Luxury 12-Day Italy Road Trip from Genoa traveling east to Florence, Rome, Viterbo, and Pisa

Your luxury holiday in Italy begins as soon as you reach the city of Genoa, where you'll be staying for 1 night. There, you’ll pick up the luxury rental vehicle of your choice and hit the roads!

Make Piazza Corvetto one of your first sightseeing stops in Genoa. Rated an average of 4.2 out of 5 stars by 3,380 travelers, a visit to this local attraction makes for a great introduction to the area.

Tonight, you will be treated to a stay at one of the best luxury hotels in Genoa. We have picked out three of the most exclusive luxury lodging and hotel options for you to choose from.

Discover a world of culinary delights in Genoa, where top-notch dining experiences await at every corner. Consider whether you need to make a reservation in advance to secure a table at your preferred restaurant.

Have a memorable dining experience in Genoa by booking a table at The Cook, renowned as a 1-star Michelin restaurant presenting an exceptional modern menu. For a different culinary experience, San Giorgio shines as one of the top destinations known for its delicious modern and ligurian cuisine in Genoa. This 1-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Il Marin is known as a top local spot for its delicious seafood and contemporary cuisine in Genoa. This 1-star Michelin awardee is a highly recommended choice for an unforgettable meal.

After savoring a delicious meal, step into the vibrant nightlife at Scurreria Beer & Bagel, where the evening is just getting started. In the same way, La Lepre offers a unique charm perfect for experiencing the local bar scene in Genoa.

Raise a toast to the start of your 12-day luxury vacation in Italy and look forward to more fantastic days to come!

Wake up to day 2 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Florence, where you'll be staying for 4 nights. The day's itinerary unfolds with a diverse array of experiences in Genoa.

Seize the day by visiting some of the best attractions in the area, like piazza De Ferrari. This extraordinary square has an average rating of 4.6 out of 5 stars from 34,312 visitors.

Next, make your way to Doge's Palace. This museum is rated an average of 4.6 out of 5 stars in 7,612 reviews.

While in Genoa, we also recommend a visit to Aquarium of Genoa. Hosting around 1,200,000 visitors every year, Aquarium of Genoa is one of the best places to visit. This public aquarium has been rated an average of 4.5 out of 5 stars in 62,259 reviews.

If you’re keen to explore even more, then consider a visit to porto antico. With an average rating of 4.5 out of 5 stars by 12,414 travelers, this port is a highly recommended stop on your sightseeing around Genoa.

Relax and unwind in style as you spend the night at one of the top luxury hotels in in Florence.

After a long day of discovering the unique quirks of Italy, it’s an excellent idea to sit down for a lovely meal or enjoy a refreshing drink. We’ve gathered the most recommended dining and drinking spots in Florence so you can check out the menus and make advance reservations.

Discover the culinary delights of Florence by securing a reservation at Enoteca Pinchiorri. Esteemed for its , this restaurant offers a remarkable selection of italian contemporary cuisine. For an alternative dining experience, try Santa Elisabetta, renowned for its delicious creative and mediterranean dishes. This esteemed 2-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to Gucci Osteria da Massimo Bottura, a highly recommended local eatery celebrated for its mouthwatering italian contemporary and international menu. With its 1-star Michelin recognition, it offers an unforgettable dining adventure.

Explore the vibrant nightlife at Manifattura after your meal, a hub for lively evenings and memorable moments. Or, head to SE·STO on Arno Rooftop Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Archea Brewery is perfect for those looking to extend their night with a touch of local flavor.

Raise your glass and relax after another big day of your luxury holiday in Italy!

On day 3 of your luxurious vacation in Italy, you’ll start and end your day in Florence, but spend most of the day exploring attractions outside of the city. After a long day of sightseeing, you'll drive back to Florence, where you'll stay for 3 nights more.

Start your sightseeing with a visit to The Boboli Gardens. This park is a popular stop on travelers’ itineraries in Florence, with an average rating of 4.2 out of 5 stars by 25,341 visitors.

Piazzale Michelangelo is another popular place of interest you can visit today. The average rating of 4.8 out of 5 stars from 77,744 reviews gives you an idea of other visitors’ experience at this attraction.

