10-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Santa Maria degli Angeli, Siena, Florence, and Lucca

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Experience the freedom of the open road in Italy as you embark on an unforgettable 10-day road trip! This experience caters to every traveler, featuring destinations like Perugia, Santa Maria degli Angeli, Spello, Siena, Florence, Pisa, Lucca, Corniglia, Vernazza, Manarola, and Orvieto.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Perugia, 1 night in Santa Maria degli Angeli, 1 night in Siena, 2 nights in Florence, and 2 nights in Lucca. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Cathedral Of Santa Maria Del Fiore.

As you hit the open road and drive through Perugia, Santa Maria degli Angeli, Spello, Siena, Florence, Pisa, Lucca, Corniglia, Vernazza, Manarola, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
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Day
City & Overnight
Attractions
Frontone Gardens
The Fontana MaggiorePiazza IV NovembreNational GalleryCarducci GardensRocca PaolinaNational Archaeological Museum of Umbria
Basilica of San Francesco d'AssisiPortico of Monte FrumentarioPiazza del ComuneBasilica di Santa ChiaraRocca MaggiorePorta Consolare
Palazzo SalimbeniFortezza MediceaBasilica of San DomenicoSiena Cathedralpiazza del CampoTower of Mangia
Palazzo PittiPonte VecchioUffizi GalleryBasilica of Santa Croce in Florencepiazza della Signoria
Basilica of Santa Maria NovellaCentral MarketCathedral of Santa Maria del FioreGalleria dell'AccademiaDavidpiazzale Michelangelo

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Day 1

Day 1

  • Perugia - Arrival day
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  • Frontone Gardens
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Welcome to Perugia, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights immersing yourself in Perugia's charm before embarking on the next leg of your journey.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Frontone Gardens, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Perugia. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Ristorante Settimo Sigillo, a highly-rated dining destination in Perugia. If you're eager to try something different, consider Caffè Baglioni, another top spot with a tantalizing menu. You might also want to secure a reservation at Bar Pellas. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Perugia this evening.

Unwind after your meal by stepping into Tommi Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Valentina offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Caffe Dal Perugino, another top-rated bar in the area.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Perugia
  • More

Drive 2 km, 29 min

  • The Fontana Maggiore
  • Piazza IV Novembre
  • National Gallery
  • Carducci Gardens
  • Rocca Paolina
  • National Archaeological Museum of Umbria
  • More

On day 2 of your road trip, you will have an entire day to explore Perugia. You’ll stay in Perugia for 1 night and discover all the best things to see and do in the area.

Prepare for a day full of family-friendly attractions, breathtaking views, and picturesque spots. When you’re ready, kick off your sightseeing adventure at The Fontana Maggiore. This often recommended monument is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Piazza Iv Novembre, one of the city’s best highlights.

Next, check out National Gallery, one of the most intriguing places to see in Perugia. This art gallery is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Carducci Gardens. Wander around and soak in the instagrammable atmosphere this park offers. Then, head to Rocca Paolina, a top-rated historical landmark that adds another dimension to your day. Finally, visit the locally appreciated National Archaeological Museum Of Umbria, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at La Taverna, a top-rated dining destination in Perugia. If you're in the mood to try something new, consider Ristorante del Sole, another top spot with a mouthwatering menu. You might also want to secure a reservation at Al Mangiar Bene. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Perugia this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Caffè Fortebraccio, a well-loved spot among locals and tourists. Or, head to Caffe Del Banco. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Dempsey's Perugia, another top-rated place in the area.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Perugia
  • Assisi
  • More

Drive 55 km, 1 hour 48 min

  • Basilica of San Francesco d'Assisi
  • Portico of Monte Frumentario
  • Piazza del Comune
  • Basilica di Santa Chiara
  • Rocca Maggiore
  • Porta Consolare
  • More

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Santa Maria degli Angeli and Spello. In the evening, you’ll end up in Santa Maria degli Angeli, where you will stay for 1 night.

Get ready for an exciting day in Perugia. Today’s sightseeing agenda includes a church, a historical landmark, a public square, a castle, a monument and much more! Begin your adventure at Basilica Of San Francesco D'assisi. This is a captivating church you should not miss. Another must-see is Portico Of Monte Frumentario, an often recommended historical landmark in Perugia.

