10-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Siena, and Rome
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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Genoa, 2 nights in Florence, 2 nights in Siena, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Genoa, Riomaggiore, Manarola, Corniglia, Pisa, Florence, Siena, San Gimignano, Montalcino, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
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Day 1
- Genoa - Arrival day
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- piazza De Ferrari
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 3 nights immersing yourself in Genoa's charm before embarking on the next leg of your journey.
Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.
Make sure to reserve a table at 7 Sensi cucina decontaminata, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Alla Lunga Ristorante, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Grand Hotel Savoia, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Unwind after your meal by stepping into Scurreria Beer & Bagel. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, La Lepre offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Pisacane Iii, another top-rated bar in the area.
Raise a toast to the start of your 10-day road trip in Italy!
Day 2
- Genoa
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Drive 15 km, 1 hour 20 min
- Lighthouse of Genoa
- Galata - Museo del mare
- Aquarium of Genoa
- porto antico
- Via Garibaldi
- Piazza della Vittoria
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On day 2 of your road trip, you will have an entire day to explore Genoa. You’ll stay in Genoa for 2 nights and discover all the best things to see and do in the area.
Genoa is brimming with adventures. Today’s wonderful stops include a lighthouse, a maritime museum, an aquarium, a public square, a street and much more! Begin your sightseeing adventure at the often recommended Lighthouse Of Genoa and allow yourself time to explore. Just a short distance away you'll find your next stop, Galata Museo Del Mare (complex), a history-steeped maritime museum that draws visitors from far and near.
Continue your journey to Aquarium Of Genoa, one of the city’s most impressive spots that you shouldn’t miss. Another great site to visit is the notable Porto Antico. When you're finished at the public square, Via Garibaldi awaits your visit. This street is an UNESCO world heritage-designated highlight on today's itinerary. Last up is a public square - the frequently visited Piazza Della Vittoria.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at Zeffirino, a highly-rated dining destination in Genoa. If you're eager to try something different, consider Trattoria Vegia Zena, another top spot with a tantalizing menu. You might also want to secure a reservation at Trattoria delle Grazie. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Genoa this evening.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 3
- Genoa
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Drive 240 km, 4 hours 21 min
- Riomaggiore
- Manarola Overlook Viewpoint
- Cinque Terre National Park
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Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Genoa, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
Bring your curiosity for today’s adventure around Genoa. Some of the village’s most loved attractions await! Riomaggiore is the perfect place to start. This sightseeing destination is one of the most frequently visited places to visit in Genoa. Next, head to Manarola Overlook Viewpoint, a curiosity-inducing observation deck, known for its romantic features.
In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Cinque Terre National Park. This eye-catching national park is a highly recommended experience. Visit these for an interesting touch to your journey.
When you’re done exploring for the day, you’ll return to Genoa and your accommodation.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at Osteria Sant'Ilario, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider La Cialtroneria, another top spot with a mouthwatering menu. You might also want to secure a reservation at Manhattan Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.
Raise your glass to another unforgettable day in Italy!
Day 4
- Genoa
- Florence
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Drive 263 km, 3 hours 47 min
- Knights' Square
- Leaning Tower of Pisa
- Pisa Cathedral
- Piazza del Duomo, Pisa
- Battistero di San Giovanni
- Campo santo
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Dive into day 4 of your remarkable road trip in Italy. Today you will explore Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 2 nights.
Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Genoa allows for both. Start by heading to Knights' Square. This intriguing public square provides an insightful glimpse into the city's identity. Next, discover Leaning Tower Of Pisa, a breathtaking monument, promising a delightful encounter.
Continue your sightseeing with a visit to Pisa Cathedral, a worthwhile church. When you’re done, don’t forget to make a stop at the timeless Piazza Del Duomo, Pisa. Not far away from the public square, you will find the breathtaking Campo Santo, perfect for a quick visit. Round off your day at Battistero Di San Giovanni, another gem in Genoa with breathtaking features to discover.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Unwind after your meal by stepping into Manifattura. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Se·sto On Arno Rooftop Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Il Vinile, another top-rated bar in the area.
Celebrate another amazing day of your road trip adventure in Italy!
Day 5
- Florence
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Drive 8 km, 1 hour 3 min
- Cathedral of Santa Maria del Fiore
- Palazzo Vecchio
- Ponte Vecchio
- Uffizi Gallery
- Basilica of Santa Croce in Florence
- piazzale Michelangelo
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Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.
Savor the day by visiting some of the best places to see in Florence, including a church, a palace, a historical landmark, an art gallery, an observation deck and much more! Start your adventure at Cathedral Of Santa Maria Del Fiore. This astonishing church is a must-visit for travelers looking for a unique holiday experience. Make your way to Palazzo Vecchio located in Florence for another exciting encounter.
Next, immerse yourself in the setting of Ponte Vecchio. Its history-steeped features will captivate you. After the historical landmark, continue your tour of the city with a visit to Uffizi Gallery. Visitors usually appreciate the picture-perfect features of this art gallery. Next up is Basilica Of Santa Croce In Florence, a highly recommended church. For a change of pace, head to Piazzale Michelangelo. As one of the most widely recognized attractions in Florence, this observation deck is the perfect place to end your self-guided sightseeing tour.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Dine in style at Ditta Artigianale, a top recommendation for dinner tonight. Or, for a change of pace, Trattoria Da Burde boasts a menu that's sure to impress. Also, be sure to check out Casa Toscana. Known as a local hotspot, it’s a great choice for tonight in Florence.
