7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kavala Prefecture, Xanthi, Serres, and Larissa and surrounding area

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
Photo of the White Tower in Thessaloniki, Greece.
Photo of Aristotelous Square at Thessaloniki city, Panoramic view.
Photo of Aristotelous square, the heart of Thessaloniki city, Greece.
Photo of beautiful Rotonda in Thessaloniki on a hot sunny summer day.
Photo of Agia Anna monastery guesthouses in Mount Athos, Thessaloniki.
Photo of aerial view of Thessaloniki alongisde an old fortification, Greece.
Photo of a narrow street in the old town of Thessaloniki, Greece.
Photo of aerial panoramic view of the main symbol of Thessaloniki city.
Photo of Byzantine fortress situated on the north-eastern corner of the acropolis of Thessaloniki in Greece.
Photo of tourist enjoys the view of Galerius Arch in Thessaloniki city in Greece.
Archaeoiogical Museum of Thessaloniki,Thessaloniki.
Aristotelous Square,Thessaloniki
View of the pier of Neoi Epivates suburb of Thessaloniki, Greece.
Photo of Ammolofoi beach near Kavala, Greece, Europe. Nice sand and clear water.
Photo of aerial view the city of Kavala in northern Greek, ancient aqueduct Kamares, homes and beaches.
Photo of aerial view of Ammolofoi sand beach near Kavala, Greece, Europe.
Photo of sunset on the beaches of Keramoti, Kavala, Greece.
Photo of sun loungers on the beach in Kavala, Greece.
Photo of landscape of Vrasidas beach near Kavala, Macedonia, Greece, Europe.
Photo of yellow sand beach against Kavala city in background. Kavala is famous summer greek resort town.
Photo of aerial view the beach of city Kavala in northern Greek, ancient aqueduct Kamares and homes in the background.
Photo of sunny spring panorama of Aegean Sea. Colorful sunrise in Kavala city.
Photo of aerial view of harbor of boats in Kavala, Greece.
Photo of aerial view the city of Kavala in northern Greek.
Photo of beautiful sunset on the beaches of Keramoti, Kavala, Greece
Photo of aerial view the city of Kavala in northern Greece.
Photo of cityscape with medieval aqueduct Kamares in the Kavala city.
Photo of seaside city of Kavala in Greece, Coloful evening scene.
Photo of aerial view the city of Kavala in northern Greece.
Photo of cityscape with medieval aqueduct Kamares in the Kavala city.
Photo of yellow sand beach against Kavala city in background, Kavala is famous summer greek resort town.
Photo of colorful House in Kavala Old Town.
Photo of the ancient city of Philippi, Kavala District.
photo of panoramic view of the old town of Xanthi with river and bridge, Greece.
photo of Town square and church in Xanthi, Eastern Macedonia and Thrace, Greece.
photo of aerial view the old town of Xanthi city in northern Greece.
photo of picturesque narrow street and buildings in the old town of Xanthi, Greece.
photo of The old town of Xanthi with river and bridge, Greece.
photo of the Monastery of Agios Nikolaos in Vistonida Lake. The aquatic biotope of lake, hosts more than 200 species of wild birds spend the wintertime in this area. Xanthi Prefecture. Greece.
photo of aerial drone view of Agios Nikolaos Monastery on the Vistonida Lake at Porto Lagos, Xanthi, Greece.
photo of Xanthi Greece May 2022, Inside view of Mountain Monastery of the Holy Trinity in Xanthi Greece, with blue sky.
photo of Traditional stone arched bridge over river in Xanthi, Thrace, Greece. Vivid nature landscape, bridge reflecting on river water.
photo of The New Cathedral Church Hagia Sophia in Xanthi, Greece.
photo of Kottani village in the municipality Myki in the Xanthi regional unit of Greece, close to the Greek-Bulgarian Borders. This is a very beautiful place to visit.
photo of aerial view of Myki, village in the prefecture of Xanthi, Greece. It belongs to the group of villages of the prefecture with Muslim population, which are more often called Pomakochoria.
photo of church in Xanthi, Eastern Macedonia and Thrace, Greece.
photo of Nestos river at boarders on Xanthi cities, Greece.
photo of picturesque narrow street and buildings at night in the old town of Xanthi, Greece.
photo of view of Historical monastery of Saint John the Prodrome, founded in the in the 13th century, located 12 km. NE of Serres, Greece.
photo of view of Monastery of Timios Prodromos of Serres, Macedonia, Greece.
photo of view of View of Serres city, Greece.
photo of view of Lake of Serre-Ponçon in the French Alps, a dammed artificial reservoir gathering the water of the Durance river, Serres, Greece.
photo of view of Catholic of the holy monastery of St. John the Baptist in Akritochori, Serres, Greece.
photo of view of Serre Chevalier major ski resort in Southeastern, Serres, Greece.
photo of view of View of Kerkini Lake at sunset in Greece.
photo of view of The historic monastery of Panagia (Virgin Mary) Eikosifinissa, Pangeo mountain, Serres, Macedonia, Greece.
photo of view of Snow capped Beles mountain, reflected on the surface ol lake Kerkini, Serres, Macedonia, Greece.
photo of view of Small waterfall in Serre Chevalier Valley, Serres, Greece.
photo of view of Sunset at lake Kerkini, probably the most important wetland and protected biosphere in Greece. Serres, Macedonia, Greece.
photo of view of Boat on water during a sunny day at Lake Kerkini in Serres, Greece.
photo of view of Pelicans resting at lake Kerkini, Serres, Macedonia, Greece.
photo of view of Historical monastery of Saint John the Prodrome, founded in the in the 13th century, Serres, Greece.
Photo of aerial view of Saint Achilios of Larissa and part of the city, Thessaly Greece.
Photo of the famous Larissa castle at sunset near Argos town. Argolis ,Greece.
Photo of the town of Argos seen from Larissa, a Venetian fortress built on top of the old Greek citadel, Greece.
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Experience the freedom of the open road in Greece as you embark on an unforgettable 7-day road trip! This experience caters to every traveler, featuring destinations like Thessaloniki, Kavala Prefecture, Alexandroupoli, Xanthi, Krinides, Lydia, Aggitis, Serres, Vergina, Katerini, Larissa, Makrinitsa, Portaria, and Volos.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Thessaloniki, 1 night in Kavala Prefecture, 1 night in Xanthi, 1 night in Serres, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable The Umbrellas Sculpture By Zogolopoulos, learn more about the unique Arch Of Galerius And Rotunda, and immerse yourself in the vibrant atmosphere of Agias Sofias Square.