When you’re ready for the next sight, head to Piazza Del Comune. From there, take a leisurely stroll to Basilica Di Santa Chiara, another of the town’s frequently visited attractions. We recommend continuing your self-guided tour at Rocca Maggiore, a symbolic place of interest in the town. If time allows, add Porta Consolare to your itinerary. This often recommended monument offers the perfect finishing touch to your day in Perugia.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Santa Maria degli Angeli. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings stands out as an excellent choice for a post-dinner cocktail.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 4

Day 4

  • Assisi
  • Siena
  • More

Drive 132 km, 2 hours 19 min

  • Palazzo Salimbeni
  • Fortezza Medicea
  • Basilica of San Domenico
  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Siena, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Siena. You’ll stay here for 1 night.

Today, you'll explore some of the most beautiful places in Santa Maria degli Angeli, including a palace, a monument, a church, a public square and much more! Start your day with a visit to Palazzo Salimbeni. This increasingly popular palace is a must-visit in the city. When you’re ready for your next discovery, continue to Fortezza Medicea (siena), which may be one of the most breathtaking places you will experience today.

One of the best things about exploring Santa Maria degli Angeli on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Basilica Of San Domenico, a frequently visited church in the city. If you’re up for more discoveries, don’t forget to reserve some time for Siena Cathedral and Piazza Del Campo. End your day with a visit to Tower Of Mangia, a curiosity-inducing monument that’s sure to leave a lasting impression.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Enoteca I Terzi, a top pick for dinner tonight. Alternatively, Ristorante Tar-Tufo beckons with its unique menu offerings. Also, consider Antica Trattoria Papei. With its consistent customer satisfaction, it’s an excellent option for dining in Siena tonight.

Continue your lively evening at Meet Life Cafè, a perfect place for winding down or revving up the night, depending on which mood you’re in. Maudit Pub is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Impero Siena ensures a night out tailored to your taste.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5

  • Siena
  • Florence
  • More

Drive 73 km, 1 hour 26 min

  • Palazzo Pitti
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • piazza della Signoria
  • More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Florence. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Immerse yourself in Siena’s rich culture with today's sightseeing itinerary. Start your journey at Pitti Palace. This awe-inspiring palace is sure to ignite your curiosity. Next, dive into the history-steeped features of Ponte Vecchio, a must-visit historical landmark in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Uffizi Gallery, a spectacular art gallery. For a change of scene, check out Basilica Of Santa Croce In Florence, known for its heritage-rich features. We also recommend visiting Piazza Della Signoria. This public square is a must for anyone looking to experience the city to the fullest.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a lovely meal at Ristorante Oliviero 1962, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Di Poneta Novoli is another top choice with a popular menu. You could also check for a table at Caffe San Firenze. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Manifattura, a well-loved spot among locals and tourists. Or, head to Se·sto On Arno Rooftop Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Il Vinile, another top-rated place in the area.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 6

Day 6

  • Florence
  • More

Drive 11 km, 1 hour 6 min

  • Basilica of Santa Maria Novella
  • Central Market
  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • David
  • piazzale Michelangelo
  • More

Day 6 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Discover a day packed with family-friendly attractions, romantic experiences, and breathtaking views in Florence. Begin your sightseeing with Basilica Di Santa Maria Novella, Firenze (fi). This interesting church is one of the top attractions in the city. Proceed to Central Market, another must-visit attraction.

As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Cathedral Of Santa Maria Del Fiore. This top-rated church is a traveler-favorite. Not far away, you’ll find Galleria Dell'accademia, another key site on your sightseeing itinerary. David is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Piazzale Michelangelo and uncover why it's recognized as one of the city's most spectacular attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at Ditta Artigianale, an excellent option for tonight's dining. Looking for something different? Trattoria Da Burde offers a tantalizing alternative with its diverse menu. And don’t miss Casa Toscana. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Cap off your dinner by heading to Bar 50 Rosso, ideal for a leisurely evening with a drink in hand. Bitter Bar is another bar that offers an enjoyable setting. Similarly, Archea Brewery is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 7

Day 7

  • Florence
  • Lucca
  • More

Drive 107 km, 2 hours 14 min

  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Walls of Lucca
  • St Martin Cathedral
  • Piazza dell'Anfiteatro
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Pisa and Lucca. When you’re not sightseeing, take time to relax at your selected hotel in Lucca, where you’ll be staying for 2 nights.

