7-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Matera, Naples, Rome, and Santa Maria degli Angeli

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Explore the best of Italy on a 7-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 1 night in Matera, 1 night in Naples, 1 night in Rome, and 1 night in Santa Maria degli Angeli. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Lungomare Regina Margherita
Belvedere di Piazza Giovanni PascoliSassi di MateraCasa NohaCattedrale di Maria Santissima della Bruna e Sant'EustachioChurch of Saint Peter 'Barisano'Palombaro lungo
Naples National Archaeological Museumpiazza del PlebiscitoArchaeological Park of Pompeii
ColosseumRoman ForumSt Peter's Basilica
Circus MaximusPiazza NavonaPantheonTrevi FountainSpanish StepsVilla Borghese
Church of Santa Maria sopra Minerva in AssisiChiesa Nuova di San Francesco ConvertitoTrulli di Alberobello Puglia
Saint Pietro of Schiavoni Archeologica Area

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Lungomare Regina Margherita
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Welcome to Brindisi, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Brindisi's charm before embarking on the next leg of your journey.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Amici Dei Musei Brindisi, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Brindisi. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Bracerie Escosazio, a popular restaurant in Brindisi. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Brindisi at Penny, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Piadineria. It’s yet another ideal choice to enhance your time in Brindisi tonight.

Cap off your dinner by heading to Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, ideal for a leisurely evening with a drink in hand. Eden Cafè is another bar that offers an enjoyable setting. Similarly, Altair Cafè is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise a toast to the start of your 7-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Matera
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Drive 156 km, 2 hours 25 min

  • Belvedere di Piazza Giovanni Pascoli
  • Sassi di Matera
  • Casa Noha
  • Cattedrale di Maria Santissima della Bruna e Sant'Eustachio
  • Church of Saint Peter 'Barisano'
  • Palombaro lungo
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Matera. In the evening, you’ll end up in Matera, where you will stay for 1 night.

Enjoy the perfect balance of relaxation and exploration in Brindisi today. One of the most underrated attractions included on the itinerary is Belvedere Di Piazza Giovanni Pascoli. This awe-inspiring observation deck will help you start your sightseeing on top. Then, take a leisurely stroll to Sassi Di Matera and learn what makes this visually striking archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the curiosity-inducing Casa Noha. After exploring the museum, head to Cattedrale Di Maria Santissima Della Bruna E Sant'eustachio. This up-and-coming church is a highlight in Brindisi. As your day continues, stop by Church Of Saint Peter 'barisano', known for its breathtaking features. Lastly, don’t forget to check out the up-and-coming Palombaro Lungo. Enjoy exploring this incredible cave system at your own pace.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Matera. Matera offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Matera. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Ristorante Le Bubbole, a top-rated dining destination in Matera. If you're in the mood to try something new, consider Baccanti, another top spot with a mouthwatering menu.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Matera
  • Naples
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Drive 311 km, 4 hours 12 min

  • Naples National Archaeological Museum
  • piazza del Plebiscito
  • Archaeological Park of Pompeii
  • More

Embark on another extraordinary experience on day 3 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Naples and Pompei. At the end of the day, you will enjoy the comforts of a top-rated hotel in Naples, which will be your home away from home for 1 night.

Matera is brimming with adventures. Today’s wonderful stops include a museum, a public square, and an archeological site. Begin your sightseeing adventure at the well-known Naples National Archaeological Museum and allow yourself time to explore. Just a short distance away you'll find your next stop, Piazza Del Plebiscito, a history-steeped public square that draws visitors from far and near.

Continue your journey to Archaeological Park Of Pompeii, one of the city’s most locally renowned spots that you shouldn’t miss.

When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Naples. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Savor the flavors at L'Oca Nera Irish Pub, a top pick for dinner tonight. Alternatively, Mimì alla Ferrovia beckons with its unique menu offerings. Also, consider Spuzzulè Winebar. With its consistent customer satisfaction, it’s an excellent option for dining in Naples tonight.

Continue the enjoyment post-dinner at Happening Cocktail Bar, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Shanti Art Musik Bar offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Gran Caffè Gambrinus. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 4

Day 4

  • Naples
  • Rome
  • More

Drive 237 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • St Peter's Basilica
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Rome and Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 1 night.

Colosseum is must-visit archeological site and a great starting point for the day. Next, continue your journey to Roman Forum, a globally renowned archeological site, located just a leisurely stroll away.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Don’t miss out on dining at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Let the evening flow smoothly from dinner to drinks at La Botticella Of Poggi Giovanni, a top-rated bar in the area. For other recommendations, Almalu Trastevere provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Viminale Di Pepi Maurilio offers a memorable night with diverse drink options and excellent service.

Raise your glass to another unforgettable day in Italy!

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Day 5

Day 5

  • Rome
  • Assisi
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Drive 189 km, 3 hours 19 min

  • Circus Maximus
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Spanish Steps
  • Villa Borghese
  • More

On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Santa Maria degli Angeli, where you’ll be staying for 1 night.

Savor the day by visiting some of the best places to see in Rome, including an archeological site, a public square, a monument, a park and much more! Start your adventure at Circus Maximus. This locally renowned archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Navona located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Pantheon. Its culturally significant features will captivate you. After the monument, continue your tour of the city with a visit to Trevi Fountain. Visitors usually appreciate the history-steeped features of this monument. Next up is Spanish Steps, a highly recommended public square. For a change of pace, head to Villa Borghese. As one of the most impressive attractions in Rome, this park is the perfect place to end your self-guided sightseeing tour.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Santa Maria degli Angeli, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Round off your dining experience by visiting Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a prime location for a drink.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 6

Day 6

  • Assisi
  • Brindisi
  • More

Drive 676 km, 7 hours 18 min

  • Church of Santa Maria sopra Minerva in Assisi
  • Chiesa Nuova di San Francesco Convertito
  • Trulli di Alberobello Puglia
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Santa Maria degli Angeli and Alberobello. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Brindisi. You will spend 1 night here for some well-deserved relaxation.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Santa Maria degli Angeli allows for both. Start by heading to Church Of Santa Maria Sopra Minerva In Assisi. This often recommended church provides an insightful glimpse into the town's identity. Next, discover Chiesa Nuova Di San Francesco Convertito, a heritage-rich church, promising a delightful encounter.

Continue your sightseeing with a visit to Trulli Di Alberobello Puglia, an interesting historical landmark.

When you’re done exploring for the day, you’ll drive to your hotel in Brindisi. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Brindisi's best restaurants.

Enjoy a delicious meal at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a highly-rated dining destination in Brindisi. If you're eager to try something different, consider Bento, another top spot with a tantalizing menu. You might also want to secure a reservation at Cozza Nera. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Brindisi this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • Brindisi - Departure day
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  • Saint Pietro of Schiavoni Archeologica Area
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Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Saint Pietro Of Schiavoni Archeologica Area, an eye-catching archeological site before you head out.

On your last day in Italy, take time to indulge in shopping at Brindisi’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

Treat yourself to a delightful dinner at Rendez-Vous Cafè Bistrot, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pizzeria La Nassa? It's another excellent option with a diverse menu.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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