As you hit the open road and drive through Thessaloniki, Kavala Prefecture, Alexandroupoli, Xanthi, Krinides, Lydia, Aggitis, Serres, Vergina, Katerini, Larissa, Makrinitsa, Portaria, and Volos, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ladadika
Aristotelous SquareAgias Sofias SquareWhite Tower of ThessalonikiThe Umbrellas by Zongolopoulos
Kavala FortFaliro ParkLighthouse of AlexandroupoliThe House of ShadowDimokratias Square
Ancient theatre of PhilippiArchaeological Museum of PhilippiHoly Baptistery of Saint Lydia of PhilippiCave Aggitis River
Liberty SquarePolycentric Museum of Aigai (Aegae) - Main BuildingMuseum of the Royal Tombs at Aigai (Aegae)Katerini Municipal Park
Makrinitsa Central SquareCentaurs' pathSaint Konstantinos ParkΠαραλία Βόλου
Arch of Galerius

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Day 1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Say hello to Thessaloniki! Your exciting road trip through Greece is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Thessaloniki for 1 night before you continue your adventure!

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Kitchen Bar, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of The Greek, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Phanós, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Following your dinner, dive into the local bar culture at Beetle Bar. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Vogatsikou 3, the perfect place for those looking to experience the best of the nightlife. Similarly, Souel provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise a toast to the start of your 7-day road trip in Greece!

