11-Day Italy Self-Drive Road Trip With Itinerary from Pescara to Florence and Rome

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Explore the best of Italy on a 11-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Pescara, Florence, Siena, Rome, Naples, and Pompei. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Pescara, 3 nights in Florence, and 4 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Pescara, Florence, Siena, Rome, Naples, and Pompei, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Locomotiva FS 740351
Museo delle Genti d'AbruzzoGabriele D'Annunzio's Birthplace MuseumPescara Cathedral
Ponte VecchioUffizi GalleryPalazzo VecchioPiazza della Repubblicapiazza della Signoria
Basilica of San LorenzoGalleria dell'AccademiaBasilica of Santa Croce in FlorenceThe Boboli Gardenspiazzale MichelangeloOltrarno
Pinacoteca NazionaleSiena CathedralPubblico PalaceTower of Mangiapiazza del CampoBasilica of San Domenico
ColosseumRoman ForumTrevi FountainPiazza di Spagna

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Day 1

Day 1

  • Pescara - Arrival day
  • More
  • Locomotiva FS 740351
  • More

Your road trip adventure in Italy begins as soon as you reach Pescara and pick up your car. You’ll stay in Pescara for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Locomotiva Fs 740.351, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pescara. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Taverna 58, a top-rated dining spot in Pescara. If you're in the mood for something new, try Ristorante Carlo Ferraioli, another premier location with a delectable menu. You might also want to book a table at Sesamo Nero. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pescara.

After your meal, keep the night alive at a bar like Posa Caffè Pescara, known for its lively atmosphere. Bar Mixer is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Temple Bar Irish Pub offers an excellent atmosphere for those looking to amp up the evening.

Raise a toast to the start of your 11-day road trip in Italy!

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Day 2

Day 2

  • Pescara
  • More

Drive 3 km, 28 min

  • Museo delle Genti d'Abruzzo
  • Gabriele D'Annunzio's Birthplace Museum
  • Pescara Cathedral
  • More

Day 2 offers a multitude of experiences. You will stay in Pescara for 1 night more, offering you enough time to explore at a relaxed pace.

Brace yourself for today’s incredible lineup of attractions in Pescara, featuring fun adventures, photo-friendly spots, and historic treasures. Start at Museo Delle Genti D'abruzzo, a locally appreciated museum in the city. Then, head to Gabriele D'annunzio's Birthplace Museum and soak in the ambiance of this history-steeped museum.

There are many interesting places to see in Pescara and when you are ready for more, go to Pescara Cathedral. This is one of the city’s most beloved spots.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Bring home unique finds from Pescara's bustling shopping hub, Centro Commerciale Pescara Porta Nuova. Enjoy a leisurely exploration of unique stores where locals shop. Don’t forget to browse souvenirs and local specialties that make perfect gifts for your loved ones. Beyond shopping, Centro Commerciale Pescara Porta Nuova offers plenty of options, including restaurants, primary services, unique landmarks, and community events.

As dinnertime approaches, it's time to head out for a bite to eat in Pescara. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Ciacco, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Bar Sara? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante Franco as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Pescara.

After your meal, keep the night alive at a bar like Bar Napoli, known for its lively atmosphere. Bar Supermarket is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Post Bar offers an excellent atmosphere for those looking to amp up the evening.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 3

Day 3

  • Pescara
  • Florence
  • More

Drive 400 km, 4 hours 47 min

  • Ponte Vecchio
  • Uffizi Gallery
  • Palazzo Vecchio
  • Piazza della Repubblica
  • piazza della Signoria
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Florence, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 3 nights.

Get ready for an exciting day in Pescara. Today’s sightseeing agenda includes a historical landmark, an art gallery, a palace, a public square and much more! Begin your adventure at Ponte Vecchio. This is a wondrous historical landmark you should not miss. Another must-see is Uffizi Gallery, an astonishing art gallery in Pescara.