As you’ve unraveled the marvels of Florence, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Siena may take around 1 hour 12 min. Upon your arrival in Siena, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Start your sightseeing with a visit to Siena Cathedral. This domus is a popular stop on travelers’ itineraries in Siena, with an average rating of 4.8 out of 5 stars by 21,656 visitors.

Piazza del Campo is another popular place of interest you can visit today. The average rating of 4.8 out of 5 stars from 64,175 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to Fortezza Medicea (Siena). Visitors have rated this fortress an average of 4.5 out of 5 stars in 9,835 reviews.

When you’ve completed everything you want to see and do, you will drive back to your luxury accommodation in Florence.

After exploring the unique sights of Italy, savor a delicious meal or get refreshed with a drink. We’ve gathered the most recommended restaurants and bars in the city of Florence for you so you can browse their menus in advance and make a reservation.

With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

Day 4 of your luxury road trip in Italy begins and concludes in the city of Florence. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Florence, where you still have 2 nights nights remaining.

Seize the day by visiting some of the best attractions in the area, like Central Market. This extraordinary point of interest has an average rating of 4.4 out of 5 stars from 43,100 visitors.

Next, make your way to piazza della Signoria. This square is rated an average of 4.8 out of 5 stars in 66,956 reviews.

While in Florence, we also recommend a visit to Uffizi Gallery. Hosting around 2,011,219 visitors every year, Uffizi Gallery is one of the best places to visit. This national museum has been rated an average of 4.7 out of 5 stars in 61,794 reviews.

If you’re keen to explore even more, then consider a visit to Ponte Vecchio. With an average rating of 4.7 out of 5 stars by 118,099 travelers, this deck arch bridge is a highly recommended stop on your sightseeing around Florence.

Make your way to Pitti Palace, perhaps the most famous art museum in Florence. This attraction welcomes around 198,270 visitors annually and is rated an average of 4.6 out of 5 stars in 23,445 reviews.

After a day filled with travel and exploration, we recommend you treat yourself to a meal or a drink at the finest restaurants and bars in Florence. Savor the local cuisine and relax as you recount the day's experiences.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

Day 5 of your luxury road trip in Italy begins and concludes in the city of Florence. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Florence, where you still have 1 night nights remaining.

Take the opportunity to see Basilica of Santa Croce in Florence. This attraction has an average rating of 4.7 out of 5 stars from 28,544 visitors.

Galleria dell'Accademia is another sightseeing hotspot in the area. This national museum has been rated an average of 4.6 out of 5 stars by 34,429 travelers. Up to 1,719,645 people visit Galleria dell'Accademia every year.

Florence is also the home of Cathedral of Santa Maria del Fiore. Around 76,359 people have rated this church an average of 4.8 out of 5 stars.

Another place you’ll want to visit is Basilica di Santa Maria Novella, Firenze (FI). With an average rating of 4.7 out of 5 stars from a total of 23,075 reviews, a visit to this archives is a great idea.

After exploring the unique sights of Italy, savor a delicious meal or get refreshed with a drink. We’ve gathered the most recommended restaurants and bars in the city of Florence for you so you can browse their menus in advance and make a reservation.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

Wake up to day 6 of your luxury holiday in Italy! Remember to have a hearty breakfast because today will be filled with memorable adventures in Otricoli and Vatican City. With a flexible itinerary, you're free to adapt and explore additional attractions or enjoy spontaneous discoveries.

Fasten your seatbelt and make your way to your next stop. Otricoli, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Florence to Otricoli may take around 2 hours 22 min without traffic disruptions. Upon arrival in Otricoli, we highly recommend checking out some of the top attractions.

When you’re ready for some sightseeing, make your way to Ocriculum Archaeological Park. This much-appreciated park is rated 4.5 out of 5 stars in 228 reviews.

When you arrive in Vatican City, it's time to take a break from the road.

When you're ready to see some sights, Sistine Chapel is a great place to start. This chapel is rated an average of 4.7 out of 5 stars by 52,083 visitors.

Another popular attraction you can visit today is St. Peter's Basilica. This major basilica has an average rating of 4.8 out of 5 stars from 131,043 travelers. Every year, 11,000,000 travelers come to experience this site to make the most of their time in Vatican City.

We also recommend a stop at Vatican Museums. This site gets more than 1,612,530 visitors annually. The art museum has been rated an average of 4.6 out of 5 stars by 133,310 visitors.

