Irish Pub likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Pescara
  • Rome
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Drive 212 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
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Embark on another extraordinary experience on day 2 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 2 nights.

Today’s well-planned self-sightseeing route offers several family-friendly attractions, breathtaking views, and picturesque spots. Whether you decide to explore Pescara on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Colosseum is the first of them. Spend some time admiring this historic archeological site before continuing your journey. Roman Forum is your next stop. This world-famous archeological site is one of the best-rated sights in Pescara.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Pantheon. This standout monument is a sight to behold. To round off your sightseeing experience, visit Piazza Navona.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Extend your evening after a delightful meal by visiting La Botticella Of Poggi Giovanni, which offers the perfect atmosphere for a night out. Moreover, Almalu Trastevere is another popular option for a drink or two. Likewise, Bar Viminale Di Pepi Maurilio also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 3

Day 3

  • Rome
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Drive 15 km, 1 hour 20 min

  • Vatican Museums
  • Sistine Chapel
  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • Villa Borghese
  • More

On day 3 of your road trip, you’ll start and end your day in Rome, where you'll stay for 1 night more.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most timeless attractions included on the itinerary is Vatican Museums.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the wondrous Trevi Fountain. After exploring the monument, head to Piazza Di Spagna. This globally renowned public square is a highlight in Rome. As your day continues, stop by Spanish Steps, known for its enchanting features. Lastly, don’t forget to check out the famous Villa Borghese. Enjoy exploring this incredible park at your own pace.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Sant' Eustachio Caffè, a well-loved spot among locals and tourists. Or, head to Yellowsquare Rome. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Caffè Portofino, another top-rated place in the area.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4

  • Rome
  • Florence
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Drive 276 km, 3 hours 31 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Piazza della Repubblica
  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • More

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 1 night.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Rome allows for both. Start by heading to Basilica Of Santa Croce In Florence. This locally renowned church provides an insightful glimpse into the city's identity. Next, discover Uffizi Gallery, a historic art gallery, promising a delightful encounter.

Continue your sightseeing with a visit to Ponte Vecchio, a wondrous historical landmark. When you’re done, don’t forget to make a stop at the interesting Piazza Della Repubblica. Not far away from the public square, you will find the visually striking Piazza Della Signoria, perfect for a quick visit. Round off your day at Cathedral Of Santa Maria Del Fiore, another gem in Rome with romantic features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Ristorante Oliviero 1962, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Di Poneta Novoli? It's another excellent option with a diverse menu. Consider reserving a table at Caffe San Firenze as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.

Round off your dining experience by visiting Manifattura, a prime location for a drink. Alternatively, explore the distinctive characteristics of Se·sto On Arno Rooftop Bar, a bar catering to every mood and preference. Il Vinile likewise offers a unique atmosphere, perfect for a memorable night out.

Savor another day of unforgettable experiences in Italy!

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Day 5

Day 5

  • Florence
  • Pescara
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Drive 425 km, 5 hours 36 min

  • Fortezza Medicea
  • Basilica of San Domenico
  • Siena Cathedral
  • piazza del Campo
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Siena, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Pescara. You’ll stay here for 1 night.

Set out on a day brimming with family-friendly attractions, breathtaking views, and photo-friendly spots. Start at the frequently visited Fortezza Medicea (siena), a picture-perfect monument in Florence. Next, go to Basilica Of San Domenico.

After visiting Fortezza Medicea (siena) and Basilica Of San Domenico, have a stroll along Florence's streets and take in the local charm. Continue your sightseeing by heading to Siena Cathedral. This history-steeped church offers a unique experience. Piazza Del Campo is another noteworthy attraction worthwhile a visit.

At the end of the day, you will drive to Pescara, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Pescara, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at Ciacco, an excellent option for tonight's dining. Looking for something different? Bar Sara offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Franco. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pescara.

After your meal, keep the night alive at a bar like Bar Napoli, known for its lively atmosphere. Bar Supermarket is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Post Bar offers an excellent atmosphere for those looking to amp up the evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 6

Day 6

  • Pescara - Departure day
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  • Nature Reserve Pineta Dannunziana
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Nature Reserve Pineta Dannunziana. This curiosity-inducing nature reserve is a popular place to see in the city.

Make the most of your final day in Italy by visiting Pescara’s iconic markets and shopping establishments in the buzzing Centro Commerciale Pescara Porta Nuova. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.

You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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