12-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, Santa Maria degli Angeli, and Rome

Day 2 of your road trip will take you to the best attractions Genoa has to offer. Cherish the 1 night you have left in Genoa by discovering the best things there are to see and do in the city.

Bring your curiosity for today’s adventure around Genoa. Some of the city’s most loved attractions await! Lighthouse Of Genoa is the perfect place to start. This lighthouse is one of the most curiosity-inducing places to visit in Genoa. Next, head to Royal Palace Museum, an up-and-coming museum, known for its history-steeped features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Via Garibaldi. This history-steeped street is a highly recommended experience. Nearby, you'll also find Palazzo Podestà and Aquarium Of Genoa. Visit these for an interesting touch to your journey. Finish the day with a visit to Porto Antico, a romantic public square in Genoa.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Experience shopping bliss at Genoa as you explore Via Garibaldi. Take a leisurely stroll through unique boutiques and shops, where local treasures are waiting to be found. Beyond shopping, Via Garibaldi offers more options, including unique attractions, key services, and vibrant events.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at Zeffirino, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at Trattoria Vegia Zena, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Trattoria delle Grazie. It’s yet another ideal choice to enhance your time in Genoa tonight.

Relax and recharge in preparation for another adventurous day in Italy!

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Vernazza, Corniglia, Manarola, and Riomaggiore, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in La Spezia. You’ll stay here for 1 night.

Today’s route brings family-friendly attractions, romantic experiences, and scenic views. The first attraction of today is Ruins Of Doria Tower. This intriguing monument is a visually striking place to see in Genoa. Continue your discovery at Church Of St. Margaret Of Antioch, a historic church with stories to tell.

As you stroll around Genoa, take in the distinct atmosphere and learn what makes this village so unique. Maximize your sightseeing with a visit to Cinque Terre National Park. This locally renowned national park offers a mesmerizing encounter with Genoa. Next, make your way to Manarola Overlook Viewpoint to add another highlight to your day. After that, visit Riomaggiore, an often recommended point of interest that’s sure to impress. If you’re up for more, end your self-guided sightseeing tour at Church Of San Giovanni Battista Of Riomaggiore, an underrated church in the village. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Genoa.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of La Spezia's best restaurants.

Enjoy a delicious meal at The Colombaio Park, a highly-rated dining destination in La Spezia.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

A blend of family-friendly attractions, romantic experiences, and breathtaking views await you in La Spezia on today’s itinerary. First up is the increasingly popular church, Santa Maria Della Spina. Afterward, continue to Palazzo Blu, an art gallery every traveler should visit.

As you explore La Spezia’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Knights' Square. This worthwhile public square is an essential stop. Following that, head to Leaning Tower Of Pisa, another must-visit site that will enhance your experience. Don’t forget to stop by Piazza Del Duomo, Pisa, a timeless public square in the city. Finally, end your day with a visit to Pisa Cathedral, an UNESCO world heritage-listed church that offers the perfect conclusion to your sightseeing of the day.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely dining experience at Ristorante Oliviero 1962, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Di Poneta Novoli, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Caffe San Firenze. It’s yet another ideal choice to enhance your time in Florence tonight.

Cap off your dinner by heading to Manifattura, ideal for a leisurely evening with a drink in hand. Se·sto On Arno Rooftop Bar is another bar that offers an enjoyable setting. Similarly, Il Vinile is also a popular place to go on a night out, perfect for relaxing and socializing.

Savor another day of unforgettable experiences in Italy!

Day 5 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Get ready to discover some of the most iconic wonders in Florence, including a church, a public square, a palace, a historical landmark, an art gallery and much more! Start your day at Cathedral Of Santa Maria Del Fiore. This enchanting church is a widely recognized place to see in Florence. Then, wander over to Piazza Della Signoria. If enchanting sites excite you, this public square will be right up your alley. Nearby, you’ll also find Palazzo Vecchio. This respected palace is a favorite among visitors.

Florence offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Ponte Vecchio is a world-famous spot in the city that will captivate you with its unique charm. When you’re done at the historical landmark, don’t forget to check out the history-steeped Uffizi Gallery. Take a moment to appreciate the fascinating details of this astonishing art gallery. Wrap up your self-guided tour of Florence's top attractions with a visit to Basilica Of Santa Croce In Florence.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Round off your dining experience by visiting Bar 50 Rosso, a prime location for a drink. Alternatively, explore the distinctive characteristics of Bitter Bar, a bar catering to every mood and preference. Archea Brewery likewise offers a unique atmosphere, perfect for a memorable night out.

Celebrate another amazing day of your road trip adventure in Italy!

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Siena and San Gimignano. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in San Gimignano. You will spend 2 nights here for some well-deserved relaxation.

