9-Day Italy Road Trip from Genoa to Pisa, Viterbo, Rome, and Florence

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Experience the freedom of the open road in Italy as you embark on an unforgettable 9-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Pisa, Viterbo, Rome, Florence, and Siena.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Pisa, 1 night in Viterbo, 2 nights in Rome, and 2 nights in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Genoa, Pisa, Viterbo, Rome, Florence, and Siena, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Genoa - arrival day

  • Genoa - Arrival day
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  • porto antico
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat in Genoa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Trattoria Vegia Zena, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider Trattoria delle Grazie, another top spot with a mouthwatering menu. You might also want to secure a reservation at Manhattan Bar. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Genoa this evening.

Continue the enjoyment post-dinner at Scurreria Beer & Bagel, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, La Lepre offers a vibrant space for indulging in well-crafted drinks and engaging conversation.

Raise a toast to the start of your 9-day road trip in Italy!

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Day 2

Day 2 – Genoa, and Pisa

  • Pisa
  • Genoa
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Drive 176 km, 2 hours 17 min

  • piazza De Ferrari
  • Doge's Palace
  • Genoa Cathedral
  • Aquarium of Genoa
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Genoa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Kick off the day at Piazza De Ferrari, a top pick for today’s sightseeing. This square is rated an average of 4.6 out of 5 stars in 34,312 reviews.

Today is also your chance to visit Doge's Palace. Doge's Palace is a museum with an average rating of 4.6 out of 5 stars from 7,612 reviews.

Genoa Cathedral is another top attraction we highly recommend you visit today. This cathedral is rated an average of 4.6 out of 5 stars by 8,971 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit Aquarium Of Genoa. This public aquarium is rated an average of 4.5 out of 5 stars by 62,259 visitors. Visiting Aquarium Of Genoa means you'll be one of 1,200,000 people who do so every year.

At the end of the day, you will drive to Pisa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Pisa's best restaurants.

Treat yourself to a wonderful meal at Ristorante Capodimonte Pisa, a top-rated dining spot in Pisa. If you're in the mood for something new, try Baribaldi Pisa, another premier location with a delectable menu. You might also want to book a table at Restaurant -Pizzeria Il Mio Capriccio. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pisa.

If you’re not ready to end the night just yet, Jeffer Cocktails & Friends offers a perfect venue to relax and savor a drink. Similarly, Le Parisien Wine Bar is well-suited for those looking to unwind in a social setting. Las Volta Cocktailbar is another excellent spot to enjoy a nightcap after a delightful meal.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 3

Day 3 – Pisa, and Viterbo

  • Viterbo
  • Pisa
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Drive 282 km, 3 hours 36 min

  • Knights' Square
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
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On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Pisa. When you’re not sightseeing, take time to relax at your selected hotel in Viterbo, where you’ll be staying for 1 night.

Make Knights' Square your first stop of the day. Previous visitors have rated this square an average of 4.5 out of 5 stars in 9,051 reviews.

Next up, make a stop at Leaning Tower Of Pisa. With an average rating of 4.7 out of 5 stars by 116,882 visitors, it's easy to understand why so many people visit this bell tower every year. In fact, this attraction welcomes 3,200,000 annual visitors.

Piazza Del Duomo, Pisa is another attraction you can visit on this day of your vacation. This square has an average rating of 4.7 out of 5 stars by 104,550 visitors.

When you’re finished at Piazza Del Duomo, Pisa, the perfect next stop is Pisa Cathedral. This cathedral is rated an average of 4.8 out of 5 stars in 8,361 reviews.

When you’re done exploring for the day, you’ll drive to Viterbo, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Viterbo. Enjoy a satisfying meal that will recharge you for tonight's adventures.

With its reputation for pleasing customers, it’s a fantastic choice for tonight in Viterbo.

Say good night to Viterbo and look forward to another great day of your road trip in Italy!

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Day 4

Day 4 – Viterbo, Vatican City, and Rome

  • Rome
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Drive 117 km, 1 hour 46 min

  • Vatican Museums
  • Sistine Chapel
  • Saint Peter's Square
  • St Peter's Basilica
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Dive into day 4 of your remarkable road trip in Italy. Today you will explore Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 2 nights.