When you’re ready for the next sight, head to Palazzo Vecchio. From there, take a leisurely stroll to Piazza Della Repubblica, another of the city’s popular attractions. We recommend ending your self-guided tour of the city with a remarkable public square. Piazza Della Signoria is a truly remarkable place to visit in Pescara.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your lively evening at Manifattura, a perfect place for winding down or revving up the night, depending on which mood you’re in. Se·sto On Arno Rooftop Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Il Vinile ensures a night out tailored to your taste.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4

  • Florence
  • More

Drive 16 km, 1 hour 9 min

  • Basilica of San Lorenzo
  • Galleria dell'Accademia
  • Basilica of Santa Croce in Florence
  • The Boboli Gardens
  • piazzale Michelangelo
  • Oltrarno
  • More

On day 4 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 2 nights and discover all the best things to see and do in the area.

Don’t miss Oltrarno in Florence today, a must-see neighborhood that offers a glimpse into the city’s vibrant character. Take your time exploring its best features, and enjoy the convenience of nearby top-rated landmarks.

Today’s well-planned self-sightseeing route offers several fun adventures, photo-friendly spots, and historic treasures. Whether you decide to explore Florence on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Basilica Of San Lorenzo is the first of them. Spend some time admiring this respected church before continuing your journey. Galleria Dell'accademia is your next stop. This locally renowned art gallery is one of the best-rated sights in Florence.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Basilica Of Santa Croce In Florence. This heritage-rich church is a sight to behold. To round off your sightseeing experience, visit The Boboli Gardens and Piazzale Michelangelo.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Explore the vibrant nightlife at Bar 50 Rosso after your meal, a hub for lively evenings and memorable moments. Or, head to Bitter Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Archea Brewery is perfect for those looking to extend their night with a touch of local flavor.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 155 km, 2 hours 38 min

  • Pinacoteca Nazionale
  • Siena Cathedral
  • Pubblico Palace
  • Tower of Mangia
  • piazza del Campo
  • Basilica of San Domenico
  • More

Wake up to day 5 of your extraordinary road trip in Italy. With 1 night left in Florence, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Get ready for an exciting day in Florence. Today’s sightseeing agenda includes an art gallery, a church, a palace, a monument, a public square and much more! Begin your adventure at Pinacoteca Nazionale. This is a locally appreciated art gallery you should not miss. Another must-see is Siena Cathedral, a popular church in Florence.

When you’re ready for the next sight, head to Pubblico Palace. From there, take a leisurely stroll to Tower Of Mangia, another of the city’s often recommended attractions. We recommend ending your self-guided tour of the city with a respected public square. Piazza Del Campo is a truly remarkable place to visit in Florence.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Ristorante Buca Mario, a highly-rated dining destination in Florence. If you're eager to try something different, consider Agricola Toscana, another top spot with a tantalizing menu. You might also want to secure a reservation at Eataly Firenze. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

Continue your lively evening at Gosh*, a perfect place for winding down or revving up the night, depending on which mood you’re in. Antico Caffè Del Moro - Art Bar Firenze is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Quelo Bar ensures a night out tailored to your taste.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Florence
  • Rome
  • More

Drive 282 km, 4 hours

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Piazza di Spagna
  • More

On day 6 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 4 nights.

Today’s route brings family-friendly attractions, breathtaking views, and picturesque spots. The first attraction of today is Colosseum. This iconic archeological site is an UNESCO world heritage-listed place to see in Florence. Continue your discovery at Roman Forum, a culturally significant archeological site with stories to tell.

As you stroll around Florence, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Trevi Fountain. This timeless monument offers a visually striking encounter with Florence. Piazza Di Spagna is the last of our recommendations for today. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Florence.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at La Bottega Roma, an excellent option for tonight's dining. Looking for something different? Pasta In Corso offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria Vecchia Roma. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Almalu Trastevere, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • Rome
  • More

Drive 9 km, 1 hour 9 min

  • Pantheon
  • Piazza Navona
  • Castel Sant'Angelo
  • St Peter's Basilica
  • Trastevere
  • Via del Corso
  • More

On day 7 of your road trip, you’ll start and end your day in Rome, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Rome and Vatican City. You still have 3 nights left in Rome.

