6-Day Italy Road Trip from Pisa traveling south to Perugia, Rome, and Arezzo

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Pisa, and Cascine Vecchie. When you’re not sightseeing, take time to relax at your selected hotel in Perugia, where you’ll be staying for 1 night.

Be one of the day’s first visitors at Cittadella Nuova. This fortress is rated an average of 4.4 out of 5 stars by 3,114 visitors.

When you’re finished at Cittadella Nuova, head to Piazza Del Duomo, Pisa. This one-of-a-kind square is rated an average of 4.7 out of 5 stars in 104,550 reviews.

Beyond the above-mentioned attractions, you also have the opportunity to visit Pisa Cathedral. This cathedral is rated an average of 4.8 out of 5 stars by 8,361 visitors.

If you’re keen to explore more, then consider a visit to Leaning Tower Of Pisa. This bell tower is a much-appreciated attraction with an average rating of 4.7 out of 5 stars from 116,882 visitors. Around 3,200,000 travelers visit Leaning Tower Of Pisa every year.

After soaking in Pisa’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Cascine Vecchie. Expect your car journey to take a minimum of 12 min. When you arrive in Cascine Vecchie, it's time to take a break from the road.

When you're ready to see some sights, Parco Regionale Migliarino, San Rossore, Massaciuccoli is a great place to start. This park is rated an average of 4.4 out of 5 stars by 9,632 visitors.

When you’re done exploring for the day, you’ll drive to Perugia, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Perugia, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Don’t miss out on dining at Ristorante Settimo Sigillo, a top-rated dining destination in Perugia. If you're in the mood to try something new, consider Bar Pellas, another top spot with a mouthwatering menu. You might also want to secure a reservation at La Taverna. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Perugia this evening.

Keep the evening going at Tommi Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Valentina, which offers a similarly pleasant setting and great drinks. Another option is Caffe Dal Perugino, which provides an inviting environment for unwinding after a busy day out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Embrace the thrill of the open road as you wave goodbye to Perugia and set your GPS to Vatican City, Vatican City. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 17 min. Upon reaching Vatican City, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Your sightseeing of the day begins at Vatican Museums, a remarkable art museum where it’s easy to get lost in exploration. This top attraction is rated an average of 4.6 out of 5 stars in 133,310 reviews. Each year, this popular place of interest welcomes approximately 1,612,530 visitors.

Next, satisfy your wanderlust at Saint Peter's Square. This square has an average rating of 4.8 out of 5 stars from 38,954 travelers.

Sistine Chapel is another must-visit attraction. This renowned chapel offers a memorable experience, well worth a stop on your self-guided sightseeing tour. Rated 4.7 out of 5 stars by 52,083 travelers, it's one of the more popular places to see in the area.

Beyond the above-mentioned sites, you also have the opportunity to visit St. Peter's Basilica. This well-loved major basilica boasts a 4.8 out of 5-star rating from 131,043 reviews. In a single year, approximately 11,000,000 visitors add this sightseeing spot to their travel itineraries.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Discover the culinary delights of Rome by securing a reservation at La Pergola. Esteemed for its 3-star Guide Michelin recognition, this restaurant offers a remarkable selection of mediterranean, and contemporary cuisine. For an alternative dining experience, try Il Pagliaccio, renowned for its delicious creative, and innovative dishes. This esteemed 2-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to Enoteca La Torre, a highly recommended local eatery celebrated for its mouthwatering mediterranean, and creative menu. With its 2-star Michelin recognition, it offers an unforgettable dining adventure.

If you’re not ready to end the night just yet, La Botticella Of Poggi Giovanni offers a perfect venue to relax and savor a drink. Similarly, Sant' Eustachio Caffè is well-suited for those looking to unwind in a social setting. Caffè Portofino is another excellent spot to enjoy a nightcap after a delightful meal.

Say good night to Rome and look forward to another great day of your road trip in Italy!

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Arezzo. You will spend 1 night here for some well-deserved relaxation.

When you're ready to see some sights, Roman Forum is a great place to start. This square is rated an average of 4.7 out of 5 stars by 114,450 visitors.

Another popular attraction you can visit today is Colosseum. This roman amphitheatre has an average rating of 4.7 out of 5 stars from 328,821 travelers. Every year, 7,400,000 travelers come to experience this site to make the most of their time in Rome.

We also recommend a stop at Trevi Fountain. The sculpture has been rated an average of 4.8 out of 5 stars by 343,494 visitors.

If you're keen to explore more, consider visiting Pantheon. This roman temple is a popular attraction with an average rating of 4.8 out of 5 stars from 189,682 reviews. As a top-rated attraction, it's no surprise that 30,000,000 people visit Pantheon every year.

Piazza Navona is another easily accessible place to visit on this day of your trip. Stop by this square, rated 4.7 out of 5 stars in 158,771 reviews, to discover more of what makes it unique.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Arezzo. Arezzo offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Arezzo. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Experience a taste of local culinary excellence while in Arezzo by securing a table at Octavin. An esteemed 1-star Michelin restaurant, it features an exceptional creative menu. If you're in the mood for something new, try La Clandestina, another premier location with a delectable menu.

After savoring a delicious meal, step into the vibrant nightlife at Liquid Bar, where the evening is just getting started.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Embark on another extraordinary experience on day 5 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Arezzo, and Siena. At the end of the day, you will enjoy the comforts of a top-rated hotel in Pisa, which will be your home away from home for 1 night.

When you’re ready for some sightseeing, make your way to Piazza Grande. This much-appreciated square is rated 4.6 out of 5 stars in 14,465 reviews.

When you’re ready to jump back into the car and say goodbye to Arezzo, you’ll hit the road in the direction of Siena. This drive usually takes around 1 hour 9 min. When you arrive, enjoy some sightseeing.

Kick off the day at Palazzo Salimbeni, a top pick for today’s sightseeing. This palazzo is rated an average of 4.5 out of 5 stars in 2,537 reviews.

Today is also your chance to visit Piazza Del Campo. Piazza Del Campo is a square with an average rating of 4.8 out of 5 stars from 64,175 reviews.

Siena Cathedral is another top attraction we highly recommend you visit today. This domus is rated an average of 4.8 out of 5 stars by 21,656 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit Fortezza Medicea (siena). This fortress is rated an average of 4.5 out of 5 stars by 9,835 visitors.

When you’re done exploring for the day, you’ll drive to Pisa, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Pisa's best restaurants.

Treat yourself to a delightful dinner at Ristorante alle Bandierine, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Barrique Cocktail And Bistrot? It's another excellent option with a diverse menu. Consider reserving a table at Filter Coffee Lab as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Pisa.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar Mocambo, a well-loved spot among locals and tourists. Or, head to Tree. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Chupiteria, another top-rated place in the area.

Celebrate another amazing day of your road trip adventure in Italy!