7-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Matera, Naples, Rome, and Santa Maria degli Angeli

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Explore the best of Italy on a 7-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 1 night in Matera, 1 night in Naples, 1 night in Rome, and 1 night in Santa Maria degli Angeli. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Lungomare Regina Margherita
Belvedere di Piazza Giovanni PascoliSassi di MateraCasa NohaCattedrale di Maria Santissima della Bruna e Sant'EustachioChurch of Saint Peter 'Barisano'Palombaro lungo
Naples National Archaeological Museumpiazza del PlebiscitoArchaeological Park of Pompeii
ColosseumRoman ForumSt Peter's Basilica
Circus MaximusPiazza NavonaPantheonTrevi FountainSpanish StepsVilla Borghese
Church of Santa Maria sopra Minerva in AssisiChiesa Nuova di San Francesco ConvertitoTrulli di Alberobello Puglia
Saint Pietro of Schiavoni Archeologica Area

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Lungomare Regina Margherita
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Your road trip adventure in Italy begins as soon as you reach Brindisi and pick up your car. You’ll stay in Brindisi for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Amici Dei Musei Brindisi, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Brindisi. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Bracerie Escosazio, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Penny offers an enticing alternative with its varied menu. Additionally, Piadineria is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Brindisi.

Round off your dining experience by visiting Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, a prime location for a drink. Alternatively, explore the distinctive characteristics of Eden Cafè, a bar catering to every mood and preference. Altair Cafè likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 7-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Matera
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Drive 156 km, 2 hours 25 min

  • Belvedere di Piazza Giovanni Pascoli
  • Sassi di Matera
  • Casa Noha
  • Cattedrale di Maria Santissima della Bruna e Sant'Eustachio
  • Church of Saint Peter 'Barisano'
  • Palombaro lungo
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Dive into day 2 of your remarkable road trip in Italy. Today you will explore Matera, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Matera. You’ll stay here for 1 night.

Set out on a day brimming with fun adventures, romantic experiences, and scenic views. Start at the often recommended Belvedere Di Piazza Giovanni Pascoli, a visually striking observation deck in Brindisi. Next, go to Sassi Di Matera.

After visiting Belvedere Di Piazza Giovanni Pascoli and Sassi Di Matera, have a stroll along Brindisi's streets and take in the local charm. Continue your sightseeing by heading to Casa Noha. This UNESCO world heritage-listed museum offers a unique experience. Cattedrale Di Maria Santissima Della Bruna E Sant'eustachio is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Church Of Saint Peter 'barisano', one of the most breathtaking places to visit in Brindisi. If you still have some time left for sightseeing, we also recommend stopping by Palombaro Lungo.

At the end of the day, you will drive to Matera, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Matera, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Ristorante Le Bubbole, a highly-rated dining destination in Matera. If you're eager to try something different, consider Baccanti, another top spot with a tantalizing menu.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 3

Day 3

  • Matera
  • Naples
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Drive 311 km, 4 hours 12 min

  • Naples National Archaeological Museum
  • piazza del Plebiscito
  • Archaeological Park of Pompeii
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Embark on another extraordinary experience on day 3 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Naples and Pompei. At the end of the day, you will enjoy the comforts of a top-rated hotel in Naples, which will be your home away from home for 1 night.

Today, you'll explore some of the most beautiful places in Matera, including a museum, a public square, and an archeological site. Start your day with a visit to Naples National Archaeological Museum. This popular museum is a must-visit in the city. When you’re ready for your next discovery, continue to Piazza Del Plebiscito, which may be one of the most respected places you will experience today.

One of the best things about exploring Matera on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Archaeological Park Of Pompeii, a popular archeological site in the city.

When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a lovely dining experience at L'Oca Nera Irish Pub, a popular restaurant in Naples. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Naples at Mimì alla Ferrovia, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Spuzzulè Winebar. It’s yet another ideal choice to enhance your time in Naples tonight.

Unwind after your meal by stepping into Happening Cocktail Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Shanti Art Musik Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Gran Caffè Gambrinus, another top-rated bar in the area.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4

  • Naples
  • Rome
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Drive 237 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • St Peter's Basilica
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Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Rome and Vatican City. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 1 night here for some well-deserved relaxation.

Begin your adventure at Colosseum. This is a timeless archeological site you should not miss. Another must-see is Roman Forum, a world-famous archeological site in Naples.

When you’re ready for the next sight, head to St. Peter's Basilica.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Almalu Trastevere, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 5

Day 5

  • Rome
  • Assisi
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Drive 189 km, 3 hours 19 min

  • Circus Maximus
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Spanish Steps
  • Villa Borghese
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On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Santa Maria degli Angeli, where you’ll be staying for 1 night.

Today’s well-planned self-sightseeing route offers several fun adventures, scenic views, and photo-friendly spots. Whether you decide to explore Rome on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Circus Maximus is the first of them. Spend some time admiring this standout archeological site before continuing your journey. Piazza Navona is your next stop. This globally renowned public square is one of the best-rated sights in Rome.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Pantheon. This culturally significant monument is a sight to behold. To round off your sightseeing experience, visit Trevi Fountain and Spanish Steps. If time allows, end your day with Villa Borghese, a mesmerizing park that offers a memorable conclusion to your exploration.

At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Santa Maria degli Angeli. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Cap off your dinner by heading to Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, ideal for a leisurely evening with a drink in hand.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 6

Day 6

  • Assisi
  • Brindisi
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Drive 676 km, 7 hours 18 min

  • Church of Santa Maria sopra Minerva in Assisi
  • Chiesa Nuova di San Francesco Convertito
  • Trulli di Alberobello Puglia
  • More

On day 6 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Santa Maria degli Angeli and Alberobello. In the evening, you’ll end up in Brindisi, where you will stay for 1 night.

Get ready for a day filled with fun adventures, picturesque spots, and history-rich sites in the charming town of Santa Maria degli Angeli. Your adventure starts at Church Of Santa Maria Sopra Minerva In Assisi, an underrated local hot spot. Another notable attraction to explore is Chiesa Nuova Di San Francesco Convertito. This increasingly popular church is known for its monumental appeal.

After soaking in the highlights of these sights, take some time to wander Santa Maria degli Angeli's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Trulli Di Alberobello Puglia. This visually striking historical landmark offers a fascinating experience that many visitors find memorable.

When you’re done exploring for the day, you’ll drive to your hotel in Brindisi. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Brindisi's best restaurants.

Make sure to reserve a table at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, an iconic dining spot in Brindisi. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bento, a popular restaurant in Brindisi. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Cozza Nera, a hidden gem nestled in Brindisi. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Say good night to Brindisi and look forward to another great day of your road trip in Italy!

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Day 7

Day 7

  • Brindisi - Departure day
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  • Saint Pietro of Schiavoni Archeologica Area
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Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Saint Pietro Of Schiavoni Archeologica Area, a photogenic archeological site before you head out.

Make the most of your final day in Italy by visiting Brindisi’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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