Trastevere is a neighborhood that stands out as one of the must-see places in Rome. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

Start your day at Pantheon. This standout monument is an iconic place to see in Rome. Then, wander over to Piazza Navona. If history-steeped sites excite you, this public square will be right up your alley. Nearby, you’ll also find Castel Sant'angelo. This visually striking castle is a favorite among visitors.

Rome offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, St. Peter's Basilica is a wondrous spot in the city that will captivate you with its unique charm.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

If you’re not ready to end the night just yet, Sant' Eustachio Caffè offers a perfect venue to relax and savor a drink. Similarly, Yellowsquare Rome is well-suited for those looking to unwind in a social setting. Caffè Portofino is another excellent spot to enjoy a nightcap after a delightful meal.

Savor another day of unforgettable experiences in Italy!

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Day 8

Day 8

  • Rome
  • More

Drive 455 km, 5 hours 20 min

  • Naples National Archaeological Museum
  • Cappella Sansevero
  • Spaccanapoli
  • More

On day 8 of your road trip, you’ll start and end your day in Rome, where you'll stay for 2 nights more.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most interesting attractions included on the itinerary is Naples National Archaeological Museum. This respected museum will help you start your sightseeing on top. Then, take a leisurely stroll to Cappella Sansevero and learn what makes this detailed museum unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the beloved Spaccanapoli.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Hotel de Russie, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of The Parrot Bar, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Explore the vibrant nightlife at The Apartment Bar Roma after your meal, a hub for lively evenings and memorable moments. Or, head to Hotel Hassler Roma for a great selection of flavorful drinks and a charming setting.

Raise your glass to another unforgettable day in Italy!

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Day 9

Day 9

  • Rome
  • More

Drive 507 km, 5 hours 48 min

  • Basilica
  • Castel Sant'Elmo
  • Archbasilica of St. John Lateran
  • Monti
  • More

On day 9 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you will return to Rome for 1 night more, there’s no need to rush. Experience Pompei, Naples, and Rome to the fullest today with this curated day itinerary!

A top thing to do today is to explore Monti, a must-see neighborhood in Pompei. It's the perfect starting point for exploring the top attractions in the area.

Today’s agenda in Rome includes an archeological site, a castle, and a church. Basilica is must-visit archeological site and a great starting point for the day. Next, continue your journey to Castel Sant'elmo, an interesting castle, located just a leisurely stroll away. Next, head to Archbasilica Of St. John Lateran, a picture-perfect church, also available for your discovery today.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at Sofitel Roma Villa Borghese, an excellent option for tonight's dining. Looking for something different? Centro offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Tema. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 10

Day 10

  • Rome
  • Pescara
  • More

Drive 220 km, 2 hours 46 min

  • Nature Reserve Pineta Dannunziana
  • Church Stella Maris
  • Ponte del Mare
  • More

On day 10 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Pescara. When you’re not sightseeing, take time to relax at your selected hotel in Pescara, where you’ll be staying for 1 night.

Bring your curiosity for today’s adventure around Rome. Some of the city’s most loved attractions await. Nature Reserve Pineta Dannunziana is the perfect place to start. This nature reserve is one of the most often recommended places to visit in Rome. Next, head to Church Stella Maris, a curiosity-inducing church, known for its photogenic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Ponte Del Mare. This visually striking boardwalk offers a unique experience that is highly recommended.

When you’re done exploring for the day, you’ll drive to your hotel in Pescara. Check in and spend some time relaxing before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pescara. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delightful dinner at MuuLab. Cucina e Distillati, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Taverna Antica? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante La griglia dell'Orso as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Pescara.

After your meal, keep the night alive at a bar like Enoteca Visaggio Cocktails And Wine, known for its lively atmosphere. Giro' Loungebar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Caffè Ideale offers an excellent atmosphere for those looking to amp up the evening.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 11

Day 11

  • Pescara - Departure day
  • More
  • Parrocchia Spirito Santo
  • More

Day 11 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Parrocchia Spirito Santo, a monumental church before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.

You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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