Relax and unwind in style as you spend the night at one of the top luxury hotels in in Rome.

After a day filled with travel and exploration, we recommend you treat yourself to a meal or a drink at the finest restaurants and bars in Rome. Savor the local cuisine and relax as you recount the day's experiences.

Set out on a gastronomic journey in Rome by reserving a table at La Pergola. Renowned for its , this restaurant presents an outstanding menu of mediterranean and contemporary cuisine. For a different taste, head over to Il Pagliaccio, renowned for its delectable creative and innovative dishes. This distinguished 2-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Enoteca La Torre, a highly rated local gem known for its exquisite mediterranean and creative menu. With a 2-star Michelin acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, La Botticella of Poggi Giovanni stands out as an excellent choice for a post-dinner cocktail. Alternatively, Sant' Eustachio Caffè offers an ideal atmosphere to enjoy the pleasures of the night. Caffè Portofino is also a great option that provides a perfect setting for a relaxing evening.

Reminisce about your day, look through photos, and prepare for another great day to come! Your stress-free luxury holiday in Italy has plenty more in store for you.

Day 7 of your luxury road trip in Italy begins and concludes in the city of Rome. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Rome, where you still have 2 nights nights remaining.

Begin your sightseeing with a visit to Circus Maximus. This circus is rated an average of 4.4 out of 5 stars in 44,741 reviews.

Next up, make your way to Pantheon. This roman temple has an average rating of 4.8 out of 5 stars from 189,682 reviews. Usually, around 30,000,000 people visit Pantheon every year.

When you’re ready for your next sight of the day, continue to Trevi Fountain. This sculpture has an average rating of 4.8 out of 5 stars from 343,494 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza di Spagna. This square is rated an average of 4.7 out of 5 stars by 113,658 visitors.

If you’re keen to explore even more, then consider a visit to Spanish Steps. This monumental staircase is a much-appreciated attraction with an average rating of 4.5 out of 5 stars from 57,211 visitors.

After a full day of exploring, treat yourself to a delightful dinner or a refreshing drink at the best spots in Rome. Choose from a selection of excellent restaurants and bars and find the perfect place for your evening.

This renowned restaurant holds , and offers an exceptional menu of cuisine.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Raise a toast to another amazing day of your luxury holiday in Rome, Italy and seize the opportunity to celebrate.

Day 8 of your luxury road trip in Italy begins and concludes in the city of Rome. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Rome, where you still have 1 night nights remaining.

When you're ready to see some sights, Campo de' Fiori is a great place to start. This square is rated an average of 4.4 out of 5 stars by 51,133 visitors.

Another popular attraction you can visit today is Piazza Navona. This square has an average rating of 4.7 out of 5 stars from 158,771 travelers.

We also recommend a stop at Castel Sant'Angelo. This site gets more than 918,591 visitors annually. The museum has been rated an average of 4.7 out of 5 stars by 72,431 visitors.

If you're keen to explore more, consider visiting piazza del Popolo. This square is a popular attraction with an average rating of 4.6 out of 5 stars from 89,807 reviews.

Villa Borghese is another easily accessible place to visit on this day of your trip. Stop by this urban zone of rome, rated 4.6 out of 5 stars in 69,749 reviews, to discover more of what makes it unique.

In Rome, delicious dining experiences are never far from reach. Take your pick and consider whether you need to book a table in advance.

Reminisce about your day, look through photos, and prepare for another great day to come! Your stress-free luxury holiday in Italy has plenty more in store for you.

On day 9 of your luxury holiday in Italy, your road trip route will take you exploring the best of Rome. With a day brimming with amazing attractions ahead, fuel up with a hearty breakfast to savor every moment of your luxury vacation in Italy.

Make largo di Torre Argentina your first stop of the day. Previous visitors have rated this square an average of 4.5 out of 5 stars in 30,433 reviews.

Next up, make a stop at Altare della Patria. With an average rating of 4.8 out of 5 stars by 49,843 visitors, it's easy to understand why so many people visit this architectural structure every year. In fact, this attraction welcomes 1,683,070 annual visitors.

Roman Forum is another attraction you can visit on this day of your vacation. This square has an average rating of 4.7 out of 5 stars by 114,450 visitors.

