Luxury 10-Day Italy Road Trip from Genoa to Florence, Viterbo, Rome, and Siena

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Experience travel that redefines comfort and elegance with this 10-day luxury road trip in Italy. Witness Italy's awe-inspiring scenery, delight in the finest culinary offerings, and enjoy the ultimate comfort in top-tier accommodations.

Italy offers the ultimate luxury holiday experience for anyone up for an unforgettable adventure, including couples, families, solo travelers, and friends.

Your exclusive luxury holiday package will bring you to the country's most popular attractions and restaurants in the best destinations in Italy. With this perfectly planned vacation itinerary, you will stay 2 nights in Genoa, 2 nights in Florence, 1 night in Viterbo, 3 nights in Rome, and 1 night in Siena, experiencing the ultimate luxury vacation in Italy.

Finding the perfect luxury lodging is going to make your vacation in Italy feel truly special. The home for your 10-day luxury holiday will be only the most exclusive 5-star hotels in Italy. You will choose from the best selection of luxury hotels and places to stay, all conveniently located along your carefully planned self-drive route.

Upon arriving in Italy, you will collect the luxury rental vehicle of your choice. We will provide you with the best car rental for the entirety of your 10-day luxury self-drive holiday, including CDW insurance. From there, you will drive off at a relaxed pace to discover some of the best travel destinations in Italy.

Throughout your exclusive vacation in Italy, you will get to experience some of the best attractions and activities offered in the country. Each moment promises to be filled with unforgettable memories and unique experiences.

Between attractions and activities, you will have plenty of time to stroll along the best shopping streets and markets in Italy. Here you can find unique souvenirs to preserve the memory of your luxury holiday in Italy.

This exclusive travel plan is designed to include everything you need to have the best vacation in Italy. By booking this luxury holiday package, you can avoid spending hours researching and planning your 10-day road trip in Italy. Let the experts figure out the details, so you can focus on enjoying.

To deliver the best experience possible, we make it easy for you to customize each day of your luxury holiday in Italy before and after booking. Our flexible trip planning means you will be able to explore Genoa, Florence, Viterbo, Rome, Siena, and Pisa at your own pace.

Book with us to get access to 24/7 personal travel support throughout your entire journey. Enjoy a step-by-step guide in our easy-to-use mobile app, including all travel documents for your exclusive getaway to Italy.

The best flights, activities, tours, and hotels in Italy fill up quickly, so book your luxury vacation package in advance. Select a date and start planning your luxury holiday in Italy today!

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Day 1

Day 1 – Genoa - arrival day

  • Genoa - Arrival day
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  • Piazza De Ferrari
  • More

Your luxury holiday in Italy begins as soon as you reach the city of Genoa. There, you’ll pick up the luxury rental vehicle of your choice and hit the roads!

When you're ready to see some sights, Piazza De Ferrari is a great place to start. This square is rated an average of 4.6 out of 5 stars by 34,312 visitors.

Tonight, you will be treated to a stay at one of the best luxury hotels in Genoa. We have picked out three of the most exclusive luxury lodging and hotel options for you to choose from.

Treat yourself after a day of exploration. Make a reservation at the finest dining and drinking spots in Genoa.

Make sure to reserve a table at Trattoria Vegia Zena, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria delle Grazie, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Manhattan Bar, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your evening by exploring the vibrant nightlife scene at Scurreria Beer & Bagel, a prime destination for a thrilling night out. Also, don’t forget to check out La Lepre, a bar that offers unique local touches.

Raise a toast to the start of your 10-day luxury vacation in Italy and look forward to more fantastic days to come!

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Day 2

Day 2 – Genoa, Boccadasse, and Florence

  • Florence
  • Genoa
  • More

Drive 246 km, 3 hours 27 min

  • Via Garibaldi
  • Aquarium of Genoa
  • Porto Antico
  • More

Wake up to day 2 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Florence, where you'll be staying for 2 nights. The day's itinerary unfolds with a diverse array of experiences in Genoa, and Boccadasse.