Get ready for a day filled with fun adventures, breathtaking views, and photo-friendly spots in the charming city of Florence. Your adventure starts at Basilica Of San Domenico, an underrated local hot spot. Another notable attraction to explore is Piazza Del Campo. This famous public square is known for its respected appeal.

After soaking in the highlights of these sights, take some time to wander Florence's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Tower Of Mangia. This UNESCO world heritage-designated monument offers a fascinating experience that many visitors find memorable. Siena Cathedral is also worth visiting, along with Piccolomini Library. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Porta San Giovanni. This frequently visited monument provides a fitting finale to your sightseeing.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in San Gimignano. San Gimignano offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Say good night to San Gimignano and look forward to another great day of your road trip in Italy!

Day 7 offers a multitude of experiences. You will stay in San Gimignano for 1 night more, offering you enough time to explore at a relaxed pace.

Immerse yourself in San Gimignano’s rich culture with today's sightseeing itinerary. Start your journey at Piazza Del Duomo. This inviting public square is sure to ignite your curiosity. Next, dive into the UNESCO world heritage-designated features of Palazzo Comunale, Pinacoteca, Torre Grossa, a must-visit museum in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Sangimignano1300, an intriguing museum. For a change of scene, check out Parco Della Rocca, known for its visually striking features. We also recommend visiting Rocca Di Montestaffoli. This castle is a must for anyone looking to experience the village to the fullest. Lastly, end your day with a visit to Chiesa Di Sant'agostino, yet another worthwhile attraction in San Gimignano.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of San Gimignano's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor another day of unforgettable experiences in Italy!

Embark on another extraordinary experience on day 8 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Santa Maria degli Angeli. At the end of the day, you will enjoy the comforts of a top-rated hotel in Santa Maria degli Angeli, which will be your home away from home for 1 night.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in San Gimignano allows for both. Start by heading to Basilica Of Santa Maria Degli Angeli. This popular church provides an insightful glimpse into the village's identity. Next, discover Basilica Of San Francesco D'assisi, a breathtaking church, promising a delightful encounter.

Continue your sightseeing with a visit to Porta San Giacomo, an increasingly popular sightseeing destination. When you’re done, don’t forget to make a stop at the intriguing Portico Of Monte Frumentario. Not far away from the historical landmark, you will find the enchanting Piazza Del Comune, perfect for a quick visit. Round off your day at Rocca Maggiore, another gem in San Gimignano with grand features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and spend some time relaxing before you head out to tour the town.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Santa Maria degli Angeli. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

After savoring a delicious meal, step into the vibrant nightlife at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, where the evening is just getting started.

Raise your glass to another unforgettable day in Italy!

On day 9 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 2 nights.

Discover a day packed with fun adventures, scenic views, and photo-friendly spots in Santa Maria degli Angeli. Begin your sightseeing with Colosseum. This globally renowned archeological site is one of the top attractions in the city. Proceed to Roman Forum, another must-visit attraction.

As you wander through the inviting streets of Santa Maria degli Angeli, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Pantheon. This world-famous monument is a traveler-favorite. Not far away, you’ll find Piazza Di Spagna, another key site on your sightseeing itinerary. Piazza Del Popolo is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

At the end of the day, you'll drive back to Rome, where you'll stay for 1 night more.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most wondrous attractions included on the itinerary is Vatican Museums.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the extraordinary Sistine Chapel. After exploring the chapel, head to Castel Sant'angelo. This astonishing castle is a highlight in Rome. As your day continues, stop by Piazza Navona, known for its history-steeped features. Lastly, don’t forget to check out the world-famous Trevi Fountain. Enjoy exploring this incredible monument at your own pace.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a wonderful meal at RomAntica, a top-rated dining spot in Rome. If you're in the mood for something new, try Coso Ristorante, another premier location with a delectable menu. You might also want to book a table at DEROMA - Farine Romane. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

To truly maximize your evening out, consider visiting Sant' Eustachio Caffè after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Yellowsquare Rome, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Dive into day 11 of your remarkable road trip in Italy. Today you will explore Orvieto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Today's adventure in Rome promises more breathtaking discoveries and enriching experiences! Begin at Well Of St. Patrick. This culturally significant monument is a highlight of any visit in the village. Then, enjoy Orvieto Cathedral, another romantic attraction that never fails to captivate visitors. Next, head over to Orvieto Underground, one of the village’s most worthwhile attractions, known for its standout features.

If you’re looking for more, spend time soaking in the atmosphere of Torre Del Moro Orvieto. This respected monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Pozzo Della Cava, a locally appreciated cave, and take a stroll around the area.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delightful dinner at Osteria Sant'Ilario, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Cialtroneria? It's another excellent option with a diverse menu. Consider reserving a table at Manhattan Bar as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Genoa.

Get a good night's sleep and look forward to another great day on the road in Italy!