Luxury One-Week Italy Road Trip from Genoa traveling east to Pisa, Perugia, Rome, and Florence

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Set off on the ultimate travel extravagance with this 8-day luxury road trip across Italy. Every aspect of your journey is crafted to provide a sophisticated and comfortable experience. Enjoy a holiday where luxury unfolds at every turn in each stop of your adventure in Italy.

Italy offers the ultimate luxury holiday experience for anyone up for an unforgettable adventure, including couples, families, solo travelers, and friends.

Your exclusive luxury holiday package will bring you to the country's most popular attractions and restaurants in the best destinations in Italy. With this perfectly planned vacation itinerary, you will stay 2 nights in Genoa, 1 night in Pisa, 1 night in Perugia, 2 nights in Rome, and 1 night in Florence, experiencing the ultimate luxury vacation in Italy.

Finding the perfect luxury lodging is going to make your vacation in Italy feel truly special. The home for your 8-day luxury holiday will be only the most exclusive 5-star hotels in Italy. You will choose from the best selection of luxury hotels and places to stay, all conveniently located along your carefully planned self-drive route.

Upon arriving in Italy, you will collect the luxury rental vehicle of your choice. We will provide you with the best car rental for the entirety of your 8-day luxury self-drive holiday, including CDW insurance. From there, you will drive off at a relaxed pace to discover some of the best travel destinations in Italy.

Throughout your exclusive vacation in Italy, you will get to experience some of the best attractions and activities offered in the country. Each moment promises to be filled with unforgettable memories and unique experiences.

Between attractions and activities, you will have plenty of time to stroll along the best shopping streets and markets in Italy. Here you can find unique souvenirs to preserve the memory of your luxury holiday in Italy.

This exclusive travel plan is designed to include everything you need to have the best vacation in Italy. By booking this luxury holiday package, you can avoid spending hours researching and planning your 8-day road trip in Italy. Let the experts figure out the details, so you can focus on enjoying.

To deliver the best experience possible, we make it easy for you to customize each day of your luxury holiday in Italy before and after booking. Our flexible trip planning means you will be able to explore Genoa, Pisa, Siena, Perugia, Rome, and Florence at your own pace.

Book with us to get access to 24/7 personal travel support throughout your entire journey. Enjoy a step-by-step guide in our easy-to-use mobile app, including all travel documents for your exclusive getaway to Italy.

The best flights, activities, tours, and hotels in Italy fill up quickly, so book your luxury vacation package in advance. Select a date and start planning your luxury holiday in Italy today!

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Day 1

Day 1 – Genoa - arrival day

  • Genoa - Arrival day
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  • Porto Antico
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Your luxury holiday in Italy begins as soon as you reach the city of Genoa. There, you’ll pick up the luxury rental vehicle of your choice and hit the roads!

An excellent attraction to start your day with is Porto Antico. This port is rated an average of 4.5 out of 5 stars in 12,414 reviews.

Tonight, you will be treated to a stay at one of the best luxury hotels in Genoa. We have picked out three of the most exclusive luxury lodging and hotel options for you to choose from.

After exploring the unique sights of Italy, savor a delicious meal or get refreshed with a drink. We’ve gathered the most recommended restaurants and bars in the city of Genoa for you so you can browse their menus in advance and make a reservation.

Have a fantastic dining experience at Trattoria Vegia Zena, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria delle Grazie offers an enticing alternative with its varied menu. Additionally, Manhattan Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Continue the enjoyment post-dinner at Scurreria Beer & Bagel, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, La Lepre offers a vibrant space for indulging in well-crafted drinks and engaging conversation.

Raise a toast to the start of your 8-day luxury vacation in Italy and look forward to more fantastic days to come!

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Day 2

Day 2 – Genoa, and Pisa

  • Pisa
  • Genoa
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Drive 176 km, 2 hours 17 min

  • Piazza De Ferrari
  • Doge's Palace
  • Cattedrale di San Lorenzo
  • Aquarium of Genoa
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On day 2 of your luxury holiday in Italy, your road trip route will take you exploring the best of Genoa. The day's journey will conclude in Pisa, a city that offers you comfort and relaxation for 1 night. With a day brimming with amazing attractions ahead, fuel up with a hearty breakfast to savor every moment of your luxury vacation in Italy.

