6-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Portofino and Florence

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Photo of Sand beach in Camogli by Genoa, Italy.
Photo of Piazza De Ferrari main square in Genoa Italy.
Photo of Courtyard of Palazzo Reale in Genoa, Italy.
Photo of View of Genoa at sunset from "Spianata Castelletto", Italy.
Photo of Sestri Levante - Paradise Bay of Silence with its boats and its lovely beach. Beautiful coast at Province of Genoa in Liguria, Italy - Europe.
Photo of Genoa, Liguria, Italy downtown city skyline from above at dusk.
Photo of The Aquarium of Genoa is the largest aquarium in Italy. Located in the old harbor area of Genova.
Photo of Genoa port from above at night.
Photo of Palace of St George (Palazzo San Giorgio), Genoa, Italy.
Photo of Genova Brignole Railway Station in the evening.
Photo of View of Bogliasco. Bogliasco is a ancient fishing village in Italy, Genoa, Liguria. Mediterranean Sea, sandy beach and architecture of Bogliasco town.
Photo of Beach with tourists in San Fruttuoso bay with the ancient Abbey (San Fruttuoso di Capodimonte), X-XI century, and Andrea Doria tower. Portofino and Camogli, Genoa province, Liguria, Italy, Europe.
Photo of View of Pieve Ligure and on Sori on the background, italian towns of ligurian riviera, Genoa (Genova) province, Italy.
photo of view of Bogliasco, Genoa, Italy town skyline on the Mediterranean sea at sunset.
Photo of Portofino in Italy by Pascvii
Aerial view of the Cattedrale di Santa Maria del Fiore in Florence, Italy, overlooking the city
Photo of Florence Aerial View of Ponte Vecchio Bridge during Beautiful Sunny Day, Italy.
Photo of Woman enjoys beautiful view on famous Duomo cathedral in Florence, standing on empty cathedral square during morning time.
Photo of Summer street cafe on Piazza della Repubblica in Florence, Toscana province, Italy.
Photo of Giotto's Campanile - An aerial dusk view of Giotto's Campanile and the historical Old Town of Florence, as seen from the top of Brunelleschi's Dome of the Florence Cathedral. Florence, Tuscany, Italy.
Photo of Ponte Vecchio, old bridge over Arno River, Florence, Tuscany, Italy.
Photo of The Colossus of the Apennines, majestic stone sculpture by Giambologna located in the park of Villa Demidoff in Florence, Italy.
Photo of Fountain of Neptune in Florence in early morning.
Photo of Sunset view of Florence, Ponte Vecchio, Palazzo Vecchio and Florence Duomo, Italy. Architecture and landmark of Florence. Cityscape of Florence.
Vintage carousel and tourists in Piazza della Repubblica (Republic Square) and the arch in honor of the first king of united Italy on background in Florence, Italy.
Photo of Arches of the Vasari Corridor (Corridoio Vasariano) in Florence, Tuscany, Italy. View of the Lungarno degli Archibusieri.
cheerful senior woman cycling with her electric mountain bike above downtown of Florence with stunning view over the old city, Tuscany, Italy
Facade of Palazzo Pitti palace with Gallery of Modern Art large building on Piazza dei Pitti square in historical centre of Florence city, blue sky white clouds, Tuscany, Italy
photo of view of Florence,Italy.
photo of view of Florence,Italy.
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Escape the ordinary with this exciting 6-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Portofino, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazza Della Signoria, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Portofino, Manarola, Corniglia, Vernazza, Pisa, Florence, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
porto antico
piazza De FerrariGenoa CathedralDoge's PalaceAquarium of GenoaLighthouse of GenoaArea Marina Protetta di Portofino
Manarola Overlook ViewpointCinque Terre National ParkRuins of Doria TowerScalinata Lardarina
Leaning Tower of PisaPiazza del Duomo, PisaPorta NuovaUffizi GalleryPonte Vecchiopiazza della Signoria
Basilica of Santa Croce in FlorenceVilla Calcinaia - Conti CapponiPorta San GiovanniSanGimignano1300Piazza del Duomo, San Gimignano
Via Garibaldi

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Day 1

Day 1

  • Genoa - Arrival day
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  • porto antico
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Porto Antico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at 7 Sensi cucina decontaminata, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Alla Lunga Ristorante is another top choice with a popular menu. You could also check for a table at Grand Hotel Savoia. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Genoa tonight.

Keep the excitement of the evening going by visiting a bar or two. Scurreria Beer & Bagel is an excellent place to start. You could also check out La Lepre, offering a different kind of charm. A last recommendation for the day is Bar Pisacane Iii. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 48 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Aquarium of Genoa
  • Lighthouse of Genoa
  • Area Marina Protetta di Portofino
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Genoa and San Fruttuoso di Camogli. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Portofino. You will spend 2 nights here for some well-deserved relaxation.