Savor the day by visiting some of the best places to see in Florence, including a church, a public square, a monument, a historical landmark and much more! Start your adventure at Pisa Cathedral. This worthwhile church is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Del Duomo, Pisa located in Florence for another exciting encounter.

Next, immerse yourself in the setting of Leaning Tower Of Pisa. Its breathtaking features will captivate you. After the monument, continue your tour of the city with a visit to Mura Di Lucca. Visitors usually appreciate the enchanting features of this historical landmark. Next up is St Martin Cathedral, a highly recommended church. For a change of pace, head to Piazza Dell'anfiteatro. As one of the most captivating attractions in Florence, this public square is the perfect place to end your self-guided sightseeing tour.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Lucca. Lucca offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Lucca. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Gli Orti di Via Elisa, a top-rated dining spot in Lucca. If you're in the mood for something new, try Bar Caffè Ristretto, another premier location with a delectable menu. You might also want to book a table at Ristorante Schiaffino. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Lucca.

To truly maximize your evening out, consider visiting Lebowski - Cocktail Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Blend, another bar with an inviting ambiance. Similarly, Franklin'33 also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Say good night to Lucca and look forward to another great day of your road trip in Italy!

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Day 8

Day 8

  • Lucca
  • More

Drive 219 km, 4 hours 10 min

  • Scalinata Lardarina
  • Chiesa Di San Pietro
  • Ruins of Doria Tower
  • Church of St. Margaret of Antioch
  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • More

Wake up to day 8 of your extraordinary road trip in Italy. With 1 night left in Lucca, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Set out on a day brimming with family-friendly attractions, romantic experiences, and scenic views. Start at the underrated Scalinata Lardarina, an instagrammable hiking area in Lucca. Next, go to Chiesa Di San Pietro.

After visiting Scalinata Lardarina and Chiesa Di San Pietro, have a stroll along Lucca's streets and take in the local charm. Continue your sightseeing by heading to Ruins Of Doria Tower. This visually striking monument offers a unique experience. Church Of St. Margaret Of Antioch is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Cinque Terre National Park, one of the most mesmerizing places to visit in Lucca. If you still have some time left for sightseeing, we also recommend stopping by Manarola Overlook Viewpoint.

When you’re done exploring for the day, you’ll return to Lucca and your accommodation.

As you explore more of Lucca, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delicious dinner at Osteria Nova, an excellent option for tonight's dining. Looking for something different? La Bottega di Anna e Leo offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Per 21. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Lucca.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Tana Del Boia, known for its inviting atmosphere. Vinarkia Della Pavona - Cocktail Bar is another great option if you’re looking for a place to get the night started. Similarly, Magellano provides a great setting to enjoy the night away.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 9

Day 9

  • Lucca
  • Perugia
  • More

Drive 317 km, 4 hours 20 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Museo dell'Opera del Duomo
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Orvieto. At the end of the day, you will enjoy the comforts of a top-rated hotel in Perugia, which will be your home away from home for 1 night.

Get ready for a day filled with family-friendly attractions, scenic views, and photo-friendly spots in the charming village of Lucca. Your adventure starts at Well Of St. Patrick, an interesting local hot spot. Another notable attraction to explore is Orvieto Cathedral. This notable church is known for its awe-inspiring appeal.

After soaking in the highlights of these sights, take some time to wander Lucca's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Museo Dell'opera Del Duomo. This noteworthy museum offers a fascinating experience that many visitors find memorable. Orvieto Underground is also worth visiting, along with Torre Del Moro Orvieto. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Pozzo Della Cava. This beloved cave provides a fitting finale to your sightseeing.

When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Perugia, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely dining experience at Perugia Plaza Hotel, a popular restaurant in Perugia. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Perugia at Elfo Pub Perugia, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Sangallo Palace Hotel. It’s yet another ideal choice to enhance your time in Perugia tonight.

Round off your dining experience by visiting Il Birrino, a prime location for a drink. Alternatively, explore the distinctive characteristics of Quei Bravi Ragazzi, a bar catering to every mood and preference. Lo Chalet - Lounge Bar likewise offers a unique atmosphere, perfect for a memorable night out.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 10

Day 10

  • Perugia - Departure day
  • More
  • Etruscan Arch
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Etruscan Arch, a stunning historical landmark before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

Dine in style at Alphaville, a top recommendation for dinner tonight. Or, for a change of pace, Osteria a Priori boasts a menu that's sure to impress.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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