When you’re ready for some sightseeing, make your way to Piazza De Ferrari. This much-appreciated square is rated 4.6 out of 5 stars in 34,312 reviews.

Next up is Doge's Palace. This museum has an average rating of 4.6 out of 5 stars from 7,612 visitors.

Another top sightseeing recommendation is Genoa Cathedral. This cathedral has been rated 4.6 out of 5 stars in 8,971 reviews.

Aquarium Of Genoa is another attraction you have the opportunity to visit today. This public aquarium has an average rating of 4.5 out of 5 stars from 62,259 reviews. This popular attraction gets 1,200,000 visits every year.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Pisa. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

Discover a world of culinary delights in Pisa, where top-notch dining experiences await at every corner. Consider whether you need to make a reservation in advance to secure a table at your preferred restaurant.

Treat yourself to a delicious dinner at Ristorante Capodimonte Pisa, an excellent option for tonight's dining. Looking for something different? Baribaldi Pisa offers a tantalizing alternative with its diverse menu. And don’t miss Restaurant -Pizzeria Il Mio Capriccio. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Pisa.

Round off your dining experience by visiting Jeffer Cocktails & Friends, a prime location for a drink. Alternatively, explore the distinctive characteristics of Le Parisien Wine Bar, a bar catering to every mood and preference. Las Volta Cocktailbar likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to another amazing day of your luxury holiday in Genoa, Italy and seize the opportunity to celebrate.

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Day 3

Day 3 – Pisa, Siena, and Perugia

  • Perugia
  • Pisa
  • Siena
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Drive 235 km, 3 hours 35 min

  • Leaning Tower of Pisa
  • Piazza del Duomo
  • Duomo di Siena
  • Piazza del Campo
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Wake up to day 3 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Perugia, where you'll be staying for 1 night. The day's itinerary unfolds with a diverse array of experiences in Pisa, and Siena.

Kick off the day at Leaning Tower Of Pisa, a top pick for today’s sightseeing. Attracting approximately 3,200,000 visits every year, this attraction is a must-see. This bell tower is rated an average of 4.7 out of 5 stars in 116,882 reviews.

Today is also your chance to visit Piazza Del Duomo, Pisa. Piazza Del Duomo, Pisa is a square with an average rating of 4.7 out of 5 stars from 104,550 reviews.

Continue your road trip and head to your next destination, Siena. This car ride takes around 1 hour 50 min.

An excellent attraction to start your day with is Siena Cathedral. This domus is rated an average of 4.8 out of 5 stars in 21,656 reviews.

Continue your journey at Piazza Del Campo. This square is rated 4.8 out of 5 stars by 64,175 travelers from near and far.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Perugia. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After a day filled with travel and exploration, we recommend you treat yourself to a meal or a drink at the finest restaurants and bars in Perugia. Savor the local cuisine and relax as you recount the day's experiences.

Make sure to book a table at Ristorante Settimo Sigillo, a popular restaurant in Perugia. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Perugia at Bar Pellas, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is La Taverna. As a dining spot that gains high praise from guests, it’s an ideal choice to enhance your time to Perugia tonight.

To truly maximize your evening out, consider visiting Tommi Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Valentina, another bar with an inviting ambiance. Similarly, Caffe Dal Perugino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Raise your glass and relax after another big day of your luxury holiday in Italy!

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Day 4

Day 4 – Perugia, Vatican City, and Rome

  • Rome
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Drive 184 km, 3 hours

  • Vatican Museums
  • Saint Peter's Square
  • Sistine Chapel
  • St Peter's Basilica
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Wake up to day 4 of your luxury holiday in Italy! Remember to have a hearty breakfast because today will be filled with memorable adventures in Vatican City. With a flexible itinerary, you're free to adapt and explore additional attractions or enjoy spontaneous discoveries.

After soaking in Perugia’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Vatican City, Vatican City. Expect your car journey to take a minimum of 2 hours 17 min. When you arrive in Vatican City, it's time to take a break from the road.

Seize the day by visiting some of the best attractions in the area, like Vatican Museums. This extraordinary art museum has an average rating of 4.6 out of 5 stars from 133,310 visitors. Each year, around 1,612,530 people visit this remarkable site to admire its features and learn more about it.

Next, make your way to Saint Peter's Square. This square is rated an average of 4.8 out of 5 stars in 38,954 reviews.