Make Via Garibaldi your first stop of the day. Previous visitors have rated this point of interest an average of 4.6 out of 5 stars in 5,399 reviews.

Next up, make a stop at Aquarium Of Genoa. With an average rating of 4.5 out of 5 stars by 62,259 visitors, it's easy to understand why so many people visit this public aquarium every year. In fact, this attraction welcomes 1,200,000 annual visitors.

Porto Antico is another attraction you can visit on this day of your vacation. This port has an average rating of 4.5 out of 5 stars by 12,414 visitors.

Boccadasse’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Genoa behind. This drive usually takes around 14 min. Boccadasse welcomes you with a multitude of unique vacation experiences.

Make Church Of St. Anthony Of Boccadasse one of your first sightseeing stops in Boccadasse. Rated an average of 4.6 out of 5 stars by 957 travelers, a visit to this local attraction makes for a great introduction to the area.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Florence. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After a day filled with travel and exploration, we recommend you treat yourself to a meal or a drink at the finest restaurants and bars in Florence. Savor the local cuisine and relax as you recount the day's experiences.

Experience a harmony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Known for its 3-star Michelin status, Enoteca Pinchiorri offers a delightful variety of dishes highlighting its delicious italian contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Santa Elisabetta, a highly recommended restaurant known for its enticing creative, and mediterranean cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Gucci Osteria da Massimo Bottura, a highly acclaimed restaurant celebrated for its exceptional italian contemporary, and international menu.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Manifattura, a well-loved spot among locals and tourists. Or, head to Se·sto On Arno Rooftop Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.

Reminisce about your day, look through photos, and prepare for another great day to come! Your stress-free luxury holiday in Italy has plenty more in store for you.

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Day 3

Day 3 – Florence

  • Florence
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Drive 11 km, 57 min

  • Cathedral of Santa Maria del Fiore
  • Accademia Gallery
  • David of Michelangelo
  • Piazzale Michelangelo
  • More

Day 3 of your luxury road trip in Italy begins and concludes in the city of Florence. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Florence, where you still have 1 night nights remaining.

Be one of the day’s first visitors at Central Market. This sightseeing destination is rated an average of 4.4 out of 5 stars by 43,100 visitors.

When you’re finished at Central Market, head to Cathedral Of Santa Maria Del Fiore. This one-of-a-kind church is rated an average of 4.8 out of 5 stars in 76,359 reviews.

Beyond the above-mentioned attractions, you also have the opportunity to visit Galleria Dell'accademia. This national museum is rated an average of 4.6 out of 5 stars by 34,429 visitors. Visiting Galleria Dell'accademia means you'll be one of 1,719,645 people who do so every year.

If you’re keen to explore more, then consider a visit to David. This statue is a much-appreciated attraction with an average rating of 4.8 out of 5 stars from 10,476 visitors.

To round off your sightseeing experience, make your way to Piazzale Michelangelo. This famous square is rated an average of 4.8 out of 5 stars by 77,744 travelers.

Treat yourself after a day of exploration. Make a reservation at the finest dining and drinking spots in Florence.

Treat yourself to a delicious dinner at Trattoria Da Burde, an excellent option for tonight's dining. Looking for something different? Ristorante Buca Mario offers a tantalizing alternative with its diverse menu. And don’t miss Eataly Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

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Day 4

Day 4 – Florence, and Viterbo

  • Viterbo
  • Florence
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Drive 221 km, 3 hours 2 min

  • Piazza della Signoria
  • Palazzo Vecchio
  • Uffizi Gallery
  • Ponte Vecchio
  • The Boboli Gardens
  • More

On day 4 of your luxury holiday in Italy, your road trip route will take you exploring the best of Florence. The day's journey will conclude in Viterbo, a city that offers you comfort and relaxation for 1 night. With a day brimming with amazing attractions ahead, fuel up with a hearty breakfast to savor every moment of your luxury vacation in Italy.

