12-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Lecce, Naples, and Rome
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Explore the best of Italy on a 12-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome. This road trip itinerary in Italy seamlessly combines exploration with relaxation.
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 4 nights in Lecce, 4 nights in Naples, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
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Day 1
- Brindisi - Arrival day
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- Colonne Romane
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Welcome to Brindisi, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Brindisi's charm before embarking on the next leg of your journey.
Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out End Of The Via Appia Antica, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Brindisi. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.
Dine in style at Bracerie Escosazio, a top recommendation for dinner tonight. Or, for a change of pace, Penny boasts a menu that's sure to impress. Also, be sure to check out Piadineria. Known as a local hotspot, it’s a great choice for tonight in Brindisi.
Explore the vibrant nightlife at Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse after your meal, a hub for lively evenings and memorable moments. Or, head to Eden Cafè for a great selection of flavorful drinks and a charming setting. Furthermore, Altair Cafè is perfect for those looking to extend their night with a touch of local flavor.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Brindisi
- Lecce
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Drive 39 km, 53 min
- Chiesa Rettoria del Santissimo Crocifisso
- Castello Carlo V
- Benedictine Monastery
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Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Brindisi and Lecce. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Lecce. You will spend 4 nights here for some well-deserved relaxation.
Today’s route brings fun adventures, photo-friendly spots, and historic treasures. The first attraction of today is Chiesa Rettoria Del Santissimo Crocifisso. This increasingly popular church is an eye-catching place to see in Brindisi. Continue your discovery at Castle Of Charles V, a historic castle with stories to tell.
As you stroll around Brindisi, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Benedictine Monastery. This beloved monastery offers a heritage-rich encounter with Brindisi. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Brindisi.
When you’re done exploring for the day, you’ll drive to your hotel in Lecce. Check in and spend some time relaxing before you head out to tour the city.
After a day of adventure, treat yourself to an exquisite dinner at one of Lecce's best restaurants.
Make sure to reserve a table at Alle due Corti, an iconic dining spot in Lecce. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Il Ristoro dei Templari Trattoria Pizzeria Braceria, a popular restaurant in Lecce. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Cucina di Mamma Elvira, a hidden gem nestled in Lecce. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Continue your evening by exploring the vibrant nightlife scene at Sensi, a prime destination for a thrilling night out. Also, don’t forget to check out Caffè Alvino, a bar that offers unique local touches. Likewise, Jolly Roger provides an excellent alternative for a fun evening.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 3
- Lecce
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Drive 0.7 km, 9 min
- Jewish Museum Lecce
- Basilica di Santa Croce
- Palazzo dei Celestini (Provincia di Lecce)
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Day 3 of your road trip across Italy promises a magnificent time exploring Lecce. You have 3 nights left in Lecce. Take the opportunity to experience more of the best attractions and activities in the city.
Enjoy the perfect balance of relaxation and exploration in Lecce today. One of the most intriguing attractions included on the itinerary is Jewish Museum Lecce. This culturally significant museum will help you start your sightseeing on top. Then, take a leisurely stroll to Basilica Di Santa Croce and learn what makes this culturally significant church unique.
Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the frequently visited Palazzo Dei Celestini (provincia Di Lecce).
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Make sure to reserve a table at Miro Coffee Bistrot & Lounge Bar, an iconic dining spot in Lecce. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Oscar Cafè, a popular restaurant in Lecce. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Vecchia Osteria da Totu, a hidden gem nestled in Lecce. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Continue your lively evening at Bar Il Palio, a perfect place for winding down or revving up the night, depending on which mood you’re in. Al Ventuno is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Avio ensures a night out tailored to your taste.
Head back to your accommodation in Lecce and get some rest in preparation for another magical day of your road trip in Italy!
Day 4
- Lecce
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Drive 229 km, 2 hours 55 min
- Trullo Siamese monumento negozio souvenir
- Trulli di Alberobello Puglia
- Casa D'Amore
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On day 4 of your road trip in Italy, you’ll start and end your day in Lecce, but spend the day exploring what’s beyond the city. Since you will return to Lecce for 2 nights more, there’s no need to rush. Experience Alberobello to the fullest today with this curated day itinerary!
Start by visiting Trullo Siamese - Negozio Souvenirs, a prime spot to begin your journey. This history-steeped gift shop is sure to impress. Next on your list is Trulli Di Alberobello Puglia, another must-visit landmark and well-known historical landmark renowned for its romantic features.