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Day 2

Day 2

  • Thessaloniki
  • Kavala
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Drive 161 km, 2 hours 30 min

  • Aristotelous Square
  • Agias Sofias Square
  • White Tower of Thessaloniki
  • The Umbrellas by Zongolopoulos
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On day 2 of your road trip in Greece, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Thessaloniki. In the evening, you’ll end up in Kavala Prefecture, where you will stay for 1 night.

A blend of fun adventures, romantic experiences, and breathtaking views await you in Thessaloniki on today’s itinerary. First up is the interesting public square, Aristotelous Square. Afterward, continue to Agias Sofias Square, a public square every traveler should visit.

As you explore Thessaloniki’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to White Tower Of Thessaloniki. This extraordinary monument is an essential stop. Following that, head to The Umbrellas Sculpture By Zogolopoulos, another must-visit site that will enhance your experience.

When you’re done exploring for the day, you’ll drive to your hotel in Kavala Prefecture. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Kavala Prefecture, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a wonderful meal at Meltemi, a top-rated dining spot in Kavala Prefecture. If you're in the mood for something new, try Tsalapeteinos (Tsalapeteinos Urban Farm), another premier location with a delectable menu. You might also want to book a table at Marine Cafe Bar Restaurant. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Kavala Prefecture.

After enjoying a fulfilling meal, continue your evening at Sofita, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Beyond Cafe-bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Brickwall Pub provides an excellent environment for a relaxed and enjoyable evening.

Get a good night's sleep and look forward to another great day on the road in Greece!

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Day 3

Day 3

  • Kavala
  • Xanthi
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Drive 254 km, 3 hours 23 min

  • Kavala Fort
  • Faliro Park
  • Lighthouse of Alexandroupoli
  • The House of Shadow
  • Dimokratias Square
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Dive into day 3 of your remarkable road trip in Greece. Today you will explore Kavala Prefecture, Alexandroupoli, and Xanthi, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Xanthi. You’ll stay here for 1 night.

Today’s well-planned self-sightseeing route offers several family-friendly attractions, romantic experiences, and breathtaking views. Whether you decide to explore Kavala Prefecture on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Kavala Fortress is the first of them. Spend some time admiring this history-steeped castle before continuing your journey. Faliro Park is your next stop. This underrated park is one of the best-rated sights in Kavala Prefecture.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Lighthouse Of Alexandroupoli. This symbolic lighthouse is a sight to behold. To round off your sightseeing experience, visit The House Of Shadow and Republic Square.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Xanthi. Xanthi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Xanthi's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Fanarakia, a top pick for dinner tonight. Alternatively, KooKooVaya Urban Gastronomy beckons with its unique menu offerings. Also, consider Amalthia. With its consistent customer satisfaction, it’s an excellent option for dining in Xanthi tonight.

Continue your evening by exploring the vibrant nightlife scene at Βaiser Cafe-bar, a prime destination for a thrilling night out. Also, don’t forget to check out Mikro Cafe, a bar that offers unique local touches. Likewise, Nostos provides an excellent alternative for a fun evening.

Relax and reminisce about your day in Greece and look forward to more memorable moments to come!

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Day 4

Day 4

  • Xanthi
  • Serres Regional Unit
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Drive 194 km, 3 hours 15 min

  • Ancient theatre of Philippi
  • Archaeological Museum of Philippi
  • Holy Baptistery of Saint Lydia of Philippi
  • Cave Aggitis River
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Embark on another extraordinary experience on day 4 of your road trip in Greece. Today, you will make 3 stops and experience some of the highlights of Krinides, Lydia, and Aggitis. At the end of the day, you will enjoy the comforts of a top-rated hotel in Serres, which will be your home away from home for 1 night.