Get ready for a day filled with fun adventures, romantic experiences, and breathtaking views in the charming city of Genoa. Your adventure starts at Piazza De Ferrari, a locally renowned local hot spot. Another notable attraction to explore is Genoa Cathedral. This worthwhile church is known for its visually striking appeal.

After soaking in the highlights of these sights, take some time to wander Genoa's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Doge's Palace. Aquarium Of Genoa is also worth visiting, along with Lighthouse Of Genoa. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Area Marina Protetta Di Portofino. This intriguing nature reserve provides a fitting finale to your sightseeing.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Portofino. Portofino offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Portofino. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Trattoria Concordia, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Puny. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 3

Day 3

  • Portofino
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Drive 211 km, 4 hours 15 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Ruins of Doria Tower
  • Scalinata Lardarina
  • More

On day 3 of your road trip in Italy, you’ll start and end your day in Portofino, but spend the day exploring what’s beyond the village. Since you will return to Portofino for 1 night more, there’s no need to rush. Experience Manarola, Corniglia, and Vernazza to the fullest today with this curated day itinerary!

Start by visiting Manarola Overlook Viewpoint, a prime spot to begin your journey. This majestic observation deck is sure to impress. Next on your list is Cinque Terre National Park, another must-visit landmark and captivating national park renowned for its UNESCO world heritage-listed features.

While exploring and sightseeing, take time to savor the culture of Portofino by sampling some local delicacies. When you’re ready for more sightseeing, head to Ruins Of Doria Tower. This history-steeped monument is an essential place to visit for anyone looking for the full Portofino experience. We also recommend visiting Scalinata Lardarina, an often recommended hiking area.

When you’re done exploring for the day, you’ll return to Portofino and your accommodation.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Portofino. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at I Gemelli, a top-rated dining destination in Portofino. If you're in the mood to try something new, consider Ristorante Taverna del marinaio, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Lo Stella. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Portofino this evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4

  • Portofino
  • Florence
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Drive 230 km, 3 hours 24 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Porta Nuova
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Florence. In the evening, you’ll end up in Florence, where you will stay for 1 night.

Get ready for an exciting day in Portofino. Today’s sightseeing agenda includes a monument, a public square, an art gallery, a historical landmark and much more! Begin your adventure at Leaning Tower Of Pisa. This is a timeless monument you should not miss. Another must-see is Piazza Del Duomo, Pisa, a wondrous public square in Portofino.

When you’re ready for the next sight, head to Porta Nuova. From there, take a leisurely stroll to Uffizi Gallery, another of the city’s top-rated attractions. We recommend continuing your self-guided tour at Ponte Vecchio, a history-steeped place of interest in the city. If time allows, add Piazza Della Signoria to your itinerary. This astonishing public square offers the perfect finishing touch to your day in Portofino.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a delicious meal at Ristorante Oliviero 1962, a highly-rated dining destination in Florence. If you're eager to try something different, consider Di Poneta Novoli, another top spot with a tantalizing menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

Continue your evening by exploring the vibrant nightlife scene at Manifattura, a prime destination for a thrilling night out. Also, don’t forget to check out Se·sto On Arno Rooftop Bar, a bar that offers unique local touches. Likewise, Il Vinile provides an excellent alternative for a fun evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 5

Day 5

  • Florence
  • Genoa
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Drive 313 km, 4 hours 42 min

  • Basilica of Santa Croce in Florence
  • Villa Calcinaia - Conti Capponi
  • Porta San Giovanni
  • SanGimignano1300
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Florence, Greti, and San Gimignano, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Enjoy the perfect balance of relaxation and exploration in Florence today. One of the most well-known attractions included on the itinerary is Basilica Of Santa Croce In Florence. This photogenic church will help you start your sightseeing on top. Then, take a leisurely stroll to Villa Calcinaia - Conti Capponi and learn what makes this enchanting winery unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the beloved Porta San Giovanni. After exploring the monument, head to Sangimignano1300. This increasingly popular museum is a highlight in Florence. As your day continues, stop by Piazza Del Duomo, known for its grand features.

When you’re done exploring for the day, you’ll drive to your hotel in Genoa. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Zeffirino, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Vegia Zena, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria delle Grazie, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 6

Day 6

  • Genoa - Departure day
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  • Via Garibaldi
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Via Garibaldi, a history-steeped street before you head out.

Maximize your last day in Italy and go on a shopping spree in Genoa’s shopping center, the lively Via XX Settembre. Browse for souvenirs to remind you of your wonderful journey in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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