When you’re finished at Roman Forum, the perfect next stop is Colosseum. This roman amphitheatre is rated an average of 4.7 out of 5 stars in 328,821 reviews. Colosseum attracts approximately 7,400,000 visitors annually.

If you’re keen to explore even more, then consider a visit to Basilica di Santa Maria Maggiore. This major basilica is a top place to visit, with a rating of 4.8 out of 5 stars from 27,678 reviews.

Relax and unwind in style as you spend the night at one of the top luxury hotels in in Viterbo.

In Viterbo, delicious dining experiences are never far from reach. Take your pick and consider whether you need to book a table in advance.

As a top-rated it is an ideal choice in the city.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

Wake up to day 10 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Pisa, where you'll be staying for 1 night. The day's itinerary unfolds with a diverse array of experiences in Viterbo.

Take the opportunity to see Piazza del Plebiscito. This attraction has an average rating of 4.3 out of 5 stars from 3,004 visitors.

Palazzo dei Papi di Viterbo is another sightseeing hotspot in the area. This palace has been rated an average of 4.5 out of 5 stars by 6,905 travelers.

Viterbo is also the home of Fontana Grande. Around 672 people have rated this park an average of 4.4 out of 5 stars.

Relax and unwind in style as you spend the night at one of the top luxury hotels in in Pisa.

Treat yourself after a day of exploration. Make a reservation at the finest dining and drinking spots in Pisa.

Extend your evening after a delightful meal by visiting JEFFER cocktails & friends, which offers the perfect atmosphere for a night out. Moreover, Le Parisien Wine Bar is another popular option for a drink or two. Likewise, Las Volta cocktailbar also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to another amazing day of your luxury holiday in Viterbo, Italy and seize the opportunity to celebrate.

Wake up to day 11 of your luxury holiday in Italy! Remember to have a hearty breakfast because today will be filled with memorable adventures in Pisa. With a flexible itinerary, you're free to adapt and explore additional attractions or enjoy spontaneous discoveries.

When you're ready to see some sights, Knights' Square is a great place to start. This square is rated an average of 4.5 out of 5 stars by 9,051 visitors.

Another popular attraction you can visit today is Leaning Tower of Pisa. This bell tower has an average rating of 4.7 out of 5 stars from 116,882 travelers. Every year, 3,200,000 travelers come to experience this site to make the most of their time in Pisa.

We also recommend a stop at Pisa Cathedral. The cathedral has been rated an average of 4.8 out of 5 stars by 8,361 visitors.

If you're keen to explore more, consider visiting Piazza del Duomo, Pisa. This square is a popular attraction with an average rating of 4.7 out of 5 stars from 104,550 reviews.

Campo santo is another easily accessible place to visit on this day of your trip. Stop by this cemetery, rated 4.6 out of 5 stars in 586 reviews, to discover more of what makes it unique.

Relax and unwind in style as you spend the night at one of the top luxury hotels in in Genoa.

Discover a world of culinary delights in Genoa, where top-notch dining experiences await at every corner. Consider whether you need to make a reservation in advance to secure a table at your preferred restaurant.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

Today is the last day of your 12-day luxury holiday in Italy and it’s soon time to start your journey home. This is your chance to get one last glimpse of Genoa before saying goodbye.

Make the most of your final day in Italy by visiting Genoa’s iconic markets and shopping establishments. Your stay’s proximity to the city’s retail haven invites an unhurried and unforgettable exploration of its variety of stores and establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy. Take home a piece of Italy with these souvenirs, keeping your adventures close.

Make the most of what's left of your luxury vacation and head out to the stunning Via Garibaldi. This extraordinary sightseeing destination and attraction is rated an average of 4.6 out of 5 stars in 5,399 reviews, and is an excellent choice for your last sightseeing in Genoa.

Treat yourself to a final feast. Savor the unique flavors of Genoa one last time before you head to the airport.

Savor the flavors at OVER SEA. , a top pick for dinner tonight. Alternatively, Osteria di Vico Palla beckons with its unique menu offerings.

You will then say farewell to Genoa and begin your journey home. We wish you safe travels and a warm welcome home, with unforgettable memories and incredible photos from your luxury holiday in Italy in your luggage!