While in Vatican City, we also recommend a visit to Sistine Chapel. This chapel has been rated an average of 4.7 out of 5 stars in 52,083 reviews.

If you’re keen to explore even more, then consider a visit to St. Peter's Basilica. This attraction gets around 11,000,000 yearly visitors. With an average rating of 4.8 out of 5 stars by 131,043 travelers, this major basilica is a highly recommended stop on your sightseeing around Vatican City.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Rome. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After a long day of exploring, it’s a great idea to relax with a lovely dinner or a refreshing drink. We’ve gathered the most recommended dining and drinking spots in Rome for you, so you can check out the menus and make your reservation in advance.

Experience a harmony of flavors at La Pergola in Rome by securing a reservation in advance. Known for its 3-star Michelin status, La Pergola offers a delightful variety of dishes highlighting its delicious mediterranean, and contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Il Pagliaccio, a highly recommended restaurant known for its enticing creative, and innovative cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Enoteca La Torre, a highly acclaimed restaurant celebrated for its exceptional mediterranean, and creative menu.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Sant' Eustachio Caffè is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Caffè Portofino ensures a night out tailored to your taste.

Reminisce about your day, look through photos, and prepare for another great day to come! Your stress-free luxury holiday in Italy has plenty more in store for you.

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Day 5

Day 5 – Rome

  • Rome
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Drive 7 km, 1 hour 10 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • Roman Forum
  • Colosseum
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Day 5 of your luxury road trip in Italy begins and concludes in the city of Rome. Set out by car to explore incredible attractions in the nearby area. After a day filled with sightseeing, you'll return to Rome, where you still have 1 night nights remaining.

When you’re ready for some sightseeing, make your way to Castel Sant'angelo. This much-appreciated museum is rated 4.7 out of 5 stars in 72,431 reviews. Each year, 918,591 people visit this site to admire its unique features.

Next up is Piazza Navona. This square has an average rating of 4.7 out of 5 stars from 158,771 visitors.

Another top sightseeing recommendation is Pantheon. This roman temple has been rated 4.8 out of 5 stars in 189,682 reviews. Every year, 30,000,000 travelers include this attraction on their travel itinerary.

Roman Forum is another attraction you have the opportunity to visit today. This square has an average rating of 4.7 out of 5 stars from 114,450 reviews.

To continue your sightseeing, head over to Colosseum. This roman amphitheatre is rated an average of 4.7 out of 5 stars in 328,821 reviews. Approximately 7,400,000 people come to see this attraction every year.

Treat yourself after a day of exploration. Make a reservation at the finest dining and drinking spots in Rome.

Treat yourself to a delightful dinner at DEROMA - Farine Romane, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Taverna Italiana? It's another excellent option with a diverse menu. Consider reserving a table at Centro as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

After savoring a delicious meal, step into the vibrant nightlife at The Apartment Bar Roma, where the evening is just getting started. In the same way, Hotel Hassler Roma offers a unique charm perfect for experiencing the local bar scene in Rome.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

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Day 6

Day 6 – Rome, and Florence

  • Florence
  • Rome
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Drive 280 km, 3 hours 54 min

  • Altar of the Fatherland
  • Trevi Fountain
  • Piazza di Spagna
  • Piazza del Popolo
  • Villa Borghese
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On day 6 of your luxury holiday in Italy, your road trip route will take you exploring the best of Rome. The day's journey will conclude in Florence, a city that offers you comfort and relaxation for 1 night. With a day brimming with amazing attractions ahead, fuel up with a hearty breakfast to savor every moment of your luxury vacation in Italy.

Begin your sightseeing with a visit to Altare Della Patria. This architectural structure gets 1,683,070 visitors each year and is rated an average of 4.8 out of 5 stars in 49,843 reviews.

Next up, make your way to Trevi Fountain. This sculpture has an average rating of 4.8 out of 5 stars from 343,494 reviews.

When you’re ready for your next sight of the day, continue to Piazza Di Spagna. This square has an average rating of 4.7 out of 5 stars from 113,658 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza Del Popolo. This square is rated an average of 4.6 out of 5 stars by 89,807 visitors.

If you’re keen to explore even more, then consider a visit to Villa Borghese. This urban zone of rome is a much-appreciated attraction with an average rating of 4.6 out of 5 stars from 69,749 visitors.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Florence. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After a long day of discovering the unique quirks of Italy, it’s an excellent idea to sit down for a lovely meal or enjoy a refreshing drink. We’ve gathered the most recommended dining and drinking spots in Florence so you can check out the menus and make advance reservations.

