4-Day Italy Self-Drive Road Trip With Itinerary from Genoa to Pisa

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Escape the ordinary with this exciting 4-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Uffizi Gallery.

As you hit the open road and drive through Genoa, Manarola, Pisa, Florence, and San Gimignano, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Aquarium of Genoa
Manarola Overlook ViewpointPisa CathedralPiazza del Duomo, PisaLeaning Tower of PisaKnights' SquareSanta Maria della Spina
Ponte VecchioUffizi Gallerypiazzale MichelangeloSanGimignano1300
piazza De Ferrari

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Day 1

Day 1

  • Genoa - Arrival day
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  • Aquarium of Genoa
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 1 night before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aquarium Of Genoa, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Dine in style at 7 Sensi cucina decontaminata, a top recommendation for dinner tonight. Or, for a change of pace, Alla Lunga Ristorante boasts a menu that's sure to impress. Also, be sure to check out Grand Hotel Savoia. Known as a local hotspot, it’s a great choice for tonight in Genoa.

Round off your dining experience by visiting Scurreria Beer & Bagel, a prime location for a drink. Alternatively, explore the distinctive characteristics of La Lepre, a bar catering to every mood and preference. Bar Pisacane Iii likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 4-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Pisa
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Drive 220 km, 4 hours 2 min

  • Manarola Overlook Viewpoint
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Knights' Square
  • Santa Maria della Spina
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Manarola and Pisa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Genoa is brimming with adventures. Today’s wonderful stops include an observation deck, a church, a public square, a monument and much more! Begin your sightseeing adventure at the increasingly popular Manarola Overlook Viewpoint and allow yourself time to explore. Just a short distance away you'll find your next stop, Pisa Cathedral, a breathtaking church that draws visitors from far and near.

Continue your journey to Piazza Del Duomo, Pisa, one of the village’s most wondrous spots that you shouldn’t miss. Another great site to visit is the globally renowned Leaning Tower Of Pisa. When you're finished at the monument, Knights' Square awaits your visit. This public square is a breathtaking highlight on today's itinerary. Last up is a church - the often recommended Santa Maria Della Spina.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Anima di Grano Pizzeria Napoletana Pisa Italy, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider il Mercante, another top spot with a mouthwatering menu. You might also want to secure a reservation at La Ghiotteria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pisa this evening.

Cap off your dinner by heading to Jeffer Cocktails & Friends, ideal for a leisurely evening with a drink in hand. Le Parisien Wine Bar is another bar that offers an enjoyable setting. Similarly, Las Volta Cocktailbar is also a popular place to go on a night out, perfect for relaxing and socializing.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 3

Day 3

  • Pisa
  • Genoa
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Drive 377 km, 5 hours 37 min

  • Ponte Vecchio
  • Uffizi Gallery
  • piazzale Michelangelo
  • SanGimignano1300
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Florence and San Gimignano. When you’re not sightseeing, take time to relax at your selected hotel in Genoa, where you’ll be staying for 1 night.

Start by visiting Ponte Vecchio, a prime spot to begin your journey. This visually striking historical landmark is sure to impress. Next on your list is Uffizi Gallery, another must-visit landmark and impressive art gallery renowned for its picture-perfect features.

While exploring and sightseeing, take time to savor the culture of Pisa by sampling some local delicacies. When you’re ready for more sightseeing, head to Piazzale Michelangelo. This enchanting observation deck is an essential place to visit for anyone looking for the full Pisa experience. We also recommend visiting Sangimignano1300, an increasingly popular museum.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Zeffirino, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Vegia Zena offers an enticing alternative with its varied menu. Additionally, Trattoria delle Grazie is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 4

Day 4

  • Genoa - Departure day
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  • piazza De Ferrari
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Day 4 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Piazza De Ferrari, an awe-inspiring public square before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Treat yourself to a delightful dinner at Osteria Sant'Ilario, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Cialtroneria? It's another excellent option with a diverse menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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