Bring your curiosity for today’s adventure around Xanthi. Some of the town’s most loved attractions await! Ancient Theatre Of Philippi is the perfect place to start. This archeological site is one of the most frequently visited places to visit in Xanthi. Next, head to Archaeological Museum Of Philippi, an underrated museum, known for its photogenic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Holy Baptistery Of Saint Lydia Of Philippi. This stunning church is a highly recommended experience. Nearby, you'll also find Aggitis River Cave. Visit these for an interesting touch to your journey.

At the end of the day, you will drive to Serres, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Serres. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at Oyzadikon To Bakalikon, a top recommendation for dinner tonight. Or, for a change of pace, KENTRIKON Ouzomezedopoleio boasts a menu that's sure to impress. Also, be sure to check out Sousouráda. Known as a local hotspot, it’s a great choice for tonight in Serres.

Keep the evening going at Avissunia Kafe, a great choice for enjoying the after-dinner hours with a drink. You could also go to Resalto Pub, which offers a similarly pleasant setting and great drinks. Another option is 1800 Cafe Bar, which provides an inviting environment for unwinding after a busy day out.

Savor another day of unforgettable experiences in Greece!

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Day 5

Day 5

  • Serres Regional Unit
  • Larissa
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Drive 277 km, 3 hours 49 min

  • Liberty Square
  • Polycentric Museum of Aigai (Aegae) - Main Building
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Katerini Municipal Park
  • More

Experience an unparalleled adventure on day 5 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Serres, Vergina, and Katerini. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Larissa. You will spend 1 night here for some well-deserved relaxation.

Prepare for a day full of fun adventures, picturesque spots, and budget-friendly activities. When you’re ready, kick off your sightseeing adventure at Liberty Square. This curiosity-inducing public square is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Polycentric Museum Of Aigai (aegae) - Main Building, one of the city’s best highlights.

Next, check out Museum Of The Royal Tombs At Aigai (aegae), one of the most locally appreciated places to see in Serres. This museum is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Katerini Municipal Park. Wander around and soak in the romantic atmosphere this park offers.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Larissa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at Nonna Rossa, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Vosporos | Restaurant • Bar? It's another excellent option with a diverse menu. Consider reserving a table at THE ALLEY as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Larissa.

Cap off your dinner by heading to Sherlock Easy Bar, ideal for a leisurely evening with a drink in hand. Kiou is another bar that offers an enjoyable setting. Similarly, Wisedog is also a popular place to go on a night out, perfect for relaxing and socializing.

Relax and recharge in preparation for another adventurous day in Greece!

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Day 6

Day 6

  • Larissa
  • Thessaloniki
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Drive 294 km, 4 hours 15 min

  • Makrinitsa Central Square
  • Centaurs' path
  • Saint Konstantinos Park
  • Παραλία Βόλου
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On day 6 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, Makrinitsa, Portaria, and Volos. When you’re not sightseeing, take time to relax at your selected hotel in Thessaloniki, where you’ll be staying for 1 night.

Immerse yourself in Larissa’s rich culture with today's sightseeing itinerary. Start your journey at Makrinitsa. This respected public square is sure to ignite your curiosity. Next, dive into the mesmerizing features of Centaurs' Path, a must-visit hiking area in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Saint Konstantinos Park, a frequently visited park. For a change of scene, check out Paralia Voloy, known for its serene features.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Thessaloniki. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Mamalouka, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Clochard offers an enticing alternative with its varied menu. Additionally, Sofi's House Restaurant is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

Keep the excitement of the evening going by visiting a bar or two. Castra- All Day Terrace Bar is an excellent place to start. You could also check out Barbaben - Bar/ba/ben, offering a different kind of charm. A last recommendation for the day is Apallou. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise your glass to another unforgettable day in Greece!

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Day 7

Day 7

  • Thessaloniki - Departure day
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  • Arch of Galerius
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Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Arch Of Galerius And Rotunda. This interesting monument is a popular place to see in the city.

As your final day in Greece unfolds, enjoy a last-minute shopping spree in Thessaloniki's best shopping area, Tsimiski Street. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Greece. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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