After soaking in Viterbo’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Vatican City, Vatican City. Expect your car journey to take a minimum of 1 hour 26 min. When you arrive in Vatican City, it's time to take a break from the road.

Take the opportunity to see Vatican Museums. This attraction has an average rating of 4.6 out of 5 stars from 133,310 visitors and gets around 1,612,530 visits every year.

Sistine Chapel is another sightseeing hotspot in the area. This chapel has been rated an average of 4.7 out of 5 stars by 52,083 travelers.

Vatican City is also the home of Saint Peter's Square. Around 38,954 people have rated this square an average of 4.8 out of 5 stars.

Another place you’ll want to visit is St. Peter's Basilica, which hosts up to 11,000,000 visitors every year. With an average rating of 4.8 out of 5 stars from a total of 131,043 reviews, a visit to this major basilica is a great idea.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean, and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative, and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean, and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, La Botticella Of Poggi Giovanni stands out as an excellent choice for a post-dinner cocktail. Alternatively, Sant' Eustachio Caffè offers an ideal atmosphere to enjoy the pleasures of the night. Caffè Portofino is also a great option that provides a perfect setting for a relaxing evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5 – Rome

  • Rome
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Drive 9 km, 1 hour 11 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
  • Castel Sant'Angelo
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Day 5 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Begin your sightseeing with a visit to Colosseum. This roman amphitheatre gets 7,400,000 visitors each year and is rated an average of 4.7 out of 5 stars in 328,821 reviews.

Next up, make your way to Roman Forum. This square has an average rating of 4.7 out of 5 stars from 114,450 reviews.

When you’re ready for your next sight of the day, continue to Pantheon. This roman temple has an average rating of 4.8 out of 5 stars from 189,682 visitors. Up to 30,000,000 people visit this place of interest annually.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza Navona. This square is rated an average of 4.7 out of 5 stars by 158,771 visitors.

If you’re keen to explore even more, then consider a visit to Castel Sant'angelo. This museum is a much-appreciated attraction with an average rating of 4.7 out of 5 stars from 72,431 visitors. Approximately 918,591 travelers visit Castel Sant'angelo every year.

To do something one-of-a-kind on this day of your trip, you can join a tour. You can discover all of the most fun and eye-opening experiences in your destination below and secure your spot here.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Dine in style at DEROMA - Farine Romane, a top recommendation for dinner tonight. Or, for a change of pace, La Taverna Italiana boasts a menu that's sure to impress. Also, be sure to check out Centro. Known as a local hotspot, it’s a great choice for tonight in Rome.

Continue your lively evening at The Apartment Bar Roma, a perfect place for winding down or revving up the night, depending on which mood you’re in. Hotel Hassler Roma is another excellent bar that offers a great selection of drinks to suit any mood.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 6

Day 6 – Rome, and Florence

  • Florence
  • Rome
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Drive 280 km, 3 hours 54 min

  • Altare della Patria
  • Trevi Fountain
  • Piazza di Spagna
  • piazza del Popolo
  • Villa Borghese
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Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 2 nights.

Your sightseeing of the day begins at Altare Della Patria, a remarkable architectural structure where it’s easy to get lost in exploration. This top attraction is rated an average of 4.8 out of 5 stars in 49,843 reviews. Each year, this popular place of interest welcomes approximately 1,683,070 visitors.

Next, satisfy your wanderlust at Trevi Fountain. This sculpture has an average rating of 4.8 out of 5 stars from 343,494 travelers.

Piazza Di Spagna is another must-visit attraction. This renowned square offers a memorable experience, well worth a stop on your self-guided sightseeing tour. Rated 4.7 out of 5 stars by 113,658 travelers, it's one of the more popular places to see in the area.

Beyond the above-mentioned sites, you also have the opportunity to visit Piazza Del Popolo. This well-loved square boasts a 4.6 out of 5-star rating from 89,807 reviews.

