7-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Matera, Naples, Rome, and Santa Maria degli Angeli

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Ostuni white town skyline at sunset, Brindisi, Apulia southern Italy. Europe.
Ostuni white town skyline at sunset, Brindisi, Apulia southern Italy. Europe.
A sidewalk cafe with covered patio at the seaside promenade and boardwalk in the city of Brindisi, Italy, in the Puglia region.
Alfonsino castle, located at the entrance to the port of the Italian town of Brindisi, is an interesting example of defensive architecture.
Empty streets and closed shops and cafes on a summer morning on the main street, Corso Umberto, through the town center of the coastal city of Brindisi, Italy.
Photo of Brindisi harbour.
Morning as tourists begin to explore the Brindisi Duomo Cathedral and Bell tower in the Piazza Duomo in Brindisi, Italy, part of the southern Puglia region.
military monument seen from the harbor of Brindisi
photo of view of Panoramic view of Brindisi. Puglia. Italy.
photo of view of Brindisi, Italy.
photo of view of Barletta, Brindisi, Italy.
photo of view of Seafront. Brindisi. Puglia. Italy.
photo of view of Panoramic view of Ostuni white town, Brindisi, Puglia (Apulia), Italy,
photo of view of Piazza Duomo with Brindisi Cathedral near Archiological museum, Brindisi, Italy.
Photo of best view of the Matera skyline, Italy.
Photo of aerial view of Matera, Puglia, Italy.
Photo of St. Francesco d'Assisi Church, Matera, Italy.
Photo of buildings in the old town of Matera, Basilicata, Southern Italy with blue sky and white clouds.
Photo of the church of Madonna de Idris ( Chiesa Rupestre di Santa Maria di Idris ) in the rock. Cave church in Sassi old town, Matera, Italy.
Photo of night view of the St. Domenico church and Materdomini church over the Hypogeum ruins in the city centre ,Matera, Italy.
Photo of church of Madonna della Bruna and Sant'Eustachio, Matera Cathedral ,Italy.
Photo of panoramic view of the ancient town of Matera (Sassi di Matera) illuminated during beautiful evening twilight at dusk, Basilicata, southern Italy.
Photo of Matera old town view in Italy.
Photo of the medieval church of San Giovanni Battista (Saint John the Baptist) Matera, Basilicata, Italy.
Photo of art museum located inside the building Palazzo Lanfranchi, which is located in Piazzetta Pascoli, in the Historic Centre of Matera Basilicata, Italy.
Photo of happy tourist girl with arms raised up enjoys the stunning view of the Sassi di Matera in Italy.
Photo of historic Town of Matera ,Italy.
Photo of the ancient town of Matera (Sassi di Matera), European Capital of Culture 2019, in beautiful golden morning light with blue sky and clouds, Basilicata, southern Italy.
Photo of historic Town of Matera ,Italy.
Twilight panorama of Naples in Italy
Photo of Morning view of Amalfi cityscape on coast line of mediterranean sea, Italy.
Photo of View of Piazza del Plebiscito, Naples,Italy.
Panoramic view of the ancient city of Pompeii with houses and streets. Pompeii is an ancient Roman city died from the eruption of Mount Vesuvius in the 1st century. Naples, Italy.
Photo of Panorama of Naples, view of the port in the Gulf of Naples and Mount Vesuvius. The province of Campania. Italy.
Photo of Maschio Angioino Castle in Naples during a sunny sunrise.
Photo of Obelisk Guglia of the Immaculate Virgin on Piazza Gesu Nuovo in Naples (Napoli), Italy.
Photo of Boats at Marina Grande embankment in Capri Island in Tyrrhenian sea, Italy.
Photo of Stunning rooftop view of Naples from above during sunset.
Photo of Kilometers-long promenade along cascades at the Palace of Caserta, Italy.
Photo of The neighborhood called Quartieri Spagnoli in Naples, Italy. Street view of old town. Narrow street of Napoli. Bright sunny day. Gulf of Naples, blue sky, sea on background. Cacti on the terrace.
Photo of Sunset in Positano, Amalfi Coast, Salerno - Naples, Italy.
Photo of Ancient ruins of Pompei city (Scavi di Pompei), Naples, Italy.
photo of view of Colorful architecture in Naples city, Italy. Summer cityscape at sunset. Famous travel destination.
photo of view of Panoramic view of Naples city and Gulf of Naples, Italy. Blue sea and the sky with clouds at sunset. Famous travel destination.
Colosseum, Rome, Italy.
Photo of piazza de spagna in Rome, Italy.
Photo of Fountain di Trevi in Rome, Italy.
Bridge Il Tevere a Ponte Vittorio Emanuele II in Rome, Italy.
Hadrian Mausoleum, Rome, Italy.
 Vatican dome of San Pietro and Sant Angelo Bridge, over Tiber river in Rome, Italy.
panoramic view of Rome and St. Peter's Basilica, Italy.
View of Pantheon in the morning, Rome, Italy.
Rome, Italy. Stunning twilight view of Forum ancient ruins, seen from Capitoline hill with Colosseum in background.
Aerial view of forum romanum and surrounding areas of historical centre of italian capital rome.
Cozy old street in Trastevere in Rome, Italy. Trastevere is rione of Rome, on the west bank of the Tiber in Rome, Lazio, Italy. Architecture and landmark of Rome.
Aerial panorama of St. Peter's Square in Vatican with Rome in the background. Italy.
photo of view of Illuminated Fontana Di Trevi, Trevi Fountain at Dusk, Rome, Italy.
photo of view of Spanish Step, Rome, Italy.
photo of view of Museum Luasanne, Rome, Italy.
photo of view Roma Wall of Lugo, Rome, Italy.
photo of view of Roman Bridge Cordoba, Rome, Italy.
photo of view of Roman ruins in Rome, Forum, Rome, Italy.
photo of view of Roman Bridge of Cordoba, Rome, Italy.
photo of view of The Iconic, the legendary Coliseum of Rome, Italy.
photo of view of Rome, Italy: The Roman Forum, Latin: Forum Romanum, Italian: Foro Romano, Rome, Italy.
photo of view of Trevi Fountain (Fontana di Trevi) in Rome, Italy. Trevi is most famous fountain of Rome. Architecture and landmark of Rome, Postcard of Rome, Italy.
View at the Basilica of Santa Maria degli Angeli near Assisi in Italy
Photo of iIluminated facade of the Papal Basilica of Saint Mary of the Angels in Santa Maria degli Angeli, Assisi, region of Umbria, Italy.
Aerial view on Santa Maria degli Angeli a Pizzofalcone in Napoli, Italy.
Photo of Fontana delle Naiadi and Santa Maria degli Angeli e dei Martiri Basilica in Rome, Italy
Photo of Basilica of Santa Maria delia  in Italy.
Photo of Santa Maria degli Angeli on the path of San Francesco.Italy
Photo of Murano islands water canal with Santa Maria degli Angeli church in Italy.
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Explore the best of Italy on a 7-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 1 night in Matera, 1 night in Naples, 1 night in Rome, and 1 night in Santa Maria degli Angeli. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Lungomare Regina Margherita
Belvedere di Piazza Giovanni PascoliSassi di MateraCasa NohaCattedrale di Maria Santissima della Bruna e Sant'EustachioChurch of Saint Peter 'Barisano'Palombaro lungo
Naples National Archaeological Museumpiazza del PlebiscitoArchaeological Park of Pompeii
ColosseumRoman ForumSt Peter's Basilica
Circus MaximusPiazza NavonaPantheonTrevi FountainSpanish StepsVilla Borghese
Church of Santa Maria sopra Minerva in AssisiChiesa Nuova di San Francesco ConvertitoTrulli di Alberobello Puglia
Saint Pietro of Schiavoni Archeologica Area

