12-Day Italy Self-Drive Road Trip With Itinerary from Ancona to Florence, Lucca, Siena, Rome, and Santa Maria degli Angeli

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 2 nights.

Get ready for an exciting day in Ancona. Today’s sightseeing agenda includes a historical landmark, an art gallery, a palace, a public square and much more! Begin your adventure at Ponte Vecchio. This is a world-famous historical landmark you should not miss. Another must-see is Uffizi Gallery, a famous art gallery in Ancona.

When you’re ready for the next sight, head to Palazzo Vecchio. From there, take a leisurely stroll to Loggia Dei Lanzi, another of the city’s underrated attractions. We recommend continuing your self-guided tour at Piazza Della Signoria, a romantic place of interest in the city.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.

Let the evening flow smoothly from dinner to drinks at Manifattura, a top-rated bar in the area. For other recommendations, Se·sto On Arno Rooftop Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Il Vinile offers a memorable night with diverse drink options and excellent service.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Day 3 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Discover a day packed with family-friendly attractions, photo-friendly spots, and historic treasures in Florence. Begin your sightseeing with David. This locally renowned statue is one of the top attractions in the city. Proceed to Galleria Dell'accademia, another must-visit attraction.

As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Cathedral Of Santa Maria Del Fiore. This top-rated church is a traveler-favorite. Not far away, you’ll find Museo Dell'opera Del Duomo, another key site on your sightseeing itinerary. Basilica Of Santa Croce In Florence is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Piazzale Michelangelo and uncover why it's recognized as one of the city's most top-rated attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Make sure to reserve a table at Ditta Artigianale, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Da Burde, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Casa Toscana, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting Bar 50 Rosso, a prime location for a drink. Alternatively, explore the distinctive characteristics of Bitter Bar, a bar catering to every mood and preference. Archea Brewery likewise offers a unique atmosphere, perfect for a memorable night out.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Lucca. You’ll stay here for 2 nights.

Leaning Tower Of Pisa is must-visit monument and a great starting point for the day. Next, continue your journey to Angelo Caduto, an increasingly popular point of interest, located just a leisurely stroll away. Next, head to Pisa Cathedral, a historic church, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Florence. When you're ready, let your sightseeing route take you to the iconic Piazza Del Duomo, Pisa. If you’re looking for more, Cittadella Nuova is also an increasingly popular attraction that is worthwhile a visit.

When you’re done exploring for the day, you’ll drive to your hotel in Lucca. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Lucca's best restaurants.

Treat yourself to a delicious dinner at Gli Orti di Via Elisa, an excellent option for tonight's dining. Looking for something different? Bar Caffè Ristretto offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Schiaffino. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Lucca.

Round off your dining experience by visiting Lebowski - Cocktail Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Blend, a bar catering to every mood and preference. Franklin'33 likewise offers a unique atmosphere, perfect for a memorable night out.

Say good night to Lucca and look forward to another great day of your road trip in Italy!

Day 5 of your road trip across Italy promises a magnificent time exploring Lucca. You have 1 night left in Lucca. Take the opportunity to experience more of the best attractions and activities in the city.

Today’s well-planned self-sightseeing route offers several family-friendly attractions, romantic experiences, and breathtaking views. Whether you decide to explore Lucca on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Piazza Dell'anfiteatro is the first of them. Spend some time admiring this enchanting public square before continuing your journey. Guinigi Tower is your next stop. This intriguing monument is one of the best-rated sights in Lucca.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit St Martin Cathedral. This breathtaking church is a sight to behold. To round off your sightseeing experience, visit Palazzo Ducale Di Lucca and Mura Di Lucca. If time allows, end your day with Parrocchia Di San Concordio, an eye-catching church that offers a memorable conclusion to your exploration.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Lucca, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delightful dinner at Osteria Nova, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Bottega di Anna e Leo? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante Per 21 as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lucca.