While exploring and sightseeing, take time to savor the culture of Lecce by sampling some local delicacies. When you’re ready for more sightseeing, head to Casa D'amore. This respected historical landmark is an essential place to visit for anyone looking for the full Lecce experience.
When you’re done exploring for the day, you’ll return to Lecce and your accommodation.
As you explore more of Lecce, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Treat yourself to a delightful dinner at L'OSTRICA UBRIACA di viale della Libertà, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try L'angolino di Via Matteotti? It's another excellent option with a diverse menu. Consider reserving a table at Bar L'Incontro | Caffetteria, Pasticceria, Rosticceria as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lecce.
After your delicious meal, get a taste of the vibrant nightlife with a visit to Quanto Basta, known for its inviting atmosphere.
Head back to your accommodation in Lecce and get some rest in preparation for another magical day of your road trip in Italy!
Day 5
- Lecce
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Drive 381 km, 4 hours 31 min
- Sassi di Matera
- Sasso Caveoso
- Casa Grotta del Casalnuovo
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Wake up to day 5 of your extraordinary road trip in Italy. With 1 night left in Lecce, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
Savor the day by visiting some of the best places to see in Lecce, including an archeological site, a cave system, and a cave. Start your adventure at Sassi Di Matera. This notable archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Sasso Caveoso located in Lecce for another exciting encounter.
Next, immerse yourself in the setting of Casa Grotta Del Casalnuovo. Its UNESCO world heritage-designated features will captivate you.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Lecce.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Lecce. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Don’t miss out on dining at Opera Lounge - Lecce, a top-rated dining destination in Lecce. If you're in the mood to try something new, consider A'Roma l'Osteria, another top spot with a mouthwatering menu. You might also want to secure a reservation at Bar Meeting Di Mattia De Vincenza. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lecce this evening.
Say good night to Lecce and look forward to another great day of your road trip in Italy!
Day 6
- Lecce
- Naples
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Drive 414 km, 4 hours 28 min
- Castel Nuovo
- piazza del Plebiscito
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On day 6 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Naples. In the evening, you’ll end up in Naples, where you will stay for 4 nights.
Get ready for an exciting day in Lecce. Today’s sightseeing agenda includes a castle and a public square. Begin your adventure at Castel Nuovo. This is a notable castle you should not miss. Another must-see is Piazza Del Plebiscito, a top-rated public square in Lecce.
At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Don’t miss out on dining at L'Oca Nera Irish Pub, a top-rated dining destination in Naples. If you're in the mood to try something new, consider Mimì alla Ferrovia, another top spot with a mouthwatering menu. You might also want to secure a reservation at Spuzzulè Winebar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Naples this evening.
Round off your dining experience by visiting Happening Cocktail Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Shanti Art Musik Bar, a bar catering to every mood and preference. Gran Caffè Gambrinus likewise offers a unique atmosphere, perfect for a memorable night out.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 7
- Naples
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Drive 11 km, 1 hour 22 min
- Castel Sant'Elmo
- Naples National Archaeological Museum
- Cappella Sansevero
- Napoli Sotterranea Percorso Ufficiale
- Cattedrale di Santa Maria Assunta
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Day 7 of your road trip will take you to the best attractions Naples has to offer. Cherish the 3 nights you have left in Naples by discovering the best things there are to see and do in the city.
Bring your curiosity for today’s adventure around Naples. Some of the city’s most loved attractions await! Castel Sant'elmo is the perfect place to start. This castle is one of the most notable places to visit in Naples. Next, head to Naples National Archaeological Museum, a locally renowned museum, known for its detailed features.
In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Cappella Sansevero. This heritage-rich museum is a highly recommended experience. Nearby, you'll also find Napoli Sotterranea Percorso Ufficiale and Cattedrale Di Santa Maria Assunta. Visit these for an interesting touch to your journey.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.
Enjoy a lovely meal at Antica Pizzeria Di Matteo, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Mercure Napoli Centro Angioino is another top choice with a popular menu. You could also check for a table at La Lazzara Trattoria e Pizzeria. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Naples tonight.
To truly maximize your evening out, consider visiting Archivio Storico - Cocktail Bar & Wonderfood after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Archeobar, another bar with an inviting ambiance. Similarly, Babette Pub also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Raise your glass to another unforgettable day in Italy!