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Lungomare Regina Margherita
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Welcome to Brindisi, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Brindisi's charm before embarking on the next leg of your journey.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Amici Dei Musei Brindisi, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Brindisi. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Bracerie Escosazio, an excellent option for tonight's dining. Looking for something different? Penny offers a tantalizing alternative with its diverse menu. And don’t miss Piadineria. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Brindisi.

Extend your evening after a delightful meal by visiting Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, which offers the perfect atmosphere for a night out. Moreover, Eden Cafè is another popular option for a drink or two. Likewise, Altair Cafè also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 7-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Matera
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Drive 156 km, 2 hours 25 min

  • Belvedere di Piazza Giovanni Pascoli
  • Sassi di Matera
  • Casa Noha
  • Cattedrale di Maria Santissima della Bruna e Sant'Eustachio
  • Church of Saint Peter 'Barisano'
  • Palombaro lungo
  • More

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Matera. When you’re not sightseeing, take time to relax at your selected hotel in Matera, where you’ll be staying for 1 night.

Today’s route brings fun adventures, romantic experiences, and breathtaking views. The first attraction of today is Belvedere Di Piazza Giovanni Pascoli. This curiosity-inducing observation deck is a romantic place to see in Brindisi. Continue your discovery at Sassi Di Matera, a history-steeped archeological site with stories to tell.

As you stroll around Brindisi, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Casa Noha. This increasingly popular museum offers an UNESCO world heritage-listed encounter with Brindisi. Next, make your way to Cattedrale Di Maria Santissima Della Bruna E Sant'eustachio to add another highlight to your day. After that, visit Church Of Saint Peter 'barisano', a frequently visited church that’s sure to impress. If you’re up for more, end your self-guided sightseeing tour at Palombaro Lungo, a worthwhile cave system in the city. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Brindisi.