Cap off your dinner by heading to La Tana Del Boia, ideal for a leisurely evening with a drink in hand. Vinarkia Della Pavona - Cocktail Bar is another bar that offers an enjoyable setting. Similarly, Magellano is also a popular place to go on a night out, perfect for relaxing and socializing.

Head back to your accommodation in Lucca and get some rest in preparation for another magical day of your road trip in Italy!

On day 7 of your road trip, you will have an entire day to explore Siena. You’ll stay in Siena for 1 night and discover all the best things to see and do in the area.

Get ready for a day filled with family-friendly attractions, photo-friendly spots, and historic treasures in the charming city of Siena. Your adventure starts at Pinacoteca Nazionale, a locally appreciated local hot spot. Another notable attraction to explore is Musei Dell’accademia Dei Fisiocritici. This curiosity-inducing museum is known for its photogenic appeal.

After soaking in the highlights of these sights, take some time to wander Siena's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Porta Tufi. This historic historical landmark offers a fascinating experience that many visitors find memorable.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Osteria Quattro Venti, an excellent option for tonight's dining. Looking for something different? Fischi per Fiaschi offers a tantalizing alternative with its diverse menu. And don’t miss Osteria da Divo. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Siena.

If you’re not ready to end the night just yet, Charlie Mixology Bar Di Aldinucci Riccardo offers a perfect venue to relax and savor a drink. Similarly, Bar Pinacoteca is well-suited for those looking to unwind in a social setting. San Paolo Pub is another excellent spot to enjoy a nightcap after a delightful meal.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Embark on another extraordinary experience on day 8 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 2 nights.

Discover a day packed with fun adventures, scenic views, and photo-friendly spots in Siena. Begin your sightseeing with Colosseum. This world-famous archeological site is one of the top attractions in the city. Proceed to Roman Forum, another must-visit attraction.

As you wander through the inviting streets of Siena, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Trevi Fountain. This wondrous monument is a traveler-favorite. Not far away, you’ll find Pantheon, another key site on your sightseeing itinerary. Piazza Navona is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.

Relax and recharge in preparation for another adventurous day in Italy!

On day 9 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you will return to Rome for 1 night more, there’s no need to rush. Experience Vatican City to the fullest today with this curated day itinerary!

Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Vatican City, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city. Be sure to also visit Monti, a neighborhood that showcases another side of Vatican City.

Start your adventure at Vatican Museums. This globally renowned art museum is a must-visit for travelers looking for a unique holiday experience. Make your way to Sistine Chapel located in Rome for another exciting encounter.

Next, immerse yourself in the setting of St. Peter's Basilica.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

If you’re not ready to end the night just yet, Sant' Eustachio Caffè offers a perfect venue to relax and savor a drink. Similarly, Yellowsquare Rome is well-suited for those looking to unwind in a social setting. Caffè Portofino is another excellent spot to enjoy a nightcap after a delightful meal.

Raise your glass to another unforgettable day in Italy!

On day 10 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Santa Maria degli Angeli. In the evening, you’ll end up in Santa Maria degli Angeli, where you will stay for 1 night.

Immerse yourself in Rome’s rich culture with today's sightseeing itinerary. Start your journey at Basilica Of San Francesco D'assisi. This UNESCO world heritage-listed church is sure to ignite your curiosity. Next, dive into the symbolic features of Rocca Maggiore, a must-visit castle in the town.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Piazza Del Comune, an increasingly popular public square. For a change of scene, check out Church Of Santa Maria Sopra Minerva In Assisi, known for its instagrammable features.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and spend some time relaxing before you head out to tour the town.

Indulge in a memorable dining experience at one of Santa Maria degli Angeli's most popular restaurants, and connect with friendly locals for an authentic adventure.

Following your dinner, dive into the local bar culture at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings. Enjoy this evening's relaxed ambiance with delightful drinks.

Raise your glass and celebrate another amazing day of your road trip in Italy!