When there’s still energy left for exploring, Villa Borghese awaits. If you’ve been interested in experiencing an urban zone of rome, this is a top pick rated 4.6 out of 5 stars by 69,749 previous visitors.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy an outstanding dining experience at Enoteca Pinchiorri, a 3-star Michelin restaurant offering an exceptional italian contemporary menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 2-star Michelin-awardee, Santa Elisabetta, known for its delicious creative, and mediterranean cuisine. Another highly-recommended restaurant in Florence is Gucci Osteria da Massimo Bottura, a renowned restaurant with a 1-star Guide Michelin recognition, known for its delicious italian contemporary, and international menu.

Continue your lively evening at Manifattura, a perfect place for winding down or revving up the night, depending on which mood you’re in. Se·sto On Arno Rooftop Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Archea Brewery ensures a night out tailored to your taste.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 7

Day 7 – Florence, and Siena

  • Florence
  • Siena
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Drive 160 km, 2 hours 56 min

  • piazza del Campo
  • Siena Cathedral
  • piazzale Michelangelo
  • Galleria dell'Accademia
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Wake up to day 7 of your extraordinary road trip in Italy. With 1 night left in Florence, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Make Piazzale Michelangelo one of your first sightseeing stops in Florence. Rated an average of 4.8 out of 5 stars by 77,744 travelers, a visit to this local attraction makes for a great introduction to the area.

Galleria Dell'accademia is a worthwhile attraction you can visit next. This national museum is a valued place of interest in the area, with an average rating of 4.6 out of 5 stars from 34,429 reviews. Up to 1,719,645 travelers visit this site every year to make their time in Florence special.

Today is also the perfect opportunity to drop by Central Market. This point of interest has been rated an average of 4.4 out of 5 stars by 43,100 visitors.

When you’ve had your share of Florence, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Siena. Your travel time is around 1 hour 16 min.

Your sightseeing of the day begins at Piazza Del Campo, a remarkable square where it’s easy to get lost in exploration. This top attraction is rated an average of 4.8 out of 5 stars in 64,175 reviews.

Next, satisfy your wanderlust at Siena Cathedral. This domus has an average rating of 4.8 out of 5 stars from 21,656 travelers.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at Trattoria Da Burde, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Buca Mario, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eataly Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 8

Day 8 – Florence, and Genoa

  • Genoa
  • Florence
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Drive 235 km, 3 hours 7 min

  • piazza della Signoria
  • Uffizi Gallery
  • Ponte Vecchio
  • Cathedral of Santa Maria del Fiore
  • Giotto's Bell Tower
  • More

On day 8 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

A top pick for your self-guided sightseeing tour today is Piazza Della Signoria. Previous visitors have rated this square an average of 4.8 out of 5 stars in 66,956 reviews.

Uffizi Gallery is a local recommendation that you also can pay a visit today. This national museum is rated an average of 4.7 out of 5 stars in 61,794 reviews. The attraction welcomes 2,011,219 visitors every year.

Another attraction you won't want to miss is Ponte Vecchio. This deck arch bridge is rated an average of 4.7 out of 5 stars in 118,099 reviews.

Cathedral Of Santa Maria Del Fiore is another outstanding experience in Florence. Around 76,359 travelers have rated this church an average of 4.8 out of 5 stars.

If you long for more, Giotto's Bell Tower is not far away. This point of interest is a lovely addition to your itinerary. Previous visitors have rated it an average of 4.8 out of 5 stars in 4,849 reviews. The attraction gets an estimated 2,011,219 visitors every year.

When you’re done exploring for the day, you’ll drive to Genoa, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Have a memorable dining experience in Genoa by booking a table at San Giorgio, renowned as a 1-star Michelin restaurant presenting an exceptional modern, and ligurian menu. For a different culinary experience in Genoa, The Cook shines as one of the top destinations, known for its delicious modern cuisine. This 1-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Il Marin is known as a top local spot for its delicious seafood, and contemporary cuisine in Genoa. This 1-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Head back to your accommodation in Genoa and get some rest in preparation for another magical day of your road trip in Italy!

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Day 9

Day 9 – Genoa - departure day

  • Genoa - Departure day
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  • Via Garibaldi
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Day 9 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Begin your sightseeing with a visit to Via Garibaldi. This point of interest is rated an average of 4.6 out of 5 stars in 5,399 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're in the mood to try something new, consider Osteria di Vico Palla, another top spot with a mouthwatering menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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