Discover the culinary delights of Florence by securing a reservation at Enoteca Pinchiorri. Esteemed for its 3-star Guide Michelin recognition, this restaurant offers a remarkable selection of italian contemporary cuisine. For an alternative dining experience, try Santa Elisabetta, renowned for its delicious creative, and mediterranean dishes. This esteemed 2-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to Gucci Osteria da Massimo Bottura, a highly recommended local eatery celebrated for its mouthwatering italian contemporary, and international menu. With its 1-star Michelin recognition, it offers an unforgettable dining adventure.

Keep the evening going at Manifattura, a great choice for enjoying the after-dinner hours with a drink. You could also go to Se·sto On Arno Rooftop Bar, which offers a similarly pleasant setting and great drinks. Another option is Archea Brewery, which provides an inviting environment for unwinding after a busy day out.

Reminisce about your day, look through photos, and prepare for another great day to come! Your luxury holiday in Italy has plenty more in store for you.

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Day 7

Day 7 – Florence, and Genoa

  • Genoa
  • Florence
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Drive 243 km, 3 hours 44 min

  • Piazza della Signoria
  • Cathedral of Santa Maria del Fiore
  • Ponte Vecchio
  • Piazzale Michelangelo
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Wake up to day 7 of your luxury road trip holiday in Italy! Today, you will get the opportunity to visit multiple fantastic bucket-list destinations in the country as you head towards the city of Genoa, where you'll be staying for 1 night. The day's itinerary unfolds with a diverse array of experiences in Florence.

Seize the day by visiting some of the best attractions in the area, like Piazza Della Signoria. This extraordinary square has an average rating of 4.8 out of 5 stars from 66,956 visitors.

Next, make your way to Cathedral Of Santa Maria Del Fiore. This church is rated an average of 4.8 out of 5 stars in 76,359 reviews.

While in Florence, we also recommend a visit to Central Market. This sightseeing destination has been rated an average of 4.4 out of 5 stars in 43,100 reviews.

If you’re keen to explore even more, then consider a visit to Ponte Vecchio. With an average rating of 4.7 out of 5 stars by 118,099 travelers, this deck arch bridge is a highly recommended stop on your sightseeing around Florence.

Make your way to Piazzale Michelangelo, perhaps the most famous square in Florence. This attraction is rated an average of 4.8 out of 5 stars in 77,744 reviews.

Relax and unwind in style as you spend the night at one of the top luxury hotels in Genoa. Recharge after a day of exploring, enjoying luxurious comfort and serene surroundings.

After exploring the unique sights of Italy, savor a delicious meal or get refreshed with a drink. We’ve gathered the most recommended restaurants and bars in the city of Genoa for you so you can browse their menus in advance and make a reservation.

Start your culinary exploration in Genoa by securing a reservation at The Cook. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of modern cuisine. For another dining delight, visit San Giorgio, celebrated for its delectable modern, and ligurian menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Marin, a top local spot known for its tantalizing seafood, and contemporary menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Celebrate another great day of your luxury holiday in Italy with a toast! Enjoy a great night’s sleep at your lovely hotel and get ready for another fun day to come.

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Day 8

Day 8 – Genoa - departure day

  • Genoa - Departure day
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  • Via Garibaldi
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Today is the last day of your 8-day luxury holiday in Italy and it’s soon time to start your journey home. This is your chance to get one last glimpse of Genoa before saying goodbye.

On your last day in Italy, take time to indulge in shopping at Genoa’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.

Make the most of what's left of your luxury vacation and head out to the stunning Via Garibaldi. This extraordinary point of interest and attraction is rated an average of 4.6 out of 5 stars in 5,399 reviews, and is an excellent choice for your last sightseeing in Genoa.

Treat yourself to a final feast. Savor the unique flavors of Genoa one last time before you head to the airport.

Savor the flavors at OVER SEA. , a top pick for dinner tonight. Alternatively, Osteria di Vico Palla beckons with its unique menu offerings.

You will then say farewell to Genoa and begin your journey home. We wish you safe travels and a warm welcome home, with unforgettable memories and incredible photos from your luxury holiday in Italy in your luggage!

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