Drop by the renowned Piazza Della Signoria. This popular square has been rated an average of 4.8 out of 5 stars by 66,956 visitors.

Another unforgettable place to experience is Palazzo Vecchio. Rated 4.7 out of 5 stars by 19,049 visitors, this palazzo deserves a spot on today's sightseeing itinerary.

We also recommend a visit to Uffizi Gallery. Hosting around 2,011,219 visitors every year, the fascinating Uffizi Gallery is one of the best places to visit in Florence. This national museum has been rated an average of 4.7 out of 5 stars in 61,794 reviews.

Another favorite attraction in the area is Ponte Vecchio. This deck arch bridge and popular place of interest enjoys a rating of 4.7 out of 5 stars from 118,099 local and international travelers.

If you’re keen to explore even more, then consider a visit to The Boboli Gardens. With an average rating of 4.2 out of 5 stars from 25,341 travelers, this park is an attraction many avid travelers highly recommend visiting while in Florence.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Viterbo. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

Treat yourself after a day of exploration. Make a reservation at the finest dining and drinking spots in Viterbo.

Raise your glass and relax after another big day of your luxury holiday in Italy!

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Day 5

Day 5 – Viterbo, Vatican City, and Rome

  • Rome
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Drive 117 km, 1 hour 46 min

  • Vatican Museums
  • Sistine Chapel
  • Saint Peter's Square
  • St Peter's Basilica
  • More

Wake up to day 5 of your luxury holiday in Italy! Remember to have a hearty breakfast because today will be filled with memorable adventures in Vatican City. With a flexible itinerary, you're free to adapt and explore additional attractions or enjoy spontaneous discoveries.

When you’re ready to jump back into the car and say goodbye to Viterbo, you’ll hit the road in the direction of Vatican City, Vatican City. Witness the landscapes transform as you cross the border to Vatican City. This drive usually takes around 1 hour 26 min. When you arrive, enjoy some sightseeing.

Seize the day by visiting some of the best attractions in the area, like Vatican Museums. This extraordinary art museum has an average rating of 4.6 out of 5 stars from 133,310 visitors. Each year, around 1,612,530 people visit this remarkable site to admire its features and learn more about it.

Next, make your way to Sistine Chapel. This chapel is rated an average of 4.7 out of 5 stars in 52,083 reviews.

While in Vatican City, we also recommend a visit to Saint Peter's Square. This square has been rated an average of 4.8 out of 5 stars in 38,954 reviews.

If you’re keen to explore even more, then consider a visit to St. Peter's Basilica. This attraction gets around 11,000,000 yearly visitors. With an average rating of 4.8 out of 5 stars by 131,043 travelers, this major basilica is a highly recommended stop on your sightseeing around Vatican City.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Rome. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After a long day of discovering the unique quirks of Italy, it’s an excellent idea to sit down for a lovely meal or enjoy a refreshing drink. We’ve gathered the most recommended dining and drinking spots in Rome so you can check out the menus and make advance reservations.

Prepare for an extraordinary culinary adventure in Rome by booking a table at La Pergola, a 3-star Michelin restaurant that boasts an exceptional mediterranean, and contemporary menu. For a different flavor experience, head to Il Pagliaccio, renowned for its delectable creative, and innovative dishes. This 2-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Enoteca La Torre, a local gem known for its delightful mediterranean, and creative cuisine in Rome. Nestled in the city's heart, this 2-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.

After enjoying a fulfilling meal, continue your evening at La Botticella Of Poggi Giovanni, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Sant' Eustachio Caffè offers a welcoming atmosphere for easing into the nightlife. Similarly, Caffè Portofino provides an excellent environment for a relaxed and enjoyable evening.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

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Day 6

Day 6 – Rome

  • Rome
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Drive 6 km, 1 hour 18 min

  • Trevi Fountain
  • Altar of the Fatherland
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • More

Day 6 of your luxury road trip in Italy begins and concludes in the city of Rome. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Rome, where you still have 2 nights nights remaining.