When you’re done exploring for the day, you’ll drive to your hotel in Matera. Check in and spend some time relaxing before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Matera. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to reserve a table at Ristorante Le Bubbole, an iconic dining spot in Matera. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Baccanti, a popular restaurant in Matera. With a menu designed to delight, it ensures a dining experience that transcends the ordinary.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Matera
  • Naples
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Drive 311 km, 4 hours 12 min

  • Naples National Archaeological Museum
  • piazza del Plebiscito
  • Archaeological Park of Pompeii
  • More

Embark on another extraordinary experience on day 3 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Naples and Pompei. At the end of the day, you will enjoy the comforts of a top-rated hotel in Naples, which will be your home away from home for 1 night.

Brace yourself for today’s incredible lineup of attractions in Matera, featuring family-friendly attractions, photo-friendly spots, and history-rich sites. Start at Naples National Archaeological Museum, an interesting museum in the city. Then, head to Piazza Del Plebiscito and soak in the ambiance of this enchanting public square.

There are many interesting places to see in Matera, and when you are ready for more, go to Archaeological Park Of Pompeii. This is one of the city’s most well-known breathtaking spots of interest.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at L'Oca Nera Irish Pub, a top-rated dining destination in Naples. If you're in the mood to try something new, consider Mimì alla Ferrovia, another top spot with a mouthwatering menu. You might also want to secure a reservation at Spuzzulè Winebar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Naples this evening.

Unwind after your meal by stepping into Happening Cocktail Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Shanti Art Musik Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Gran Caffè Gambrinus, another top-rated bar in the area.

Head back to your accommodation in Naples and get some rest in preparation for another magical day of your road trip in Italy!

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Day 4

Day 4

  • Naples
  • Rome
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Drive 237 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • St Peter's Basilica
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome and Vatican City. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Bring your curiosity for today’s adventure around Naples. Some of the city’s most loved attractions await! Colosseum is the perfect place to start. This archeological site is one of the most globally renowned places to visit in Naples. Next, head to Roman Forum, a globally renowned archeological site, known for its picture-perfect features.

Visit these for an interesting touch to your journey.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at La Bottega Roma, an excellent option for tonight's dining. Looking for something different? Pasta In Corso offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria Vecchia Roma. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

After enjoying a fulfilling meal, continue your evening at La Botticella Of Poggi Giovanni, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Almalu Trastevere offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides an excellent environment for a relaxed and enjoyable evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 5

Day 5

  • Rome
  • Assisi
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Drive 189 km, 3 hours 19 min

  • Circus Maximus
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Spanish Steps
  • Villa Borghese
  • More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Santa Maria degli Angeli. You will spend 1 night here for some well-deserved relaxation.

Today’s well-planned self-sightseeing route offers several family-friendly attractions, scenic views, and picturesque spots. Whether you decide to explore Rome on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Circus Maximus is the first of them. Spend some time admiring this culturally significant archeological site before continuing your journey. Piazza Navona is your next stop. This world-famous public square is one of the best-rated sights in Rome.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Pantheon. This monumental monument is a sight to behold. To round off your sightseeing experience, visit Trevi Fountain and Spanish Steps. If time allows, end your day with Villa Borghese, a romantic park that offers a memorable conclusion to your exploration.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and spend some time relaxing before you head out to tour the town.

As dinnertime approaches, it's time to head out for a bite to eat in Santa Maria degli Angeli. If you are looking to dine at a popular restaurant in the town, it's often a good idea to reserve a table in advance.

Round off your dining experience by visiting Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a prime location for a drink.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Assisi
  • Brindisi
  • More

Drive 676 km, 7 hours 18 min

  • Church of Santa Maria sopra Minerva in Assisi
  • Chiesa Nuova di San Francesco Convertito
  • Trulli di Alberobello Puglia
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli and Alberobello, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Brindisi. You’ll stay here for 1 night.

Santa Maria degli Angeli is home to plenty of attractions that offer family-friendly attractions, picturesque spots, and historic treasures! Start at Church Of Santa Maria Sopra Minerva In Assisi, an intriguing church that is worthwhile a visit in the town. Nearby, you’ll find Chiesa Nuova Di San Francesco Convertito, enchanting visitors with its standout appeal. Continue your exploration at Trulli Di Alberobello Puglia. This historical landmark is one of the town’s most popular spots.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Brindisi. Brindisi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Brindisi's best restaurants.

Treat yourself to a wonderful meal at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a top-rated dining spot in Brindisi. If you're in the mood for something new, try Bento, another premier location with a delectable menu. You might also want to book a table at Cozza Nera. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Brindisi.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 7

Day 7

  • Brindisi - Departure day
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  • Saint Pietro of Schiavoni Archeologica Area
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Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This increasingly popular archeological site is a popular place to see in the city.

Make the most of your final day in Italy by visiting Brindisi’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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