Day 8
- Naples
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Drive 135 km, 3 hours 35 min
- Belvedere Sorrento
- Costiera Amalfitana Positano
- Fiordo di Furore
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At the end of the day, you'll drive back to Naples, where you'll stay for 2 nights more.
Today’s route brings family-friendly attractions, romantic experiences, and breathtaking views. The first attraction of today is Belvedere Sorrento. This up-and-coming observation deck is an instagrammable place to see in Naples. Continue your discovery at Costiera Amalfitana Positano, a mesmerizing beach with stories to tell.
As you stroll around Naples, take in the distinct atmosphere and learn what makes this village so unique. Maximize your sightseeing with a visit to Fiordo Di Furore. This curiosity-inducing fjord offers a majestic encounter with Naples. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Naples.
When you’re done exploring for the day, you’ll return to Naples and your accommodation.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Savor the flavors at Opera Restaurant, a top pick for dinner tonight. Alternatively, Trattoria San Ferdinando beckons with its unique menu offerings. Also, consider Anonymous Trattoria Gourmet. With its consistent customer satisfaction, it’s an excellent option for dining in Naples tonight.
After savoring a delicious meal, step into the vibrant nightlife at Gran Caffè Cimmino, where the evening is just getting started. In the same way, Flanagan's Bar offers a unique charm perfect for experiencing the local bar scene in Naples. Bar Napoli is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.
Relax and recharge in preparation for another adventurous day in Italy!
Day 9
- Naples
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Drive 123 km, 3 hours 11 min
- Amalfi Coast
- Villa Cimbrone Gardens
- Villa Rufolo
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On day 9 of your road trip, you’ll start and end your day in Naples, where you'll stay for 1 night more.
Get ready for a day filled with family-friendly attractions, romantic experiences, and scenic views in the charming village of Naples. Your adventure starts at Amalfi Coast, a widely recognized local hot spot. Another notable attraction to explore is Villa Cimbrone Gardens.
After soaking in the highlights of these sights, take some time to wander Naples's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Villa Rufolo. This history-steeped historical landmark offers a fascinating experience that many visitors find memorable.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.
As dinnertime approaches, it's time to head out for a bite to eat in Naples. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to a wonderful meal at Piazza Sannazaro, a top-rated dining spot in Naples. If you're in the mood for something new, try Osteria Il Gobbetto, another premier location with a delectable menu. You might also want to book a table at Trattoria Castel Nuovo. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Naples.
Round off your dining experience by visiting Parthenope Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Gran Caffè Mexico, a bar catering to every mood and preference. Novecento Wine Bar likewise offers a unique atmosphere, perfect for a memorable night out.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 10
- Naples
- Rome
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Drive 232 km, 3 hours 26 min
- Colosseum
- Roman Forum
- Trevi Fountain
- Pantheon
- Piazza Navona
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On day 10 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 1 night.
Bring your curiosity for today’s adventure around Naples. Some of the city’s most loved attractions await! Colosseum is the perfect place to start. This archeological site is one of the most timeless places to visit in Naples. Next, head to Roman Forum, a timeless archeological site, known for its historic features.
In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Trevi Fountain. This visually striking monument is a highly recommended experience. Nearby, you'll also find Pantheon and Piazza Navona. Visit these for an interesting touch to your journey.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.
Extend your evening after a delightful meal by visiting La Botticella Of Poggi Giovanni, which offers the perfect atmosphere for a night out. Moreover, Almalu Trastevere is another popular option for a drink or two. Likewise, Bar Viminale Di Pepi Maurilio also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.
Say good night to Rome and look forward to another great day of your road trip in Italy!
Day 11
- Rome
- Brindisi
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Drive 581 km, 6 hours 17 min
- St Peter's Basilica
- The Last Judgment
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Dive into day 11 of your remarkable road trip in Italy. Today you will explore Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Brindisi. You’ll stay here for 1 night.
Next, go to The Last Judgment.
When you’re done exploring for the day, you’ll drive to your hotel in Brindisi. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Brindisi's most popular restaurants, and connect with friendly locals for an authentic adventure.
Enjoy a lovely meal at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Bento is another top choice with a popular menu. You could also check for a table at Cozza Nera. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Brindisi tonight.
Raise your glass to another unforgettable day in Italy!
Day 12
- Brindisi - Departure day
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- Saint Pietro of Schiavoni Archeologica Area
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This increasingly popular archeological site is a popular place to see in the city.
Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.
If you're in the mood for something new, try Pizzeria La Nassa, another premier location with a delectable menu.
You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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