Make Trevi Fountain your first stop of the day. Previous visitors have rated this sculpture an average of 4.8 out of 5 stars in 343,494 reviews.

Next up, make a stop at Altare Della Patria. With an average rating of 4.8 out of 5 stars by 49,843 visitors, it's easy to understand why so many people visit this architectural structure every year. In fact, this attraction welcomes 1,683,070 annual visitors.

Roman Forum is another attraction you can visit on this day of your vacation. This square has an average rating of 4.7 out of 5 stars by 114,450 visitors.

When you’re finished at Roman Forum, the perfect next stop is Colosseum. This roman amphitheatre is rated an average of 4.7 out of 5 stars in 328,821 reviews. Colosseum attracts approximately 7,400,000 visitors annually.

If you’re keen to explore even more, then consider a visit to Circus Maximus. This circus is a top place to visit, with a rating of 4.4 out of 5 stars from 44,741 reviews.

Exploring new destinations can leave you craving great food and drinks. Satisfy your cravings and unwind by visiting the finest restaurants and bars in Rome.

Enjoy a lovely meal at DEROMA - Farine Romane, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Taverna Italiana is another top choice with a popular menu. You could also check for a table at Centro. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Raise a toast to another amazing day of your luxury holiday in Rome, Italy and seize the opportunity to celebrate.

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Day 7

Day 7 – Rome

  • Rome
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Drive 11 km, 1 hour 12 min

  • Castel Sant'Angelo
  • Piazza di Spagna
  • Spanish Steps
  • Piazza del Popolo
  • Villa Borghese
  • More

Day 7 of your luxury road trip in Italy begins and concludes in the city of Rome. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Rome, where you still have 1 night nights remaining.

Journey into the unknown at Castel Sant'angelo, a unique attraction awaiting your visit. This remarkable museum has an average rating of 4.7 out of 5 stars from 72,431 reviews. Every year, Castel Sant'angelo welcomes more than 918,591 curious visitors.

When you’re ready to continue your sightseeing, Piazza Di Spagna is a recommended place to visit. This square is rated an average of 4.7 out of 5 stars in 113,658 reviews.

Another must-see attraction in Rome is Spanish Steps. Rated an average of 4.5 out of 5 stars by 57,211 travelers, this popular tourist destination in Rome offers an experience you will remember.

Piazza Del Popolo is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.6 out of 5 stars in 89,807 reviews.

Lastly, don't miss out on Villa Borghese. Rated 4.6 out of 5 stars by 69,749 local and international travelers, it's a popular place to visit.

Discover a world of culinary delights in Rome, where top-notch dining experiences await at every corner. Consider whether you need to make a reservation in advance to secure a table at your preferred restaurant.

Don’t miss out on dining at Ristorante Tema, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Maccheroni, another top spot with a mouthwatering menu. You might also want to secure a reservation at RoYaL Art Cafè Roma. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

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Day 8

Day 8 – Rome, and Siena

  • Siena
  • Rome
  • More

Drive 239 km, 3 hours 16 min

  • Largo di Torre Argentina
  • Pantheon
  • Piazza Navona
  • Campo de' Fiori
  • More

Wake up to day 8 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Siena, where you'll be staying for 1 night. The day's itinerary unfolds with a diverse array of experiences in Rome.

Journey into the unknown at Largo Di Torre Argentina, a unique attraction awaiting your visit. This remarkable square has an average rating of 4.5 out of 5 stars from 30,433 reviews.

When you’re ready to continue your sightseeing, Pantheon is a recommended place to visit. This roman temple is rated an average of 4.8 out of 5 stars in 189,682 reviews. Based on recent data, the attraction hosts 30,000,000 visitors per year.

Another must-see attraction in Rome is Piazza Navona. Rated an average of 4.7 out of 5 stars by 158,771 travelers, this popular tourist destination in Rome offers an experience you will remember.

Campo De' Fiori is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.4 out of 5 stars in 51,133 reviews.