To truly maximize your evening out, consider visiting Bar 50 Rosso after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Bitter Bar, another bar with an inviting ambiance. Similarly, Archea Brewery also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 6
- Florence
- Siena
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Drive 159 km, 3 hours 8 min
- Fortezza Medicea
- Tower of Mangia
- piazza del Campo
- Facciatone
- Siena Cathedral
- Piazza del Duomo, San Gimignano
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Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Siena and San Gimignano. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 2 nights.
Today, you'll explore some of the most beautiful places in Florence, including a monument, a public square, an observation deck, a church and much more! Start your day with a visit to Fortezza Medicea (siena). This up-and-coming monument is a must-visit in the city. When you’re ready for your next discovery, continue to Tower Of Mangia, which may be one of the most respected places you will experience today.
One of the best things about exploring Florence on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Piazza Del Campo, an impressive public square in the city. If you’re up for more discoveries, don’t forget to reserve some time for Facciatone and Siena Cathedral. End your day with a visit to Piazza Del Duomo, a curiosity-inducing public square that’s sure to leave a lasting impression.
When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.
Treat yourself to a delightful dinner at Enoteca I Terzi, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorante Tar-Tufo? It's another excellent option with a diverse menu. Consider reserving a table at Antica Trattoria Papei as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Siena.
If you’re not ready to end the night just yet, Meet Life Cafè offers a perfect venue to relax and savor a drink. Similarly, Maudit Pub is well-suited for those looking to unwind in a social setting. Bar Impero Siena is another excellent spot to enjoy a nightcap after a delightful meal.
Say good night to Siena and look forward to another great day of your road trip in Italy!
Day 7
- Siena
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Drive 84 km, 1 hour 54 min
- Fortress of Montalcino
- Piazza del Popolo
- Church of Our Lady of Soccour
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At the end of the day, you'll drive back to Siena, where you'll stay for 1 night more.
Today’s agenda in Siena includes a castle, a public square, and a church. Fortress Of Montalcino is must-visit castle and a great starting point for the day. Next, continue your journey to Piazza Del Popolo, a curiosity-inducing public square, located just a leisurely stroll away. Next, head to Church Of Our Lady Of Soccour, an inviting church, also available for your discovery today.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Siena.
As you explore more of Siena, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Enjoy a lovely dining experience at Osteria Quattro Venti, a popular restaurant in Siena. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Siena at Fischi per Fiaschi, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Osteria da Divo. It’s yet another ideal choice to enhance your time in Siena tonight.
Continue your lively evening at Charlie Mixology Bar Di Aldinucci Riccardo, a perfect place for winding down or revving up the night, depending on which mood you’re in. Bar Pinacoteca is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, San Paolo Pub ensures a night out tailored to your taste.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 8
- Siena
- Rome
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Drive 242 km, 3 hours 37 min
- Colosseum
- Roman Forum
- Trevi Fountain
- Pantheon
- Piazza Navona
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Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 1 night here for some well-deserved relaxation.
Brace yourself for today’s incredible lineup of attractions in Siena, featuring family-friendly attractions, breathtaking views, and photo-friendly spots. Start at Colosseum, a timeless archeological site in the city. Then, head to Roman Forum and soak in the ambiance of this UNESCO world heritage-listed archeological site.
There are many interesting places to see in Siena, and when you are ready for more, go to Trevi Fountain. This is one of the city’s most wondrous history-steeped spots of interest. After exploring the monument, visit the globally renowned Pantheon. Not far away, you'll also find Piazza Navona. This public square is a visually striking highlight in Siena.
At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Enjoy a lovely meal at La Bottega Roma, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Pasta In Corso is another top choice with a popular menu. You could also check for a table at Trattoria Vecchia Roma. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.
After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at La Botticella Of Poggi Giovanni, a well-loved spot among locals and tourists. Or, head to Almalu Trastevere. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Bar Viminale Di Pepi Maurilio, another top-rated place in the area.
Relax and recharge in preparation for another adventurous day in Italy!
Day 9
- Rome
- Genoa
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Drive 511 km, 5 hours 45 min
- St Peter's Basilica
- Piazza di Spagna
- Spanish Steps
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On day 9 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City and Rome. In the evening, you’ll end up in Genoa, where you will stay for 1 night.
A blend of family-friendly attractions, romantic experiences, and scenic views await you in Rome on today’s itinerary. First up is the timeless major basilica, St. Peter's Basilica. Afterward, continue to Piazza Di Spagna, a public square every traveler should visit.
As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Spanish Steps. This extraordinary public square is an essential stop.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As you explore more of Genoa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Make sure to reserve a table at Vivarelli, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Ugo, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of TAZZE PAZZE Specialty Coffee, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 10
- Genoa - Departure day
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- Chiesa di San Giorgio
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Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, we recommend visiting Chiesa Di San Giorgio, a photogenic church before you head out.
Make the most of your final day in Italy by visiting Genoa’s iconic markets and shopping establishments in the buzzing Via XX Settembre. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.
You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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