6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Portofino and Florence

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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Portofino, Levanto, Vernazza, Corniglia, Manarola, Pisa, Florence, Greve in Chianti, and San Gimignano. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Portofino, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Cathedral Of Santa Maria Del Fiore, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Portofino, Levanto, Vernazza, Corniglia, Manarola, Pisa, Florence, Greve in Chianti, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
porto anticoAquarium of GenoaGalata - Museo del mareLighthouse of GenoaArea Marina Protetta di PortofinoLa Cervara - San Girolamo Abbey at Monte di Portofino
Punta MescoSentiero Monterosso - VernazzaRuins of Doria TowerCinque Terre National ParkManarola Overlook Viewpoint
Leaning Tower of PisaPiazza del Duomo, PisaThe Boboli GardensBasilica of Santa Croce in FlorenceCathedral of Santa Maria del Fiore
Ponte VecchioUffizi GalleryCastle of VerrazzanoSanGimignano1300
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Genoa's charm before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Genoa. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at 7 Sensi cucina decontaminata, a highly-rated dining destination in Genoa. If you're eager to try something different, consider Alla Lunga Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at Grand Hotel Savoia. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Genoa this evening.

After enjoying a fulfilling meal, continue your evening at Scurreria Beer & Bagel, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, La Lepre offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Pisacane Iii provides an excellent environment for a relaxed and enjoyable evening.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 64 km, 2 hours 18 min

  • porto antico
  • Aquarium of Genoa
  • Galata - Museo del mare
  • Lighthouse of Genoa
  • Area Marina Protetta di Portofino
  • La Cervara - San Girolamo Abbey at Monte di Portofino
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Genoa, San Fruttuoso di Camogli, and Paraggi. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Portofino. You will spend 2 nights here for some well-deserved relaxation.

Today's adventure in Genoa promises more breathtaking discoveries and enriching experiences! Begin at Porto Antico. This visually striking public square is a highlight of any visit in the city. Then, enjoy Aquarium Of Genoa, another mesmerizing attraction that never fails to captivate visitors. Next, head over to Galata Museo Del Mare (complex), one of the city’s most up-and-coming attractions, known for its photogenic features.

If you’re looking for more, spend time soaking in the atmosphere of Lighthouse Of Genoa. This historic lighthouse is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Area Marina Protetta Di Portofino, a curiosity-inducing nature reserve, and take a stroll around the area.

When you’re done exploring for the day, you’ll drive to your hotel in Portofino. Check in and spend some time relaxing before you head out to tour the village.

As you explore more of Portofino, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Dine in style at Trattoria Concordia, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti boasts a menu that's sure to impress. Also, be sure to check out Ristorante Puny. Known as a local hotspot, it’s a great choice for tonight in Portofino.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 3

Day 3

  • Portofino
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Drive 214 km, 4 hours 48 min

  • Punta Mesco
  • Sentiero Monterosso - Vernazza
  • Ruins of Doria Tower
  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • More

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Portofino, we encourage you to seize the day and discover the unexplored beauty of the village’s surroundings!

Discover a day packed with family-friendly attractions, romantic experiences, and natural wonders in Portofino. Begin your sightseeing with Punta Mesco. This worthwhile hiking area is one of the top attractions in the city. Proceed to Sentiero Monterosso - Vernazza, another must-visit attraction that enhances the city’s allure.

As you wander through the inviting streets of Portofino, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Ruins Of Doria Tower. This intriguing monument is a traveler-favorite. Not far away, you’ll find Cinque Terre National Park, another key site on your sightseeing itinerary. Conclude your day at Manarola Overlook Viewpoint and uncover why it's recognized as one of the city's most curiosity-inducing attractions.

When you’re done exploring for the day, you’ll return to Portofino and your accommodation.

As you explore more of Portofino, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at I Gemelli, an iconic dining spot in Portofino. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Taverna del marinaio, a popular restaurant in Portofino. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Lo Stella, a hidden gem nestled in Portofino. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 4

Day 4

  • Portofino
  • Florence
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Drive 233 km, 3 hours 54 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • The Boboli Gardens
  • Basilica of Santa Croce in Florence
  • Cathedral of Santa Maria del Fiore
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Pisa and Florence, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 1 night.

Get ready to discover some of the most iconic wonders in Portofino, including a monument, a public square, a botanical garden, a church and much more! Start your day at Leaning Tower Of Pisa. This breathtaking monument is a world-famous place to see in Portofino. Then, wander over to Piazza Del Duomo, Pisa. If historic sites excite you, this public square will be right up your alley. Nearby, you’ll also find The Boboli Gardens. This enchanting botanical garden is a favorite among visitors.

Portofino offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Basilica Of Santa Croce In Florence is a well-known spot in the city that will captivate you with its unique charm. When you’re done at the church, don’t forget to check out the inviting Cathedral Of Santa Maria Del Fiore. Take a moment to appreciate the fascinating details of this spectacular church in Portofino.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.

If you’re not ready to end the night just yet, Manifattura offers a perfect venue to relax and savor a drink. Similarly, Se·sto On Arno Rooftop Bar is well-suited for those looking to unwind in a social setting. Il Vinile is another excellent spot to enjoy a nightcap after a delightful meal.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • Genoa
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Drive 314 km, 4 hours 50 min

  • Ponte Vecchio
  • Uffizi Gallery
  • Castle of Verrazzano
  • SanGimignano1300
  • More

On day 5 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence, Greve in Chianti, and San Gimignano. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

Enjoy the perfect balance of relaxation and exploration in Florence today. One of the most timeless attractions included on the itinerary is Ponte Vecchio. This visually striking historical landmark will help you start your sightseeing on top. Then, take a leisurely stroll to Uffizi Gallery and learn what makes this instagrammable art gallery unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the intriguing Castle Of Verrazzano. After exploring the castle, head to Sangimignano1300. This worthwhile museum is a highlight in Florence.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Genoa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Zeffirino, an excellent option for tonight's dining. Looking for something different? Trattoria Vegia Zena offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria delle Grazie. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Genoa.

Raise your glass to another unforgettable day in Italy!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Via Garibaldi, a romantic street before you head out.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area, Porto Antico. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Have a fantastic dining experience at Osteria Sant'Ilario, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Cialtroneria offers an enticing alternative with its varied menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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