Lastly, don't miss out on Foro Italico. Rated 4.6 out of 5 stars by 25,438 local and international travelers, it's a popular place to visit.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Siena. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

Exploring new destinations can leave you craving great food and drinks. Satisfy your cravings and unwind by visiting the finest restaurants and bars in Siena.

Don’t miss out on dining at Antica Trattoria Papei, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Osteria Quattro Venti, another top spot with a mouthwatering menu. You might also want to secure a reservation at Osteria da Divo. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Siena this evening.

Cap off your dinner by heading to Meet Life Cafè, ideal for a leisurely evening with a drink in hand. Maudit Pub is another bar that offers an enjoyable setting. Similarly, Bar Impero Siena is also a popular place to go on a night out, perfect for relaxing and socializing.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

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Day 9

Day 9 – Siena, Pisa, and Genoa

  • Genoa
  • Pisa
  • More

Drive 287 km, 3 hours 52 min

  • Leaning Tower of Pisa
  • Cattedrale di Pisa
  • Piazza del Duomo
  • Camposanto
  • More

On day 9 of your luxury holiday in Italy, your road trip route will take you exploring the best of Pisa. The day's journey will conclude in Genoa, a city that offers you comfort and relaxation for 1 night. With a day brimming with amazing attractions ahead, fuel up with a hearty breakfast to savor every moment of your luxury vacation in Italy.

Embrace the thrill of the open road as you wave goodbye to Siena and set your GPS to Pisa. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 48 min. Upon reaching Pisa, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Make Leaning Tower Of Pisa one of your first sightseeing stops in Pisa. Rated an average of 4.7 out of 5 stars by 116,882 travelers, a visit to this local attraction makes for a great introduction to the area. This bell tower attracts 3,200,000 visitors every year.

Pisa Cathedral is a worthwhile attraction you can visit next. This cathedral is a valued place of interest in the area, with an average rating of 4.8 out of 5 stars from 8,361 reviews.

Today is also the perfect opportunity to drop by Piazza Del Duomo, Pisa. This square has been rated an average of 4.7 out of 5 stars by 104,550 visitors.

If you’re keen to explore more, head to Campo Santo. A trip to this popular cemetery is also your opportunity to see if it lives up to the reputable 4.6 out of 5-star rating as given by 586 previous visitors.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Genoa. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

Discover a world of culinary delights in Genoa, where top-notch dining experiences await at every corner. Consider whether you need to make a reservation in advance to secure a table at your preferred restaurant.

Experience a symphony of flavors at The Cook in Genoa by securing a reservation in advance. Renowned for its 1-star Michelin distinction, The Cook delights its guests with its exceptional variety of meals showcasing delicious modern cuisine. For a palate-pleasing alternative, make sure to dine at San Giorgio, acclaimed for its delectable modern, and ligurian specialties. This local 1-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Il Marin, a top-rated restaurant known for its outstanding menu. Known as a top-rated 1-star Michelin establishment, it's a top choice for seafood, and contemporary cuisine in the city.

Raise a toast to another amazing day of your luxury holiday in Pisa, Italy and seize the opportunity to celebrate.

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Day 10

Day 10 – Genoa - departure day

  • Genoa - Departure day
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  • Piazza Corvetto
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Today is the last day of your 10-day luxury holiday in Italy and it’s soon time to start your journey home. This is your chance to get one last glimpse of Genoa before saying goodbye.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Make the most of what's left of your luxury vacation and head out to the stunning Piazza Corvetto. This extraordinary point of interest and attraction is rated an average of 4.2 out of 5 stars in 3,380 reviews, and is an excellent choice for your last sightseeing in Genoa.

Treat yourself to a final feast. Savor the unique flavors of Genoa one last time before you head to the airport.

Savor the flavors at OVER SEA. , a top pick for dinner tonight. Alternatively, Osteria di Vico Palla beckons with its unique menu offerings.

You will then say farewell to Genoa and begin your journey home. We wish you safe travels and a warm welcome home, with unforgettable memories and incredible photos from your luxury holiday in Italy in your luggage!

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