6-Day Italy Self-Drive Road Trip With Itinerary from Pescara to Rome and Florence

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Explore the best of Italy on a 6-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Pescara, Rome, Florence, and Siena. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pescara, 2 nights in Rome, and 1 night in Florence. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Vatican Museums.

As you hit the open road and drive through Pescara, Rome, Florence, and Siena, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ponte del Mare
ColosseumRoman ForumPantheonPiazza Navona
Vatican MuseumsSistine ChapelTrevi FountainPiazza di SpagnaSpanish StepsVilla Borghese
Basilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioPiazza della RepubblicaCathedral of Santa Maria del Fiorepiazza della Signoria
Fortezza MediceaBasilica of San DomenicoSiena Cathedralpiazza del Campo
Nature Reserve Pineta Dannunziana

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Day 1

Day 1

  • Pescara - Arrival day
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  • Ponte del Mare
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Your road trip adventure in Italy begins as soon as you reach Pescara and pick up your car. You’ll stay in Pescara for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ponte Del Mare, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Pescara. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Taverna 58, a top-rated dining spot in Pescara. If you're in the mood for something new, try Ristorante Carlo Ferraioli, another premier location with a delectable menu. You might also want to book a table at Sesamo Nero. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pescara.

After savoring a delicious meal, step into the vibrant nightlife at Posa Caffè Pescara, where the evening is just getting started. In the same way, Bar Mixer offers a unique charm perfect for experiencing the local bar scene in Pescara. Temple Bar Irish Pub is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 6-day road trip in Italy!

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Day 2

Day 2

  • Pescara
  • Rome
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Drive 212 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
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On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Today’s agenda in Pescara includes an archeological site, a monument, and a public square. Colosseum is must-visit archeological site and a great starting point for the day. Next, continue your journey to Roman Forum, a timeless archeological site, located just a leisurely stroll away. Next, head to Pantheon, a culturally significant monument, also available for your discovery today.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at La Bottega Roma, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Pasta In Corso is another top choice with a popular menu. You could also check for a table at Trattoria Vecchia Roma. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 3

Day 3

  • Rome
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Drive 15 km, 1 hour 20 min

  • Vatican Museums
  • Sistine Chapel
  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • Villa Borghese
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On day 3 of your road trip, you’ll start and end your day in Rome, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Vatican City and Rome. You still have 1 night left in Rome.

Discover a day packed with fun adventures, romantic experiences, and scenic views in Rome. Begin your sightseeing with Vatican Museums. This world-famous art museum is one of the top attractions in the city. Proceed to Sistine Chapel, another must-visit attraction.

As you wander through the inviting streets of Rome, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Trevi Fountain. This wondrous monument is a traveler-favorite. Not far away, you’ll find Piazza Di Spagna, another key site on your sightseeing itinerary. Spanish Steps is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Villa Borghese and uncover why it's recognized as one of the city's most astonishing attractions.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a lovely dining experience at RomAntica, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at Coso Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated DEROMA - Farine Romane. It’s yet another ideal choice to enhance your time in Rome tonight.

Explore the vibrant nightlife at Sant' Eustachio Caffè after your meal, a hub for lively evenings and memorable moments. Or, head to Yellowsquare Rome for a great selection of flavorful drinks and a charming setting. Furthermore, Caffè Portofino is perfect for those looking to extend their night with a touch of local flavor.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 4

Day 4

  • Rome
  • Florence
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Drive 276 km, 3 hours 31 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Piazza della Repubblica
  • Cathedral of Santa Maria del Fiore
  • piazza della Signoria
  • More

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 1 night.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most locally renowned attractions included on the itinerary is Basilica Of Santa Croce In Florence. This culturally significant church will help you start your sightseeing on top. Then, take a leisurely stroll to Uffizi Gallery and learn what makes this history-steeped art gallery unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the iconic Ponte Vecchio. After exploring the historical landmark, head to Piazza Della Repubblica. This captivating public square is a highlight in Rome. As your day continues, stop by Cathedral Of Santa Maria Del Fiore, known for its enchanting features. Lastly, don’t forget to check out the spectacular Piazza Della Signoria. Enjoy exploring this incredible public square at your own pace.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • Pescara
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Drive 425 km, 5 hours 36 min

  • Fortezza Medicea
  • Basilica of San Domenico
  • Siena Cathedral
  • piazza del Campo
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Siena, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Pescara. You’ll stay here for 1 night.

Get ready to discover some of the most iconic wonders in Florence, including a monument, a church, and a public square. Start your day at Fortezza Medicea (siena). This culturally significant monument is an increasingly popular place to see in Florence. Then, wander over to Basilica Of San Domenico. If symbolic sites excite you, this church will be right up your alley. Nearby, you’ll also find Siena Cathedral. This enchanting church is a favorite among visitors.

Florence offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Piazza Del Campo is a widely recognized spot in the city that will captivate you with its unique charm.

When you’re done exploring for the day, you’ll drive to your hotel in Pescara. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Pescara's best restaurants.

Treat yourself to a wonderful meal at Ciacco, a top-rated dining spot in Pescara. If you're in the mood for something new, try Bar Sara, another premier location with a delectable menu. You might also want to book a table at Ristorante Franco. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pescara.

After savoring a delicious meal, step into the vibrant nightlife at Bar Napoli, where the evening is just getting started. In the same way, Bar Supermarket offers a unique charm perfect for experiencing the local bar scene in Pescara. Post Bar is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 6

Day 6

  • Pescara - Departure day
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  • Nature Reserve Pineta Dannunziana
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Day 6 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Nature Reserve Pineta Dannunziana, a romantic nature reserve before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.

Dine in style at MuuLab. Cucina e Distillati, a top recommendation for dinner tonight. Or, for a change of pace, La Taverna Antica boasts a menu that's sure to impress.

You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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